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公开(公告)号：US07731965B2
公开(公告)日：2010-06-08
申请号：US11135040
申请日：2005-05-23
申请人： Jessie W. Shih , Joan D. Tyner , Matthew S. Matias , Mary S. Pinkus , Susan E. Brophy , David J. Dagfal , David J. Hawksworth , Bryan C. Tieman
发明人： Jessie W. Shih , Joan D. Tyner , Matthew S. Matias , Mary S. Pinkus , Susan E. Brophy , David J. Dagfal , David J. Hawksworth , Bryan C. Tieman
IPC分类号： A61K39/395 , A61K39/00 , C12P21/08
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/92
摘要： The present invention relates to antibodies that specifically bind to human BNP and immunoassays using said antibodies in the quantification of human BNP or a fragment of human BNP in a test sample.
摘要翻译： 本发明涉及在测试样品中定量人BNP或人BNP片段时使用所述抗体特异性结合人BNP和免疫测定的抗体。
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2.发明申请Antibodies and Improved Test Sample Handling Methods for Use in Assays for Myeloperoxidase 审中-公开抗体和改进的测试样品处理方法用于髓过氧化物酶的测定公开(公告)号：US20090148866A1
公开(公告)日：2009-06-11
申请号：US12122244
申请日：2008-05-16
申请人： Saul A. Datwyler , David J. Hawksworth , Stephen C. Hsu , Matthew S. Matias , David P. Pacenti , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman , Joan D. Tyner , Robert N. Ziemann , Lowell J. Tyner
发明人： Saul A. Datwyler , David J. Hawksworth , Stephen C. Hsu , Matthew S. Matias , David P. Pacenti , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman , Joan D. Tyner , Robert N. Ziemann , Lowell J. Tyner
IPC分类号： G01N33/573 , C12N5/06 , C12Q1/28 , C07K16/18
CPC分类号： C12Q1/28 , C07K16/40 , C07K2317/20 , C07K2317/92 , G01N33/573 , G01N33/6893 , G01N2800/50 , G01N2800/56
摘要： The present disclosure relates to isolated antibodies that can be used in an assay to determine the concentration levels of myeloperoxidase (MPO) in a test sample. Additionally, the present disclosure also relates to the use of improved test sample handling methods in assays in order to preserve the original MPO levels in the test sample.
摘要翻译： 本公开涉及可用于测定样品中髓过氧化物酶（MPO）的浓度水平的测定中的分离的抗体。 此外，本公开还涉及在测定中使用改进的测试样品处理方法，以便保留测试样品中的原始MPO水平。
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公开(公告)号：US07998480B2
公开(公告)日：2011-08-16
申请号：US12189232
申请日：2008-08-11
申请人： Susan E. Brophy , Joan D. Tyner , Lowell J. Tyner, legal representative , Bailin X. Tu , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman
发明人： Susan E. Brophy , Joan D. Tyner , Bailin X. Tu , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman
IPC分类号： A61K39/395 , C12N5/10 , G01N33/53
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/92 , G01N33/74 , G01N2333/58 , G01N2800/325 , Y10S435/975
摘要： The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.
摘要翻译： 本发明涉及以高结合亲和力免疫特异性结合人脑利钠肽或人脑利钠肽片段的抗体，用于产生和选择所述抗体的方法，人脑利钠肽的免疫测定或人脑利钠肽片段 所述抗体和含有所述抗体的治疗组合物。
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公开(公告)号：US20090123473A1
公开(公告)日：2009-05-14
申请号：US12189232
申请日：2008-08-11
申请人： Susan E. Brophy , Joan D. Tyner , Bailin X. Tu , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman , Lowell J. Tyner
发明人： Susan E. Brophy , Joan D. Tyner , Bailin X. Tu , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman , Lowell J. Tyner
IPC分类号： A61K31/395 , C07K16/00 , C12N5/06 , G01N33/53
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/92 , G01N33/74 , G01N2333/58 , G01N2800/325 , Y10S435/975
摘要： The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.
摘要翻译： 本发明涉及以高结合亲和力免疫特异性结合人脑利钠肽或人脑利钠肽片段的抗体，用于产生和选择所述抗体的方法，人脑利钠肽的免疫测定或人脑利钠肽片段 所述抗体和含有所述抗体的治疗组合物。
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公开(公告)号：US20100015637A1
公开(公告)日：2010-01-21
申请号：US12485114
申请日：2009-06-16
申请人： Susan E. Brophy , Lianli Chi , Saul A. Datwyler , David J. Hawksworth , Don M. Laird , Sharmila Manoj , Mary S. Pinkus , Dominick L. Pucci , Carol S. Ramsay , David C. Sogin , Bailin Tu , Joan D. Tyner , Lowell J Tyner , Zhiguang Yu , Robert N. Ziemann
发明人： Susan E. Brophy , Lianli Chi , Saul A. Datwyler , David J. Hawksworth , Don M. Laird , Sharmila Manoj , Mary S. Pinkus , Dominick L. Pucci , Carol S. Ramsay , David C. Sogin , Bailin Tu , Joan D. Tyner , Lowell J Tyner , Zhiguang Yu , Robert N. Ziemann
CPC分类号： C07K16/22 , C07K14/475 , C07K2317/92 , G01N33/74 , G01N2333/475
摘要： The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.
摘要翻译： 本公开涉及糖基化和去糖基化的人PlGF-1，使用糖基化和去糖基化的人PlGF-1的方法，与人PlGF-1结合的抗体，使用抗体和人PlGF-1免疫测定和试剂盒的方法。
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6.发明授权Recombinant antibodies against hepatitis C virus and methods of obtaining and using same 失效针对丙型肝炎病毒的重组抗体及其获得和使用方法公开(公告)号：US07858752B2
公开(公告)日：2010-12-28
申请号：US11633810
申请日：2006-12-05
申请人： Bailin Tu , Joan D. Tyner , James W. Scheffel , Michael K. White , Jeffrey M. Werneke , Robert N. Ziemann , David J. Hawksworth , Mary S. Pinkus , Robin A. Gutierrez
发明人： Bailin Tu , Joan D. Tyner , James W. Scheffel , Michael K. White , Jeffrey M. Werneke , Robert N. Ziemann , David J. Hawksworth , Mary S. Pinkus , Robin A. Gutierrez
CPC分类号： G01N33/5767 , C07K16/109 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/92
摘要： Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diagnostic reagents for the detection of HCV, and/or as standardization reagents or positive control reagents in assays for the detection of HCV. The recombinant antibodies can also be used in the treatment or prevention of a HCV infection.
摘要翻译： 提供了对丙型肝炎（HCV）抗原蛋白特异性的重组抗体，包括嵌合抗体。 重组抗体特异性结合HCV蛋白的诊断相关区域，因此适合用作检测HCV的诊断试剂，和/或用于检测HCV的测定中的标准化试剂或阳性对照试剂。 重组抗体也可用于治疗或预防HCV感染。
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7.发明授权Recombinant antibodies against hepatitis C virus and methods of obtaining and using same 有权针对丙型肝炎病毒的重组抗体及其获得和使用方法公开(公告)号：US08734793B2
公开(公告)日：2014-05-27
申请号：US12951735
申请日：2010-11-22
申请人： Bailin Tu , Joan D. Tyner , James W. Scheffel , Michael K. White , Jeffrey M. Werneke , Robert N. Ziemann , David J. Hawksworth , Mary S. Pinkus , Robin A. Gutierrez
发明人： Bailin Tu , Joan D. Tyner , James W. Scheffel , Michael K. White , Jeffrey M. Werneke , Robert N. Ziemann , David J. Hawksworth , Mary S. Pinkus , Robin A. Gutierrez
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： G01N33/5767 , C07K16/109 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/92
摘要： Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diagnostic reagents for the detection of HCV, and/or as standardization reagents or positive control reagents in assays for the detection of HCV. The recombinant antibodies can also be used in the treatment or prevention of a HCV infection.
摘要翻译： 提供了对丙型肝炎（HCV）抗原蛋白特异性的重组抗体，包括嵌合抗体。 重组抗体特异性结合HCV蛋白的诊断相关区域，因此适合用作检测HCV的诊断试剂，和/或用于检测HCV的测定中的标准化试剂或阳性对照试剂。 重组抗体也可用于治疗或预防HCV感染。
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8.发明申请Recombinant antibodies against hepatitis C virus and methods of obtaining and using same 失效针对丙型肝炎病毒的重组抗体及其获得和使用方法公开(公告)号：US20080131912A1
公开(公告)日：2008-06-05
申请号：US11633810
申请日：2006-12-05
申请人： Bailin Tu , Joan D. Tyner , James W. Scheffel , Michael K. White , Jeffrey M. Werneke , Robert N. Ziemann , David J. Hawksworth , Mary S. Pinkus , Robin A. Gutierrez
发明人： Bailin Tu , Joan D. Tyner , James W. Scheffel , Michael K. White , Jeffrey M. Werneke , Robert N. Ziemann , David J. Hawksworth , Mary S. Pinkus , Robin A. Gutierrez
CPC分类号： G01N33/5767 , C07K16/109 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/92
摘要： Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diagnostic reagents for the detection of HCV, and/or as standardization reagents or positive control reagents in assays for the detection of HCV. The recombinant antibodies can also be used in the treatment or prevention of a HCV infection.
摘要翻译： 提供了对丙型肝炎（HCV）抗原蛋白特异性的重组抗体，包括嵌合抗体。 重组抗体特异性结合HCV蛋白的诊断相关区域，因此适合用作检测HCV的诊断试剂，和/或用于检测HCV的测定中的标准化试剂或阳性对照试剂。 重组抗体也可用于治疗或预防HCV感染。
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9.发明申请RECOMBINANT ANTIBODIES AGAINST HEPATITIS C VIRUS AND METHODS OF OBTAINING AND USING SAME 有权抗重度丙型肝炎病毒的重组抗体及其获取和使用方法公开(公告)号：US20110263436A1
公开(公告)日：2011-10-27
申请号：US12951735
申请日：2010-11-22
申请人： Bailin Tu , Joan D. Tyner , James W. Scheffel , Michael K. White , Jeffrey M. Werneke , Robert N. Ziemann , David J. Hawksworth , Mary S. Pinkus , Robin A. Gutierrez
发明人： Bailin Tu , Joan D. Tyner , James W. Scheffel , Michael K. White , Jeffrey M. Werneke , Robert N. Ziemann , David J. Hawksworth , Mary S. Pinkus , Robin A. Gutierrez
CPC分类号： G01N33/5767 , C07K16/109 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/92
摘要： Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diagnostic reagents for the detection of HCV, and/or as standardization reagents or positive control reagents in assays for the detection of HCV. The recombinant antibodies can also be used in the treatment or prevention of a HCV infection.
摘要翻译： 提供了对丙型肝炎（HCV）抗原蛋白特异性的重组抗体，包括嵌合抗体。 重组抗体特异性结合HCV蛋白的诊断相关区域，因此适合用作检测HCV的诊断试剂，和/或用于检测HCV的测定中的标准化试剂或阳性对照试剂。 重组抗体也可用于治疗或预防HCV感染。
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公开(公告)号：US08741287B2
公开(公告)日：2014-06-03
申请号：US12485114
申请日：2009-06-16
申请人： Susan E. Brophy , Lianli Chi , Saul A Datwyler , David J. Hawksworth , Don M. Laird , Sharmila Manoj , Mary S. Pinkus , Dominick L. Pucci , Carol S. Ramsay , David C. Sogin , Bailin Tu , Zhiguang Yu , Robert N. Ziemann , Lowell J. Tyner
发明人： Susan E. Brophy , Lianli Chi , Saul A Datwyler , David J. Hawksworth , Don M. Laird , Sharmila Manoj , Mary S. Pinkus , Dominick L. Pucci , Carol S. Ramsay , David C. Sogin , Bailin Tu , Joan D. Tyner , Zhiguang Yu , Robert N. Ziemann
IPC分类号： A61K39/395 , C12Q3/00 , G01N33/53
CPC分类号： C07K16/22 , C07K14/475 , C07K2317/92 , G01N33/74 , G01N2333/475
摘要： The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.
摘要翻译： 本公开涉及糖基化和去糖基化的人PlGF-1，使用糖基化和去糖基化的人PlGF-1的方法，与人PlGF-1结合的抗体，使用抗体和人PlGF-1免疫测定和试剂盒的方法。
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