公开(公告)号：US20080194730A1

公开(公告)日：2008-08-14

申请号：US12077644

申请日：2008-03-20

申请人： Joachim Klee ,  Uwe Walz ,  Uwe Lehmann

发明人： Joachim Klee ,  Uwe Walz ,  Uwe Lehmann

IPC分类号： A61K6/08

CPC分类号： A61K6/0023 ,  C08L33/00

摘要： An aqueous one-pack self-etching and self-priming dental adhesive composition having a pH of at most 2, which comprises: (i) a polymerizable N-substituted alkylacrylic or acrylic acid amide monomer which optionally contains an inorganic acidic moiety selected from a phosphonic acid moiety or a sulfonic acid moiety, and (ii) a curing system.

摘要翻译： 一种pH值至多为2的含水单组份自蚀刻和自吸牙科粘合剂组合物，其包含：（i）可聚合的N-取代烷基丙烯酸或丙烯酸酰胺单体，其任选地含有选自以下的无机酸性部分： 膦酸部分或磺酸部分，和（ii）固化体系。

公开(公告)号：US20070293642A1

公开(公告)日：2007-12-20

申请号：US10596747

申请日：2004-12-15

申请人： Joachim Klee ,  Uwe Lehmann ,  Uwe Walz

发明人： Joachim Klee ,  Uwe Lehmann ,  Uwe Walz

IPC分类号： C07F9/09 ,  A61K6/00 ,  C08F30/02 ,  A61K6/083

CPC分类号： A61K6/0023 ,  C07F9/091 ,  C08L33/00 ,  C08L43/02

摘要： One-part self-etching, self-priming dental adhesive composition having a pH of at most 2, which comprises (a) a polymerizable acidic phosphoric acid ester monomer (b) one or more polymerizable acidic monomers (c) a polymerizable N-substituted alkylacrylic or acrylic acid amide monomer; (d) optionally an organic and/or inorganic acid; (e) an organic water soluble solvent and/or water; and (f) polymerization initiator, inhibitor and stabilizer.

摘要翻译： 一部分自蚀刻自粘牙科粘合剂组合物，其pH最多为2，其包含（a）可聚合酸性磷酸酯单体（b）一种或多种可聚合酸性单体（c）可聚合的N-取代的 烷基丙烯酸或丙烯酰胺单体; （d）任选的有机和/或无机酸; （e）有机水溶性溶剂和/或水; 和（f）聚合引发剂，抑制剂和稳定剂。

公开(公告)号：US20060246017A1

公开(公告)日：2006-11-02

申请号：US10548362

申请日：2004-03-05

申请人： Joachim Klee ,  Uwe Walz ,  Uwe Lehmann ,  Huaibing Liu

发明人： Joachim Klee ,  Uwe Walz ,  Uwe Lehmann ,  Huaibing Liu

IPC分类号： A61K8/46 ,  C09D5/16 ,  C07F9/02

CPC分类号： A61K6/083 ,  A61K6/0023 ,  C07F9/091 ,  C07F9/093 ,  C08F30/02 ,  C08L43/02 ,  C08L33/00

摘要： The present invention provides a polymerizable phosphoric acid ester derivative having the following formula (A): wherein Z is COOR1, COSR1, CON(R1)2, CONR1 R2, or CONHR1, R1 and R2 independently are a hydrogen atom, a substituted or unsubstituted C1 to C18 alkyl group optionally substituted by a C3 to C8 cycloalkyl group, a substituted or unsubstituted C3 to C8 cycloalkyl group, a substituted or unsubstituted C4 to C,18 aryl or heteroaryl group, a substituted or unsubstituted C5 to C18 alkylaryl or alkylheteroaryl group, or a substituted or unsubstituted C7 to C30 aralkyl group, whereby two R1 residues may form together with the N-atom to which they are bonded a 5- to 7-membered heterocyclic ring which may contain beside said N-atom a further nitrogen atom or an oxygen atom, and whereby the substituted groups may be substituted by 1 to 5 C1 to C5 alkyl group(s); a is an integer of from 1 to 10, preferably 1 to 5; b is an integer of from 1 to 10, preferably 1 to 5; and R represents an organic residue containing a+b carbon atoms selected from primary and secondary aliphatic carbon atoms, secondary alicyclic carbon atoms, and aromatic carbon atoms, each of said carbon atoms linking a phosphate or 2-(oxa-ethyl)acryl derivative group.

摘要翻译： 本发明提供具有下式（A）的可聚合磷酸酯衍生物：其中Z为COOR 1，COS 1，CON（R 1） 2/2，CONR 1，R 2，或CONHR 1，R 1，/ SUB >和R 2独立地是氢原子，取代或未取代的C 1至C 18烷基，任选被C 1 -C 6烷基取代， 3个C 8环烷基，取代或未取代的C 3〜C 8环烷基，取代或未取代的C 1〜 取代或未取代的C 5〜C 18烷基芳基或烷基杂芳基 或者取代或未取代的C 7〜C 20芳烷基，由此两个R 1残基可以与N-原子一起形成 它们与5至7元杂环键合，该杂环可以在所述N-原子旁边另外含有硝基 原子或氧原子，并且其中取代基可以被1至5个C 1至C 5烷基取代; a为1〜10的整数，优选为1〜5; b为1〜10的整数，优选为1〜5; R表示含有选自伯和仲脂族碳原子，仲脂环族碳原子和芳族碳原子的+ b个碳原子的有机残基，所述碳原子各自连接磷酸酯或2-（氧杂 - 乙基）丙烯酰基衍生物基团 。

公开(公告)号：US20080103229A1

公开(公告)日：2008-05-01

申请号：US12002550

申请日：2007-12-18

申请人： Uwe Walz ,  Joachim Klee

发明人： Uwe Walz ,  Joachim Klee

IPC分类号： A61K6/08

CPC分类号： A61K6/083 ,  C07D211/94 ,  C08F265/04 ,  C08F290/00 ,  C08F290/06 ,  C08F291/00 ,  C08F293/005 ,  C08K5/3435 ,  C08L51/003 ,  C08L53/00 ,  C08L25/00

摘要： Dental composition having an improved light and thermal stability, including a mixture of at least a polymerizable resin, at least a polymerizable monomer, at least a polymerization initiator and/or a sensitizer and stabilizer, and at least an organic and/or inorganic filler and pigments in a content of 0 to 90 percent and at least one of the stable radicals.

摘要翻译： 具有改善的光和热稳定性的牙科组合物，包括至少可聚合树脂，至少可聚合单体，至少聚合引发剂和/或敏化剂和稳定剂的混合物，以及至少一种有机和/或无机填料和 含量为0至90％的颜料和至少一种稳定的基团。

公开(公告)号：US20050054748A1

公开(公告)日：2005-03-10

申请号：US10943355

申请日：2004-09-17

申请人： Joachim Klee ,  Uwe Walz ,  Rolf Mulhaupt

发明人： Joachim Klee ,  Uwe Walz ,  Rolf Mulhaupt

IPC分类号： A61K6/00 ,  A61K6/083 ,  C07C255/23 ,  A61K6/08

CPC分类号： A61K6/0023 ,  A61K6/0017 ,  A61K6/083 ,  A61K6/09 ,  C07C255/23 ,  C08L33/00 ,  C08L75/16

摘要： A dental composition including a mono- and/or a poly-cyanoacrylate, a polymerizable monomer, a stabilizer, an initiator, and optionally, pigments and a filling material.

摘要翻译： 包含单 - 和/或聚 - 氰基丙烯酸酯，可聚合单体，稳定剂，引发剂和任选的颜料和填充材料的牙科用组合物。

公开(公告)号：US20070129458A1

公开(公告)日：2007-06-07

申请号：US11699597

申请日：2007-01-29

申请人： Uwe Walz ,  Joachim Klee

发明人： Uwe Walz ,  Joachim Klee

IPC分类号： A61K6/083

CPC分类号： A61K6/0835 ,  A61K6/0038 ,  A61K6/083 ,  A61K6/087 ,  C08L33/26 ,  C08L79/02

摘要： The invention concerns a dental composition comprising bisacrylamides that are polymerizable by free-radical polymerization and by Michael-addition polymerization with amines. The application of polymerization and addition polymerization with amines opens the possibility to completely reacted materials that have no oxygen inhibited layers. The claimed bisacrylamides have an improved hydrolytic stability.

摘要翻译： 本发明涉及包含可通过自由基聚合和通过与胺进行迈克尔加成聚合的双丙烯酰胺的牙科用组合物。 聚合和加成聚合与胺的应用开启了不具有抑氧层的完全反应的材料的可能性。 要求保护的双丙烯酰胺具有改进的水解稳定性。

公开(公告)号：US20100160485A1

公开(公告)日：2010-06-24

申请号：US12583860

申请日：2009-08-27

申请人： Joachim Klee ,  Uwe Walz ,  Uwe Lehman

发明人： Joachim Klee ,  Uwe Walz ,  Uwe Lehman

IPC分类号： A61K6/00

CPC分类号： A61K6/0023 ,  C08L33/00

摘要： An aqueous one-pack self-etching and self-priming dental adhesive composition having a pH of at most 2, which comprises: (i) a polymerizable N-substituted alkylacrylic or acrylic acid amide monomer which optionally contains an inorganic acidic moiety selected from a phosphonic acid moiety or a sulfonic acid moiety, and (ii) a curing system.

摘要翻译： 一种pH值至多为2的含水单组份自蚀刻和自吸牙科粘合剂组合物，其包含：（i）可聚合的N-取代烷基丙烯酸或丙烯酸酰胺单体，其任选地含有选自以下的无机酸性部分： 膦酸部分或磺酸部分，和（ii）固化体系。

公开(公告)号：US20050043490A1

公开(公告)日：2005-02-24

申请号：US10938459

申请日：2004-09-10

申请人： Joachim Klee ,  Uwe Walz

发明人： Joachim Klee ,  Uwe Walz

IPC分类号： A61K6/00 ,  A61K6/083 ,  A61K6/087 ,  A61K6/09 ,  C08F283/02 ,  C08F290/06 ,  C08G18/83 ,  C08G59/10 ,  C08G59/12 ,  C08G59/14 ,  C08G59/17 ,  C08G59/42 ,  C08G63/02 ,  C08F267/04

CPC分类号： A61K6/0017 ,  A61K6/0032 ,  A61K6/083 ,  A61K6/087 ,  A61K6/09 ,  C08F283/02 ,  C08F290/06 ,  C08F290/061 ,  C08F290/064 ,  C08G18/835 ,  C08G59/10 ,  C08G59/12 ,  C08G59/1466 ,  C08G59/1494 ,  C08G59/4292 ,  C08G2270/00 ,  C08L63/00 ,  C08L33/00 ,  C08L75/16

摘要： An esterified macromonomer within the scope of the general formula: wherein Z is an organic moiety, R1 is hydrogen or a substituted or unsubstituted alkyl having from 1 to 12 carbon atoms, oxyalkyl having from 1 to 12 carbon atoms, alkenyl having from 2 to 12 carbon atoms, cycloalkyl having from 5 to 12 carbon atoms, aryl having from 6 to 12 carbon atoms or aralkyl having from 7 to 12 carbon atoms, each E independently is a hydroxyl group, an organic ester moiety or an inorganic ester containing moiety and at least one E is an ester containing moiety, n and m each independently is an integer from 2 to 12. The esterified macromonomer is obtainable by esterification of at least a portion of the —OH groups of a macromonomer having at least one terminal double bond with at least one derivative of an inorganic or organic acid which introduces pendant groups exhibiting at least one acid moiety selected from the group of consisting of —COOH, —PO3H2, —SO3H, —BO2H or salts thereof. The number of the acid moieties is chosen such that a polymer obtained by polymerizing those monomers has an adhesive strength to dentine of at least 2 MPa.

摘要翻译： 在通式范围内的酯化大分子单体：其中Z是有机部分，R 1是氢或具有1至12个碳原子的取代或未取代的烷基，具有1至12个碳原子的烷氧基，具有2至12个的烯基 碳原子，具有5至12个碳原子的环烷基，具有6至12个碳原子的芳基或具有7至12个碳原子的芳烷基，每个E独立地是羟基，有机酯部分或含无机酯的部分， 至少一个E是含酯部分，n和m各自独立地为2至12的整数。酯化的大分子单体可通过至少一部分具有至少一个末端双键的大分子单体的-OH基团酯化得到 引入具有至少一个选自-COOH，-PO 3 H 2，-SO 3 H，-BO 2 H或其盐的至少一个酸基部分的侧基的无机或有机酸的至少一种衍生物。 选择酸部分的数目使得通过聚合这些单体获得的聚合物对牙本质的粘合强度至少为2MPa。

公开(公告)号：US08198388B2

公开(公告)日：2012-06-12

申请号：US10596747

申请日：2004-12-15

申请人： Joachim E. Klee ,  Uwe Lehmann ,  Uwe Walz

发明人： Joachim E. Klee ,  Uwe Lehmann ,  Uwe Walz

IPC分类号： C08F30/02

CPC分类号： A61K6/0023 ,  C07F9/091 ,  C08L33/00 ,  C08L43/02

摘要： One-part self-etching, self-priming dental adhesive composition having a pH of at most 2, which comprises (a) a polymerizable acidic phosphoric acid ester monomer (b) one or more polymerizable acidic monomers (c) a polymerizable N-substituted alkylacrylic or acrylic acid amide monomer; (d) optionally an organic and/or inorganic acid; (e) an organic water soluble solvent and/or water; and (f) polymerization initiator, inhibitor and stabilizer.

摘要翻译： 一部分自蚀刻自粘牙科粘合剂组合物，其pH最多为2，其包含（a）可聚合酸性磷酸酯单体（b）一种或多种可聚合酸性单体（c）可聚合的N-取代的 烷基丙烯酸或丙烯酰胺单体; （d）任选的有机和/或无机酸; （e）有机水溶性溶剂和/或水; 和（f）聚合引发剂，抑制剂和稳定剂。

公开(公告)号：US07041709B2

公开(公告)日：2006-05-09

申请号：US10341985

申请日：2003-01-14

申请人： Joachim E. Klee ,  Uwe Lehmann ,  Uwe Walz

发明人： Joachim E. Klee ,  Uwe Lehmann ,  Uwe Walz

IPC分类号： C08J3/28

CPC分类号： B82Y30/00 ,  A61K6/0008 ,  A61K6/0023 ,  C08L83/10

摘要： A composition including nanoparticles each having an acidic polymerizable siloxane moiety. For example, a hydrolysis stable, self-etching, self-priming dental adhesive composition including 90 to 10 percent by weight of an aqueous phase, and 10 to 90 percent by weight of acidic polymerizable nanoparticles. The acidic polymerizable nanoparticles are obtainable by hydrolysis of a mixture containing one or more hydrolyzable organosilicon compounds wherein (i) at least a portion of the hydrolyzable organosilicon compounds contains one or more polymerizable groups and (ii) at least a portion of the hydrolyzable organosilicon compounds contain one or more acidic moieties.