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![Synthesis of 2-Hydroxy-N,N-dimethyl-3-[[2-[[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide](/abs-image/US/2011/03/22/US07910775B2/abs.jpg.150x150.jpg)
1.发明授权Synthesis of 2-Hydroxy-N,N-dimethyl-3-[[2-[[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide 有权合成2-羟基-N，N-二甲基-3 - [[2 - [[1（R） - （5-甲基-2-呋喃基）丙基]氨基] -3,4-二氧代-1-环丁烯-1 - 基]氨基]苯甲酰胺公开(公告)号：US07910775B2
公开(公告)日：2011-03-22
申请号：US12253356
申请日：2008-10-17
申请人： Jianguo Yin , Xiaoyong Fu , Shuyi Zhang , Timothy L. McAllister , Agnes S. Kim-Meade , Jason L. Winters , Anantha Sudhakar , Doris P. Schumacher
发明人： Jianguo Yin , Xiaoyong Fu , Shuyi Zhang , Timothy L. McAllister , Agnes S. Kim-Meade , Jason L. Winters , Anantha Sudhakar , Doris P. Schumacher
IPC分类号： C07C231/02 , C07C233/05
CPC分类号： C07D307/52 , C07C235/60
摘要： Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
摘要翻译： 公开了制备式I化合物的方法：使用式II，Q和XI或XII的化合物：其中A选自Br，Cl和I（其中Br优选）; R表示（C1-C10）烷基。 还公开了在所公开的方法中制备的中间体化合物。
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![Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[[1(r)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide](/abs-image/US/2008/12/09/US07462740B2/abs.jpg.150x150.jpg)
2.发明授权Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[[1(r)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide 有权合成2-羟基-N，正二甲基-3 - [[2 - [[1（R） - （5-甲基-2-呋喃基）丙基]氨基] -3,4-二氧代-1-环丁烯-1 - 基]氨基]苯甲酰胺公开(公告)号：US07462740B2
公开(公告)日：2008-12-09
申请号：US11430687
申请日：2006-05-09
申请人： Jianguo Yin , Xiaoyong Fu , Shuyi Zhang , Timothy L. McAllister , Agnes S. Kim-Meade , Jason L. Winters , Anantha Sudhakar , Doris P. Schumacher
发明人： Jianguo Yin , Xiaoyong Fu , Shuyi Zhang , Timothy L. McAllister , Agnes S. Kim-Meade , Jason L. Winters , Anantha Sudhakar , Doris P. Schumacher
IPC分类号： C07C231/02 , C07C233/65
CPC分类号： C07D307/52 , C07C235/60
摘要： Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
摘要翻译： 公开了制备式I化合物的方法：使用式II，Q和XI或XII的化合物：其中A选自Br，Cl和I（其中Br优选）; R表示（C1-C10）烷基。 还公开了在所公开的方法中制备的中间体化合物。
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![SYNTHESIS OF 2-HYDROXY-N,N-DIMETHYL-3-[[2-[[1(R)-(5-METHYL-2-FURANYL)PROPYL]AMINO]-3,4-DIOXO-1-CYCLOBUTEN-1-YL]AMINO]BENZAMIDE](/abs-image/US/2009/02/19/US20090048458A1/abs.jpg.150x150.jpg)
3.发明申请SYNTHESIS OF 2-HYDROXY-N,N-DIMETHYL-3-[[2-[[1(R)-(5-METHYL-2-FURANYL)PROPYL]AMINO]-3,4-DIOXO-1-CYCLOBUTEN-1-YL]AMINO]BENZAMIDE 有权2-羟基-N，N-二甲基-3 - [[2 - [[1（R） - （5-甲基-2-呋喃基）丙基]氨基] -3,4-二氧代-1-环糊精-1的合成 -YL]氨基]苯甲酰胺公开(公告)号：US20090048458A1
公开(公告)日：2009-02-19
申请号：US12253356
申请日：2008-10-17
申请人： Jianguo Yin , Xiaoyong FU , Shuyi Zhang , Timothy L. McAllister , Agnes S. Kim-Meade , Jason L. Winters , Anantha Sudhakar , Doris P. Schumacher
发明人： Jianguo Yin , Xiaoyong FU , Shuyi Zhang , Timothy L. McAllister , Agnes S. Kim-Meade , Jason L. Winters , Anantha Sudhakar , Doris P. Schumacher
IPC分类号： C07C233/65 , C07D307/36
CPC分类号： C07D307/52 , C07C235/60
摘要： Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
摘要翻译： 公开了制备式I化合物的方法：使用式II，Q和XI或XII的化合物：其中A选自Br，Cl和I（其中Br优选）; R表示（C1-C10）烷基。 还公开了在所公开的方法中制备的中间体化合物。
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![Synthesis of 2-hydroxy-N,N-dimethyl-3-[ [2-[1 (R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]aminobenzamide](/abs-image/US/2006/07/04/US07071342B2/abs.jpg.150x150.jpg)
4.发明授权Synthesis of 2-hydroxy-N,N-dimethyl-3-[ [2-[1 (R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]aminobenzamide 有权合成2-羟基-N，N-二甲基-3 - [[2- [1（R） - （5-甲基-2-呋喃基）丙基]氨基] -3,4-二氧代-1-环丁烯-1-酮 吡啶-3-基]氨基苯甲酰胺公开(公告)号：US07071342B2
公开(公告)日：2006-07-04
申请号：US10826456
申请日：2004-04-16
申请人： Jianguo Yin , Xiaoyong Fu , Shuyi Zhang , Timothy L. McAllister , Agnes S. Kim-Meade , Jason L. Winters , Anantha Sudhakar , Doris P. Schumacher
发明人： Jianguo Yin , Xiaoyong Fu , Shuyi Zhang , Timothy L. McAllister , Agnes S. Kim-Meade , Jason L. Winters , Anantha Sudhakar , Doris P. Schumacher
IPC分类号： C07D307/54
CPC分类号： C07D307/52 , C07C235/60
摘要： Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1–C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
摘要翻译： 公开了制备式I化合物的方法：使用式II，Q和XI或XII的化合物：其中A选自Br，Cl和I（其中Br优选）; R表示（C 1 -C 10）烷基。 还公开了在所公开的方法中制备的中间体化合物。
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公开(公告)号：US4366309A
公开(公告)日：1982-12-28
申请号：US253138
申请日：1981-04-13
摘要： Novel macrolide antibacterial derivatives of the components of the Antibiotic AR-5-complex are disclosed herein. The invention specifically relates to compounds wherein the macrolide ring and/or the two attached sugars are derivatized. Also disclosed are methods for the preparation of the derivatives and methods for the use thereof.
摘要翻译： 本文公开了抗生素AR-5-复合物组分的新型大环内酯抗菌衍生物。 本发明具体涉及其中大环内酯环和/或两个附着的糖被衍生化合物。 还公开了制备衍生物的方法及其使用方法。
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6.发明授权
公开(公告)号：US6096883A
公开(公告)日：2000-08-01
申请号：US210921
申请日：1998-12-14
IPC分类号： C07D205/08
CPC分类号： C07D205/08
摘要： The invention relates to intermediates of the formulae ##STR1## said intermediates being useful in a process for producing a compound of the formula ##STR2## wherein Bn is benzyl and R.sub.1, .sub.2 and R.sub.3 are as defined in the specification,
摘要翻译： 本发明涉及式的中间体，所述中间体可用于制备下式化合物的方法，其中Bn是苄基，R1,2和R3如说明书中所定义，
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公开(公告)号：US4863931A
公开(公告)日：1989-09-05
申请号：US244768
申请日：1988-09-15
IPC分类号： A61K31/4427 , A61K31/445 , A61K31/55 , A61P37/08 , A61P43/00 , C07D401/04
CPC分类号： C07D401/04
摘要： Certain benzocycloheptapyridine compounds with fluorine substitution across the exocyclic double bond are prepared and they are useful as antihistaminic agents.
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8.发明授权Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof 失效制备哌啶基二氢 - 二苯并（a，d） - 环庚烯或其氮杂衍生物的方法
公开(公告)号：US4731447A
公开(公告)日：1988-03-15
申请号：US839016
申请日：1986-03-12
IPC分类号： C07D213/81 , C07D221/16 , C07D401/04
CPC分类号： C07D213/81 , C07D221/16 , C07D401/04
摘要： A process for the preparation of piperidylidene-dihydro-dibenzo[a,d]cycloheptene or aza-derivatives thereof and intermediates in such process are disclosed.
摘要翻译： 公开了制备哌啶基二氢 - 二苯并[a，d]环庚烯或其氮杂衍生物的方法和中间体。
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![8-chloro-6,11-dihydro-11-(4-piperidylidine)-5H-benzo[5,6]cyclohepta[1-2-b] pyridine](/abs-image/US/2003/01/14/US06506767B1/abs.jpg.150x150.jpg)
9.发明授权8-chloro-6,11-dihydro-11-(4-piperidylidine)-5H-benzo[5,6]cyclohepta[1-2-b] pyridine 失效8-氯-6,11-二氢-11-（4-哌啶基）-5H-苯并[5,6]环庚并[1-2-b]吡啶公开(公告)号：US06506767B1
公开(公告)日：2003-01-14
申请号：US09108689
申请日：1998-07-01
申请人： Doris P. Schumacher , Junning Lee , Lawrence R. Rogers , Charles G. Eckhart , Naneshwar S. Sawant , Michael B. Mitchell
发明人： Doris P. Schumacher , Junning Lee , Lawrence R. Rogers , Charles G. Eckhart , Naneshwar S. Sawant , Michael B. Mitchell
IPC分类号： C07D40108
CPC分类号： C07D401/04
摘要： Crystalline polymorphs of 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cycloheptic[1,2-b]pyridine represented by the formula pharmaceutical compositions containing such polymorphs, and methods of using such polymorphs to treat allergic reactions in mammals such as man are disclosed.
摘要翻译： 由含有这种多晶型物的药物组合物表示的8-氯-6,11-二氢-11-（4-哌啶基）-5H-苯并[5,6]环庚并[1,2-b]吡啶的结晶多晶型物，以及 公开了使用这种多晶型物来治疗哺乳动物如人的过敏反应
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10.发明授权3-hydroxy .gamma.-lactone based enantionselective synthesis of azetidinones 失效基于3-羟基γ-内酯的对映选择性合成氮杂环丁酮
公开(公告)号：US5739321A
公开(公告)日：1998-04-14
申请号：US655785
申请日：1996-05-31
IPC分类号： C07D205/08 , C07D205/04
CPC分类号： C07D205/08
摘要： The invention relates to a process for producing the compound of the formula ##STR1## which comprises reacting lactone of formula II ##STR2## with an imine of formula III': ##STR3## and converting the resulting chiral diol of formula VI: ##STR4## through several steps to obtain a compound of formula I'.
摘要翻译： 本发明涉及制备式I的化合物的方法，其包括使式II的内酯与式III'的亚胺反应，并转化得到的式VI的手性二醇： 通过几步来获得式I'化合物。
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