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    Recombinant microorganisms for increased production of organic acids
    1.
    发明授权
    Recombinant microorganisms for increased production of organic acids 有权
    用于增加有机酸生产的重组微生物

    公开(公告)号：US08431373B2

    公开(公告)日：2013-04-30

    申请号：US13328894

    申请日：2011-12-16

    申请人： Jian Yi ,  Susanne Kleff ,  Michael V. Guettler

    发明人： Jian Yi ,  Susanne Kleff ,  Michael V. Guettler

    IPC分类号： C12N1/20 ,  C12N15/74

    CPC分类号： C12N9/0006 ,  C12P7/46

    摘要： Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.

    摘要翻译： 公开了用于生产有机酸的重组微生物。 重组微生物表达具有在戊糖磷酸循环中使用的酶的酶活性的多肽。 重组微生物可以包含已经被转化以表达Zwischenferment（Zwf）基因的重组放线杆菌属的基因。 重组微生物可用于生产有机酸如琥珀酸和乳酸的发酵方法。 还公开了可用于转化微生物以产生表达诸如Zwf之类的酶的重组微生物的新质粒。

    RECOMBINANT MICROORGANISMS FOR INCREASED PRODUCTION OF ORGANIC ACIDS
    2.
    发明申请
    RECOMBINANT MICROORGANISMS FOR INCREASED PRODUCTION OF ORGANIC ACIDS 有权
    用于增加有机酸生产的重组微生物

    公开(公告)号：US20120164703A1

    公开(公告)日：2012-06-28

    申请号：US13328894

    申请日：2011-12-16

    申请人： Jian YI ,  Susanne Kleff ,  Michael V. Guettler

    发明人： Jian YI ,  Susanne Kleff ,  Michael V. Guettler

    IPC分类号： C12P7/46 ,  C12N1/21

    CPC分类号： C12N9/0006 ,  C12P7/46

    摘要： Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.

    摘要翻译： 公开了用于生产有机酸的重组微生物。 重组微生物表达具有在戊糖磷酸循环中使用的酶的酶活性的多肽。 重组微生物可以包含已经被转化以表达Zwischenferment（Zwf）基因的重组放线杆菌属的基因。 重组微生物可用于生产有机酸如琥珀酸和乳酸的发酵方法。 还公开了可用于转化微生物以产生表达诸如Zwf之类的酶的重组微生物的新质粒。

    Recombinant microorganisms for increased production of organic acids
    3.
    发明授权
    Recombinant microorganisms for increased production of organic acids 有权
    用于增加有机酸生产的重组微生物

    公开(公告)号：US08119377B2

    公开(公告)日：2012-02-21

    申请号：US11722579

    申请日：2005-12-16

    申请人： Jian Yi ,  Susanne Kleff ,  Michael V. Guettler

    发明人： Jian Yi ,  Susanne Kleff ,  Michael V. Guettler

    IPC分类号： C12N1/20 ,  C12N15/74

    CPC分类号： C12N9/0006 ,  C12P7/46

    摘要： Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.

    摘要翻译： 公开了用于生产有机酸的重组微生物。 重组微生物表达具有在戊糖磷酸循环中使用的酶的酶活性的多肽。 重组微生物可以包含已经被转化以表达Zwischenferment（Zwf）基因的重组放线杆菌属的基因。 重组微生物可用于生产有机酸如琥珀酸和乳酸的发酵方法。 还公开了可用于转化微生物以产生表达诸如Zwf之类的酶的重组微生物的新质粒。

    Recombinant Microorganisms For Increased Production of Organic Acids
    4.
    发明申请
    Recombinant Microorganisms For Increased Production of Organic Acids 有权
    用于增加有机酸生产的重组微生物

    公开(公告)号：US20080305533A1

    公开(公告)日：2008-12-11

    申请号：US11722579

    申请日：2005-12-16

    申请人： Jian Yi ,  Susanne Kleff ,  Michael V. Guettler

    发明人： Jian Yi ,  Susanne Kleff ,  Michael V. Guettler

    IPC分类号： C12P7/46 ,  C12N1/21

    CPC分类号： C12N9/0006 ,  C12P7/46

    摘要： Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.

    摘要翻译： 公开了用于产生有机酸的重组微生物。 重组微生物表达具有在戊糖磷酸循环中使用的酶的酶活性的多肽。 重组微生物可以包含已经被转化以表达Zwischenferment（Zwf）基因的重组放线杆菌属的基因。 重组微生物可用于生产有机酸如琥珀酸和乳酸的发酵方法。 还公开了可用于转化微生物以产生表达诸如Zwf之类的酶的重组微生物的新质粒。

    Fermentation Method Using A Magnesium Compound Containing Oxygen
    8.
    发明申请
    Fermentation Method Using A Magnesium Compound Containing Oxygen 有权
    使用含氧化镁的发酵方法

    公开(公告)号：US20100323416A1

    公开(公告)日：2010-12-23

    申请号：US12488417

    申请日：2009-06-19

    申请人： Michael V. Guettler ,  Robert J. Hanchar ,  Denise S. Rumler ,  Susanne Kleff

    发明人： Michael V. Guettler ,  Robert J. Hanchar ,  Denise S. Rumler ,  Susanne Kleff

    IPC分类号： C12P7/02

    CPC分类号： C12P7/56 ,  C12P7/46 ,  C12P7/48

    摘要： This invention is directed to methods of obtaining a high quantity of desired acid salt in a form that is relatively easy to recover. Particularly desired as a recovery product is an organic acid. A salt form of the desired organic acid is formed that is relatively high in concentration and that is relatively soluble in an aqueous medium. The method includes a step of fermenting a fermentable carbon source in the fermentation medium in the presence of a magnesium compound containing oxygen.

    摘要翻译： 本发明涉及以相当容易恢复的形式获得大量所需酸盐的方法。 作为回收产物特别需要的是有机酸。 形成浓度相对较高并且相对可溶于水性介质的所需有机酸的盐形式。 该方法包括在含有氧化镁的化合物的存在下在发酵培养基中发酵可发酵碳源的步骤。

    Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants
    10.
    发明授权
    Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants 失效
    制备琥珀酸的方法，用于该方法的细菌变体，以及获得变体的方法

    公开(公告)号：US5573931A

    公开(公告)日：1996-11-12

    申请号：US520348

    申请日：1995-08-28

    申请人： Michael V. Guettler ,  Mahendra K. Jain ,  Denise Rumler

    发明人： Michael V. Guettler ,  Mahendra K. Jain ,  Denise Rumler

    IPC分类号： C12P7/46 ,  C12P1/04

    CPC分类号： C12R1/01 ,  C12P7/46 ,  Y10S435/822

    摘要： A method for producing succinic acid in high concentration by fermentation employs a variant of strain 130Z which is resistant to concentrations of about 1 g/l to about 8 g/l of sodium monofluoroacetate. The variant produces succinic acid in concentrations of about 80 g/l to about 110 g/l and the fermentation product contains less formic and acetic acids than the product obtained using the parent strain under identical conditions. The novel variants and a method of obtaining such variants also are described.

    摘要翻译： 通过发酵生产高浓度琥珀酸的方法采用耐大约1g / l至约8g / l单氟乙酸钠浓度的菌株130Z的变体。 该变体产生浓度为约80g / l至约110g / l的琥珀酸，并且与在相同条件下使用亲本菌株获得的产物相比，发酵产物含有较少的甲酸和乙酸。 还描述了获得这些变体的新颖变体和方法。