公开(公告)号：US08057376B2

公开(公告)日：2011-11-15

申请号：US12241441

申请日：2008-09-30

申请人： James R. Ladtkow ,  Joseph A. Scibona ,  Jeremy Kolenbrander

发明人： James R. Ladtkow ,  Joseph A. Scibona ,  Jeremy Kolenbrander

IPC分类号： B04B15/00 ,  G02B5/02

CPC分类号： G01N33/491 ,  G01N15/05 ,  G01N21/51 ,  G02B19/0028 ,  G02B19/0061

摘要： A centrifugal blood separation apparatus having an optical camera control system with a focused, stationary light source. A diffusion plate mounted on a rotor, rather than on or near the light source, allows an intense light beam to be transmitted from the light source to the rotor and then diffused at the rotor across an observation region. Different characteristics of a diffusion surface allow different lighting regions within the observation region. The diffusion plate has upper and lower plates with a diffusion surface sealed between the plates. This prevents degradation or contamination of the diffusion surface by abrasion, dirt, blood components or other materials that might incidentally contact the diffusion surface.

摘要翻译： 一种具有光学照相机控制系统的离心式血液分离装置，其具有聚焦的静止光源。 安装在转子上，而不是在光源上或附近的扩散板允许强光束从光源传递到转子，然后在转子处在观察区域上扩散。 扩散表面的不同特性允许观察区域内的不同照明区域。 扩散板具有在板之间密封的扩散表面的上板和下板。 这可防止由于磨损，污垢，血液成分或可能附带地接触扩散表面的其它材料而导致的扩散表面的降解或污染。

公开(公告)号：US20070102374A1

公开(公告)日：2007-05-10

申请号：US11163969

申请日：2005-11-04

申请人： Jeremy Kolenbrander

发明人： Jeremy Kolenbrander

IPC分类号： C02F1/38

CPC分类号： A61M1/3693 ,  A61M1/3692 ,  A61M1/3696 ,  B04B5/0442 ,  B04B2005/0471

摘要： A centrifuge for separating blood components, and methods for controlling the centrifuge. The apparatus has a fluid separation chamber having a first frustro-conical segment and a second frustro-conical segment. The second segment has a taper such that particles are subjected to substantially equal and opposite centripetal and fluid flow forces. A camera observes fluid flow, and a controller controls the flow. White blood cells are selectively captured within the second segment and are periodically flushed out of the fluid separation chamber. The camera is used to determine the quantity of particles captured. A limited quantity of high density particles, such as red blood cells, may be captured within the first segment before capturing relatively low density particles, such as white blood cells, within the second segment.

摘要翻译： 用于分离血液成分的离心机和用于控制离心机的方法。 该装置具有流体分离室，其具有第一截锥形段和第二截头圆锥段。 第二段具有锥形，使得颗粒经受基本相等且相对的向心和流体流动力。 摄像机观察流体流动，控制器控制流量。 白细胞被选择性地捕获在第二段内并被周期性地从流体分离室中冲出。 相机用于确定捕获的颗粒数量。 在第二段内捕获相对低密度的颗粒（例如白细胞）之前，可以在第一区段内捕获有限数量的高密度颗粒，例如红细胞。

公开(公告)号：US08337379B2

公开(公告)日：2012-12-25

申请号：US11772692

申请日：2007-07-02

申请人： Christopher Fletcher ,  William Sweat ,  Jeremy Kolenbrander ,  Aditya Dalvi ,  John R. Linder

发明人： Christopher Fletcher ,  William Sweat ,  Jeremy Kolenbrander ,  Aditya Dalvi ,  John R. Linder

IPC分类号： B04B9/10 ,  B04B13/00 ,  A61M37/00

CPC分类号： B04B13/00 ,  B04B5/0442 ,  B04B15/00 ,  B04B2013/006 ,  G01N15/042 ,  G01N15/05 ,  G01N33/491 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/181 ,  G06T2207/10016 ,  G06T2207/20068 ,  G06T2207/30024 ,  H04N7/18

摘要： A centrifuge for separating blood having a camera observing fluid flow, and a controller controlling the flow. The location of an interface is detected by image processing steps, which may comprise the steps of “spoiling” the image, “diffusing” the image, “edge detection”, “edge linking”, “region-based confirmation”, and “interface calculation”. “Spoiling” reduces the number of pixels to be examined preferentially on orthogonal axis oriented with respect to the expected location of the interface or phase boundary. “Diffusing” smoothes out small oscillations in the interface boundary, making the location of the interface more distinct. “Edge detection” computes the rate of change in pixel intensity, or. “Edge linking” connects adjacent maxima. “Region-based confirmation” creates a pseudo image of the regions that qualify as distinct. “Final edge calculation” uses the points where the shade changes in the pseudo image, averages the radial displacement of these points for the interface position.

摘要翻译： 一种离心机，用于分离具有观察流体流动的相机的血液，以及控制该流量的控制器。 通过图像处理步骤检测接口的位置，其可以包括破坏图像，扩散图像，边缘检测，边缘链接，基于区域的确认和接口计算的步骤。 扰乱减少了相对于接口或相位边界的预期位置定向的正交轴上优先检查的像素数。 扩散平滑了界面边界的小振荡，使界面的位置更加明显。 边缘检测计算像素强度的变化率，或。 边缘连接连接相邻的最大值。 基于区域的确认将创建符合不同区域的区域的伪图像。 最终边缘计算使用伪图像中阴影变化的点，对接口位置的这些点的径向位移进行平均。

公开(公告)号：US20090255155A1

公开(公告)日：2009-10-15

申请号：US12419902

申请日：2009-04-07

申请人： Joshua James ,  Fred Northup ,  Lawrence Scott Larson ,  Jeremy Kolenbrander ,  James Ladtkow

发明人： Joshua James ,  Fred Northup ,  Lawrence Scott Larson ,  Jeremy Kolenbrander ,  James Ladtkow

IPC分类号： G09F19/00 ,  B65B3/04 ,  F21V33/00

CPC分类号： G09F19/00 ,  G09F19/02 ,  Y10T29/49826

摘要： A dioramic apparatus includes a vessel having an inferior portion and a superior portion. The vessel includes a shell and defines an interior space. The interior space is partially filled by a liquid medium. At least one dioramic scene is disposed in the interior space. A reservoir is in fluid communication with the interior space. The reservoir includes a flow plate defining at least one liquid intake and at least one liquid output port. The at least one liquid intake is configured and arranged for receiving at least a portion of the liquid medium from the interior space when the dioramic apparatus is at least partially inverted. The at least one liquid output port is configured and arranged to output at least a portion of the liquid medium from the reservoir when the vessel is placed in an upright position.

摘要翻译： 全景设备包括具有下部和上部的容器。 容器包括壳体并限定内部空间。 内部空间被液体介质部分地填充。 至少一个全景场景被设置在内部空间中。 储存器与内部空间流体连通。 储存器包括限定至少一个液体入口和至少一个液体输出端口的流动板。 所述至少一个液体吸入口构造和布置成用于当所述全景设备至少部分倒置时从所述内部空间接收所述液体介质的至少一部分。 所述至少一个液体输出端口被构造和布置成当容器处于直立位置时从所述储存器输出液体介质的至少一部分。

公开(公告)号：US07671975B2

公开(公告)日：2010-03-02

申请号：US11613338

申请日：2006-12-20

申请人： Charles Patrick Mangan ,  Jeremy Kolenbrander

发明人： Charles Patrick Mangan ,  Jeremy Kolenbrander

IPC分类号： G01N33/48

CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M2205/331 ,  B04B13/00 ,  B04B2013/006 ,  G01N15/042 ,  G01N15/05 ,  G01N33/5002 ,  G01N2015/047

摘要： A centrifuge blood processing system for separating fluid components comprising a first light source comprising a plurality of light emitting diodes in optical communication with the centrifuge blood processing system for providing an incident light beam for illuminating an observation region on the centrifuge blood processing system, a light collection element in optical communication with the centrifuge blood processing system for collecting at least a portion of the light transmitted, scattered or both from the observation region, a programmable controller for providing an operational procedure for the monitoring system; and an independent dedicated control circuit in electrical communication with the programmable controller and electrically coupled to the light source, the control circuit receiving command parameters from the controller and controlling periods of illumination from the light source in response to the command parameters. Periods of illumination are controlled to prevent the failure of LEDs.

摘要翻译： 一种用于分离流体组分的离心机血液处理系统，包括：第一光源，包括与离心机血液处理系统光学连通的多个发光二极管，用于提供用于照射离心机血液处理系统上的观察区域的入射光束;光 与离心机血液处理系统进行光通信的收集元件，用于收集从观察区域透射，散射或两者的光的至少一部分;可编程控制器，用于为监视系统提供操作过程; 以及独立的专用控制电路，其与所述可编程控制器电连接并电耦合到所述光源，所述控制电路响应于所述命令参数从所述控制器接收命令参数并控制来自所述光源的照明周期。 控制照明周期以防止LED故障。

公开(公告)号：US07556611B2

公开(公告)日：2009-07-07

申请号：US11563898

申请日：2006-11-28

申请人： Jeremy Kolenbrander ,  William Palsulich ,  James Ladtkow ,  Dave Tyler ,  Jeffrey A. Steward ,  Dave Gibbons ,  John R. Lindner

发明人： Jeremy Kolenbrander ,  William Palsulich ,  James Ladtkow ,  Dave Tyler ,  Jeffrey A. Steward ,  Dave Gibbons ,  John R. Lindner

IPC分类号： A61M37/00 ,  G05D9/00 ,  G01F1/12

CPC分类号： F04B43/1253 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  A61M2205/123 ,  A61M2205/128 ,  A61M2205/3375 ,  A61M2205/3382 ,  A61M2205/3386 ,  A61M2205/3396 ,  A61M2205/702 ,  F04B43/0081

摘要： An extracorporeal blood processing system having a centrifugal rotor, a control system, a plurality of peristaltic pumps, and a removable tubing circuit wherein blood components can be processed. A pump-balancing process, implemented by the control system, causes selected pumps to fill and empty a reservoir in the tubing circuit. Ratios of displaced volume per pump revolution or other pumping action can be used by the control system to increase the effectiveness and efficiency of the donation process. The pump-balancing process may be performed during priming or set-up of the blood processing system or during an actual donation.

摘要翻译： 一种具有离心转子，控制系统，多个蠕动泵以及可以处理血液成分的可移除管路的体外血液处理系统。 由控制系统实现的泵平衡过程导致选定的泵填充和清空管道回路中的储存器。 控制系统可以使用泵泵转数或其他泵送动作的排量的比例来提高捐赠过程的有效性和效率。 泵平衡过程可以在启动或建立血液处理系统期间或在实际捐赠期间执行。

公开(公告)号：US20120055054A1

公开(公告)日：2012-03-08

申请号：US13296047

申请日：2011-11-14

申请人： Joshua James ,  Fred Northup ,  Lawrence Scott Larson ,  Jeremy Kolenbrander ,  James Ladtkow

发明人： Joshua James ,  Fred Northup ,  Lawrence Scott Larson ,  Jeremy Kolenbrander ,  James Ladtkow

IPC分类号： G09F19/00 ,  B23P11/00 ,  G09F27/00

CPC分类号： G09F19/00 ,  G09F19/02 ,  Y10T29/49826

摘要： A dioramic apparatus includes a vessel having an inferior portion and a superior portion. The vessel includes a shell and defines an interior space. The interior space is partially filled by a liquid medium. At least one dioramic scene is disposed in the interior space. A reservoir is in fluid communication with the interior space. The reservoir includes a flow plate defining at least one liquid intake and at least one liquid output port. The at least one liquid intake is configured and arranged for receiving at least a portion of the liquid medium from the interior space when the dioramic apparatus is at least partially inverted. The at least one liquid output port is configured and arranged to output at least a portion of the liquid medium from the reservoir when the vessel is placed in an upright position.

摘要翻译： 全景设备包括具有下部和上部的容器。 容器包括壳体并限定内部空间。 内部空间被液体介质部分地填充。 至少一个全景场景被设置在内部空间中。 储存器与内部空间流体连通。 储存器包括限定至少一个液体入口和至少一个液体输出端口的流动板。 所述至少一个液体吸入口构造和布置成用于当所述全景设备至少部分倒置时从所述内部空间接收所述液体介质的至少一部分。 所述至少一个液体输出端口被构造和布置成当容器处于直立位置时从所述储存器输出液体介质的至少一部分。

公开(公告)号：US08066888B2

公开(公告)日：2011-11-29

申请号：US12238697

申请日：2008-09-26

申请人： William Sweat ,  Jeremy Kolenbrander ,  John R. Lindner ,  Jennifer Hinz

发明人： William Sweat ,  Jeremy Kolenbrander ,  John R. Lindner ,  Jennifer Hinz

IPC分类号： B01D21/32

CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M2205/123 ,  A61M2205/3313

摘要： A blood cell collection system having means for detecting when a cell separation chamber has filled with white blood cells, and flushing the cells out of the cell separation chamber into a collect bag. A red-green sensor senses the optical characteristics of fluid leaving the cell separation chamber. A baseline value is calculated. The device calculates a ratio of the intensities of red light and green light and a peak-to-peak ratio of intensities. If either ratio exceeds thresholds computed from the baseline, the device flushes the cells into the collect bag. A camera detects white cells passing into the cell separation chamber and the device calculates the number of cells being collected. If the calculated number of collected cells exceeds a certain limit, the cell separation chamber is flushed. If the device is unable to establish a baseline, the donation can proceed, relying solely on the calculated number of collected cells.

摘要翻译： 一种血细胞收集系统，其具有用于检测细胞分离室何时已经填充有白细胞的装置，并且将细胞从细胞分离室冲洗成收集袋。 红绿色传感器检测离开细胞分离室的流体的光学特性。 计算基准值。 该装置计算红光和绿光的强度与强度的峰 - 峰比的比率。 如果任一比例超过从基线计算的阈值，则设备将细胞冲洗到收集袋中。 相机检测到进入细胞分离室的白细胞，并且该装置计算正在收集的细胞数量。 如果计算得到的细胞数超过一定限度，则细胞分离室被冲洗。 如果设备无法建立基线，捐赠可以继续进行，仅依赖于计算的收集细胞数。

公开(公告)号：US20050051466A1

公开(公告)日：2005-03-10

申请号：US10884877

申请日：2004-07-01

申请人： Lee Carter ,  Jeremy Kolenbrander ,  James Ladtkow ,  Joseph Scibona ,  Jeffrey Steward ,  Chris Fletcher

发明人： Lee Carter ,  Jeremy Kolenbrander ,  James Ladtkow ,  Joseph Scibona ,  Jeffrey Steward ,  Chris Fletcher

IPC分类号： A61M1/36 ,  B01D17/12 ,  B04B13/00 ,  G01N15/04 ,  G01N15/05

CPC分类号： G01N15/042 ,  A61M1/3693 ,  B04B13/00 ,  B04B2013/006 ,  G01N15/05 ,  G01N2015/047

摘要： The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components. In one aspect, the invention relates to optical methods, devices and device components for measuring two-dimensional distributions of transmitted light intensities, scattered light intensities or both from a separation chamber of a density centrifuge. In embodiment, two-dimensional distributions of transmitted light intensities, scattered light intensities or both measured by the methods of the present invention comprise images of a separation chamber or component thereof, such as an optical cell of a separation chamber. In another aspect, the present invention relates to multifunctional monitoring and control systems for blood processing, particularly blood processing via density centrifugation. Feedback control systems are provided wherein two-dimensional distributions of transmitted light intensities, scattered light intensities or both are measured, processed in real time and are used as the basis of output signals for controlling blood processing. In another aspect, optical cells and methods of using optical cells for monitoring and control blood processing are provided.

摘要翻译： 本发明一般涉及监测和控制血液和血液样品的处理，特别是将血液和血液样品分离成其组分的方法。 一方面，本发明涉及用于测量来自密度离心机的分离室的透射光强度，散射光强度或二者的二维分布的光学方法，装置和装置部件。 在实施例中，通过本发明的方法测量的透射光强度，散射光强度或二者的二维分布包括分离室或其分量（诸如分离室的光学单元）的图像。 另一方面，本发明涉及用于血液处理的多功能监测和控制系统，特别是通过密度离心进行血液处理。 提供反馈控制系统，其中测量透射光强度，散射光强度或二者的二维分布，实时处理，并用作控制血液处理的输出信号的基础。 在另一方面，提供了光学单元和使用光学单元来监测和控制血液处理的方法。

公开(公告)号：US08393099B2

公开(公告)日：2013-03-12

申请号：US13296047

申请日：2011-11-14

申请人： Joshua James ,  Fred Northup ,  Lawrence Scott Larson ,  Jeremy Kolenbrander ,  James Ladtkow

发明人： Joshua James ,  Fred Northup ,  Lawrence Scott Larson ,  Jeremy Kolenbrander ,  James Ladtkow

IPC分类号： G09F19/00 ,  G09F19/08 ,  E03B9/02 ,  B05B17/08 ,  B05B1/00 ,  B05B1/26 ,  F21S8/00

CPC分类号： G09F19/00 ,  G09F19/02 ,  Y10T29/49826

摘要： A dioramic apparatus includes a vessel having an inferior portion and a superior portion. The vessel includes a shell and defines an interior space. The interior space is partially filled by a liquid medium. At least one dioramic scene is disposed in the interior space. A reservoir is in fluid communication with the interior space. The reservoir includes a flow plate defining at least one liquid intake and at least one liquid output port. The at least one liquid intake is configured and arranged for receiving at least a portion of the liquid medium from the interior space when the dioramic apparatus is at least partially inverted. The at least one liquid output port is configured and arranged to output at least a portion of the liquid medium from the reservoir when the vessel is placed in an upright position.

摘要翻译： 全景设备包括具有下部和上部的容器。 容器包括壳体并限定内部空间。 内部空间被液体介质部分地填充。 至少一个全景场景被设置在内部空间中。 储存器与内部空间流体连通。 储存器包括限定至少一个液体入口和至少一个液体输出端口的流动板。 所述至少一个液体吸入口构造和布置成用于当所述全景设备至少部分倒置时从所述内部空间接收所述液体介质的至少一部分。 所述至少一个液体输出端口被构造和布置成当容器处于直立位置时从所述储存器输出液体介质的至少一部分。