公开(公告)号：US20050260177A1

公开(公告)日：2005-11-24

申请号：US11108172

申请日：2005-04-15

申请人： Jiangchun Xu ,  Michael Lodes ,  Heather Secrist ,  Darin Benson ,  Madeleine Meagher ,  John Stolk ,  Tongtong Wang ,  Yuqiu Jiang ,  Carole Smith ,  Gordon King ,  Aijun Wang ,  Jonathan Clapper ,  Yasir Skeiky ,  Gary Fanger ,  Thomas Vedvick ,  Darrick Carter

发明人： Jiangchun Xu ,  Michael Lodes ,  Heather Secrist ,  Darin Benson ,  Madeleine Meagher ,  John Stolk ,  Tongtong Wang ,  Yuqiu Jiang ,  Carole Smith ,  Gordon King ,  Aijun Wang ,  Jonathan Clapper ,  Yasir Skeiky ,  Gary Fanger ,  Thomas Vedvick ,  Darrick Carter

IPC分类号： A61K31/7088 ,  A61K45/00 ,  C07K14/47 ,  C07K14/82 ,  C07K16/30 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/574

CPC分类号： G01N33/57419 ,  A61K31/7088 ,  C07K14/47 ,  C07K16/3046 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如结肠癌。 组合物可以包含一种或多种结肠肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达结肠肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如结肠癌的疾病。 还提供了在样品中检测结肠肿瘤蛋白或编码这种蛋白的mRNA的诊断方法。

公开(公告)号：US20050147615A1

公开(公告)日：2005-07-07

申请号：US10961527

申请日：2004-10-07

申请人： Gordon King ,  Madeleine Meagher ,  Jiangchun Xu ,  Heather Secrist

发明人： Gordon King ,  Madeleine Meagher ,  Jiangchun Xu ,  Heather Secrist

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N15/12 ,  C12Q1/68 ,  A61K39/395 ,  A61K48/00 ,  C07H21/04 ,  C07K16/30 ,  C12N5/08

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是结肠癌的组合物和方法。 示例性组合物包含一种或多种结肠肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是结肠癌的诊断，预防和/或治疗。

公开(公告)号：US20060193870A1

公开(公告)日：2006-08-31

申请号：US11374388

申请日：2006-03-13

申请人： Gordon King ,  Madeleine Meagher ,  Jiangchun Xu ,  Heather Secrist ,  Yuqui Jiang

发明人： Gordon King ,  Madeleine Meagher ,  Jiangchun Xu ,  Heather Secrist ,  Yuqui Jiang

IPC分类号： A61K39/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

CPC分类号： C12Q1/6886 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C12Q2600/158 ,  G01N33/57419

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.

公开(公告)号：US06623923B1

公开(公告)日：2003-09-23

申请号：US09401064

申请日：1999-09-22

申请人： Jiangchun Xu ,  Michael J. Lodes ,  Heather Secrist ,  Madeleine Joy Meagher ,  John Stolk ,  Darin R. Benson ,  Tongtong Wang

发明人： Jiangchun Xu ,  Michael J. Lodes ,  Heather Secrist ,  Madeleine Joy Meagher ,  John Stolk ,  Darin R. Benson ,  Tongtong Wang

IPC分类号： C12Q168

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US20070161034A1

公开(公告)日：2007-07-12

申请号：US11672890

申请日：2007-02-08

申请人： Yuqiu Jiang ,  Susan Harlocker ,  Heather Secrist ,  Aijun Wang ,  John Stolk

发明人： Yuqiu Jiang ,  Susan Harlocker ,  Heather Secrist ,  Aijun Wang ,  John Stolk

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如结肠癌。 组合物可以包含一种或多种结肠肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达结肠肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如结肠癌的疾病。 还提供了在样品中检测结肠肿瘤蛋白或编码这种蛋白的mRNA的诊断方法。

公开(公告)号：US20080108070A1

公开(公告)日：2008-05-08

申请号：US11851267

申请日：2007-09-06

申请人： Jiangchun Xu ,  Gordon King ,  Madeleine Braun ,  Ruth Chenault ,  Heather Secrist ,  Susan Harlocker ,  Siqing Wang

发明人： Jiangchun Xu ,  Gordon King ,  Madeleine Braun ,  Ruth Chenault ,  Heather Secrist ,  Susan Harlocker ,  Siqing Wang

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： Methods and compositions for the diagnosis and monitoring of colon cancer are disclosed.

摘要翻译： 公开了用于诊断和监测结肠癌的方法和组合物。

公开(公告)号：US20080317755A1

公开(公告)日：2008-12-25

申请号：US11768101

申请日：2007-06-25

申请人： Gordon E. King ,  Madeleine Joy Braun ,  Jiangchun Xu ,  Heather Secrist

发明人： Gordon E. King ,  Madeleine Joy Braun ,  Jiangchun Xu ,  Heather Secrist

IPC分类号： A61K39/395 ,  C07H21/00 ,  C07K2/00 ,  C12N15/63 ,  C12N5/00 ,  A61K35/12 ,  A61K31/7052 ,  A61P35/00 ,  A61K38/02 ,  A61K38/16 ,  C07K16/00 ,  G01N33/574 ,  C07K14/00

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是结肠癌的组合物和方法。 示例性组合物包含一种或多种结肠肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及表达该多肽的细胞特异的T细胞。 公开的组合物可用于例如疾病，特别是结肠癌的诊断，预防和/或治疗。

公开(公告)号：US06759508B2

公开(公告)日：2004-07-06

申请号：US09854133

申请日：2001-05-11

申请人： Michael J. Lodes ,  Raodoh Mohamath ,  Robert A. Henderson ,  Darin R. Benson ,  Heather Secrist

发明人： Michael J. Lodes ,  Raodoh Mohamath ,  Robert A. Henderson ,  Darin R. Benson ,  Heather Secrist

IPC分类号： C07K14435

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4748 ,  C07K2319/00 ,  Y02A50/396

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

公开(公告)号：US06569433B1

公开(公告)日：2003-05-27

申请号：US09569098

申请日：2000-05-10

申请人： Steven G. Reed ,  Michael J. Lodes ,  Raymond L. Houghton ,  Paul R. Sleath ,  Patricia D. McNeill ,  Mary J. Homer ,  Heather Secrist

发明人： Steven G. Reed ,  Michael J. Lodes ,  Raymond L. Houghton ,  Paul R. Sleath ,  Patricia D. McNeill ,  Mary J. Homer ,  Heather Secrist

IPC分类号： A61K39002

CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00 ,  Y10S530/822

摘要： Compounds and methods for the diagnosis and treatment of B. microti infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a B. microti antigen and DNA sequences encoding such polypeptides. Antigenic epitopes of such antigens are also provided, together with pharmaceutical compositions and vaccines comprising such polypeptides, DNA sequences or antigenic epitopes. Diagnostic kits containing such polypeptides, DNA sequences or antigenic epitopes and a suitable detection reagent may be used for the detection of B. microti infection in patients and biological samples. Antibodies directed against such polypeptides and antigenic epitopes are also provided.

摘要翻译： 公开了用于诊断和治疗微生物感染的化合物和方法。 提供的化合物包括含有微生物抗原的至少一个抗原部分和编码这种多肽的DNA序列的多肽。 还提供了这样的抗原的抗原表位以及包含这种多肽，DNA序列或抗原表位的药物组合物和疫苗。 含有此类多肽，DNA序列或抗原表位的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的微生物感染。 还提供了针对这种多肽和抗原表位的抗体。

公开(公告)号：US06444425B1

公开(公告)日：2002-09-03

申请号：US09370838

申请日：1999-08-09

申请人： Steven G. Reed ,  Michael J. Lodes ,  Raodoh Mohamath ,  Heather Secrist

发明人： Steven G. Reed ,  Michael J. Lodes ,  Raodoh Mohamath ,  Heather Secrist

IPC分类号： C12Q168

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如肺癌。 组合物可以包含一种或多种肺肿瘤蛋白，其免疫原性部分，或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达肺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如肺癌的疾病。 还提供了基于检测样品中的肺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。