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88 条记录 (耗时 0.045 秒)

    Preparation of N-acylamino acid esters and N-acylamino acetals
    1.
    发明授权
    Preparation of N-acylamino acid esters and N-acylamino acetals 失效
    N-酰基氨基酸酯和N-酰基氨基缩醛的制备

    公开(公告)号：US06740774B1

    公开(公告)日：2004-05-25

    申请号：US09639681

    申请日：2000-08-16

    申请人： Joachim Paust ,  Hansgeorg Ernst ,  Reinhard Kaczmarek ,  Hagen Jaedicke

    发明人： Joachim Paust ,  Hansgeorg Ernst ,  Reinhard Kaczmarek ,  Hagen Jaedicke

    IPC分类号： C07C22900

    CPC分类号： C07C231/08 ,  C07C233/18 ,  C07C233/47

    摘要： A process for preparing N-acyl derivatives of the formula I, in which the substituents independently of one another have the following meanings: X is CH(OR3)2, COOR3; R1 is hydrogen, C1-C12-alkyl, aryl, unsubstituted or substituted; R2 is hydrogen, C1-C12-alkyl, aryl, unsubstituted or substituted; R3 is C1-C12-alkyl, which comprises reacting a carboxamide R1—CONH2 of the formula II with a glyoxal monoacetal derivative of the formula III, in the presence of a carboxylic acid R4—COOH of the formula IV where R4=C1-C12-alkyl, where the substituents R1 to R3 are as defined above, is described.

    摘要翻译： 制备式I的N-酰基衍生物的方法，其中取代基彼此独立地具有以下含义：X是CH（OR 3）2，COOR 3; R 1是氢，C 1 C 12 - 烷基，芳基，未取代或取代的; R 2是氢，C 1 -C 12 - 烷基，芳基，未取代或取代的; R 3是C 1 -C 12烷基，其包括使羧酰胺R 1， -CONH 2与式III的乙二醛单缩醛衍生物在式IV的羧酸R 4 -COOH的存在下反应，其中R 4 = C 1 -C 12 - 烷基，其中取代基R' 1> -R 3如上所定义。

    Cyclic 2-methyl-2,4-dialkoxy-3-buten-1-al-acetals, their preparation and use
    2.
    发明授权
    Cyclic 2-methyl-2,4-dialkoxy-3-buten-1-al-acetals, their preparation and use 失效
    环己基-2-甲基-2,4-二烷氧基-3-丁烯-1-缩醛，其制备和用途

    公开(公告)号：US4120868A

    公开(公告)日：1978-10-17

    申请号：US859020

    申请日：1977-12-09

    申请人： Hagen Jaedicke ,  Joachim Paust

    发明人： Hagen Jaedicke ,  Joachim Paust

    IPC分类号： C07D319/06 ,  C07D319/04

    CPC分类号： C07D319/06 ,  C07C403/14 ,  C07C2101/16

    摘要： New acetals, containing a 6-membered ring, of 2-methyl-2,4-dialkoxy-3-buten-1-al, are obtained by reacting the corresponding 2-methyl-2-alkoxy-3-butyn-1-al-acetals with a mixture of the appropriate alcohol and an alkali metal alcoholate of the said alcohol at from 100.degree. to 200.degree. C. The acetals are intermediates for the preparation of carotinoid-based physiologically safe food dyes.

    摘要翻译： 通过使相应的2-甲基-2-烷氧基-3-丁炔-1-基 - 丙酮与2-甲基-2,4-二烷氧基-3-丁烯-1-al的新的缩醛，含有6-元环的2-甲基-2,4-二烷氧基-3-丁烯-1- - 乙缩醛，其合适的醇和所述醇的碱金属醇化物的混合物在100至200℃下进行。缩醛是用于制备基于类胡萝卜素的生理安全食品染料的中间体。

    Preparation of cyclic acetals of 3-formyl-2-butenyltriphenylphosphonium chloride
    3.
    发明授权
    Preparation of cyclic acetals of 3-formyl-2-butenyltriphenylphosphonium chloride 失效
    制备3-甲酰基-2-丁烯基三苯基氯化鏻的环状缩醛

    公开(公告)号：US5344995A

    公开(公告)日：1994-09-06

    申请号：US85903

    申请日：1993-07-06

    申请人： Wolfgang Krause ,  Joachim Paust ,  Walter Dobler ,  Hagen Jaedicke

    发明人： Wolfgang Krause ,  Joachim Paust ,  Walter Dobler ,  Hagen Jaedicke

    IPC分类号： C07F9/54 ,  C07D319/06 ,  C07F9/655 ,  C07C43/305 ,  C07C43/313

    CPC分类号： C07F9/6552 ,  C07D319/06

    摘要： An improved process for preparing cyclic acetals of 3-formyl-2-butenyltriphenylphosphonium chloride by acetalization of 3-formyl-2-butenyl acetate with an aliphatic 1,3-diol, conversion of the resulting 4-acetoxy acetal into the corresponding 4-hydroxy acetal, Vilsmeier chlorination to give the corresponding 4-chloro acetal and subsequent reaction with triphenylphosphine entails carrying out the first 3 steps in an aliphatic or cycloaliphatic hydrocarbon or mixture of hydrocarbons with 6-8 carbons and the reaction with triphenylphosphine in an alkanol with 1-3 carbons and/or in aliphatic or cycloaliphatic hydrocarbon with 6-8 carbons or a corresponding mixture of hydrocarbons. The process is particularly advantageous when conversion of the 4-acetoxy acetal into the 4-hydroxy acetal is carried out with an aqueous alkali metal hydroxide solution in the presence of phase-transfer catalysts, and the first three, or all four, reaction stages are carried out in the same C.sub.6 -C.sub.8 -hydrocarbon.

    摘要翻译： 通过用脂肪族1,3-二醇缩醛化3-甲酰基-2-丁烯基乙酸酯与3-甲酰基-2-丁烯基三苯基氯化鏻的环状缩醛的改进方法，将得到的4-乙酰氧基缩醛转化为相应的4-羟基 缩醛，Vilsmeier氯化，得到相应的4-氯缩醛，随后与三苯基膦反应需要在脂族或脂环族烃或碳原子数为6〜8的混合物中进行前3个步骤，并与三苯基膦在链烷醇中与1- 3个碳原子和/或具有6-8个碳原子的脂族或脂环族烃或相应的烃混合物。 当在相转移催化剂存在下，用碱金属氢氧化物水溶液进行4-乙酰氧基缩醛转化为4-羟基缩醛时，该方法是特别有利的，而前三个或所有四个反应阶段是 在相同的C6-C8-烃中进行。

    Preparation of cyclic acetals of trans-4-chloro-3-methyl-but-2-en-1-al, and preparation of trans-3-methyl-but-2-ene-1,4-dial-1-monoacetals
    9.
    发明授权
    Preparation of cyclic acetals of trans-4-chloro-3-methyl-but-2-en-1-al, and preparation of trans-3-methyl-but-2-ene-1,4-dial-1-monoacetals 失效
    制备反式-4-氯-3-甲基丁-2-烯-1-醇的环状缩醛，制备反式-3-甲基 - 丁-2-烯-1,4-二甲酸-1-单缩醛

    公开(公告)号：US4335047A

    公开(公告)日：1982-06-15

    申请号：US138411

    申请日：1980-04-08

    申请人： Hagen Jaedicke ,  Joachim Paust

    发明人： Hagen Jaedicke ,  Joachim Paust

    IPC分类号： C07D319/06 ,  C07D319/04

    CPC分类号： C07D319/06

    摘要： A process for the preparation of 6-membered cyclic acetals of trans-4-chloro-3-methyl-but-2-en-1-al by reacting the corresponding acetals of 3-methyl-but-2-en-1-al (prenal), in a halohydrocarbon, with sulfuryl chloride and for their subsequent oxidation to trans-3-methyl-but-2-ene-1,4-dial-1-monoacetals (3-methyl-fumarodialdehyde-1-monoacetals). The trans-3-methyl-but-2-ene-1,4-dial-1-monoacetals are of great importance in terpene syntheses, since they make it possible to carry out successive Wittig reactions giving a very large number of compounds of biological and pharmacological importance.

    摘要翻译： 通过使相应的3-甲基 - 丁-2-烯-1-醇的缩醛反应制备反式-4-氯-3-甲基 - 丁-2-烯-1-醇的6元环状缩醛的方法 （前体）在卤代烃中与磺酰氯反应，然后氧化成反式-3-甲基 - 丁-2-烯-1,4-二甲酸-1-单缩醛（3-甲基 - 富马酸二醛-1-单缩醛）。 反式-3-甲基 - 丁-2-烯-1,4-二甲酸-1-单缩醛在萜烯合成中是非常重要的，因为它们可以进行连续的维蒂希反应，产生非常大量的生物化合物 和药理重要性。

    3-Chloro-3-methyl-butane-1,4-dial-bis-acetals and 3-methyl-but-2-ene-1,4-dial-bis-acetals, a process for the preparation of these compounds and their use
    10.
    发明授权
    3-Chloro-3-methyl-butane-1,4-dial-bis-acetals and 3-methyl-but-2-ene-1,4-dial-bis-acetals, a process for the preparation of these compounds and their use 失效
    3-氯-3-甲基 - 丁烷-1,4-二 - 双 - 缩醛和3-甲基 - 丁-2-烯-1,4-二 - 双 - 缩醛，这些化合物的制备方法及其 使用

    公开(公告)号：US4256643A

    公开(公告)日：1981-03-17

    申请号：US76412

    申请日：1979-09-17

    申请人： Hagen Jaedicke ,  Joachim Paust

    发明人： Hagen Jaedicke ,  Joachim Paust

    IPC分类号： C07D319/06 ,  C07D319/04

    CPC分类号： C07D319/06

    摘要： 3-Chloro-3-methyl-butane-1,4-dial-bis-acetals and 3-methyl-but-2-ene-1,4-dial-bis-acetals are obtained by reacting a six-membered cyclic acetal of 3-methyl-but-3-en-1-al with an alkyl nitrite in the presence of methanol and hydrogen chloride and, if desired, eliminating HCl in the conventional manner.The butanedial-bis-acetals and butenedial-bis-acetals are valuable intermediates through which the trans-3-methyl-but-2-ene-1,4-dial-1-acetals, which are sought-after products for terpene syntheses, can be obtained in an industrially particularly advantageous manner.

    摘要翻译： 3-氯-3-甲基 - 丁烷-1,4-二 - 双 - 缩醛和3-甲基 - 丁-2-烯-1,4-二 - 双 - 缩醛是通过使六元环戊缩醛 3-甲基 - 丁-3-烯-1-醇与亚硝酸烷基酯在甲醇和氯化氢的存在下反应，如果需要，以常规方式除去HCl。 丁二醛 - 双缩醛和丁二醛双缩醛是有价值的中间体，通过该中间体，用于萜烯合成的追求产物的反式-3-甲基 - 丁-2-烯-1,4-二甲酸-1-缩醛， 可以以工业上特别有利的方式获得。