公开(公告)号：US20170333710A1

公开(公告)日：2017-11-23

申请号：US15493983

申请日：2017-04-21

申请人： Jin Shimada ,  Harry A. Puryear

发明人： Jin Shimada ,  Harry A. Puryear

IPC分类号： A61N1/36 ,  A61N1/08 ,  A61N1/02

摘要： An electrical ear nerve stimulation earpiece apparatus includes an earpiece body configured to fit on or in the ear. A first electrode is coupled to a surface of the earpiece configured to stimulate a cranial nerve, and a second electrode is coupled to a surface of the earpiece configured to stimulate a spinal nerve. Circuitry coupled to or in the earpiece is operable to provide an electrical signal to at least the first and second electrodes to treat a disorder affecting the nervous system by stimulating the spinal nerve and the cranial nerve.

公开(公告)号：US20120009815A1

公开(公告)日：2012-01-12

申请号：US12892884

申请日：2010-09-28

申请人： Robert G. Walsh ,  Jin Shimada

发明人： Robert G. Walsh ,  Jin Shimada

IPC分类号： H01R13/58

CPC分类号： A61N1/056

摘要： A cardiac pacemaker or other CRT device has one or more fine wire leads to the heart. Formed of a glass, silica, sapphire or crystalline quartz fiber with a thin metal coating, a unipolar lead can have an outer diameter as small as about 300 microns or even smaller. The thin metal conductor poses unique challenges for attachment to standardized connectors as well as to stimulation electrodes. This invention describes structures and materials for creating robust and durable electrically conductive connections between the fine wire lead body and a proximal standardized connector and distal ring and tip electrodes by utilization of fine metal coils or mesh and electrically conductive adapters to aid in stabilizing the connections.

摘要翻译： 心脏起搏器或其他CRT装置具有一个或多个细导线通向心脏。 由具有薄金属涂层的玻璃，二氧化硅，蓝宝石或结晶石英纤维形成，单极铅可以具有小至约300微米甚至更小的外径。 薄金属导体对连接到标准化连接器以及刺激电极构成独特的挑战。 本发明描述了用于通过利用细金属线圈或网状物和导电适配器来帮助稳定连接而在细线引线主体和近端标准化连接器以及远端环和尖端电极之间形成坚固耐用的导电连接的结构和材料。

公开(公告)号：US20110301657A1

公开(公告)日：2011-12-08

申请号：US12806743

申请日：2010-08-18

申请人： Robert G. Walsh ,  Jin Shimada ,  Scott Engle

发明人： Robert G. Walsh ,  Jin Shimada ,  Scott Engle

IPC分类号： A61N1/39

CPC分类号： A61N1/056

摘要： Implantable medical devices intended for electrostimulation and sensing devices typically incorporate one or more electrical conductors as leads for electrical stimulation to, or retrieval of localized sensing data from, discrete points in the body, such as the heart. Certain applications require delivery of high intensity electrical pulses, i.e. CRTs, or defibrillators. As described herein a CRT delivers high energy pulses via a durable fine wire lead formed of a glass, silica, sapphire or crystalline quartz fiber core with a metal coating. A unipolar electrical conductor can have an outer diameter of about 150 microns or even smaller. The buffered fibers support conduction of high intensity electrical pulses as required for internal or external defibrillators, or other biomedical applications, as well as non-medical applications. Defibrillation pulses can be transmitted through less cross-sectional area of metal in the subject fine wire conductor than would be the case with conventional solid core metal wires. Multiple such coated fibers can act as a single conductor. An outer protective sheath of a flexible polymer material can be included.

摘要翻译： 旨在用于电刺激和感测装置的可植入医疗设备通常将一个或多个电导体作为引线用于电刺激或从身体中的离散点（例如心脏）检索局部感测数据。 某些应用需要输送高强度电脉冲，即CRT或除颤器。 如本文所述，CRT通过由具有金属涂层的玻璃，二氧化硅，蓝宝石或结晶石英纤维芯形成的耐用细线引脚提供高能量脉冲。 单极电导体可以具有约150微米或甚至更小的外径。 缓冲的纤维支持内部或外部除颤器或其他生物医学应用以及非医疗应用所需的高强度电脉冲的传导。 除了传统的实心芯金属线的情况，除颤脉冲可以通过较小的细线导体中的金属横截面积传递。 多个这样的涂覆纤维可以用作单个导体。 可以包括柔性聚合物材料的外护套。

公开(公告)号：US20070129753A1

公开(公告)日：2007-06-07

申请号：US11607266

申请日：2006-12-01

申请人： Chris Quinn ,  Jin Shimada ,  Kevin Anderson

发明人： Chris Quinn ,  Jin Shimada ,  Kevin Anderson

IPC分类号： A61M29/00

CPC分类号： A61F2/013 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/12172 ,  A61B90/39 ,  A61B2017/12054 ,  A61B2017/12081 ,  A61B2017/12095 ,  A61B2017/22035 ,  A61B2090/08021 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0071

摘要： A system and method for retrieving an implantable device includes a delivery catheter, a recapture section, and a sheath. The delivery catheter has a proximal end and a distal end. The recapture section is axially extendable from the distal end of the delivery catheter. The sheath has a proximal end and a distal end and a lumen sized to receive the delivery catheter. A portion of the lumen of the sheath is actuatable from an enlarged inside diameter to a reduced inside diameter to apply an inwardly directed force to the recapture section. The delivery catheter can be actuated with respect to the sheath to extend or retract the recapture section with respect to the delivery catheter.

摘要翻译： 用于检索可植入装置的系统和方法包括输送导管，再捕获部分和护套。 输送导管具有近端和远端。 再捕获部分可从输送导管的远端轴向延伸。 护套具有近端和远端以及尺寸适于接纳输送导管的内腔。 护套的内腔的一部分可以从扩大的内径致动到减小的内径，以向再取回部分施加向内的力。 输送导管可以相对于护套被致动以相对于输送导管延伸或缩回再捕获部分。

公开(公告)号：US06979312B2

公开(公告)日：2005-12-27

申请号：US10298864

申请日：2002-11-18

申请人： Jin Shimada

发明人： Jin Shimada

IPC分类号： A61M25/01 ,  A61M37/00

CPC分类号： A61M25/0147

摘要： The invention is a steerable catheter having a pull wire, a central lumen and a control handle. The central lumen is maintained in a circular shape without obstructions diminishing the useful inter-diameter. The pull wire friction is also reduced by using one wire of larger diameter to create the lumen for the pull wire of smaller diameter, thus reducing the friction on the pull wire and reducing the locking of the catheter body around the pull wire at bends preventing movement of the pull wire. A control handle with a simple operational mechanism that allows direct access to a continuous central lumen from the proximal end of the catheter.

摘要翻译： 本发明是具有拉线，中央管腔和控制手柄的可导向导管。 中央管腔保持圆形，没有障碍物减小有用的内径。 通过使用较大直径的一根线材来产生拉线摩擦也可以减小直径较小的拉线的内腔，从而减少拉线上的摩擦力，减少导线管在拉线周围的弯曲，以防止运动 的拉线。 具有简单操作机构的控制手柄，允许从导管的近端直接进入连续的中心腔。

公开(公告)号：US06582536B2

公开(公告)日：2003-06-24

申请号：US09833324

申请日：2001-04-12

申请人： Jin Shimada

发明人： Jin Shimada

IPC分类号： A61M2516

CPC分类号： A61M25/0012 ,  A61M25/0147

摘要： The invention is a method for manufacturing a steerable catheter having a distal end, proximal end, an outer jacket, a pull wire and a central lumen. The central lumen is maintained in a circular shape without bulges diminishing the useful inter-diameter by using an outer jacket with an elliptical shape and uneven thickness to encase a pull wire. The pull wire friction is also reduced by using one wire of larger diameter to create the lumen for the pull wire of smaller diameter, thus reducing the friction on the pull wire and reducing the locking of the catheter body around the pull wire at bends preventing movement of the pull wire. The distal end of the catheter also has a smooth tip due to heat treating of steel wire braid reinforcement that does not require the addition of bulge forming additional material to control tip shape.

摘要翻译： 本发明是一种用于制造具有远端，近端，外护套，拉线和中心腔的可导向导管的方法。 中央管腔保持圆形，没有凸起，通过使用具有椭圆形和不均匀厚度的外套来包住拉线来减小有用的内径。 通过使用较大直径的一根线材来产生拉线摩擦也可以减小直径较小的拉线的内腔，从而减少拉线上的摩擦力，减少导线管在拉线周围的弯曲，以防止运动 的拉线。 由于钢丝编织物加强件的热处理，导管的远端也具有光滑的尖端，其不需要添加形成附加材料的凸起以控制尖端形状。

公开(公告)号：US5282785A

公开(公告)日：1994-02-01

申请号：US956789

申请日：1992-10-05

申请人： James E. Shapland ,  Mark B. Knudson ,  Jin Shimada ,  Keith R. Hildebrand

发明人： James E. Shapland ,  Mark B. Knudson ,  Jin Shimada ,  Keith R. Hildebrand

IPC分类号： A61M37/00 ,  A61M16/04 ,  A61M25/00 ,  A61M29/02 ,  A61N1/05 ,  A61N1/30 ,  A61N1/32 ,  A61B17/36

CPC分类号： A61M25/104 ,  A61M16/0481 ,  A61M29/02 ,  A61M37/0092 ,  A61N1/05 ,  A61N1/306 ,  A61N1/325 ,  A61M2025/0057 ,  A61M2025/105 ,  A61N2001/0585

摘要： A drug delivery apparatus and method for delivering a drug locally to internal body tissue. The invention contemplates positioning a drug delivery device in a body passageway or within body tissue and then selectively introducing a selected drug so that it is transported across a drug transport wall of the device for direct contact with the passageway wall or body tissue. A further aspect of the present invention involves treating a dilated vessel in the area of a stenotic lesion with a fixative or other drug to render the vessel biologically inert and to form a biological stent or prevent restenosis using specifically selected drugs. A still further aspect of the present invention involves treating a tumor or local or regional tissue mass with antitumor sensitizing agents, biological modifiers, antibiotics or other types of drugs by delivery of the drug to the tumor or tissue area directly or through the passageway wall.

摘要翻译： 一种用于将药物局部递送到内部身体组织的药物递送装置和方法。 本发明考虑将药物递送装置定位在身体通道或身体组织内，然后选择性地引入所选择的药物，使得其被输送穿过装置的药物输送壁，以与通道壁或身体组织直接接触。 本发明的另一方面涉及用固定剂或其它药物在狭窄病变区域中处理扩张的血管，使血管生物学惰性并形成生物支架，或使用特定选择的药物预防再狭窄。 本发明的另一方面涉及通过将药物直接或通过通道壁递送到肿瘤或组织区域，用抗肿瘤敏化剂，生物改良剂，抗生素或其它类型的药物来治疗肿瘤或局部或区域组织块。

公开(公告)号：US08663268B2

公开(公告)日：2014-03-04

申请号：US13403420

申请日：2012-02-23

申请人： Chris Quinn ,  Jin Shimada

发明人： Chris Quinn ,  Jin Shimada

IPC分类号： A61M29/00

CPC分类号： A61M25/04 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12172 ,  A61B2017/00292 ,  A61B2017/003 ,  A61B2017/22044 ,  A61M25/0147 ,  A61M2025/0161

摘要： A method for accessing the left atrial appendage with a balloon-tipped transseptal sheath is disclosed. A transseptal sheath is delivered to the left atrium through the intraatrial septum from the right atrium. The balloon tip may be inflated to prevent the transseptal sheath from falling proximally into the right atrium. The inflated balloon tip permits safe probing and exploration of the left atrial appendage and facilitates safe maintenance of the position of the transseptal sheath within the left atrial appendage while delivering an implantable device to the left atrial appendage.

摘要翻译： 公开了一种用球囊穿透的外套进入左心耳的方法。 经心外膜通过右心房的宫内隔膜输送到左心房。 气囊末端可以被充气以防止经血管鞘向近侧落入右心房。 膨胀的气囊尖端允许对左心耳的安全探测和探查，并且有助于安全地维持左心耳内的经血管鞘的位置，同时将可植入装置递送到左心耳。

公开(公告)号：US08052715B2

公开(公告)日：2011-11-08

申请号：US11607266

申请日：2006-12-01

申请人： Chris Quinn ,  Jin Shimada ,  Kevin Anderson

发明人： Chris Quinn ,  Jin Shimada ,  Kevin Anderson

IPC分类号： A61M29/00

CPC分类号： A61F2/013 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/12172 ,  A61B90/39 ,  A61B2017/12054 ,  A61B2017/12081 ,  A61B2017/12095 ,  A61B2017/22035 ,  A61B2090/08021 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0071

摘要： A system and method for retrieving an implantable device includes a delivery catheter, a recapture section, and a sheath. The delivery catheter has a proximal end and a distal end. The recapture section is axially extendable from the distal end of the delivery catheter. The sheath has a proximal end and a distal end and a lumen sized to receive the delivery catheter. A portion of the lumen of the sheath is actuatable from an enlarged inside diameter to a reduced inside diameter to apply an inwardly directed force to the recapture section. The delivery catheter can be actuated with respect to the sheath to extend or retract the recapture section with respect to the delivery catheter.

摘要翻译： 用于检索可植入装置的系统和方法包括输送导管，再捕获部分和护套。 输送导管具有近端和远端。 再捕获部分从输送导管的远端可轴向延伸。 护套具有近端和远端以及尺寸适于接纳输送导管的内腔。 护套的内腔的一部分可以从扩大的内径致动到减小的内径，以向再取回部分施加向内的力。 输送导管可以相对于护套被致动以相对于输送导管延伸或缩回再捕获部分。

公开(公告)号：US20110220408A1

公开(公告)日：2011-09-15

申请号：US12660344

申请日：2010-02-23

申请人： Robert G. Walsh ,  Paul A. Lovoi ,  Jin Shimada ,  Kimberly Anderson

发明人： Robert G. Walsh ,  Paul A. Lovoi ,  Jin Shimada ,  Kimberly Anderson

IPC分类号： H02G15/02

CPC分类号： A61N1/05 ,  A61N1/0551 ,  A61N1/056 ,  H01R4/187 ,  H01R43/0221 ,  H01R2201/12

摘要： A cardiac pacemaker or other CRT device has one or more fine wire leads to the heart. Formed of a glass, silica, sapphire or crystalline quartz fiber with a metal coating, a unipolar lead can have an outer diameter as small as about 300 microns or even smaller. The metal buffer coating may be deposited directly on the glass/silica fiber, or upon an intermediate layer between the glass/silica fiber and metal, consisting of carbon and/or polymer. The resulting metallized glass/silica fibers are extremely durable, can be bent through small radii and will not fatigue even from millions of iterations of flexing. Bipolar fine wire leads can include several insulated metallized glass/silica fibers residing side by side, or can be coaxial with two or more insulated metal conductive paths. An outer protective sheath of a flexible polymer material can be included. The fine wire lead incorporates a thin metal conductor, which poses unique challenges for attachment to standardized connectors, as well as stimulation electrodes. The present invention describes means and materials for creating robust and durable electrically conductive connections between the fine wire lead body and a proximal standardized connector and distal ring and tip electrodes.

摘要翻译： 心脏起搏器或其他CRT装置具有一个或多个细导线通向心脏。 由具有金属涂层的玻璃，二氧化硅，蓝宝石或结晶石英纤维形成，单极引线可以具有小至约300微米甚至更小的外径。 金属缓冲涂层可以直接沉积在玻璃/二氧化硅纤维上，或者在由碳和/或聚合物组成的玻璃/二氧化硅纤维和金属之间的中间层上。 所得到的金属化玻璃/二氧化硅纤维非常耐用，可以通过小的半径弯曲，并且即使从数百万次的弯曲迭代也不会疲劳。 双极细线引线可以包括并排存在的多个绝缘的金属化玻璃/二氧化硅纤维，或者可以与两个或更多个绝缘金属导电路径同轴。 可以包括柔性聚合物材料的外护套。 细线引线采用薄金属导体，对连接到标准连接器以及刺激电极构成独特的挑战。 本发明描述了用于在细线引线主体和近端标准化连接器以及远端环和尖端电极之间形成坚固耐用的导电连接的装置和材料。