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公开(公告)号：US06479633B1
公开(公告)日：2002-11-12
申请号：US09238184
申请日：1999-01-27
申请人： Jian Ni , Reiner L. Gentz , Jeffrey Y. Su , Haodong Li
发明人： Jian Ni , Reiner L. Gentz , Jeffrey Y. Su , Haodong Li
IPC分类号： C07K100
CPC分类号： C07K14/522 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要： Human chemokine Alpha-2 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptides in a host.
摘要翻译： 公开了人趋化因子α-2多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。
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公开(公告)号：US07122639B2
公开(公告)日：2006-10-17
申请号：US10267900
申请日：2002-10-10
申请人： Jian Ni , Reiner L. Gentz , Jeffrey Y. Su , Haodong Li
发明人： Jian Ni , Reiner L. Gentz , Jeffrey Y. Su , Haodong Li
IPC分类号： A16K39/395 , G01N33/567 , C07K1/00 , C12N5/12 , C12P21/20
CPC分类号： C07K14/522 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要： Human chemokine Alpha-2-polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are method for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptides in a host.
摘要翻译： 公开了人趋化因子α-2-多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。
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公开(公告)号：US5910431A
公开(公告)日：1999-06-08
申请号：US825556
申请日：1997-03-19
申请人： Jian Ni , Reiner L. Gentz , Jeffrey Y. Su , Haodong Li
发明人： Jian Ni , Reiner L. Gentz , Jeffrey Y. Su , Haodong Li
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K48/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/08 , A61P43/00 , C07K14/52 , C07K16/24 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/08 , C12Q1/00 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C12N1/00 , C12N15/00
CPC分类号： C07K14/522 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要： Human chemokine Alpha-2 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptides in a host.
摘要翻译： 公开了人趋化因子α-2多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。
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公开(公告)号：US07309780B2
公开(公告)日：2007-12-18
申请号：US11378243
申请日：2006-03-20
申请人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
发明人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及NKAF II多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US06448044B2
公开(公告)日：2002-09-10
申请号：US08832488
申请日：1997-04-03
申请人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
发明人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
IPC分类号： C12P2102
摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及NKAF II多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US5919658A
公开(公告)日：1999-07-06
申请号：US832535
申请日：1997-04-03
申请人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
发明人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
CPC分类号： C07K14/8139 , A61K38/00 , C07K2319/00
摘要： The invention relates to cystatin F polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及半胱氨酸蛋白酶抑制剂F多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US06576745B1
公开(公告)日：2003-06-10
申请号：US09528436
申请日：2000-03-17
申请人： Haodong Li , Guo-Liang Yu , Reiner L. Gentz , Jian Ni
发明人： Haodong Li , Guo-Liang Yu , Reiner L. Gentz , Jian Ni
IPC分类号： C07K1600
CPC分类号： C07K14/8139 , A61K38/00 , C07K2319/00
摘要： The invention relates to Cystatin F polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及半胱氨酸蛋白酶抑制剂F多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US06066617A
公开(公告)日：2000-05-23
申请号：US19485
申请日：1998-01-29
申请人： Haodong Li , Guo-Liang Yu , Reiner L. Gentz , Jian Ni
发明人： Haodong Li , Guo-Liang Yu , Reiner L. Gentz , Jian Ni
IPC分类号： G01N33/53 , A61K38/00 , A61P27/02 , A61P29/00 , A61P31/00 , A61P43/00 , C07K14/81 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/68 , C07K1/00
CPC分类号： C07K14/8139 , A61K38/00 , C07K2319/00
摘要： The invention relates to Cystatin F polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
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公开(公告)号：US07078482B2
公开(公告)日：2006-07-18
申请号：US10192611
申请日：2002-07-11
申请人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
发明人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及NKAF II多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US07419662B2
公开(公告)日：2008-09-02
申请号：US10935306
申请日：2004-09-08
申请人： Jian Ni , Haodong Li , Jeffrey Y. Su
发明人： Jian Ni , Haodong Li , Jeffrey Y. Su
IPC分类号： A61K39/395 , C07K16/10
CPC分类号： C07K14/522
摘要： Human chemokine Alpha-3 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, sepsis, wound healing and psoriasis and to stimulate stem cell mobilization. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, ARDS and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.
摘要翻译： 公开了人趋化因子α-3多肽和编码这种趋化性细胞因子的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，败血症，伤口愈合和牛皮癣并刺激干细胞移动的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫和慢性和急性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧，ARDS和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。
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