公开(公告)号：US20050260177A1

公开(公告)日：2005-11-24

申请号：US11108172

申请日：2005-04-15

申请人： Jiangchun Xu ,  Michael Lodes ,  Heather Secrist ,  Darin Benson ,  Madeleine Meagher ,  John Stolk ,  Tongtong Wang ,  Yuqiu Jiang ,  Carole Smith ,  Gordon King ,  Aijun Wang ,  Jonathan Clapper ,  Yasir Skeiky ,  Gary Fanger ,  Thomas Vedvick ,  Darrick Carter

发明人： Jiangchun Xu ,  Michael Lodes ,  Heather Secrist ,  Darin Benson ,  Madeleine Meagher ,  John Stolk ,  Tongtong Wang ,  Yuqiu Jiang ,  Carole Smith ,  Gordon King ,  Aijun Wang ,  Jonathan Clapper ,  Yasir Skeiky ,  Gary Fanger ,  Thomas Vedvick ,  Darrick Carter

IPC分类号： A61K31/7088 ,  A61K45/00 ,  C07K14/47 ,  C07K14/82 ,  C07K16/30 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/574

CPC分类号： G01N33/57419 ,  A61K31/7088 ,  C07K14/47 ,  C07K16/3046 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如结肠癌。 组合物可以包含一种或多种结肠肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达结肠肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如结肠癌的疾病。 还提供了在样品中检测结肠肿瘤蛋白或编码这种蛋白的mRNA的诊断方法。

公开(公告)号：US20060269532A1

公开(公告)日：2006-11-30

申请号：US11344932

申请日：2006-02-01

申请人： Jiangchun Xu ,  Davin Dillon ,  Jennifer Mitcham ,  Susan Harlocker ,  Yuqiu Jiang ,  Robert Henderson ,  Michael Kalos ,  Gary Fanger ,  Marc Retter ,  John Stolk ,  Craig Day ,  Thomas Vedvick ,  Darrick Carter ,  Samuel Li ,  Aijun Wang ,  Yasir Skeiky ,  William Hepler ,  John Hural ,  Patricia McNeill ,  Raymond Houghton ,  Carlota Vinals y de Bassols ,  Teresa Foy ,  Yoshihiro Watanabe ,  Madeleine Meagher ,  Ta Deng

发明人： Jiangchun Xu ,  Davin Dillon ,  Jennifer Mitcham ,  Susan Harlocker ,  Yuqiu Jiang ,  Robert Henderson ,  Michael Kalos ,  Gary Fanger ,  Marc Retter ,  John Stolk ,  Craig Day ,  Thomas Vedvick ,  Darrick Carter ,  Samuel Li ,  Aijun Wang ,  Yasir Skeiky ,  William Hepler ,  John Hural ,  Patricia McNeill ,  Raymond Houghton ,  Carlota Vinals y de Bassols ,  Teresa Foy ,  Yoshihiro Watanabe ,  Madeleine Meagher ,  Ta Deng

IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

CPC分类号： C07K14/4748 ,  A61K2039/505 ,  C07K16/3069 ,  C07K2317/34 ,  C12Q1/68 ,  C12Q1/6886 ,  G01N33/57434

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US20060024301A1

公开(公告)日：2006-02-02

申请号：US11234786

申请日：2005-09-23

申请人： Jiangchun Xu ,  Davin Dillon ,  Jennifer Mitcham ,  Susan Harlocker ,  Yuqiu Jiang ,  Steven Reed ,  Michael Kalos ,  Gary Fanger ,  Marc Retter ,  John Stolk ,  Craig Day ,  Thomas Vedvick ,  Darrick Carter ,  Samuel Li ,  Aijun Wang ,  Yasir Skeiky

发明人： Jiangchun Xu ,  Davin Dillon ,  Jennifer Mitcham ,  Susan Harlocker ,  Yuqiu Jiang ,  Steven Reed ,  Michael Kalos ,  Gary Fanger ,  Marc Retter ,  John Stolk ,  Craig Day ,  Thomas Vedvick ,  Darrick Carter ,  Samuel Li ,  Aijun Wang ,  Yasir Skeiky

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K16/30 ,  C07K14/82 ,  A61K39/00 ,  A61K39/395

CPC分类号： C07K16/3069 ,  C07K2317/34 ,  C07K2317/80 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如前列腺癌。 组合物可以包含一种或多种前列腺特异性蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达前列腺特异性蛋白质的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可用于例如预防和治疗诸如前列腺癌的疾病。 还提供了基于检测样品中前列腺特异性蛋白质或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：US20060088527A1

公开(公告)日：2006-04-27

申请号：US11301554

申请日：2005-12-13

申请人： Robert Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Michael Kalos ,  Paul Sleath ,  Jeffrey Johnson ,  Marc Retter ,  Margarita Durham ,  Darrick Carter ,  Gary Fanger ,  Thomas Vedvick ,  Chaitanya Bangur ,  Andria McNabb

发明人： Robert Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Michael Kalos ,  Paul Sleath ,  Jeffrey Johnson ,  Marc Retter ,  Margarita Durham ,  Darrick Carter ,  Gary Fanger ,  Thomas Vedvick ,  Chaitanya Bangur ,  Andria McNabb

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N5/06 ,  C07K16/30

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K14/47 ,  C07K16/3023 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57423

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

公开(公告)号：US20070141087A1

公开(公告)日：2007-06-21

申请号：US11505569

申请日：2006-08-16

申请人： Steven Reed ,  Yasir Skeiky ,  Davin Dillon ,  Antonio Campos-Neto ,  Raymond Houghton ,  Thomas Vedvick ,  Daniel Twardzik ,  Michael Lodes ,  Ronald Hendrickson

发明人： Steven Reed ,  Yasir Skeiky ,  Davin Dillon ,  Antonio Campos-Neto ,  Raymond Houghton ,  Thomas Vedvick ,  Daniel Twardzik ,  Michael Lodes ,  Ronald Hendrickson

IPC分类号： A61K39/04 ,  C07K14/35

CPC分类号： C12Q1/6883 ,  A61K39/00 ,  C07K14/35 ,  C07K16/1289 ,  C07K2319/00 ,  C12Q1/689 ,  G01N33/5695

摘要： Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.

摘要翻译： 公开了用于诊断结核病的化合物和方法。 提供的化合物包括含有一种或多种结核分枝杆菌蛋白质的至少一个抗原部分的多肽和编码这种多肽的DNA序列。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的结核分枝杆菌感染。 还提供了针对这种多肽的抗体。

公开(公告)号：US20050181419A1

公开(公告)日：2005-08-18

申请号：US11082005

申请日：2005-03-15

申请人： Steven Reed ,  Yasir Skeiky ,  Davin Dillon ,  Antonio Campos-Neto ,  Raymond Houghton ,  Thomas Vedvick ,  Daniel Twardzik ,  Michael Lodes ,  Ronald Hendrickson

发明人： Steven Reed ,  Yasir Skeiky ,  Davin Dillon ,  Antonio Campos-Neto ,  Raymond Houghton ,  Thomas Vedvick ,  Daniel Twardzik ,  Michael Lodes ,  Ronald Hendrickson

IPC分类号： G01N33/569 ,  A61K38/00 ,  A61K39/00 ,  A61K39/04 ,  A61K39/395 ,  A61P31/06 ,  C07H21/02 ,  C07H21/04 ,  C07K7/00 ,  C07K14/35 ,  C07K16/12 ,  C07K17/00 ,  C07K19/00 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/08 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/19 ,  G01N33/68 ,  C07K16/10 ,  G01N33/554

CPC分类号： C12Q1/6883 ,  A61K39/00 ,  C07K14/35 ,  C07K16/1289 ,  C07K2319/00 ,  C12Q1/689 ,  G01N33/5695

摘要： Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.

公开(公告)号：US20050136069A1

公开(公告)日：2005-06-23

申请号：US11028898

申请日：2005-01-03

申请人： Steven Reed ,  Yasir Skeiky ,  Davin Dillon ,  Antonio Campos-Neto ,  Raymond Houghton ,  Thomas Vedvick ,  Daniel Twardzik ,  Michael Lodes ,  Ronald Hendrickson

发明人： Steven Reed ,  Yasir Skeiky ,  Davin Dillon ,  Antonio Campos-Neto ,  Raymond Houghton ,  Thomas Vedvick ,  Daniel Twardzik ,  Michael Lodes ,  Ronald Hendrickson

IPC分类号： G01N33/53 ,  A61K31/711 ,  A61K38/00 ,  A61K39/00 ,  A61K39/04 ,  A61K49/00 ,  A61P31/04 ,  A61P31/06 ,  A61P37/04 ,  C07K1/00 ,  C07K14/35 ,  C12N15/00 ,  C12Q1/68 ,  A61K39/02 ,  G01N33/554 ,  G01N33/569

CPC分类号： C07K14/35 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00

摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.

摘要翻译： 公开了诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种结核分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 这些化合物可以配制成针对结核分枝杆菌感染免疫的疫苗和/或药物组合物，或可用于诊断结核病。