专利检索 ap:("Susan E. Brophy" OR "Joan D. Tyner" OR "Bailin X. Tu" OR "Mary S. Pinkus" OR "Jessie W. Shih" OR "Bryan C. Tieman" OR "Lowell J. Tyner") AND inv:"Bryan C. Tieman" 第 1 页

1.

发明申请
HUMAN BNP IMMUNOSPECIFIC ANTIBODIES 失效
标题翻译：人体免疫球蛋白抗体

公开(公告)号：US20090123473A1

公开(公告)日：2009-05-14

申请号：US12189232

申请日：2008-08-11

申请人： Susan E. Brophy , Joan D. Tyner , Bailin X. Tu , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman , Lowell J. Tyner

发明人： Susan E. Brophy , Joan D. Tyner , Bailin X. Tu , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman , Lowell J. Tyner

IPC分类号： A61K31/395 , C07K16/00 , C12N5/06 , G01N33/53

CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/92 , G01N33/74 , G01N2333/58 , G01N2800/325 , Y10S435/975

摘要： The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.

摘要翻译： 本发明涉及以高结合亲和力免疫特异性结合人脑利钠肽或人脑利钠肽片段的抗体，用于产生和选择所述抗体的方法，人脑利钠肽的免疫测定或人脑利钠肽片段所述抗体和含有所述抗体的治疗组合物。

2.

发明授权
Human BNP immunospecific antibodies 失效
标题翻译：人BNP免疫特异性抗体

公开(公告)号：US07998480B2

公开(公告)日：2011-08-16

申请号：US12189232

申请日：2008-08-11

申请人： Susan E. Brophy , Joan D. Tyner , Lowell J. Tyner, legal representative , Bailin X. Tu , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman

发明人： Susan E. Brophy , Joan D. Tyner , Bailin X. Tu , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman

IPC分类号： A61K39/395 , C12N5/10 , G01N33/53

CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/92 , G01N33/74 , G01N2333/58 , G01N2800/325 , Y10S435/975

摘要： The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.

摘要翻译： 本发明涉及以高结合亲和力免疫特异性结合人脑利钠肽或人脑利钠肽片段的抗体，用于产生和选择所述抗体的方法，人脑利钠肽的免疫测定或人脑利钠肽片段所述抗体和含有所述抗体的治疗组合物。

3.

发明申请
Antibodies and Improved Test Sample Handling Methods for Use in Assays for Myeloperoxidase 审中-公开
标题翻译：抗体和改进的测试样品处理方法用于髓过氧化物酶的测定

公开(公告)号：US20090148866A1

公开(公告)日：2009-06-11

申请号：US12122244

申请日：2008-05-16

申请人： Saul A. Datwyler , David J. Hawksworth , Stephen C. Hsu , Matthew S. Matias , David P. Pacenti , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman , Joan D. Tyner , Robert N. Ziemann , Lowell J. Tyner

发明人： Saul A. Datwyler , David J. Hawksworth , Stephen C. Hsu , Matthew S. Matias , David P. Pacenti , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman , Joan D. Tyner , Robert N. Ziemann , Lowell J. Tyner

IPC分类号： G01N33/573 , C12N5/06 , C12Q1/28 , C07K16/18

CPC分类号： C12Q1/28 , C07K16/40 , C07K2317/20 , C07K2317/92 , G01N33/573 , G01N33/6893 , G01N2800/50 , G01N2800/56

摘要： The present disclosure relates to isolated antibodies that can be used in an assay to determine the concentration levels of myeloperoxidase (MPO) in a test sample. Additionally, the present disclosure also relates to the use of improved test sample handling methods in assays in order to preserve the original MPO levels in the test sample.

摘要翻译： 本公开涉及可用于测定样品中髓过氧化物酶（MPO）的浓度水平的测定中的分离的抗体。此外，本公开还涉及在测定中使用改进的测试样品处理方法，以便保留测试样品中的原始MPO水平。

4.

发明授权
Human ring specific BNP antibodies 有权
标题翻译：人环特异性BNP抗体

公开(公告)号：US07731965B2

公开(公告)日：2010-06-08

申请号：US11135040

申请日：2005-05-23

申请人： Jessie W. Shih , Joan D. Tyner , Matthew S. Matias , Mary S. Pinkus , Susan E. Brophy , David J. Dagfal , David J. Hawksworth , Bryan C. Tieman

发明人： Jessie W. Shih , Joan D. Tyner , Matthew S. Matias , Mary S. Pinkus , Susan E. Brophy , David J. Dagfal , David J. Hawksworth , Bryan C. Tieman

IPC分类号： A61K39/395 , A61K39/00 , C12P21/08

CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/92

摘要： The present invention relates to antibodies that specifically bind to human BNP and immunoassays using said antibodies in the quantification of human BNP or a fragment of human BNP in a test sample.

摘要翻译： 本发明涉及在测试样品中定量人BNP或人BNP片段时使用所述抗体特异性结合人BNP和免疫测定的抗体。

5.

发明申请
Anti-T. Cruzi Antibodies and Methods of Use 审中-公开
标题翻译：反T Cruzi抗体和使用方法

公开(公告)号：US20090203037A1

公开(公告)日：2009-08-13

申请号：US12342641

申请日：2008-12-23

申请人： Susan E. Brophy , David J. Hawksworth , Dinesh O. Shah , Robert W. Siegel , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Robert N. Ziemann

发明人： Susan E. Brophy , David J. Hawksworth , Dinesh O. Shah , Robert W. Siegel , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Robert N. Ziemann

IPC分类号： G01N33/53 , C07K16/20 , C12N1/00 , C07H21/04 , C07K1/14

CPC分类号： G01N33/56905 , C07K16/20 , C07K2317/24 , C07K2317/56 , C07K2317/92 , G01N2333/44 , G01N2469/10 , G01N2469/20 , G01N2496/00

摘要： The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.

摘要翻译： 本公开涉及使用试剂检测克氏锥虫的表位的试剂和方法。

6.

发明申请
IMMUNOASSAYS AND KITS FOR THE DETECTION OF NGAL 审中-公开

公开(公告)号：US20090269777A1

公开(公告)日：2009-10-29

申请号：US12104410

申请日：2008-04-16

申请人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Ryan F. Workman , Robert N. Ziemann

发明人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Ryan F. Workman , Robert N. Ziemann

IPC分类号： G01N33/53

CPC分类号： G01N33/566

摘要： The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.

7.

发明申请
IMMUNOASSAYS AND KITS FOR THE DETECTION OF NGAL 审中-公开
标题翻译：用于检测NGAL的免疫测定和试剂盒

公开(公告)号：US20090123946A1

公开(公告)日：2009-05-14

申请号：US12329331

申请日：2008-12-05

申请人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Ryan F. Workman , Robert N. Ziemann , Lowell J. Tyner

发明人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Ryan F. Workman , Robert N. Ziemann , Lowell J. Tyner

IPC分类号： G01N33/53

CPC分类号： G01N33/6893 , C07K16/18 , G01N33/573 , G01N2333/58 , G01N2800/347

摘要： The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.

摘要翻译： 本发明涉及NGAL免疫测定和试剂盒，以及在免疫测定和试剂盒中使用结合哺乳动物NGAL的糖基化哺乳动物NGAL和抗体的方法。除此之外，方法和试剂盒可用于确定测试样品中人NGAL单体的量，以及确定测试样品中包含的人NGAL单体对人NGAL二聚体的比例。