公开(公告)号：US20080294270A1

公开(公告)日：2008-11-27

申请号：US11753102

申请日：2007-05-24

申请人： Jian Q. Yao ,  Hai-Qing Xian ,  Jizong Gao ,  Rodney Bristol ,  Victor Zaporojan ,  Hali Wang ,  Hui Liu

发明人： Jian Q. Yao ,  Hai-Qing Xian ,  Jizong Gao ,  Rodney Bristol ,  Victor Zaporojan ,  Hali Wang ,  Hui Liu

IPC分类号： A61L27/38 ,  A61F2/28 ,  D01C3/00

CPC分类号： A61L27/3608 ,  A61L27/3604 ,  A61L27/3683

摘要： A method of preparing an implantable biological device having a first tissue part and a second tissue part includes exposing the first tissue part to a first preparation method and preventing exposure of the second biological tissue part to the first preparation method. Preventing exposure of the second biological tissue part to the first preparation method may be achieved using an embedding technique, a coating technique, a covering technique, or physical isolation. The method may further include exposing the second tissue part to a second preparation method and preventing exposure of the first biological tissue part to the second preparation method. An apparatus for preparing an implantable biologic device includes an enclosure having first and second chambers separated by a partition member wherein a substantial portion of the first tissue part is within the first chamber and a substantial portion of the second tissue part is within the second chamber.

摘要翻译： 制备具有第一组织部分和第二组织部分的可植入生物装置的方法包括将第一组织部分暴露于第一制备方法并防止第二生物组织部分暴露于第一制备方法。 可以使用嵌入技术，涂覆技术，覆盖技术或物理隔离来防止第二生物组织部分暴露于第一制备方法。 该方法可以进一步包括将第二组织部分暴露于第二制备方法并防止第一生物组织部分暴露于第二制备方法。 一种用于制备可植入生物装置的装置，包括具有由分隔构件分开的第一和第二腔室的外壳，其中所述第一组织部分的大部分位于所述第一腔室内，并且所述第二组织部分的大部分位于所述第二腔室内。

公开(公告)号：US08162961B2

公开(公告)日：2012-04-24

申请号：US11781517

申请日：2007-07-23

申请人： Victor Zaporojan ,  Jian Q. Yao ,  Rodney Bristol ,  Hui Liu ,  Hali Wang ,  Hai-Qing Xian

发明人： Victor Zaporojan ,  Jian Q. Yao ,  Rodney Bristol ,  Hui Liu ,  Hali Wang ,  Hai-Qing Xian

IPC分类号： A61B17/04

CPC分类号： A61B17/0469 ,  A61B17/0467 ,  A61B17/0482 ,  A61B17/06066 ,  A61B17/320016 ,  A61B2017/00353 ,  A61B2017/06042 ,  A61B2017/320052

摘要： Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.

摘要翻译： 用于切割和缝合生物组织的医疗装置通常包括轴和第一和第二引导构件，每个引导构件包括在第一位置处联接到所述轴的第一部分和在第二位置处联接到所述轴的第二部分。 第一部分可相对于第二部分沿着轴可移动，并且第一和第二引导构件限定弓形轮廓并且构造成响应于这种移动而弯曲。 当用于切割组织时，医疗装置还可以包括位于第一和第二引导构件之间的刀片。 当用于缝合组织时，可以在第一引导构件上设置一个或多个缝合线引导件，用于引导缝合针穿过靠近第一引导构件的组织。 还提供了使用医疗装置修复和替换弯液面的方法。

公开(公告)号：US20120179173A1

公开(公告)日：2012-07-12

申请号：US13426167

申请日：2012-03-21

申请人： Victor Zaporojan ,  Jian Q. Yao ,  Rodney Bristol ,  Hui Liu ,  Hali Wang ,  Hai-Qing Xian

发明人： Victor Zaporojan ,  Jian Q. Yao ,  Rodney Bristol ,  Hui Liu ,  Hali Wang ,  Hai-Qing Xian

IPC分类号： A61B17/04

CPC分类号： A61B17/0469 ,  A61B17/0467 ,  A61B17/0482 ,  A61B17/06066 ,  A61B17/320016 ,  A61B2017/00353 ,  A61B2017/06042 ,  A61B2017/320052

摘要： Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.

摘要翻译： 用于切割和缝合生物组织的医疗装置通常包括轴和第一和第二引导构件，每个引导构件包括在第一位置处联接到所述轴的第一部分和在第二位置处联接到所述轴的第二部分。 第一部分可相对于第二部分沿着轴可移动，并且第一和第二引导构件限定弓形轮廓并且构造成响应于这种移动而弯曲。 当用于切割组织时，医疗装置还可以包括位于第一和第二引导构件之间的刀片。 当用于缝合组织时，可以在第一引导构件上设置一个或多个缝合线引导件，用于引导缝合针穿过靠近第一引导构件的组织。 还提供了使用医疗装置修复和替换弯液面的方法。

公开(公告)号：US20090030431A1

公开(公告)日：2009-01-29

申请号：US11781517

申请日：2007-07-23

申请人： Victor Zaporojan ,  Jian Q. Yao ,  Rodney Bristol ,  Hui Liu ,  Hali Wang ,  Hai-Qing Xian

发明人： Victor Zaporojan ,  Jian Q. Yao ,  Rodney Bristol ,  Hui Liu ,  Hali Wang ,  Hai-Qing Xian

IPC分类号： A61B17/04 ,  A61B17/32

CPC分类号： A61B17/0469 ,  A61B17/0467 ,  A61B17/0482 ,  A61B17/06066 ,  A61B17/320016 ,  A61B2017/00353 ,  A61B2017/06042 ,  A61B2017/320052

摘要： Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.

摘要翻译： 用于切割和缝合生物组织的医疗装置通常包括轴和第一和第二引导构件，每个引导构件包括在第一位置处联接到所述轴的第一部分和在第二位置处联接到所述轴的第二部分。 第一部分可相对于第二部分沿着轴可移动，并且第一和第二引导构件限定弓形轮廓并且构造成响应于这种移动而弯曲。 当用于切割组织时，医疗装置还可以包括位于第一和第二引导构件之间的刀片。 当用于缝合组织时，可以在第一引导构件上设置一个或多个缝合线引导件，用于引导缝合针穿过靠近第一引导构件的组织。 还提供了使用医疗装置修复和替换弯液面的方法。

公开(公告)号：US20100297766A1

公开(公告)日：2010-11-25

申请号：US12864207

申请日：2009-02-03

申请人： Hai-Qing Xian ,  Hali Wang ,  Hui Liu ,  Jian Q. Yao ,  Jizong Gao

发明人： Hai-Qing Xian ,  Hali Wang ,  Hui Liu ,  Jian Q. Yao ,  Jizong Gao

IPC分类号： C12N5/02

CPC分类号： A61K38/4826 ,  A61K38/465 ,  C12Y301/01003 ,  C12Y304/21004

摘要： A method of removing undesired tissue from a connective tissue is provided that includes stretching the connective tissue and peeling away the undesired tissue. Some methods include soaking the connective tissue in a solution prior to and/or subsequent to stretching and peeling away the undesired tissue. The solution may include a detergent, an enzyme, a salt solution, an organic solvent, and combinations thereof.

摘要翻译： 提供从结缔组织中去除不想要的组织的方法，其包括拉伸结缔组织并剥离不想要的组织。 一些方法包括在拉伸和/或剥离不想要的组织之前和/或之后将结缔组织浸泡在溶液中。 溶液可以包括洗涤剂，酶，盐溶液，有机溶剂及其组合。

公开(公告)号：US20080306610A1

公开(公告)日：2008-12-11

申请号：US11759679

申请日：2007-06-07

申请人： Hali Wang ,  Hui Liu ,  Hai-Qing Xian ,  Jian Q. Yao ,  Victor Zaporojan

发明人： Hali Wang ,  Hui Liu ,  Hai-Qing Xian ,  Jian Q. Yao ,  Victor Zaporojan

IPC分类号： A61F2/02 ,  C12N5/02

CPC分类号： A61L27/3654 ,  A61K35/32 ,  A61K35/34 ,  A61K35/44 ,  A61L27/3633 ,  A61L27/3687 ,  A61L2430/40

摘要： Methods for processing tissues to render them suitable for implantation, e.g. in an orthopedic site. Tissues are rendered substantially acellular and substantially nonimmunogenic by exposure to processes that result in cell lysis, increasing permeability of the extracellular matrix, degrading the debris from lysis, and removing the debris. Methods of forming tissue implants, kits for processing tissue implants, and methods of using tissue implants are also disclosed.

摘要翻译： 用于处理组织以使其适合植入的方法，例如， 在矫形部位。 组织通过暴露于导致细胞裂解，增加细胞外基质的渗透性，降解碎裂从裂解中除去碎屑的过程而基本上是非细胞的并且基本上是非免疫原性的。 还公开了形成组织植入物的方法，用于处理组织植入物的试剂盒和使用组织植入物的方法。

公开(公告)号：US08608759B2

公开(公告)日：2013-12-17

申请号：US13426167

申请日：2012-03-21

申请人： Victor Zaporojan ,  Jian Q. Yao ,  Rodney E. Bristol ,  Hui Liu ,  Hali Wang ,  Hai-Qing Xian

发明人： Victor Zaporojan ,  Jian Q. Yao ,  Rodney E. Bristol ,  Hui Liu ,  Hali Wang ,  Hai-Qing Xian

IPC分类号： A61B17/04

CPC分类号： A61B17/0469 ,  A61B17/0467 ,  A61B17/0482 ,  A61B17/06066 ,  A61B17/320016 ,  A61B2017/00353 ,  A61B2017/06042 ,  A61B2017/320052

摘要： Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.

摘要翻译： 用于切割和缝合生物组织的医疗装置通常包括轴和第一和第二引导构件，每个引导构件包括在第一位置处联接到所述轴的第一部分和在第二位置处联接到所述轴的第二部分。 第一部分可相对于第二部分沿着轴可移动，并且第一和第二引导构件限定弓形轮廓并且构造成响应于这种移动而弯曲。 当用于切割组织时，医疗装置还可以包括位于第一和第二引导构件之间的刀片。 当用于缝合组织时，可以在第一引导构件上设置一个或多个缝合线引导件，用于引导缝合针穿过靠近第一引导构件的组织。 还提供了使用医疗装置修复和替换弯液面的方法。

公开(公告)号：US20110110888A1

公开(公告)日：2011-05-12

申请号：US13001284

申请日：2009-06-26

申请人： Hai-Qing Xian ,  Jian Q. Yao ,  Hali Wang ,  Massoud Daheshia ,  Hui Liu

发明人： Hai-Qing Xian ,  Jian Q. Yao ,  Hali Wang ,  Massoud Daheshia ,  Hui Liu

IPC分类号： A61K38/20 ,  C12N5/071 ,  C12M3/00 ,  A61K38/18 ,  A61K38/22 ,  A61K38/39 ,  A61K38/29 ,  A61K38/28 ,  A61K38/26 ,  A61K38/23 ,  A61K38/19 ,  A61K38/21 ,  A61P43/00

CPC分类号： A61L27/22 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/43 ,  A61L2300/64

摘要： A system and method for producing a scaffold coated and/or impregnated with at least one bioactive agent. This is accomplished by culturing at least one cell in the same medium as a scaffold, but without physical contact between the at least one cell and the scaffold. The system includes a container having a surface defining an interior compartment. A medium is disposed within the interior compartment. At least one cell is disposed within the medium, the at least one cell being capable of producing at least one bioactive agent. Further, a scaffold is disposed within the medium. The scaffold is physically separated from the at least one cell such that there is no contact between the scaffold and the at least one cell. Thus, as the at least one cell produces at least one bioactive agent, such as a growth factor, the at least one bioactive agent enters the medium, and contacts and coats and/or impregnates the scaffold. However, due to the physical separation of the scaffold and at least one cell, the at least one cell is prevented from contacting and coating and/or impregnating the scaffold. Thus, only the desired bioactive agent or agents coat and/or impregnate the scaffold.

摘要翻译： 用于生产用至少一种生物活性剂包被和/或浸渍的支架的系统和方法。 这是通过在与支架相同的培养基中培养至少一个细胞，但是在至少一个细胞和支架之间没有物理接触来实现的。 该系统包括具有限定内部隔间的表面的容器。 介质设置在内部隔室内。 至少一个细胞设置在培养基内，所述至少一个细胞能够产生至少一种生物活性剂。 此外，在培养基内设置支架。 骨架与至少一个细胞物理分离，使得支架与至少一个细胞之间不存在接触。 因此，由于至少一个细胞产生至少一种生物活性剂，例如生长因子，所述至少一种生物活性剂进入培养基，并接触并涂覆和/或浸渍支架。 然而，由于支架和至少一个电池的物理分离，防止了至少一个电池接触和涂覆和/或浸渍支架。 因此，只有所需的生物活性剂或药剂包衣和/或浸渍支架。

公开(公告)号：US20130131699A1

公开(公告)日：2013-05-23

申请号：US13679041

申请日：2012-11-16

申请人： Tao Jiang ,  Jian Q. Yao ,  Hali Wang ,  Timothy A. Hoeman ,  Ray Zubok ,  John Chernosky ,  Keith A. Roby

发明人： Tao Jiang ,  Jian Q. Yao ,  Hali Wang ,  Timothy A. Hoeman ,  Ray Zubok ,  John Chernosky ,  Keith A. Roby

IPC分类号： A61B17/68

CPC分类号： A61F2/0811 ,  A61B17/68 ,  A61F2002/0858 ,  A61F2002/0888 ,  A61F2250/0021 ,  A61F2250/0023 ,  A61F2250/0026 ,  A61L27/04 ,  A61L27/56

摘要： The present disclosure relates, in some aspects, to orthopaedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopaedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.

公开(公告)号：US20140178343A1

公开(公告)日：2014-06-26

申请号：US13799452

申请日：2013-03-13

申请人： Jian Q. Yao ,  Hali Wang

发明人： Jian Q. Yao ,  Hali Wang

IPC分类号： A61L27/36 ,  C12N5/077 ,  A61L27/38

CPC分类号： C12N5/0655 ,  A61L27/3612 ,  A61L27/3852 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/43 ,  A61L2430/06 ,  C12N2500/90 ,  C12N2501/10 ,  C12N2501/20 ,  C12N2501/30

摘要： The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage tissue pieces derived from donor or engineered tissue. The methods and supports described herein promote cell migration and integration of neighboring tissue pieces in culture to form the cartilage composition. Methods of cartilage repair using the cartilage composition are also described.