公开(公告)号：US09529065B2

公开(公告)日：2016-12-27

申请号：US14112135

申请日：2012-04-12

申请人： Jinnan Wang ,  Huijun Chen ,  Peter Börnert ,  Chun Yuan

发明人： Jinnan Wang ,  Huijun Chen ,  Peter Börnert ,  Chun Yuan

IPC分类号： G01V3/00 ,  G01R33/48 ,  G01R33/563

CPC分类号： G01R33/48 ,  G01R33/56316 ,  G01R33/5635

摘要： Interleaved black/bright imaging (IBBI) is performed using a magnetic resonance (MR) scanner wherein the black blood module of the IBBI includes: applying a first flow sensitization gradient; applying a spoiler gradient after applying the first flow sensitization gradient; applying a second flow sensitization gradient after applying the spoiler gradient wherein the second flow sensitization gradient has area equal to the first flow sensitization gradient but of opposite polarity; applying a slice selective radio frequency excitation pulse after applying the spoiler gradient; and performing a MR readout after applying the second flow sensitization gradient and after applying the slice selective radio frequency excitation wherein the readout acquires MR imaging data having blood signal suppression in the region excited by the slice selective radio frequency excitation pulse. The MR imaging data having blood signal suppression is reconstructed to generate black blood images, and MR imaging data generated by bright blood modules of the IBBI is reconstructed to generate bright blood images.

摘要翻译： 使用磁共振（MR）扫描器进行交错黑/亮成像（IBBI），其中IBBI的黑血模块包括：施加第一流感敏化梯度; 在应用第一流感敏化梯度后应用扰流板梯度; 在施加扰流板梯度之后施加第二流动增感梯度，其中第二流动增感梯度具有等于第一流动增感梯度但具有相反极性的面积; 应用扰流板梯度后应用切片选择性射频激励脉冲; 以及在应用所述第二流敏增强梯度之后并且在施加所述切片选择性射频激发之后执行MR读出，其中所述读出器获取在由所述切片选择性射频激励脉冲激发的区域中具有血液信号抑制的MR成像数据。 重建具有血液信号抑制的MR成像数据以产生黑血图像，并且重建由IBBI的亮血模块产生的MR成像数据以产生明亮的血液图像。

公开(公告)号：US20140035581A1

公开(公告)日：2014-02-06

申请号：US14112135

申请日：2012-04-12

申请人： Jinnan Wang ,  Huijun Chen ,  Peter Börnert ,  Chun Yuan

发明人： Jinnan Wang ,  Huijun Chen ,  Peter Börnert ,  Chun Yuan

IPC分类号： G01R33/48

CPC分类号： G01R33/48 ,  G01R33/56316 ,  G01R33/5635

摘要： Interleaved black/bright imaging (IBBI) is performed using a magnetic resonance (MR) scanner (10) wherein the black blood module (52) of the IBBI includes: applying a first flow sensitization gradient; applying a spoiler gradient after applying the first flow sensitization gradient; applying a second flow sensitization gradient after applying the spoiler gradient wherein the second flow sensitization gradient has area equal to the first flow sensitation gradient but of opposite polarity; applying a slice selective radio frequency excitation pulse after applying the spoiler gradient; and performing a MR readout after applying the second flow sensitization gradient and after applying the slice selective radio frequency excitation wherein the readout acquires MR imaging data having blood signal suppression in the region excited by the slice selective radio frequency excitation pulse. The MR imaging data having blood signal suppression is reconstructed to generate black blood images (20), and MR imaging data generated by bright blood modules (50) of the IBBI is reconstructed to generate bright blood images (22).

摘要翻译： 使用磁共振（MR）扫描器（10）进行交错黑/亮成像（IBBI），其中IBBI的黑血模块（52）包括：施加第一流感敏化梯度; 在应用第一流感敏化梯度后应用扰流板梯度; 在施加扰流板梯度之后施加第二流动增感梯度，其中第二流动增感梯度具有等于第一流动感觉梯度但具有相反极性的面积; 应用扰流板梯度后应用切片选择性射频激励脉冲; 以及在应用所述第二流敏增强梯度之后并且在施加所述切片选择性射频激发之后执行MR读出，其中所述读出器获取在由所述切片选择性射频激励脉冲激发的区域中具有血液信号抑制的MR成像数据。 重建具有血液信号抑制的MR成像数据以产生黑血图像（20），并重建由IBBI的亮血模块（50）产生的MR成像数据，以产生亮血图像（22）。

公开(公告)号：US09709644B2

公开(公告)日：2017-07-18

申请号：US14112183

申请日：2012-04-12

申请人： Jinnan Wang ,  Peter Börnert ,  Chun Yuan

发明人： Jinnan Wang ,  Peter Börnert ,  Chun Yuan

IPC分类号： G01V3/00 ,  G01R33/30 ,  G01R33/563

CPC分类号： G01R33/30 ,  G01R33/56316 ,  G01R33/5635

摘要： A black blood magnetic resonance imaging sequence is performed using a magnetic resonance scanner. The sequence includes: applying a first flow sensitization gradient; applying a spoiler gradient after applying the first flow sensitization gradient; applying a second flow sensitization gradient after applying the spoiler gradient wherein the second flow sensitization gradient has area equal to the first flow sensitization gradient but of opposite polarity; applying a slice-selective radio frequency excitation pulse after applying the spoiler gradient; and performing a magnetic resonance readout after applying the second flow sensitization gradient and after applying the slice selective radio frequency excitation. The readout acquires magnetic resonance imaging data having blood signal suppression in the region excited by the slice-selective radio frequency excitation pulse. The magnetic resonance imaging data is suitably reconstructed to generate a black blood image that may be displayed.

公开(公告)号：US20140043025A1

公开(公告)日：2014-02-13

申请号：US14112183

申请日：2012-04-12

申请人： Jinnan Wang ,  Peter Börnert ,  Chun Yuan

发明人： Jinnan Wang ,  Peter Börnert ,  Chun Yuan

IPC分类号： G01R33/30

CPC分类号： G01R33/30 ,  G01R33/56316 ,  G01R33/5635

摘要： A black blood magnetic resonance imaging sequence is performed using a magnetic resonance scanner. The sequence includes: applying a first flow sensitization gradient; applying a spoiler gradient after applying the first flow sensitization gradient; applying a second flow sensitization gradient after applying the spoiler gradient wherein the second flow sensitization gradient has area equal to the first flow sensitization gradient but of opposite polarity; applying a slice-selective radio frequency excitation pulse after applying the spoiler gradient; and performing a magnetic resonance readout after applying the second flow sensitization gradient and after applying the slice selective radio frequency excitation. The readout acquires magnetic resonance imaging data having blood signal suppression in the region excited by the slice-selective radio frequency excitation pulse. The magnetic resonance imaging data is suitably reconstructed to generate a black blood image that may be displayed.

摘要翻译： 使用磁共振扫描仪进行黑血液磁共振成像序列。 该序列包括：应用第一流感敏化梯度; 在应用第一流感敏化梯度后应用扰流板梯度; 在施加扰流板梯度之后施加第二流动增感梯度，其中第二流动增感梯度具有等于第一流动增感梯度但具有相反极性的面积; 应用扰流板梯度后应用切片选择射频激励脉冲; 以及在施加第二流动增感梯度之后并且在施加切片选择性射频激发之后执行磁共振读出。 读出器获取在由片选择射频激励脉冲激发的区域中具有血液信号抑制的磁共振成像数据。 适当地重建磁共振成像数据以产生可以显示的黑血图像。

公开(公告)号：US09523753B2

公开(公告)日：2016-12-20

申请号：US14112267

申请日：2012-04-13

申请人： Jinnan Wang ,  Michael Günter Helle ,  William Sean Kerwin ,  Peter Boernert ,  Chun Yuan

发明人： Jinnan Wang ,  Michael Günter Helle ,  William Sean Kerwin ,  Peter Boernert ,  Chun Yuan

IPC分类号： G01V3/00 ,  G01R33/563 ,  G01R33/56

CPC分类号： G01R33/5635 ,  G01R33/5602

摘要： Magnetic resonance (MR) spins are inverted by applying an inversion recovery (IR) radio frequency pulse (50). MR signals are acquired at an inversion time (TI) after the IR radio frequency pulse. TI is selected such that a first tissue of interest (e.g., blood) exhibits negative magnetism excited by the IR radio frequency pulse and a second tissue (e.g., intraplaque hemorrhage tissue) exhibits positive magnetism excited by the IR radio frequency pulse. The acquired magnetic resonance signals are reconstructed to generate spatial pixels or voxels wherein positive pixel or voxel values indicate spatial locations of positive magnetism and negative pixel or voxel values indicates spatial locations of negative magnetism. A first image (28) representative of the first tissue is generated from spatial pixels or voxels having negative signal intensities, and a second image (26) representative of the second tissue is generated from spatial pixels or voxels having positive signal intensities.

摘要翻译： 通过应用反转恢复（IR）射频脉冲（50）来反转磁共振（MR）自旋。 在IR射频脉冲之后，在反转时间（TI）获取MR信号。 选择TI，使得感兴趣的第一组织（例如血液）表现出由IR射频脉冲激发的负磁性，并且第二组织（例如，intraplaque出血组织）表现出由IR射频脉冲激发的正磁性。 所获取的磁共振信号被重建以产生空间像素或像素，其中正像素或体元值表示正磁性的空间位置，负像素或体素值表示负磁性的空间位置。 从具有负信号强度的空间像素或体素生成代表第一组织的第一图像（28），并且从具有正信号强度的空间像素或体素生成代表第二组织的第二图像（26）。

公开(公告)号：US20110092797A1

公开(公告)日：2011-04-21

申请号：US12922257

申请日：2009-02-20

申请人： Jinnan Wang ,  Vasily Yarnykh ,  Chun Yuan

发明人： Jinnan Wang ,  Vasily Yarnykh ,  Chun Yuan

IPC分类号： A61B5/055

CPC分类号： G01R33/56 ,  A61B5/05 ,  G01R33/5607 ,  G01R33/5617 ,  G01R33/563

摘要： An improved motion-sensitization driven equilibrium (iMSDE) sequence based upon an MLEV-4 sequence is used for black-blood vessel wall imaging. The MSDE pulse pattern that is used us a preparation sequence for other procedures employed to acquire images has been modified to produce the iMSDE sequence by the addition of a second 180 degree refocusing pulse and two motion sensitization gradients. The iMSDE sequence thus includes a group of four radio frequency (RF) pulses, as well as additional magnetic gradient pulses that are not included in the conventional MSDE sequence. Computer simulations indicate that this new pulse sequence is substantially more immune to local B1 inhomogeneity than conventional sequences. In vivo experiments have demonstrated significant signal improvement at high first-order moments (m1) conditions compared to the traditional MSDE sequence.

摘要翻译： 基于MLEV-4序列的改进的运动敏化驱动平衡（iMSDE）序列用于黑血管壁成像。 使用我们用于采集图像的其他过程的准备顺序的MSDE脉冲图案已被修改，以通过添加第二180度重聚焦脉冲和两个运动敏化梯度来产生iMSDE序列。 因此，iMSDE序列包括一组四个射频（RF）脉冲以及不包括在常规MSDE序列中的附加磁梯度脉冲。 计算机模拟表明，这种新的脉冲序列比常规序列显着地更多地免疫局部B1不均匀性。 与传统的MSDE序列相比，体内实验已经证明在高一阶矩（m1）条件下显着的信号改善。

公开(公告)号：US09448296B2

公开(公告)日：2016-09-20

申请号：US12922257

申请日：2009-02-20

申请人： Jinnan Wang ,  Vasily Yarnykh ,  Chun Yuan

发明人： Jinnan Wang ,  Vasily Yarnykh ,  Chun Yuan

IPC分类号： A61B5/05 ,  G01R33/56 ,  G01R33/561 ,  G01R33/563

CPC分类号： G01R33/56 ,  A61B5/05 ,  G01R33/5607 ,  G01R33/5617 ,  G01R33/563

摘要： An improved motion-sensitization driven equilibrium (iMSDE) sequence based upon an MLEV-4 sequence is used for black-blood vessel wall imaging. The MSDE pulse pattern that is used us a preparation sequence for other procedures employed to acquire images has been modified to produce the iMSDE sequence by the addition of a second 180 degree refocusing pulse and two motion sensitization gradients. The iMSDE sequence thus includes a group of four radio frequency (RF) pulses, as well as additional magnetic gradient pulses that are not included in the conventional MSDE sequence. Computer simulations indicate that this new pulse sequence is substantially more immune to local B1 inhomogeneity than conventional sequences. In vivo experiments have demonstrated significant signal improvement at high first-order moments (m1) conditions compared to the traditional MSDE sequence.

摘要翻译： 基于MLEV-4序列的改进的运动敏化驱动平衡（iMSDE）序列用于黑血管壁成像。 使用我们用于采集图像的其他过程的准备顺序的MSDE脉冲图案已被修改，以通过添加第二180度重聚焦脉冲和两个运动敏化梯度来产生iMSDE序列。 因此，iMSDE序列包括一组四个射频（RF）脉冲以及不包括在常规MSDE序列中的附加磁梯度脉冲。 计算机模拟表明，这种新的脉冲序列比常规序列显着地更多地免疫局部B1不均匀性。 与传统的MSDE序列相比，体内实验已经证明在高一阶矩（m1）条件下显着的信号改善。

公开(公告)号：US20140043021A1

公开(公告)日：2014-02-13

申请号：US14112267

申请日：2012-04-13

申请人： Jinnan Wang ,  Michael Günter Helle ,  William Sean Kerwin ,  Peter Boernert ,  Chun Yuan

发明人： Jinnan Wang ,  Michael Günter Helle ,  William Sean Kerwin ,  Peter Boernert ,  Chun Yuan

IPC分类号： G01R33/563

CPC分类号： G01R33/5635 ,  G01R33/5602

摘要： Magnetic resonance (MR) spins are inverted by applying an inversion recovery (IR) radio frequency pulse (50). MR signals are acquired at an inversion time (TI) after the IR radio frequency pulse. TI is selected such that a first tissue of interest (e.g., blood) exhibits negative magnetism excited by the IR radio frequency pulse and a second tissue (e.g., intraplaque hemorrhage tissue) exhibits positive magnetism excited by the IR radio frequency pulse. The acquired magnetic resonance signals are reconstructed to generate spatial pixels or voxels wherein positive pixel or voxel values indicate spatial locations of positive magnetism and negative pixel or voxel values indicates spatial locations of negative magnetism. A first image (28) representative of the first tissue is generated from spatial pixels or voxels having negative signal intensities, and a second image (26) representative of the second tissue is generated from spatial pixels or voxels having positive signal intensities.

摘要翻译： 通过应用反转恢复（IR）射频脉冲（50）来反转磁共振（MR）自旋。 在IR射频脉冲之后，在反转时间（TI）获取MR信号。 选择TI，使得感兴趣的第一组织（例如血液）表现出由IR射频脉冲激发的负磁性，并且第二组织（例如，intraplaque出血组织）表现出由IR射频脉冲激发的正磁性。 所获取的磁共振信号被重建以产生空间像素或像素，其中正像素或体元值表示正磁性的空间位置，负像素或体素值表示负磁性的空间位置。 从具有负信号强度的空间像素或体素产生代表第一组织的第一图像（28），并且从具有正信号强度的空间像素或体素产生代表第二组织的第二图像（26）。

公开(公告)号：US20130216025A1

公开(公告)日：2013-08-22

申请号：US13881179

申请日：2011-10-24

申请人： Raymond Chan ,  Jinnan Wang ,  Adrien Emmanuel Desjardins ,  Luis Felipe Gutierrez ,  Maya Ella Barley ,  Gert Wim 'T Hooft

发明人： Raymond Chan ,  Jinnan Wang ,  Adrien Emmanuel Desjardins ,  Luis Felipe Gutierrez ,  Maya Ella Barley ,  Gert Wim 'T Hooft

IPC分类号： A61B6/00

CPC分类号： A61B6/488 ,  A61B5/055 ,  A61B5/066 ,  A61B6/03 ,  A61B6/12 ,  A61B6/486 ,  A61B6/487 ,  A61B6/504 ,  A61B6/5229 ,  A61B6/54 ,  A61B6/542 ,  A61B34/20 ,  A61B2017/00075 ,  A61B2034/2051 ,  A61B2034/2061

摘要： A system and method for adaptive imaging include a shape sensing system (115, 117) coupled to an interventional device (102) to measure spatial characteristics of the interventional device in a subject. An image module (130) is configured to receive the spatial characteristics and generate one or more control signals in accordance with the spatial characteristics. An imaging device (110) is configured to image the subject in accordance with the control signals.

摘要翻译： 用于自适应成像的系统和方法包括耦合到介入装置（102）以测量受试者中介入装置的空间特征的形状感测系统（115,117）。 图像模块（130）被配置为接收空间特性并根据空间特性产生一个或多个控制信号。 成像装置（110）被配置为根据控制信号对被摄体进行成像。

公开(公告)号：US09183972B2

公开(公告)日：2015-11-10

申请号：US13146433

申请日：2010-07-05

申请人： Aimin Li ,  Chendong Shuang ,  Chao Long ,  Fuqiang Liu ,  Jinnan Wang ,  Qing Zhou ,  Yuzhi Xue ,  Youdong Zhou ,  Mancheng Zhang ,  Weiben Yang ,  Zhaolian Zhu

发明人： Aimin Li ,  Chendong Shuang ,  Chao Long ,  Fuqiang Liu ,  Jinnan Wang ,  Qing Zhou ,  Yuzhi Xue ,  Youdong Zhou ,  Mancheng Zhang ,  Weiben Yang ,  Zhaolian Zhu

IPC分类号： H01F1/01 ,  C08L33/24 ,  C08F2/44 ,  C08K3/22

CPC分类号： H01F1/01 ,  C08F2/44 ,  C08K2003/2265 ,  C08L33/24 ,  C22C2202/02 ,  Y10S428/90

摘要： This invention relates to the field of resin, particularly to a magnetic, acrylic strongly basic anion exchange microsphere resin and its manufacturing method. Its basic structure is as follow: wherein its matrix contains magnetic grains and A is a group containing quaternary ammonium salts; the manufacturing method is: taking acrylic compounds as the monomer and mixing it with the crosslinking agent and porogenic agent to form an oil phase; evenly mixing the oil phase with magnetic grains and then conducting suspension polymerization; aminating and alkylating the polymerized magnetic grains so as to form the quaternary ammonium salts, namely the magnetic, acrylic strongly basic anion exchange microsphere resin. The exchange capacity of this resin is higher than that of any magnetic strongly basic anion exchange microsphere resin available either on both Chinese and overseas markets or in literature; it is able to take the place of the traditional strongly basic anion exchange resin in separating and removing soluble organics, particularly precursors of disinfection by-products, and various anions such as nitrates and phosphates.

摘要翻译： 本发明涉及树脂领域，特别涉及磁性丙烯酸强碱性阴离子交换微球树脂及其制造方法。 其基本结构如下：其中基质含有磁性颗粒，A为含有季铵盐的基团; 制造方法是：以丙烯酸类化合物为单体，并与交联剂和致孔剂混合形成油相; 将油相与磁性颗粒均匀混合，然后进行悬浮聚合; 对聚合的磁性颗粒进行胺化和烷基化以形成季铵盐，即磁性，丙烯酸强碱性阴离子交换微球体树脂。 该树脂的交换能力高于中国和海外市场或文献中可获得的任何磁性强碱性阴离子交换微球树脂; 可以代替传统的强碱性阴离子交换树脂来分离和除去可溶性有机物，特别是消毒副产物的前体，以及各种阴离子如硝酸盐和磷酸盐。