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公开(公告)号：US20050001076A1
公开(公告)日：2005-01-06
申请号：US10877134
申请日：2004-06-25
CPC分类号： B05B1/00 , A61M11/06 , A61M15/0065 , A61M2205/0244 , B05B15/40
摘要： A microstructured nozzle consists of a number of channels produced by microstructuring a plate-shaped member. In the nozzle the channels are located between projections which are arranged side by side in rows and project from a base plate. This microstructured base plate is covered with a cover plate. The channels are narrowly defined in terms of shape, cross sectional area and length. The nozzle contains a filter as the primary structure and a secondary structure downstream of the filter. The nozzle is used, for example, with an atomiser which produces an aerosol from a fluid containing a medicament.
摘要翻译： 微结构喷嘴由通过微结构化板状构件产生的多个通道组成。 在喷嘴中，通道位于并排排列并从基板突出的突起之间。 该微结构基板用盖板覆盖。 通道在形状，横截面面积和长度方面被狭义地定义。 喷嘴包含作为主要结构的过滤器和过滤器下游的二级结构。 喷嘴例如使用从含有药物的流体产生气溶胶的雾化器使用。
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公开(公告)号：US07896264B2
公开(公告)日：2011-03-01
申请号：US10877134
申请日：2004-06-25
IPC分类号： B01D50/00
CPC分类号： B05B1/00 , A61M11/06 , A61M15/0065 , A61M2205/0244 , B05B15/40
摘要： A microstructured nozzle consists of a number of channels produced by microstructuring a plate-shaped member. In the nozzle the channels are located between projections which are arranged side by side in rows and project from a base plate. This microstructured base plate is covered with a cover plate. The channels are narrowly defined in terms of shape, cross sectional area and length. The nozzle contains a filter as the primary structure and a secondary structure downstream of the filter.The nozzle is used, for example, with an atomiser which produces an aerosol from a fluid containing a medicament.
摘要翻译： 微结构喷嘴由通过微结构化板状构件产生的多个通道组成。 在喷嘴中，通道位于并排排列并从基板突出的突起之间。 该微结构基板用盖板覆盖。 通道在形状，横截面面积和长度方面被狭义地定义。 喷嘴包含作为主要结构的过滤器和过滤器下游的二级结构。 喷嘴例如使用从含有药物的流体产生气溶胶的雾化器使用。
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公开(公告)号：US20060016449A1
公开(公告)日：2006-01-26
申请号：US11232896
申请日：2005-09-23
申请人： Joachim Eicher , Johannes Geser , Matthias Hausmann , Michael Schyra , Gilbert Wuttke , Andreas Fiol , Heinrich Kladders , Dieter Hochrainer , Bernd Zierenberg
发明人： Joachim Eicher , Johannes Geser , Matthias Hausmann , Michael Schyra , Gilbert Wuttke , Andreas Fiol , Heinrich Kladders , Dieter Hochrainer , Bernd Zierenberg
IPC分类号： A61M11/00
CPC分类号： B05B11/0054 , A61M15/0065 , B05B11/0008 , B05B11/00412 , B05B11/0044 , B05B11/00444 , B05B11/00446
摘要： For meteredly dispensing a liquid over a period of several months from a container which can be stored over a long period of time, the need is for a container which is practically diffusion-tight and in which the liquid does not come into contact with the ambient atmosphere. The cartridge according to the invention is a three-shell container comprising a collapsible bag which contains the liquid, a container which is stable in respect of shape and a stiff metal casing. The cartridge can be releasably connected to a dispensing device. The cartridge can be provided with a micro-opening with which the time for pressure equalisation between the cartridge and the ambient atmosphere can be adjusted. The cartridge is suitable for aqueous and for alcoholic liquids which contain a pharmaceutically active substance. The liquid in the cartridge is protected from external influences. The cartridge can be used in an atomiser for producing an inhalable aerosol for the treatment of illnesses.
摘要翻译： 对于可以长时间储存的容器在几个月的时间内计量分配液体，需要一种几乎不扩散的容器，其中液体不会与环境接触 大气层。 根据本发明的墨盒是一种三壳容器，其包括容纳液体的可折叠袋，相对于形状稳定的容器和刚性金属外壳。 盒可以可释放地连接到分配装置。 墨盒可以设置有微孔，可以调节墨盒和环境大气之间的压力均衡时间。 该药筒适用于含有药物活性物质的水溶液和含酒精液体。 保护盒中的液体免受外部影响。 墨盒可用于雾化器中，用于产生用于治疗疾病的可吸入气雾剂。
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公开(公告)号：US07802568B2
公开(公告)日：2010-09-28
申请号：US11232896
申请日：2005-09-23
申请人： Joachim Eicher , Johannes Geser , Matthias Hausmann , Michael Schyra , Gilbert Wuttke , Andreas Fiol , Heinrich Kladders , Dieter Hochrainer , Bernd Zierenberg
发明人： Joachim Eicher , Johannes Geser , Matthias Hausmann , Michael Schyra , Gilbert Wuttke , Andreas Fiol , Heinrich Kladders , Dieter Hochrainer , Bernd Zierenberg
CPC分类号： B05B11/0054 , A61M15/0065 , B05B11/0008 , B05B11/00412 , B05B11/0044 , B05B11/00444 , B05B11/00446
摘要： For meteredly dispensing a liquid over a period of several months from a container which can be stored over a long period of time, the need is for a container which is practically diffusion-tight and in which the liquid does not come into contact with the ambient atmosphere. The cartridge according to the invention is a three-shell container comprising a collapsible bag which contains the liquid, a container which is stable in respect of shape and a stiff metal casing. The cartridge can be releasably connected to a dispensing device. The cartridge can be provided with a micro-opening with which the time for pressure equalisation between the cartridge and the ambient atmosphere can be adjusted. The cartridge is suitable for aqueous and for alcoholic liquids which contain a pharmaceutically active substance. The liquid in the cartridge is protected from external influences. The cartridge can be used in an atomiser for producing an inhalable aerosol for the treatment of illnesses.
摘要翻译： 对于可以长时间储存的容器在几个月的时间内计量分配液体，需要一种几乎不扩散的容器，其中液体不会与环境接触 大气层。 根据本发明的墨盒是一种三壳容器，其包括容纳液体的可折叠袋，相对于形状稳定的容器和刚性金属外壳。 盒可以可释放地连接到分配装置。 墨盒可以设置有微孔，可以调节墨盒和环境大气之间的压力均衡时间。 该药筒适用于含有药物活性物质的水溶液和含酒精液体。 保护盒中的液体免受外部影响。 墨盒可用于雾化器中，用于产生用于治疗疾病的可吸入气雾剂。
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公开(公告)号：US20130199521A1
公开(公告)日：2013-08-08
申请号：US13809897
申请日：2011-07-05
申请人： Matthias Hausmann , Steffen Schuy , Joachim Eicher , Johannes Geser , Martin Meisenheimer , Florian Witte
发明人： Matthias Hausmann , Steffen Schuy , Joachim Eicher , Johannes Geser , Martin Meisenheimer , Florian Witte
IPC分类号： A61M11/00
CPC分类号： A61M11/003 , A61M11/00 , A61M11/007 , A61M11/02 , A61M11/06 , A61M15/009 , A61M2205/7545 , A61M2205/8281 , A61M2207/00 , B05B11/00412 , B05B11/3001 , B05B11/308 , B05B11/3091 , Y10T29/49826
摘要： The invention relates to a medical hand-held device, in particular an atomizer (1), for dispensing a liquid pharmaceutical preparation from a container. The pharmaceutical preparation can be based, for example, on an alcoholic solvent. The proposed atomizer has a discharge nozzle for the pharmaceutical preparation. Located upstream from the discharge nozzle (12d, 12e) there is a multiple-stage filter system, which is composed of at least three filtering components (27, 28, 12f). The filters differ from one another in terms of their filter threshold and their filter materials and/or filter effect. In particular, the use of a filter made of sintered metal is proposed in order to avoid penetration of particles into a microstructured component (12), which can also contain a very fine filter in front of the nozzle. Alternatively or in addition, it is also proposed to use an adsorption filter in the flow path between a coarse filter and the microstructured component.
摘要翻译： 本发明涉及用于从容器分配液体药物制剂的医疗手持装置，特别是雾化器（1）。 药物制剂可以基于例如醇溶剂。 所提出的雾化器具有用于药物制剂的排出喷嘴。 位于排出喷嘴（12d，12e）上游的是由至少三个过滤部件（27,28,12f）组成的多级过滤器系统。 滤波器的滤波器阈值和滤波器材料和/或滤波器效应方面的滤波器彼此不同。 特别地，提出了使用由烧结金属制成的过滤器，以避免颗粒渗透到微结构部件（12）中，微结构部件（12）也可以在喷嘴前面包含非常精细的过滤器。 或者或另外，还提出在粗过滤器和微结构部件之间的流动路径中使用吸附过滤器。
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公开(公告)号：US08061350B2
公开(公告)日：2011-11-22
申请号：US11421928
申请日：2006-06-02
申请人： Georg Boeck , Johannes Geser , Matthias Hausmann , Hans-Juergen Koelbel , Joachim Eicher , Christian Feiertag
发明人： Georg Boeck , Johannes Geser , Matthias Hausmann , Hans-Juergen Koelbel , Joachim Eicher , Christian Feiertag
IPC分类号： A61M16/00
CPC分类号： F04B53/16 , B05B9/0413 , B05B11/3001
摘要： A process and a device for dosing a pharmaceutical agent, preferably a liquid, are proposed. To achieve an enhanced dosing accuracy, a first component that is produced in batches, such as a shaped seal, is combined with a second component, such as a guide pipe selected from a suitable group guide pipes, wherein the suitable group of second components is selected based on at least one decisively significant value of the respective batch first components and is distinguished by an essential value of the second component which will optimize the sealing between the first and second components.
摘要翻译： 提出了用于给药剂（优选液体）给药的方法和装置。 为了实现增加的计量精确度，批量生产的第一部件（例如成形密封件）与第二部件组合，例如选自合适的组导管的导管，其中适当的第二部件组是 基于相应的批次第一分量的至少一个决定性有意义的值来选择，并且通过将优化第一和第二组分之间的密封的第二组分的基本值进行区分。
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公开(公告)号：US06988496B1
公开(公告)日：2006-01-24
申请号：US09511267
申请日：2000-02-23
申请人： Joachim Eicher , Johannes Geser , Matthias Hausmann , Michael Schyra , Gilbert Wuttke , Andreas Fiol , Heinrich Kladders , Dieter Hochrainer , Bernd Zierenberg
发明人： Joachim Eicher , Johannes Geser , Matthias Hausmann , Michael Schyra , Gilbert Wuttke , Andreas Fiol , Heinrich Kladders , Dieter Hochrainer , Bernd Zierenberg
CPC分类号： B05B11/0054 , A61M15/0065 , B05B11/0008 , B05B11/00412 , B05B11/0044 , B05B11/00444 , B05B11/00446
摘要： For meteredly dispensing a liquid over a period of several months from a container which can be stored over a long period of time, the need is for a container which is practically diffusion-tight and in which the liquid does not come into contact with the ambient atmosphere.The cartridge according to the invention is a three-shell container comprising a collapsible bag which contains the liquid, a container which is stable in respect of shape and a stiff metal casing. The cartridge can be releasably connected to a dispensing device. The cartridge can be provided with a micro-opening with which the time for pressure equalisation between the cartridge and the ambient atmosphere can be adjusted. The cartridge is suitable for aqueous and for alcoholic liquids which contain a pharmacologically active substance. The liquid in the cartridge is protected from external influences.The cartridge can be used in an atomiser for producing an inhalable aerosol for the treatment of illnesses.
摘要翻译： 对于可以长时间储存的容器在几个月的时间内计量分配液体，需要一种几乎不扩散的容器，其中液体不会与环境接触 大气层。 根据本发明的墨盒是一种三壳容器，其包括容纳液体的可折叠袋，相对于形状稳定的容器和刚性金属外壳。 盒可以可释放地连接到分配装置。 墨盒可以设置有微孔，可以调节墨盒和环境大气之间的压力均衡时间。 该墨盒适用于含有药理活性物质的含水液体和含酒精液体。 保护盒中的液体免受外部影响。 墨盒可用于雾化器中，用于产生用于治疗疾病的可吸入气雾剂。
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公开(公告)号：US20050194472A1
公开(公告)日：2005-09-08
申请号：US11031171
申请日：2005-01-07
申请人： Johannes Geser , Matthias Hausmann
发明人： Johannes Geser , Matthias Hausmann
CPC分类号： B05B1/00 , Y10T29/49826
摘要： A fluidic component consisting of silicon/glass, for example, is arranged in an elastomeric shaped part made of silicon rubber, for example, the contour of which is matched to the outer contour of the component and to the inner contour of a holder. The elastomeric shaped part is chamfered towards the fluidic component on its pressure side. When the holder is assembled the elastomeric shaped part is deformed by a projection provided on the mating part and is put under uniformly distributed internal tension, after which the elastomeric shaped part surrounds the fluidic component to its full height. This “floating mounting” means that there are no unacceptable local tension peaks and no deformation of the component. The mounting is sealed against the fluid even when the fluid pressure fluctuates repeatedly from a very low level to several 100 bar.
摘要翻译： 例如由硅/玻璃组成的流体组分布置在由硅橡胶制成的弹性体部分中，例如其轮廓与部件的外轮廓和保持器的内轮廓匹配。 弹性体部件在其压力侧朝向流体部件倒角。 当保持器组装时，弹性体部分被设置在配合部分上的突起变形，并且处于均匀分布的内部张力下，之后弹性体成形部分将流体部件包围到其全部高度。 这种“浮动安装”意味着没有不可接受的局部张力峰值，并且部件没有变形。 即使当液体压力从非常低的水平重复地变化到几百巴时，安装件也密封在流体上。
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公开(公告)号：US20070090205A1
公开(公告)日：2007-04-26
申请号：US11426406
申请日：2006-06-26
申请人： Hubert Kunze , Matthias Hausmann , Jens Besseler , Carsten Henning , Heinrich Kladders , Florian Witte , Johannes Geser , Markus Mast , Antonino Lanci , Christoph Dworzak , Elmar Mock
发明人： Hubert Kunze , Matthias Hausmann , Jens Besseler , Carsten Henning , Heinrich Kladders , Florian Witte , Johannes Geser , Markus Mast , Antonino Lanci , Christoph Dworzak , Elmar Mock
IPC分类号： A61M11/06
CPC分类号： B05B11/3091 , B05B11/0044 , B05B11/0054 , B05B11/3001
摘要： A nebuliser and a container in each case with an aeration device are proposed, the aeration device being designed for the direct aeration of a liquid space in the container. The container comprises a rigid, gas-tight outer case and a closure, which is opened by connecting or inserting a delivery element. A long storage life and long service life with low loss of fluid or solvent are thereby provided in the form of a simple and inexpensive construction.
摘要翻译： 提出了在每种情况下具有曝气装置的雾化器和容器，曝气装置被设计用于直接曝气容器中的液体空间。 容器包括刚性的气密外壳和通过连接或插入输送元件打开的封闭件。 因此，以简单且廉价的结构的形式提供了具有较低的流体或溶剂损失的长存储寿命和长的使用寿命。
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公开(公告)号：US07950388B2
公开(公告)日：2011-05-31
申请号：US11426406
申请日：2006-06-26
申请人： Hubert Kunze , Matthias Hausmann , Jens Besseler , Carsten Henning , Heinrich Kladders , Florian Witte , Johannes Geser , Markus Mast , Antonino Lanci , Christoph Dworzak , Elmar Mock
发明人： Hubert Kunze , Matthias Hausmann , Jens Besseler , Carsten Henning , Heinrich Kladders , Florian Witte , Johannes Geser , Markus Mast , Antonino Lanci , Christoph Dworzak , Elmar Mock
IPC分类号： A61M11/00
CPC分类号： B05B11/3091 , B05B11/0044 , B05B11/0054 , B05B11/3001
摘要： A nebuliser and a container in each case with an aeration device are proposed, the aeration device being designed for the direct aeration of a liquid space in the container. The container comprises a rigid, gas-tight outer case and a closure, which is opened by connecting or inserting a delivery element. A long storage life and long service life with low loss of fluid or solvent are thereby provided in the form of a simple and inexpensive construction.
摘要翻译： 提出了在每种情况下具有曝气装置的雾化器和容器，曝气装置被设计用于直接曝气容器中的液体空间。 容器包括刚性的气密外壳和通过连接或插入输送元件打开的封闭件。 因此，以简单且廉价的结构的形式提供了具有较低的流体或溶剂损失的长存储寿命和长的使用寿命。
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