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公开(公告)号：US20090123473A1
公开(公告)日：2009-05-14
申请号：US12189232
申请日：2008-08-11
申请人： Susan E. Brophy , Joan D. Tyner , Bailin X. Tu , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman , Lowell J. Tyner
发明人： Susan E. Brophy , Joan D. Tyner , Bailin X. Tu , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman , Lowell J. Tyner
IPC分类号： A61K31/395 , C07K16/00 , C12N5/06 , G01N33/53
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/92 , G01N33/74 , G01N2333/58 , G01N2800/325 , Y10S435/975
摘要： The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.
摘要翻译： 本发明涉及以高结合亲和力免疫特异性结合人脑利钠肽或人脑利钠肽片段的抗体，用于产生和选择所述抗体的方法，人脑利钠肽的免疫测定或人脑利钠肽片段 所述抗体和含有所述抗体的治疗组合物。
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公开(公告)号：US07998480B2
公开(公告)日：2011-08-16
申请号：US12189232
申请日：2008-08-11
申请人： Susan E. Brophy , Joan D. Tyner , Lowell J. Tyner, legal representative , Bailin X. Tu , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman
发明人： Susan E. Brophy , Joan D. Tyner , Bailin X. Tu , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman
IPC分类号： A61K39/395 , C12N5/10 , G01N33/53
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/92 , G01N33/74 , G01N2333/58 , G01N2800/325 , Y10S435/975
摘要： The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.
摘要翻译： 本发明涉及以高结合亲和力免疫特异性结合人脑利钠肽或人脑利钠肽片段的抗体，用于产生和选择所述抗体的方法，人脑利钠肽的免疫测定或人脑利钠肽片段 所述抗体和含有所述抗体的治疗组合物。
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3.发明申请Antibodies and Improved Test Sample Handling Methods for Use in Assays for Myeloperoxidase 审中-公开抗体和改进的测试样品处理方法用于髓过氧化物酶的测定公开(公告)号：US20090148866A1
公开(公告)日：2009-06-11
申请号：US12122244
申请日：2008-05-16
申请人： Saul A. Datwyler , David J. Hawksworth , Stephen C. Hsu , Matthew S. Matias , David P. Pacenti , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman , Joan D. Tyner , Robert N. Ziemann , Lowell J. Tyner
发明人： Saul A. Datwyler , David J. Hawksworth , Stephen C. Hsu , Matthew S. Matias , David P. Pacenti , Mary S. Pinkus , Jessie W. Shih , Bryan C. Tieman , Joan D. Tyner , Robert N. Ziemann , Lowell J. Tyner
IPC分类号： G01N33/573 , C12N5/06 , C12Q1/28 , C07K16/18
CPC分类号： C12Q1/28 , C07K16/40 , C07K2317/20 , C07K2317/92 , G01N33/573 , G01N33/6893 , G01N2800/50 , G01N2800/56
摘要： The present disclosure relates to isolated antibodies that can be used in an assay to determine the concentration levels of myeloperoxidase (MPO) in a test sample. Additionally, the present disclosure also relates to the use of improved test sample handling methods in assays in order to preserve the original MPO levels in the test sample.
摘要翻译： 本公开涉及可用于测定样品中髓过氧化物酶（MPO）的浓度水平的测定中的分离的抗体。 此外，本公开还涉及在测定中使用改进的测试样品处理方法，以便保留测试样品中的原始MPO水平。
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公开(公告)号：US07731965B2
公开(公告)日：2010-06-08
申请号：US11135040
申请日：2005-05-23
申请人： Jessie W. Shih , Joan D. Tyner , Matthew S. Matias , Mary S. Pinkus , Susan E. Brophy , David J. Dagfal , David J. Hawksworth , Bryan C. Tieman
发明人： Jessie W. Shih , Joan D. Tyner , Matthew S. Matias , Mary S. Pinkus , Susan E. Brophy , David J. Dagfal , David J. Hawksworth , Bryan C. Tieman
IPC分类号： A61K39/395 , A61K39/00 , C12P21/08
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/92
摘要： The present invention relates to antibodies that specifically bind to human BNP and immunoassays using said antibodies in the quantification of human BNP or a fragment of human BNP in a test sample.
摘要翻译： 本发明涉及在测试样品中定量人BNP或人BNP片段时使用所述抗体特异性结合人BNP和免疫测定的抗体。
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公开(公告)号：US20100015637A1
公开(公告)日：2010-01-21
申请号：US12485114
申请日：2009-06-16
申请人： Susan E. Brophy , Lianli Chi , Saul A. Datwyler , David J. Hawksworth , Don M. Laird , Sharmila Manoj , Mary S. Pinkus , Dominick L. Pucci , Carol S. Ramsay , David C. Sogin , Bailin Tu , Joan D. Tyner , Lowell J Tyner , Zhiguang Yu , Robert N. Ziemann
发明人： Susan E. Brophy , Lianli Chi , Saul A. Datwyler , David J. Hawksworth , Don M. Laird , Sharmila Manoj , Mary S. Pinkus , Dominick L. Pucci , Carol S. Ramsay , David C. Sogin , Bailin Tu , Joan D. Tyner , Lowell J Tyner , Zhiguang Yu , Robert N. Ziemann
CPC分类号： C07K16/22 , C07K14/475 , C07K2317/92 , G01N33/74 , G01N2333/475
摘要： The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.
摘要翻译： 本公开涉及糖基化和去糖基化的人PlGF-1，使用糖基化和去糖基化的人PlGF-1的方法，与人PlGF-1结合的抗体，使用抗体和人PlGF-1免疫测定和试剂盒的方法。
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公开(公告)号：US20090203037A1
公开(公告)日：2009-08-13
申请号：US12342641
申请日：2008-12-23
申请人： Susan E. Brophy , David J. Hawksworth , Dinesh O. Shah , Robert W. Siegel , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Robert N. Ziemann
发明人： Susan E. Brophy , David J. Hawksworth , Dinesh O. Shah , Robert W. Siegel , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Robert N. Ziemann
CPC分类号： G01N33/56905 , C07K16/20 , C07K2317/24 , C07K2317/56 , C07K2317/92 , G01N2333/44 , G01N2469/10 , G01N2469/20 , G01N2496/00
摘要： The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
摘要翻译： 本公开涉及使用试剂检测克氏锥虫的表位的试剂和方法。
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公开(公告)号：US20090269777A1
公开(公告)日：2009-10-29
申请号：US12104410
申请日：2008-04-16
申请人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Ryan F. Workman , Robert N. Ziemann
发明人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Ryan F. Workman , Robert N. Ziemann
IPC分类号： G01N33/53
CPC分类号： G01N33/566
摘要： The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
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公开(公告)号：US20090123946A1
公开(公告)日：2009-05-14
申请号：US12329331
申请日：2008-12-05
申请人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Ryan F. Workman , Robert N. Ziemann , Lowell J. Tyner
发明人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Ryan F. Workman , Robert N. Ziemann , Lowell J. Tyner
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , C07K16/18 , G01N33/573 , G01N2333/58 , G01N2800/347
摘要： The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
摘要翻译： 本发明涉及NGAL免疫测定和试剂盒，以及在免疫测定和试剂盒中使用结合哺乳动物NGAL的糖基化哺乳动物NGAL和抗体的方法。 除此之外，方法和试剂盒可用于确定测试样品中人NGAL单体的量，以及确定测试样品中包含的人NGAL单体对人NGAL二聚体的比例。
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公开(公告)号：US20090124022A1
公开(公告)日：2009-05-14
申请号：US12104413
申请日：2008-04-16
申请人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann , Lowell J. Tyner
发明人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann , Lowell J. Tyner
IPC分类号： G01N33/566 , C07K16/18 , C12N5/06
CPC分类号： C07K16/18 , C07K2317/34 , C07K2317/55 , C07K2317/92
摘要： The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
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公开(公告)号：US20120076803A1
公开(公告)日：2012-03-29
申请号：US13319657
申请日：2010-02-23
申请人： Susan E. Brophy , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Dagang Huang , Robert N. Ziemann
发明人： Susan E. Brophy , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Dagang Huang , Robert N. Ziemann
IPC分类号： A61K39/395 , C07K16/46 , C07K16/18 , C12N15/13 , C12P21/08 , G01N33/577 , C12N1/21 , C12N1/00 , C12N1/15 , C12N5/10 , C12N1/19 , G01N33/566 , C12N5/071 , G01N33/53
CPC分类号： C07K16/18 , C07K14/4716 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C07K2317/92
摘要： The subject invention relates to antibodies to troponin I as well as methods of use thereof. In particular, such antibodies may be used to detect Troponin I in a patient and may also be used in the diagnosis of, for example, a myocardial infarction or acute coronary syndrome.
摘要翻译： 本发明涉及肌钙蛋白I的抗体及其使用方法。 特别地，这样的抗体可用于检测患者中的肌钙蛋白I，并且也可用于诊断例如心肌梗塞或急性冠状动脉综合征。
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