公开(公告)号：US06479633B1

公开(公告)日：2002-11-12

申请号：US09238184

申请日：1999-01-27

申请人： Jian Ni ,  Reiner L. Gentz ,  Jeffrey Y. Su ,  Haodong Li

发明人： Jian Ni ,  Reiner L. Gentz ,  Jeffrey Y. Su ,  Haodong Li

IPC分类号： C07K100

CPC分类号： C07K14/522 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/026

摘要： Human chemokine Alpha-2 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptides in a host.

摘要翻译： 公开了人趋化因子α-2多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

公开(公告)号：US07122639B2

公开(公告)日：2006-10-17

申请号：US10267900

申请日：2002-10-10

申请人： Jian Ni ,  Reiner L. Gentz ,  Jeffrey Y. Su ,  Haodong Li

发明人： Jian Ni ,  Reiner L. Gentz ,  Jeffrey Y. Su ,  Haodong Li

IPC分类号： A16K39/395 ,  G01N33/567 ,  C07K1/00 ,  C12N5/12 ,  C12P21/20

CPC分类号： C07K14/522 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/026

摘要： Human chemokine Alpha-2-polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are method for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptides in a host.

摘要翻译： 公开了人趋化因子α-2-多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

公开(公告)号：US5910431A

公开(公告)日：1999-06-08

申请号：US825556

申请日：1997-03-19

申请人： Jian Ni ,  Reiner L. Gentz ,  Jeffrey Y. Su ,  Haodong Li

发明人： Jian Ni ,  Reiner L. Gentz ,  Jeffrey Y. Su ,  Haodong Li

IPC分类号： C12N15/02 ,  A61K31/00 ,  A61K38/00 ,  A61K48/00 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/00 ,  A61P37/08 ,  A61P43/00 ,  C07K14/52 ,  C07K16/24 ,  C12N5/10 ,  C12N15/09 ,  C12N15/19 ,  C12P21/08 ,  C12Q1/00 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C12N1/00 ,  C12N15/00

CPC分类号： C07K14/522 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/026

摘要： Human chemokine Alpha-2 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptides in a host.

摘要翻译： 公开了人趋化因子α-2多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

公开(公告)号：US07803615B1

公开(公告)日：2010-09-28

申请号：US09042583

申请日：1998-03-17

申请人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Jeffrey Y. Su ,  Craig A. Rosen

发明人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Jeffrey Y. Su ,  Craig A. Rosen

IPC分类号： C07K14/705 ,  C12N5/10 ,  C12N15/12 ,  C12N15/62 ,  C12N15/63

CPC分类号： C07K14/7151 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.

摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族的成员的新的含有死亡域的受体-5（DR5）蛋白，现在已经显示结合TRAIL。 特别地，提供编码人DR5蛋白的分离的核酸分子。 还提供了DR5多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。

公开(公告)号：US20090062510A1

公开(公告)日：2009-03-05

申请号：US11737622

申请日：2007-04-19

申请人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner L. Gentz ,  Jeffrey Y. Su

发明人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner L. Gentz ,  Jeffrey Y. Su

IPC分类号： C07K14/52

CPC分类号： C07K14/52 ,  C07H21/04

摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.

摘要翻译： 公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

公开(公告)号：US07098316B2

公开(公告)日：2006-08-29

申请号：US10314942

申请日：2002-12-10

申请人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz ,  Jeffrey Y. Su ,  Geoffrey Krissansen ,  Ping Feng

发明人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz ,  Jeffrey Y. Su ,  Geoffrey Krissansen ,  Ping Feng

IPC分类号： C07K16/00

CPC分类号： C07K14/70535 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70503 ,  C12N9/6421 ,  C12N9/6475 ,  C12N9/6489 ,  C12N9/6491 ,  C12N2799/026

摘要： The present invention relates to novel human proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells and recombinant methods for producing the proteins of the invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及包含编码这种蛋白质的基因的编码区的新型人类蛋白质和分离的核酸。 还提供了用于产生本发明的蛋白质的载体，宿主细胞和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US07419662B2

公开(公告)日：2008-09-02

申请号：US10935306

申请日：2004-09-08

申请人： Jian Ni ,  Haodong Li ,  Jeffrey Y. Su

发明人： Jian Ni ,  Haodong Li ,  Jeffrey Y. Su

IPC分类号： A61K39/395 ,  C07K16/10

CPC分类号： C07K14/522

摘要： Human chemokine Alpha-3 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, sepsis, wound healing and psoriasis and to stimulate stem cell mobilization. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, ARDS and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.

摘要翻译： 公开了人趋化因子α-3多肽和编码这种趋化性细胞因子的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，败血症，伤口愈合和牛皮癣并刺激干细胞移动的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫和慢性和急性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧，ARDS和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

公开(公告)号：US07393943B1

公开(公告)日：2008-07-01

申请号：US08761289

申请日：1996-12-06

申请人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner Gentz ,  Jeffrey Y. Su

发明人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner Gentz ,  Jeffrey Y. Su

IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N1/20 ,  C12N15/00 ,  C12N5/00 ,  C12N5/02 ,  C12N15/74

CPC分类号： C07K14/52 ,  C07H21/04

摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.

摘要翻译： 公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

公开(公告)号：US06653445B1

公开(公告)日：2003-11-25

申请号：US09010147

申请日：1998-01-21

申请人： Jian Ni ,  Craig A. Rosen ,  Reiner Gentz ,  Jeffrey Y. Su ,  Geoffrey W. Krissansen ,  Ping Feng

发明人： Jian Ni ,  Craig A. Rosen ,  Reiner Gentz ,  Jeffrey Y. Su ,  Geoffrey W. Krissansen ,  Ping Feng

IPC分类号： C07K1400

CPC分类号： C07K14/70535 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70503 ,  C12N9/6421 ,  C12N9/6475 ,  C12N9/6489 ,  C12N9/6491 ,  C12N2799/026

摘要： The present invention relates to novel human proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells and recombinant methods for producing the proteins of the invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及包含编码这种蛋白质的基因的编码区的新型人类蛋白质和分离的核酸。 还提供了用于产生本发明的蛋白质的载体，宿主细胞和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US07164612B1

公开(公告)日：2007-01-16

申请号：US10683636

申请日：2003-10-10

申请人： Nadeem N. Eleyan ,  Howard L. Levy ,  Jeffrey Y. Su

发明人： Nadeem N. Eleyan ,  Howard L. Levy ,  Jeffrey Y. Su

IPC分类号： G11C7/00

CPC分类号： G11C29/02 ,  G11C29/026 ,  G11C29/028 ,  G11C2029/5004

摘要： Post-manufacture compensation for a sensing offset can be provided, at least in part, by selectively exposing one of a pair of cross-coupled transistors in a sense amplifier to a bias voltage selected to cause a compensating shift in a characteristic of the exposed transistor. In designs susceptible to post-manufacture data dependent creep in a device characteristic, such exposure may be advantageously provided in situ by causing the sense amplifier to sense values purposefully skewed toward a predominate value selected to cause the compensating shift. In some realizations, an on-chip test block is employed to identify and characterize sensing mismatch. Typically, the techniques described herein may be employed to address sensing offsets that have developed post-manufacture due to a data-dependent effect. However, in some realizations, the techniques described herein may be used to address a sensing offset arising at least in part from other or additional sources.

摘要翻译： 可以至少部分地通过将感测放大器中的一对交叉耦合晶体管中的一个选择性地暴露于所选择的偏置电压以提供暴露的晶体管的特性的补偿偏移来提供用于感测偏移的制造后补偿 。 在易受设备特性的后制造数据依赖性蠕变的设计中，可以有利地通过使读出放大器感测到有选择地偏向所选择的主要值以引起补偿偏移的位置来提供这种曝光。 在一些实现中，使用片上测试块来识别和表征感测不匹配。 通常，本文描述的技术可以用于解决由于数据相关效应而在制造后开发的感测偏移。 然而，在一些实现中，本文描述的技术可以用于解决至少部分地从其他源或附加源产生的感测偏移。