公开(公告)号：US20110220408A1

公开(公告)日：2011-09-15

申请号：US12660344

申请日：2010-02-23

申请人： Robert G. Walsh ,  Paul A. Lovoi ,  Jin Shimada ,  Kimberly Anderson

发明人： Robert G. Walsh ,  Paul A. Lovoi ,  Jin Shimada ,  Kimberly Anderson

IPC分类号： H02G15/02

CPC分类号： A61N1/05 ,  A61N1/0551 ,  A61N1/056 ,  H01R4/187 ,  H01R43/0221 ,  H01R2201/12

摘要： A cardiac pacemaker or other CRT device has one or more fine wire leads to the heart. Formed of a glass, silica, sapphire or crystalline quartz fiber with a metal coating, a unipolar lead can have an outer diameter as small as about 300 microns or even smaller. The metal buffer coating may be deposited directly on the glass/silica fiber, or upon an intermediate layer between the glass/silica fiber and metal, consisting of carbon and/or polymer. The resulting metallized glass/silica fibers are extremely durable, can be bent through small radii and will not fatigue even from millions of iterations of flexing. Bipolar fine wire leads can include several insulated metallized glass/silica fibers residing side by side, or can be coaxial with two or more insulated metal conductive paths. An outer protective sheath of a flexible polymer material can be included. The fine wire lead incorporates a thin metal conductor, which poses unique challenges for attachment to standardized connectors, as well as stimulation electrodes. The present invention describes means and materials for creating robust and durable electrically conductive connections between the fine wire lead body and a proximal standardized connector and distal ring and tip electrodes.

摘要翻译： 心脏起搏器或其他CRT装置具有一个或多个细导线通向心脏。 由具有金属涂层的玻璃，二氧化硅，蓝宝石或结晶石英纤维形成，单极引线可以具有小至约300微米甚至更小的外径。 金属缓冲涂层可以直接沉积在玻璃/二氧化硅纤维上，或者在由碳和/或聚合物组成的玻璃/二氧化硅纤维和金属之间的中间层上。 所得到的金属化玻璃/二氧化硅纤维非常耐用，可以通过小的半径弯曲，并且即使从数百万次的弯曲迭代也不会疲劳。 双极细线引线可以包括并排存在的多个绝缘的金属化玻璃/二氧化硅纤维，或者可以与两个或更多个绝缘金属导电路径同轴。 可以包括柔性聚合物材料的外护套。 细线引线采用薄金属导体，对连接到标准连接器以及刺激电极构成独特的挑战。 本发明描述了用于在细线引线主体和近端标准化连接器以及远端环和尖端电极之间形成坚固耐用的导电连接的装置和材料。

公开(公告)号：US20090299446A1

公开(公告)日：2009-12-03

申请号：US12156129

申请日：2008-05-28

申请人： Paul A. Lovoi ,  Robert G. Walsh

发明人： Paul A. Lovoi ,  Robert G. Walsh

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/0551 ,  A61N1/3605

摘要： A cardiac pacemaker, other CRT device or neurostimulator has one or more fine wire leads. Formed of a glass, silica, sapphire or crystalline quartz fiber with a metal buffer cladding, a unipolar lead can have an outer diameter as small as about 300 microns or even smaller. The buffered fibers are extremely durable, can be bent through small radii and will not fatigue even from millions of iterations of flexing. Bipolar leads can include several conductors side by side within a glass/silica fiber, or can be concentric metal coatings in a structure including several fiber layers. An outer protective sheath of a flexible polymer material can be included.

摘要翻译： 心脏起搏器，其他CRT装置或神经刺激器具有一根或多根细线。 由具有金属缓冲包层的玻璃，二氧化硅，蓝宝石或结晶石英纤维形成，单极引线可以具有小至约300微米甚至更小的外径。 缓冲的纤维是非常耐用的，可以弯曲通过小的半径，即使从数百万次的弯曲迭代也不会疲劳。 双极引线可以在玻璃/二氧化硅纤维内并排包括多个导体，或者可以是包括几个纤维层的结构的同心金属涂层。 可以包括柔性聚合物材料的外护套。

公开(公告)号：US20130041447A1

公开(公告)日：2013-02-14

申请号：US13648840

申请日：2012-10-10

申请人： John L. Erb ,  Kimberly Anderson ,  Paul A. Lovoi

发明人： John L. Erb ,  Kimberly Anderson ,  Paul A. Lovoi

IPC分类号： A61N1/05 ,  B05D5/12 ,  H01R43/16

CPC分类号： A61N1/056 ,  Y10T29/49204

摘要： A cardiac pacemaker, other CRT device or neurostimulator has one or more fine wire leads. Formed of a glass, silica, sapphire or crystalline quartz fiber with a metal buffer cladding, a unipolar lead can have an outer diameter as small as about 300 microns or even smaller. The buffered fibers are extremely durable, can be bent through small radii and will not fatigue even from millions of iterations of flexing. Bipolar leads can include several conductors side by side within a glass/silica fiber, or can be concentric metal coatings in a structure including several fiber layers. An outer protective sheath of a flexible polymer material can be included.

摘要翻译： 心脏起搏器，其他CRT装置或神经刺激器具有一根或多根细线。 由具有金属缓冲包层的玻璃，二氧化硅，蓝宝石或结晶石英纤维形成，单极引线可以具有小至约300微米甚至更小的外径。 缓冲的纤维是非常耐用的，可以弯曲通过小的半径，即使从数百万次的弯曲迭代也不会疲劳。 双极引线可以在玻璃/二氧化硅纤维内并排包括多个导体，或者可以是包括几个纤维层的结构的同心金属涂层。 可以包括柔性聚合物材料的外护套。

公开(公告)号：US07914435B2

公开(公告)日：2011-03-29

申请号：US11811295

申请日：2007-06-07

申请人： James E. Jervis ,  Paul A. Lovoi

发明人： James E. Jervis ,  Paul A. Lovoi

IPC分类号： A61N5/00

CPC分类号： A61N5/1016

摘要： An everting applicator for brachytherapy of body cavities such as the vagina has a flexible sleeve secured to a distal mandrel, both the sleeve and the mandrel having internal lumens. The flexible sleeve has a diverging opening at its distal end, preferably bell-shaped or cone-shaped, such that when the open end is pushed against the mouth of a vagina, the sleeve will evert back upon itself, progressively unrolling to an inside out configuration wherein, fully inserted, the sleeve is fully everted back over the exterior surface of the mandrel. A radiation source, isotopic or electronic, is then inserted into the mandrel lumen to commence a therapeutic irradiation procedure of tissues of the vagina.

摘要翻译： 用于诸如阴道的体腔近距离放射治疗的止痛器具有固定到远端心轴的柔性套管，套筒和心轴都具有内腔。 柔性套管在其远端具有分叉的开口，优选为钟形或锥形，使得当开口端被推靠在阴道口时，套筒将自身退回，逐渐展开到内侧 配置，其中，完全插入，套筒完全退回到心轴的外表面上。 然后将辐射源，同位素或电子插入到心轴腔中，以开始阴道组织的治疗辐射程序。

公开(公告)号：US07812725B2

公开(公告)日：2010-10-12

申请号：US11644075

申请日：2006-12-21

申请人： Jarie G. Bolander ,  Paul A. Lovoi ,  Geoff A. Zawolkow

发明人： Jarie G. Bolander ,  Paul A. Lovoi ,  Geoff A. Zawolkow

IPC分类号： G08B13/14

CPC分类号： H04B5/0037 ,  H02J17/00 ,  H02J50/20

摘要： A system for tracking items using passive RFID tags utilizes separate data and power frequencies. Within an area in which the items are located, one or more data readers are provided but many more separate power modules are distributed through the space, for powering up the tags. With the power nodes distributed, the tags are powered from a relatively short distance, enabling the tags to transmit through a greater distance. One or more of the readers can include a power-node control which sends an RF signal to control on/off status of specific power nodes within the area, so that power nodes can be activated zone by zone, to thereby permit the reader to determine location by zone of products as their RFID tags are read.

摘要翻译： 使用无源RFID标签跟踪物品的系统使用单独的数据和电源频率。 在项目所在的区域内，提供了一个或多个数据读取器，但是通过该空间分配了更多的分开的电源模块，以便为标签加电。 在功率节点分布的情况下，标签从相对较短的距离供电，使标签能够通过更大的距离进行传输。 一个或多个读取器可以包括发送RF信号以控制区域内的特定功率节点的开/关状态的功率节点控制，使得功率节点可以逐区激活，从而允许读取器确定 读取产品的区域作为RFID标签。

公开(公告)号：US20100127181A1

公开(公告)日：2010-05-27

申请号：US12321593

申请日：2009-01-21

申请人： Paul A. Lovoi ,  Steve Axelrod

发明人： Paul A. Lovoi ,  Steve Axelrod

IPC分类号： G01T1/02

CPC分类号： G01T1/00 ,  G01T1/026

摘要： A radiation sensor array is carried on a flexible sheet of film, for placement on the skin of a patient adjacent to a brachytherapy location beneath the skin. With the array approximately centered on a position where radiation source to skin distance is estimated to be minimum, the array of sensors is used to monitor radiation dose received at the skin. With a controller connected to the array and preferably also to the radiation source in the applicator, the radiation dose received at all skin points of interest can be monitored, a point of maximum dose and a projected approach to limit dose can be calculated, and in response the system can warn the operator or control a brachytherapy procedure so as to discontinue radiation or control the radiation level or source position in real time. The system can also include percutaneous sensors.

摘要翻译： 辐射传感器阵列承载在柔性薄膜片上，用于放置在与皮肤附近的近距离放射治疗位置相邻的患者的皮肤上。 以阵列为中心，辐射源至皮肤距离估计为最小的位置，传感器阵列用于监测皮肤接收的辐射剂量。 通过将控制器连接到阵列并且优选地也连接到施用器中的辐射源，可以监测在所有皮肤感兴趣点处接收的辐射剂量，可以计算最大剂量点和限制剂量的预计接近点，并且在 响应系统可以警告操作者或控制近距离放射治疗程序，以便实时中止辐射或控制辐射水平或源位置。 该系统还可以包括经皮传感器。

公开(公告)号：US07686755B2

公开(公告)日：2010-03-30

申请号：US11471277

申请日：2006-06-19

申请人： Peter C. Smith ,  Michael Klein ,  Heike Hausen ,  Paul A. Lovoi

发明人： Peter C. Smith ,  Michael Klein ,  Heike Hausen ,  Paul A. Lovoi

IPC分类号： A61N5/00

CPC分类号： A61N5/1015 ,  A61B2017/22051 ,  A61B2090/0481 ,  A61N2005/1003 ,  A61N2005/1005 ,  A61N2005/1094

摘要： Brachytherapy applicators incorporate various forms of selective shielding devices for controlling the direction and intensity of radiation directed at a patient's tissue. In some forms the applicators include a retractable sheath, in some a series of retractable fingers. In other forms the applicator, having an inflatable balloon, has a shield which is retractable from a position adjacent to the balloon or retracted from the balloon, or a shield can itself be inflatable, separately or together with the balloon.

摘要翻译： 近程放射治疗仪包括各种形式的选择性屏蔽装置，用于控制指向患者组织的辐射的方向和强度。 在一些形式中，施用器包括可伸缩护套，在一些可伸缩的手指中。 在其他形式中，具有可膨胀气囊的施用器具有可从邻近气囊的位置缩回或从球囊缩回的护罩，或者屏蔽件本身可以与气囊分开地或与气囊一起充气。

公开(公告)号：US20100074407A1

公开(公告)日：2010-03-25

申请号：US12284289

申请日：2008-09-19

申请人： Steve Axelrod ,  Thomas W. Rusch ,  Paul A. Lovoi ,  Anuradha Walawalkar ,  Sara Z. Yao

发明人： Steve Axelrod ,  Thomas W. Rusch ,  Paul A. Lovoi ,  Anuradha Walawalkar ,  Sara Z. Yao

IPC分类号： A61N5/10

CPC分类号： A61N5/10 ,  A61N5/1001 ,  A61N2005/1091 ,  A61N2005/1094 ,  A61N2005/1095

摘要： An apparatus and method for treatment of lesions or imperfections in or near exposed anatomic surfaces using low-level ionizing radiation includes a substantially transparent applicator to administer radiation from an energy source to a surface area with the lesion. The applicator is positioned over the lesion to be treated, a treatment plan is created to achieve the desired therapeutic effect to the lesion, and execution of the treatment plan is executed by the energy source. Verification of the treatment to plan and safety methods are disclosed.

摘要翻译： 用于使用低级电离辐射治疗暴露的解剖表面内或附近的损伤或缺陷的装置和方法包括基本上透明的施用器，以将能量源的辐射施加到具有损伤的表面区域。 施用器位于要治疗的病变上，创建治疗计划以实现对病变的期望的治疗效果，并且由能量源执行治疗计划的执行。 公开了对计划和安全方法的处理的验证。

公开(公告)号：US20090209802A1

公开(公告)日：2009-08-20

申请号：US11871116

申请日：2007-10-11

申请人： Darius Francescatti ,  David J. Hoffmann ,  Scott Tremberth ,  Michael Klein ,  Paul A. Lovoi ,  James E. Jervis

发明人： Darius Francescatti ,  David J. Hoffmann ,  Scott Tremberth ,  Michael Klein ,  Paul A. Lovoi ,  James E. Jervis

IPC分类号： A61N5/00

CPC分类号： A61N5/1015 ,  A61M2025/1063

摘要： Methods and applicator apparatus are disclosed for brachytherapy treatment of tissue surrounding a cavity in a patient, particularly a resection cavity. In treatment regimes requiring recovery time between successive radiation treatments, applicators of the invention are retained under the skin, with the skin allowed to at least partially heal, and are re-accessed later for one or more subsequent treatments. To reduce patient discomfort an anesthetic agent can be infused through the applicator to patient tissue, for insertion, balloon inflation or removal of the applicator.

摘要翻译： 公开了用于近距离放射治疗患者，特别是切除腔中的腔周围的组织的方法和施用装置。 在需要在连续辐射治疗之间恢复时间的治疗方案中，本发明的施用器保留在皮肤下，允许皮肤至少部分愈合，并且稍后重新进行一次或多次随后的治疗。 为了减少患者的不适，麻醉剂可以通过施用器输注到患者组织，用于插入，球囊充气或去除涂抹器。

公开(公告)号：US20080009658A1

公开(公告)日：2008-01-10

申请号：US11471013

申请日：2006-06-19

申请人： Peter C. Smith ,  Michael Klein ,  Heike Hausen ,  Paul A. Lovoi

发明人： Peter C. Smith ,  Michael Klein ,  Heike Hausen ,  Paul A. Lovoi

IPC分类号： A61N5/00

CPC分类号： A61N5/1015 ,  A61B2017/22051 ,  A61B2090/0481 ,  A61N2005/1003 ,  A61N2005/1005 ,  A61N2005/1094

摘要： Brachytherapy applicators incorporate various forms of selective shielding devices for controlling the direction and intensity of radiation directed at a patient's tissue. In some forms the applicators include a retractable sheath, in some a series of retractable fingers. In other forms the applicator, having an inflatable balloon, has a shield which is retractable from a position adjacent to the balloon or retracted from the balloon, or a shield can itself be inflatable, separately or together with the balloon.