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公开(公告)号：US20060245065A1
公开(公告)日：2006-11-02
申请号：US11457187
申请日：2006-07-13
申请人： Joanna Aizenberg , Mischa Megens , Shu Yang
发明人： Joanna Aizenberg , Mischa Megens , Shu Yang
IPC分类号： G02B27/10
CPC分类号： G02B3/0025 , G02B1/041 , G02B3/0056 , G02B3/14
摘要： An apparatus includes a planar substrate and an array of substantially transparent spherical micro-lenses forming a pattern. The pattern has an internal two-dimensional lattice symmetry on the planar substrate. Each micro-lens includes a convex bulge or a concave depression in a surface of the planar substrate. The micro-lenses and substrate include hydrogel that swells and contracts in a manner that is responsive to an environmental condition.
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公开(公告)号：US20060245066A1
公开(公告)日：2006-11-02
申请号：US11457243
申请日：2006-07-13
申请人： Joanna Aizenberg , Mischa Megens , Shu Yang
发明人： Joanna Aizenberg , Mischa Megens , Shu Yang
IPC分类号： G02B27/10
CPC分类号： G02B3/0025 , G02B1/041 , G02B3/0056 , G02B3/14
摘要： An apparatus includes a planar substrate and an array of substantially transparent spherical micro-lenses forming a pattern. The pattern has an internal two-dimensional lattice symmetry on the planar substrate. Each micro-lens includes a convex bulge or a concave depression in a surface of the planar substrate. The micro-lenses and substrate include hydrogel that swells and contracts in a manner that is responsive to an environmental condition.
摘要翻译： 一种装置包括平面基板和形成图案的基本透明的球形微透镜阵列。 该图案在平面基板上具有内部二维晶格对称性。 每个微透镜在平面基板的表面中包括凸起的凸起或凹陷的凹陷。 微透镜和底物包括以对环境条件作出响应的方式膨胀和收缩的水凝胶。
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公开(公告)号：US07106519B2
公开(公告)日：2006-09-12
申请号：US10631996
申请日：2003-07-31
申请人： Joanna Aizenberg , Mischa Megens , Shu Yang
发明人： Joanna Aizenberg , Mischa Megens , Shu Yang
IPC分类号： G02B27/10
CPC分类号： G02B3/0025 , G02B1/041 , G02B3/0056 , G02B3/14
摘要： An apparatus includes a planar substrate and an array of substantially transparent spherical micro-lenses forming a pattern. The pattern has an internal two-dimensional lattice symmetry on the planar substrate. Each micro-lens includes a convex bulge or a concave depression in a surface of the planar substrate. The micro-lenses and substrate include hydrogel that swells and contracts in a manner that is responsive to an environmental condition.
摘要翻译： 一种装置包括平面基板和形成图案的基本透明的球形微透镜阵列。 该图案在平面基板上具有内部二维晶格对称性。 每个微透镜在平面基板的表面中包括凸起的凸起或凹陷的凹陷。 微透镜和底物包括以对环境条件作出响应的方式膨胀和收缩的水凝胶。
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公开(公告)号：US07297474B2
公开(公告)日：2007-11-20
申请号：US11457243
申请日：2006-07-13
申请人： Joanna Aizenberg , Mischa Megens , Shu Yang
发明人： Joanna Aizenberg , Mischa Megens , Shu Yang
IPC分类号： G02B3/00
CPC分类号： G02B3/0025 , G02B1/041 , G02B3/0056 , G02B3/14
摘要： An apparatus includes a planar substrate and an array of substantially transparent spherical micro-lenses forming a pattern. The pattern has an internal two-dimensional lattice symmetry on the planar substrate. Each micro-lens includes a convex bulge or a concave depression in a surface of the planar substrate. The micro-lenses and substrate include hydrogel that swells and contracts in a manner that is responsive to an environmental condition.
摘要翻译： 一种装置包括平面基板和形成图案的基本透明的球形微透镜阵列。 该图案在平面基板上具有内部二维晶格对称性。 每个微透镜在平面基板的表面中包括凸起的凸起或凹陷的凹陷。 微透镜和底物包括以对环境条件作出响应的方式膨胀和收缩的水凝胶。
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公开(公告)号：US07253958B2
公开(公告)日：2007-08-07
申请号：US11457187
申请日：2006-07-13
申请人： Joanna Aizenberg , Mischa Megens , Shu Yang
发明人： Joanna Aizenberg , Mischa Megens , Shu Yang
IPC分类号： G02B27/10
CPC分类号： G02B3/0025 , G02B1/041 , G02B3/0056 , G02B3/14
摘要： An apparatus includes a planar substrate and an array of substantially transparent spherical micro-lenses forming a pattern. The pattern has an internal two-dimensional lattice symmetry on the planar substrate. Each micro-lens includes a convex bulge or a concave depression in a surface of the planar substrate. The micro-lenses and substrate include hydrogel that swells and contracts in a manner that is responsive to an environmental condition.
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公开(公告)号：US20050024730A1
公开(公告)日：2005-02-03
申请号：US10631996
申请日：2003-07-31
申请人： Joanna Aizenberg , Mischa Megens , Shu Yang
发明人： Joanna Aizenberg , Mischa Megens , Shu Yang
CPC分类号： G02B3/0025 , G02B1/041 , G02B3/0056 , G02B3/14
摘要： An apparatus includes a planar substrate and an array of substantially transparent spherical micro-lenses forming a pattern. The pattern has an internal two-dimensional lattice symmetry on the planar substrate. Each micro-lens includes a convex bulge or a concave depression in a surface of the planar substrate. The micro-lenses and substrate include hydrogel that swells and contracts in a manner that is responsive to an environmental condition.
摘要翻译： 一种装置包括平面基板和形成图案的基本透明的球形微透镜阵列。 该图案在平面基板上具有内部二维晶格对称性。 每个微透镜在平面基板的表面中包括凸起的凸起或凹陷的凹陷。 微透镜和底物包括以对环境条件作出响应的方式膨胀和收缩的水凝胶。
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公开(公告)号：US07892817B2
公开(公告)日：2011-02-22
申请号：US11569084
申请日：2005-05-13
申请人： Menno Willem Jose Prins , Martinus Barnardus Van Der Mark , Paulus Cornelis Duineveld , Mischa Megens , Josephus Arnoldus Henricus Maria Kahlman
发明人： Menno Willem Jose Prins , Martinus Barnardus Van Der Mark , Paulus Cornelis Duineveld , Mischa Megens , Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： C12M3/00
CPC分类号： G01N33/54373 , B82Y5/00 , B82Y25/00 , G01N27/745
摘要： A method and a device are provided for distinguishing a specific binding from a less specific binding between at least one magnetic nanoparticle and a surface of another entity by applying a magnetic field and detecting a physical parameter relating to magnetic nanoparticle rotational or motional freedom while the magnetic nanoparticle is attached to the surface. The method and device may be applied to in-vivo and in-vitro biomolecular diagnostics. The sensor combines in one sensor the detection of magnetic particles or labels and determination of the binding quality and the properties of magnetic particles or labels which are bound to the surface of another entity.
摘要翻译： 提供了一种方法和装置，用于通过施加磁场和检测与磁性纳米颗粒旋转或运动自由相关的物理参数来区分特定结合与至少一个磁性纳米颗粒与另一个实体的表面之间的较小特异性结合，同时磁性 纳米颗粒附着在表面。 该方法和装置可以应用于体内和体外生物分子诊断。 该传感器将一个传感器结合在一起，检测磁性颗粒或标签，并确定结合质量以及结合到另一个实体表面的磁性颗粒或标签的性质。
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公开(公告)号：US20100083855A1
公开(公告)日：2010-04-08
申请号：US12517251
申请日：2007-12-03
IPC分类号： B41F31/00
CPC分类号： B05D1/28 , B05C1/027 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： The invention provides a method and apparatus for laminating a sheet to a substrate in a stress free and distortion-less manner. The method comprises providing the sheet and substrate such that an attractive force between them exists that is capable of bringing the sheet and surface together at least when their distance is shorter than a critical distance. The method creates these conditions by locally making an initial contact between the sheet and substrate such that at a contact front, being the boundary between areas where the substrate and sheet are in contact and those where they are not in contact, these conditions exist. In a further step the sheet and substrate are allowed to gradually make contact such that the contact front advances along either of the substrate or sheet surface therewith increasing the contacting area between the substrate and the sheet. The method is advantages when used during imprint lithography or embossing processes or other processes where feature patterns need to be transferred from the substrate to the surface or vice versa.
摘要翻译： 本发明提供了一种以无应力和无失真的方式将片层压到基片上的方法和装置。 该方法包括提供片材和基底，使得它们之间的吸引力存在，其能够至少当其距离短于临界距离时将片材和表面组合在一起。 该方法通过局部地在片材和衬底之间进行初始接触而产生这些条件，使得在作为衬底和片材接触的区域与未接触的区域之间的边界的接触面处存在这些条件。 在另外的步骤中，允许片材和基底逐渐接触，使得接触前端沿着基底或片材表面前进，从而增加基底和片材之间的接触面积。 该方法是在压印光刻或压花加工或特征图案需要从基底转移到表面或反之亦然的其它过程中使用时的优点。
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公开(公告)号：US20080191688A1
公开(公告)日：2008-08-14
申请号：US11814826
申请日：2006-01-30
申请人： Josephus Arnoldus Henricus Maria Kahlman , Rachel Estelle Thilwind , Menno Willem Jose Prins , Mischa Megens , Reinhold Wimberger-Friedl
发明人： Josephus Arnoldus Henricus Maria Kahlman , Rachel Estelle Thilwind , Menno Willem Jose Prins , Mischa Megens , Reinhold Wimberger-Friedl
IPC分类号： G01N33/543
CPC分类号： G01N27/745 , G01N33/54333 , G01N33/553
摘要： A sensor device (15) for detecting magnetic particles (13) has a binding surface (40) with binding sites thereon and comprises: at least one sensor element (23) for detecting the presence of magnetic particles (13), means for attracting magnetic structures comprising at least one magnetic particle (13) toward and onto the binding surface (40) of the sensor device (15), and means for re-arranging and randomizing the position of individual magnetic particles (13) with respect to the binding sites on the binding surface (40) to give binding sites on all individual particles (13) a substantial probability to have a contact time with binding sites on the binding surface (40). With such sensor device (15), the speed of detection of target molecules in a fluid is enhanced.
摘要翻译： 用于检测磁性颗粒（13）的传感器装置（15）具有在其上具有结合位置的结合表面（40），并包括：用于检测磁性颗粒（13）的存在的至少一个传感器元件（23），用于吸引磁性颗粒 包括朝向和传递到传感器装置（15）的结合表面（40）上的至少一个磁性颗粒（13）的结构，以及用于重新排列和随机化各个磁性颗粒（13）相对于结合位点 在结合表面（40）上以在所有单独的颗粒（13）上产生与结合表面（40）上的结合位点具有接触时间的可能性。 利用这种传感器装置（15），提高了流体中目标分子的检测速度。
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公开(公告)号：US09808323B2
公开(公告)日：2017-11-07
申请号：US13321580
申请日：2010-05-03
申请人： Maya Barley , Szabolcs Deladi , Godefridus Antonius Harks , Jan Frederik Suijver , Mischa Megens
发明人： Maya Barley , Szabolcs Deladi , Godefridus Antonius Harks , Jan Frederik Suijver , Mischa Megens
CPC分类号： A61B90/36 , A61B18/1492 , A61B34/20 , A61B2017/00106 , A61B2090/062 , A61B2090/065 , A61B2090/376 , G06F19/00
摘要： The invention relates to a visualization apparatus for visualizing quality of applying energy to an object. The quality of applying energy at a location on the object (3) is visualized based on a) a provided image of the object and b) a provided quality value representing the quality of applying energy to the object at the location on the object (3), wherein a visual property assigning unit (9) assigns a visual property to the location depending on the quality value and a display (10) displays the provided image and the assigned visual property at the location on the object shown in the image. In general a person who applies energy to the object is focused on the location at which energy is applied. Since quality information is shown at the location on which the person is already focused, the quality dependent information can easily be absorbed by the person.
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