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1.发明申请Compounds for immunotherapy and diagnosis of colon cancer and methods for their use 审中-公开用于结肠癌免疫治疗和诊断的化合物及其使用方法公开(公告)号：US20050260177A1
公开(公告)日：2005-11-24
申请号：US11108172
申请日：2005-04-15
申请人： Jiangchun Xu , Michael Lodes , Heather Secrist , Darin Benson , Madeleine Meagher , John Stolk , Tongtong Wang , Yuqiu Jiang , Carole Smith , Gordon King , Aijun Wang , Jonathan Clapper , Yasir Skeiky , Gary Fanger , Thomas Vedvick , Darrick Carter
发明人： Jiangchun Xu , Michael Lodes , Heather Secrist , Darin Benson , Madeleine Meagher , John Stolk , Tongtong Wang , Yuqiu Jiang , Carole Smith , Gordon King , Aijun Wang , Jonathan Clapper , Yasir Skeiky , Gary Fanger , Thomas Vedvick , Darrick Carter
IPC分类号： A61K31/7088 , A61K45/00 , C07K14/47 , C07K14/82 , C07K16/30 , C12N15/09 , C12Q1/68 , G01N33/574
CPC分类号： G01N33/57419 , A61K31/7088 , C07K14/47 , C07K16/3046 , C07K2319/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如结肠癌。 组合物可以包含一种或多种结肠肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达结肠肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如结肠癌的疾病。 还提供了在样品中检测结肠肿瘤蛋白或编码这种蛋白的mRNA的诊断方法。
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公开(公告)号：US06623923B1
公开(公告)日：2003-09-23
申请号：US09401064
申请日：1999-09-22
申请人： Jiangchun Xu , Michael J. Lodes , Heather Secrist , Madeleine Joy Meagher , John Stolk , Darin R. Benson , Tongtong Wang
发明人： Jiangchun Xu , Michael J. Lodes , Heather Secrist , Madeleine Joy Meagher , John Stolk , Darin R. Benson , Tongtong Wang
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.
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公开(公告)号：US20060088527A1
公开(公告)日：2006-04-27
申请号：US11301554
申请日：2005-12-13
申请人： Robert Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael Kalos , Paul Sleath , Jeffrey Johnson , Marc Retter , Margarita Durham , Darrick Carter , Gary Fanger , Thomas Vedvick , Chaitanya Bangur , Andria McNabb
发明人： Robert Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael Kalos , Paul Sleath , Jeffrey Johnson , Marc Retter , Margarita Durham , Darrick Carter , Gary Fanger , Thomas Vedvick , Chaitanya Bangur , Andria McNabb
IPC分类号： A61K39/395 , C07H21/04 , C12N5/06 , C07K16/30
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K14/47 , C07K16/3023 , C07K2317/34 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12Q1/6886 , C12Q2600/158 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
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公开(公告)号：US06509448B2
公开(公告)日：2003-01-21
申请号：US09736457
申请日：2000-12-13
申请人： Tongtong Wang , Chaitanya S. Bangur , Michael J. Lodes , Gary R. Fanger , Thomas S. Vedvick , Darrick Carter , Marc W. Retter , Jane Mannion , Liqun Fan , Aijun Wang
发明人： Tongtong Wang , Chaitanya S. Bangur , Michael J. Lodes , Gary R. Fanger , Thomas S. Vedvick , Darrick Carter , Marc W. Retter , Jane Mannion , Liqun Fan , Aijun Wang
IPC分类号： C07K1618
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K2319/00 , C12Q1/6886 , C12Q2600/158 , Y10S977/911 , Y10S977/912 , Y10S977/916
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
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公开(公告)号：US06504010B1
公开(公告)日：2003-01-07
申请号：US09702705
申请日：2000-10-30
申请人： Tongtong Wang , Chaitanya S. Bangur , Michael J. Lodes , Gary R. Fanger , Thomas S. Vedvick , Darrick Carter , Marc W. Retter , Jane Mannion , Liqun Fan
发明人： Tongtong Wang , Chaitanya S. Bangur , Michael J. Lodes , Gary R. Fanger , Thomas S. Vedvick , Darrick Carter , Marc W. Retter , Jane Mannion , Liqun Fan
IPC分类号： C07K14435
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K2319/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
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公开(公告)号：US20080292633A1
公开(公告)日：2008-11-27
申请号：US11929565
申请日：2007-10-30
申请人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
发明人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
IPC分类号： A61K39/395 , C07H21/00 , C07K14/00 , C12N15/00 , C12N5/00 , A61K35/12 , C07K16/00 , G01N33/574 , C12N5/02
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K14/47 , C07K16/3023 , C07K2317/34 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12Q1/6886 , C12Q2600/158 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
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公开(公告)号：US20080171048A1
公开(公告)日：2008-07-17
申请号：US11929572
申请日：2007-10-30
申请人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
发明人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K14/47 , C07K16/3023 , C07K2317/34 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12Q1/6886 , C12Q2600/158 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
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公开(公告)号：US06667154B1
公开(公告)日：2003-12-23
申请号：US09671325
申请日：2000-09-26
申请人： Tongtong Wang , Chaitanya S. Bangur , Michael J. Lodes , Gary R. Fanger , Thomas S. Vedvick , Darrick Carter , Marc W. Retter , Jane Mannion , Liqun Fan
发明人： Tongtong Wang , Chaitanya S. Bangur , Michael J. Lodes , Gary R. Fanger , Thomas S. Vedvick , Darrick Carter , Marc W. Retter , Jane Mannion , Liqun Fan
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K2319/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.
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公开(公告)号：US07425607B2
公开(公告)日：2008-09-16
申请号：US11301554
申请日：2005-12-13
申请人： Robert A Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D Kalos , Paul R Sleath , Jeffrey C Johnson , Marc W Retter , Margarita Durham , Darrick Carter , Gary R Fanger , Thomas S Vedvick , Chaitanya S Bangur , Andria McNabb
发明人： Robert A Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D Kalos , Paul R Sleath , Jeffrey C Johnson , Marc W Retter , Margarita Durham , Darrick Carter , Gary R Fanger , Thomas S Vedvick , Chaitanya S Bangur , Andria McNabb
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K14/47 , C07K16/3023 , C07K2317/34 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12Q1/6886 , C12Q2600/158 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是肺癌的组合物和方法。 说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。
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公开(公告)号：US06858204B2
公开(公告)日：2005-02-22
申请号：US10017754
申请日：2001-10-29
申请人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
发明人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K2319/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
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