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公开(公告)号：US20090123473A1
公开(公告)日：2009-05-14
申请号：US12189232
申请日：2008-08-11
申请人： Susan E. Brophy , Joan D. Tyner , Bailin X. Tu , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman , Lowell J. Tyner
发明人： Susan E. Brophy , Joan D. Tyner , Bailin X. Tu , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman , Lowell J. Tyner
IPC分类号： A61K31/395 , C07K16/00 , C12N5/06 , G01N33/53
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/92 , G01N33/74 , G01N2333/58 , G01N2800/325 , Y10S435/975
摘要： The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.
摘要翻译： 本发明涉及以高结合亲和力免疫特异性结合人脑利钠肽或人脑利钠肽片段的抗体，用于产生和选择所述抗体的方法，人脑利钠肽的免疫测定或人脑利钠肽片段 所述抗体和含有所述抗体的治疗组合物。
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2.发明申请Antibodies and Improved Test Sample Handling Methods for Use in Assays for Myeloperoxidase 审中-公开抗体和改进的测试样品处理方法用于髓过氧化物酶的测定公开(公告)号：US20090148866A1
公开(公告)日：2009-06-11
申请号：US12122244
申请日：2008-05-16
申请人： Saul A. Datwyler , David J. Hawksworth , Stephen C. Hsu , Matthew S. Matias , David P. Pacenti , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman , Joan D. Tyner , Robert N. Ziemann , Lowell J. Tyner
发明人： Saul A. Datwyler , David J. Hawksworth , Stephen C. Hsu , Matthew S. Matias , David P. Pacenti , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman , Joan D. Tyner , Robert N. Ziemann , Lowell J. Tyner
IPC分类号： G01N33/573 , C12N5/06 , C12Q1/28 , C07K16/18
CPC分类号： C12Q1/28 , C07K16/40 , C07K2317/20 , C07K2317/92 , G01N33/573 , G01N33/6893 , G01N2800/50 , G01N2800/56
摘要： The present disclosure relates to isolated antibodies that can be used in an assay to determine the concentration levels of myeloperoxidase (MPO) in a test sample. Additionally, the present disclosure also relates to the use of improved test sample handling methods in assays in order to preserve the original MPO levels in the test sample.
摘要翻译： 本公开涉及可用于测定样品中髓过氧化物酶（MPO）的浓度水平的测定中的分离的抗体。 此外，本公开还涉及在测定中使用改进的测试样品处理方法，以便保留测试样品中的原始MPO水平。
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公开(公告)号：US20090203037A1
公开(公告)日：2009-08-13
申请号：US12342641
申请日：2008-12-23
申请人： Susan E. Brophy , David J. Hawksworth , Dinesh O. Shah , Robert W. Siegel , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Robert N. Ziemann
发明人： Susan E. Brophy , David J. Hawksworth , Dinesh O. Shah , Robert W. Siegel , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Robert N. Ziemann
CPC分类号： G01N33/56905 , C07K16/20 , C07K2317/24 , C07K2317/56 , C07K2317/92 , G01N2333/44 , G01N2469/10 , G01N2469/20 , G01N2496/00
摘要： The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
摘要翻译： 本公开涉及使用试剂检测克氏锥虫的表位的试剂和方法。
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公开(公告)号：US20090269777A1
公开(公告)日：2009-10-29
申请号：US12104410
申请日：2008-04-16
申请人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Ryan F. Workman , Robert N. Ziemann
发明人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Ryan F. Workman , Robert N. Ziemann
IPC分类号： G01N33/53
CPC分类号： G01N33/566
摘要： The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
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公开(公告)号：US20090123946A1
公开(公告)日：2009-05-14
申请号：US12329331
申请日：2008-12-05
申请人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Ryan F. Workman , Robert N. Ziemann , Lowell J. Tyner
发明人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Ryan F. Workman , Robert N. Ziemann , Lowell J. Tyner
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , C07K16/18 , G01N33/573 , G01N2333/58 , G01N2800/347
摘要： The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
摘要翻译： 本发明涉及NGAL免疫测定和试剂盒，以及在免疫测定和试剂盒中使用结合哺乳动物NGAL的糖基化哺乳动物NGAL和抗体的方法。 除此之外，方法和试剂盒可用于确定测试样品中人NGAL单体的量，以及确定测试样品中包含的人NGAL单体对人NGAL二聚体的比例。
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公开(公告)号：US20090124022A1
公开(公告)日：2009-05-14
申请号：US12104413
申请日：2008-04-16
申请人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann , Lowell J. Tyner
发明人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann , Lowell J. Tyner
IPC分类号： G01N33/566 , C07K16/18 , C12N5/06
CPC分类号： C07K16/18 , C07K2317/34 , C07K2317/55 , C07K2317/92
摘要： The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
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公开(公告)号：US20120076803A1
公开(公告)日：2012-03-29
申请号：US13319657
申请日：2010-02-23
申请人： Susan E. Brophy , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Dagang Huang , Robert N. Ziemann
发明人： Susan E. Brophy , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Dagang Huang , Robert N. Ziemann
IPC分类号： A61K39/395 , C07K16/46 , C07K16/18 , C12N15/13 , C12P21/08 , G01N33/577 , C12N1/21 , C12N1/00 , C12N1/15 , C12N5/10 , C12N1/19 , G01N33/566 , C12N5/071 , G01N33/53
CPC分类号： C07K16/18 , C07K14/4716 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C07K2317/92
摘要： The subject invention relates to antibodies to troponin I as well as methods of use thereof. In particular, such antibodies may be used to detect Troponin I in a patient and may also be used in the diagnosis of, for example, a myocardial infarction or acute coronary syndrome.
摘要翻译： 本发明涉及肌钙蛋白I的抗体及其使用方法。 特别地，这样的抗体可用于检测患者中的肌钙蛋白I，并且也可用于诊断例如心肌梗塞或急性冠状动脉综合征。
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公开(公告)号：US20100216720A1
公开(公告)日：2010-08-26
申请号：US12391937
申请日：2009-02-24
申请人： Susan E. Brophy , Bailin Tu , Joan D. Tyner , Dagang Huang , Robert N. Ziemann , Lowell J. Tyner
发明人： Susan E. Brophy , Bailin Tu , Joan D. Tyner , Dagang Huang , Robert N. Ziemann , Lowell J. Tyner
IPC分类号： A61K38/10 , G01N33/53 , C12P21/00 , C12N5/10 , C12N5/06 , C12N1/21 , C12N15/63 , A61K38/08 , C07K16/00 , C07H21/04
CPC分类号： C07K16/18 , C07K14/4716 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C07K2317/92
摘要： The subject invention relates to antibodies to troponin I as well as methods of use thereof. In particular, such antibodies may be used to detect Troponin I in a patient and may also be used in the diagnosis of, for example, a myocardial infarction or acute coronary syndrome.
摘要翻译： 本发明涉及肌钙蛋白I的抗体及其使用方法。 特别地，这样的抗体可用于检测患者中的肌钙蛋白I，并且也可用于诊断例如心肌梗塞或急性冠状动脉综合征。
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9.发明申请SOLUBLE FMS-LIKE TYROSINE KINASE-1 (sFLT-1) ANTIBODY AND RELATED COMPOSITION, KIT, METHODS OF USING, AND MATERIALS AND METHOD FOR MAKING 失效可溶性FMS-样酪氨酸激酶-1（sFLT-1）抗体及相关组合物，试剂盒，使用方法，材料和制备方法公开(公告)号：US20100266575A1
公开(公告)日：2010-10-21
申请号：US12643847
申请日：2009-12-21
申请人： Susan E. Brophy , Saul A. Datwyler , David J. Hawksworth , Don C. Laird , Sharmila Manoj , Dominick L. Pucci , Bryan C. Tieman , Joan Tyner , Lowell J. Tyner , Zhiguang Yu
发明人： Susan E. Brophy , Saul A. Datwyler , David J. Hawksworth , Don C. Laird , Sharmila Manoj , Dominick L. Pucci , Bryan C. Tieman , Joan Tyner , Lowell J. Tyner , Zhiguang Yu
IPC分类号： A61K39/395 , C07K16/40 , G01N33/573 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00 , A61P9/12
CPC分类号： C07K16/2863 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid.
摘要翻译： 特异性结合sFlt-1或其片段的分离的抗体，其具有（i）包含SEQ ID NO：2的氨基酸序列的可变重结构域，（ii）包含SEQ ID NO：2的氨基酸序列的可变轻区域区域 SEQ ID NO：4，或（iii）（i）和（ii）两者，药物组合物和包含这种抗体的试剂盒，制备这种抗体的方法，确定sFlt- 1或其片段，治疗或预防性地需要sFlt-1拮抗剂的方法，分离的核酸，其包含编码（i）SEQ ID NO：1的氨基酸序列的核苷酸序列， 2，（ii）SEQ ID NO：4或（iii）（i）和（ii），任选地作为载体的一部分，以及包含并表达这种核酸的宿主细胞。
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公开(公告)号：US20120142022A1
公开(公告)日：2012-06-07
申请号：US13354312
申请日：2012-01-19
申请人： Bailin Tu , Joan D. Tyner , Lowell J. Tyner
发明人： Bailin Tu , Joan D. Tyner , Lowell J. Tyner
IPC分类号： G01N33/53 , C07H21/04 , G01N33/566 , C07K14/435 , C12P21/06 , C12N5/07
CPC分类号： C07K14/47 , C07K2317/56 , C07K2317/92 , Y10T436/105831
摘要： The present invention relates to glycosylated mammalian NGAL, and methods of using said glycosylated mammalian NGAL.
摘要翻译： 本发明涉及糖基化哺乳动物NGAL，以及使用所述糖基化哺乳动物NGAL的方法。
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