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    Rapid and Sensitive Biosensing
    1.
    发明申请
    Rapid and Sensitive Biosensing 有权
    快速和敏感的生物传感

    公开(公告)号：US20080191688A1

    公开(公告)日：2008-08-14

    申请号：US11814826

    申请日：2006-01-30

    申请人： Josephus Arnoldus Henricus Maria Kahlman ,  Rachel Estelle Thilwind ,  Menno Willem Jose Prins ,  Mischa Megens ,  Reinhold Wimberger-Friedl

    发明人： Josephus Arnoldus Henricus Maria Kahlman ,  Rachel Estelle Thilwind ,  Menno Willem Jose Prins ,  Mischa Megens ,  Reinhold Wimberger-Friedl

    IPC分类号： G01N33/543

    CPC分类号： G01N27/745 ,  G01N33/54333 ,  G01N33/553

    摘要： A sensor device (15) for detecting magnetic particles (13) has a binding surface (40) with binding sites thereon and comprises: at least one sensor element (23) for detecting the presence of magnetic particles (13), means for attracting magnetic structures comprising at least one magnetic particle (13) toward and onto the binding surface (40) of the sensor device (15), and means for re-arranging and randomizing the position of individual magnetic particles (13) with respect to the binding sites on the binding surface (40) to give binding sites on all individual particles (13) a substantial probability to have a contact time with binding sites on the binding surface (40). With such sensor device (15), the speed of detection of target molecules in a fluid is enhanced.

    摘要翻译： 用于检测磁性颗粒（13）的传感器装置（15）具有在其上具有结合位置的结合表面（40），并包括：用于检测磁性颗粒（13）的存在的至少一个传感器元件（23），用于吸引磁性颗粒 包括朝向和传递到传感器装置（15）的结合表面（40）上的至少一个磁性颗粒（13）的结构，以及用于重新排列和随机化各个磁性颗粒（13）相对于结合位点 在结合表面（40）上以在所有单独的颗粒（13）上产生与结合表面（40）上的结合位点具有接触时间的可能性。 利用这种传感器装置（15），提高了流体中目标分子的检测速度。

    Rapid and sensitive biosensing
    2.
    发明授权
    Rapid and sensitive biosensing 有权
    快速敏感的生物传感

    公开(公告)号：US08828740B2

    公开(公告)日：2014-09-09

    申请号：US11814826

    申请日：2006-01-30

    申请人： Josephus Arnoldus Henricus Maria Kahlman ,  Rachel Estelle Thilwind ,  Menno Willem Jose Prins ,  Mischa Megens ,  Reinhold Wimberger-Friedl

    发明人： Josephus Arnoldus Henricus Maria Kahlman ,  Rachel Estelle Thilwind ,  Menno Willem Jose Prins ,  Mischa Megens ,  Reinhold Wimberger-Friedl

    IPC分类号： G01N33/553 ,  G01N27/74 ,  G01N33/543

    CPC分类号： G01N27/745 ,  G01N33/54333 ,  G01N33/553

    摘要： A sensor device (15) for detecting magnetic particles (13) has a binding surface (40) with binding sites thereon and includes at least one sensor element (23) for detecting the presence of magnetic particles (13), an element or elements for attracting magnetic structures having at least one magnetic particle (13) toward and onto the binding surface (40) of the sensor device (15), and an element or elements for re-arranging and randomizing the position of individual magnetic particles (13) with respect to the binding sites on the binding surface (40) to give binding sites on all individual particles (13) a substantial probability to have a contact time with binding sites on the binding surface (40). With such sensor device (15), the speed of detection of target molecules in a fluid is enhanced.

    摘要翻译： 用于检测磁性颗粒（13）的传感器装置（15）具有在其上具有结合位置的结合表面（40），并且包括用于检测磁性颗粒（13）的存在的至少一个传感器元件（23），用于 吸引具有至少一个磁性颗粒（13）的磁性结构朝向和传递到传感器装置（15）的结合表面（40）上，以及用于重新排列和随机化各个磁性颗粒（13）的位置的元件或元件， 相对于结合表面（40）上的结合位点以在所有单个颗粒（13）上产生与结合表面（40）上的结合位点具有接触时间的可能性。 利用这种传感器装置（15），提高了流体中目标分子的检测速度。

    Microarray characterization system and method
    4.
    发明授权
    Microarray characterization system and method 有权
    微阵列表征系统及方法

    公开(公告)号：US08686376B2

    公开(公告)日：2014-04-01

    申请号：US12999639

    申请日：2009-06-23

    申请人： Reinhold Wimberger-Friedl ,  Peter Dirksen ,  Marius Iosif Boamfa ,  Erik Martinus Hubertus Petrus Van Dijk

    发明人： Reinhold Wimberger-Friedl ,  Peter Dirksen ,  Marius Iosif Boamfa ,  Erik Martinus Hubertus Petrus Van Dijk

    IPC分类号： F21V9/16

    CPC分类号： G01N21/6452 ,  B01L3/5027 ,  G02B21/0028

    摘要： A system for detecting a plurality of analytes in a sample includes an aperture array and a lens array for generating and focusing a plurality of excitation sub-beams on different sub-regions of a substrate. These sub-regions can be provided with different binding sites for binding different analytes in the sample. By detecting the different luminescent responses in a detector, the presence or amount of different analytes can be determined simultaneously. Alternatively or in addition, collection of the luminescence radiation can be performed using the lens array for directly collecting the luminescence response and for guiding the collected luminescence response to corresponding apertures. The excitation sub-beams may be focused at the side of the substrate opposite of the lens array, and an immersion fluid is provided between the lens array and the substrate to increase the collection efficiency of the luminescence radiation.

    摘要翻译： 用于检测样品中多个分析物的系统包括孔径阵列和用于在衬底的不同子区域上产生和聚焦多个激发子束的透镜阵列。 这些子区域可以具有不同的结合位点，用于结合样品中的不同分析物。 通过检测检测器中的不同发光响应，可以同时测定不同分析物的存在或量。 或者或另外，可以使用透镜阵列来执行发光辐射的收集，用于直接收集发光响应并且用于将所收集的发光响应引导到相应的孔。 激发子光束可以聚焦在与透镜阵列相对的一侧的基板处，并且在透镜阵列和基板之间提供浸没流体以增加发光辐射的收集效率。

    MAGNETIC SAMPLE PURIFICATION
    6.
    发明申请
    MAGNETIC SAMPLE PURIFICATION 有权
    磁性样品净化

    公开(公告)号：US20120270332A1

    公开(公告)日：2012-10-25

    申请号：US13500446

    申请日：2010-09-27

    申请人： Reinhold Wimberger-Friedl ,  Remco Christiaan Den Dulk

    发明人： Reinhold Wimberger-Friedl ,  Remco Christiaan Den Dulk

    IPC分类号： G01N1/28 ,  H01F1/00

    CPC分类号： B03C1/01 ,  B01L3/502761 ,  B03C1/015 ,  B03C1/288 ,  G01N35/0098 ,  Y10T436/25375

    摘要： The invention relates to means for extracting magnetic particles (M) from a sample (S). The sample (S) is arranged adjacent to a liquid carrier (C), which is immiscible with it, in a configuration stable under the influence of gravity, and the magnetic particles (M) are moved by a magnetic field (B) from the sample (S) into the carrier (C). Preferably, the magnetic particles (M) are non-wetting with respect to the carrier (C) and will therefore form agglomerates in the carrier (C).

    摘要翻译： 本发明涉及从样品（S）中提取磁性颗粒（M）的方法。 样品（S）以与重力不同的液体载体（C）相邻配置，在重力作用下是稳定的，磁性粒子（M）通过磁场（B）从 样品（S）进入载体（C）。 优选地，磁性颗粒（M）相对于载体（C）不润湿，因此将在载体（C）中形成附聚物。

    APPARATUS AND METHODS FOR THE PRODUCTION OF ULTRASOUND CONTRAST AGENTS
    7.
    发明申请
    APPARATUS AND METHODS FOR THE PRODUCTION OF ULTRASOUND CONTRAST AGENTS 审中-公开
    用于生产超声对比剂的装置和方法

    公开(公告)号：US20090130025A1

    公开(公告)日：2009-05-21

    申请号：US11577820

    申请日：2005-10-25

    申请人： Marcel Rene Bohmer ,  Reinhold Wimberger-Friedl

    发明人： Marcel Rene Bohmer ,  Reinhold Wimberger-Friedl

    IPC分类号： A61K49/22

    CPC分类号： B01F3/04439 ,  A61K49/223 ,  B01F5/0475 ,  B01F5/0476

    摘要： Disclosed is a method of making gas bubbles in a liquid, the bubbles having substantially uniform size suitable for responding to ultrasound or other diagnostic tools. Gas (P2) is forced through one or more pores or nozzles, into the liquid (P1), the nozzles or pores being of substantially uniform diameter, the flow of the gas being controlled to thereby cause the formation of substantially monodisperse gas bubbles in the liquid. Moreover, an apparatus is disclosed for making a suspension of gas bubbles in a liquid of a size suitable for responding to ultrasound or other diagnostic tools. Said apparatus comprises means for forcing a gas through an array of nozzles or pores into the liquid, the nozzles or pores being of substantially uniform diameter, and first means for controlling; a flow parameter of the gas so that gas is suspended as substantially monodisperse gas bubbles in the liquid. Furthermore a kit for preparing a dispersion of gas bubbles of substantially uniform size suitable for ultrasound purposes, is disclosed.

    摘要翻译： 公开了一种在液体中制造气泡的方法，气泡具有适合于响应超声波或其它诊断工具的基本均匀的尺寸。 气体（P2）被迫通过一个或多个孔或喷嘴进入液体（P1），喷嘴或孔具有基本上均匀的直径，气体的流动受到控制，从而在该气体中形成基本上单分散的气泡 液体。 此外，公开了一种用于使气泡悬浮在适于响应于超声波或其它诊断工具的尺寸的液体中的装置。 所述设备包括用于迫使气体通过喷嘴或孔阵列进入液体的装置，喷嘴或孔具有基本均匀的直径，以及用于控制的第一装置; 气体的流动参数，使得气体作为基本上单分散的气泡悬浮在液体中。 此外，公开了一种用于制备适合于超声波目的基本均匀尺寸的气泡分散体的试剂盒。

    COLLIMATOR
    8.
    发明申请
    COLLIMATOR 审中-公开

    公开(公告)号：US20090015930A1

    公开(公告)日：2009-01-15

    申请号：US10596316

    申请日：2004-12-08

    申请人： Rifat A.M. Hikmet ,  Ties Van Bommel ,  Peter Van De Witte ,  Reinhold Wimberger-Friedl ,  Dirk Burdinski

    发明人： Rifat A.M. Hikmet ,  Ties Van Bommel ,  Peter Van De Witte ,  Reinhold Wimberger-Friedl ,  Dirk Burdinski

    IPC分类号： G02B27/30 ,  B29D11/00 ,  B05D1/04 ,  G01T1/00 ,  G21F3/00 ,  B29C35/08

    CPC分类号： B82Y30/00 ,  G02B5/005 ,  G02B5/206 ,  G02B27/30 ,  G21K1/025

    摘要： A collimator panel comprises: a solid panel having a first face for receiving uncollimated radiation and a second opposite face for providing collimated radiation; and a plurality of elongate particles disposed in the panel and orientated to provide the collimating function. A method of manufacturing a collimator panel comprises the steps of: suspending a plurality of elongate particles in a liquid; applying an electric or magnetic field to the suspension to orientate the particles; and solidifying the liquid to fix the orientation of the particles, thereby forming a collimator panel. A method of manufacturing the elongate particles is also provided.

    摘要翻译： 准直器面板包括：具有用于接收未预激射辐射的第一面的实心面板和用于提供准直辐射的第二相对面; 以及设置在面板中并且定向以提供准直功能的多个细长颗粒。 制造准直器面板的方法包括以下步骤：将多个细长颗粒悬浮在液体中; 对悬浮液施加电场或磁场以使颗粒定向; 并固化液体以固定颗粒的取向，由此形成准直板。 还提供了制造细长颗粒的方法。

    Biosensors with Improved Sensitivity
    9.
    发明申请
    Biosensors with Improved Sensitivity 审中-公开
    具有提高灵敏度的生物传感器

    公开(公告)号：US20080245971A1

    公开(公告)日：2008-10-09

    申请号：US12088943

    申请日：2006-09-27

    申请人： Reinhold Wimberger-Friedl ,  Hendrik Roelof Stapert

    发明人： Reinhold Wimberger-Friedl ,  Hendrik Roelof Stapert

    IPC分类号： G01J1/58

    CPC分类号： G01N21/6454 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0819 ,  B01L2300/0877 ,  G01N21/05 ,  G01N21/6428 ,  G01N2021/0346

    摘要： A sensor is described for use with at least one optical detector (5), the sensor comprising a substrate (11) with optical outlets, a porous membrane (12) and micro fluidic channels (13) for conducting analyte fluid towards sensing locations (10) of the porous membrane (12). The sensing locations (10) are adapted for at least restraining light variable molecules (23) which bind to analytes to be determined. The optical output of the light variable molecules changes when they are in close proximity to a target molecule. The micro fluidic channels (13) are shaped to reflect light emitted from the sensing locations (10) towards the optical outlets and the substrate has diffracting optical elements (15) aligned with microfluidic channels to diffract light towards the optical outlets. The diffracting optical elements can be lenses.

    摘要翻译： 传感器被描述为与至少一个光学检测器（5）一起使用，传感器包括具有光学出口的基底（11），多孔膜（12）和微流体通道（13），用于将分析物流体传导到感测位置（10 ）多孔膜（12）。 感测位置（10）适于至少限制结合要测定的待分析物的光可变分子（23）。 光可变分子的光学输出在它们紧邻目标分子时变化。 微流体通道（13）成形为将从感测位置（10）发射的光朝向光学出口反射，并且衬底具有与微流体通道对准的衍射光学元件（15），以将光朝向光学出口衍射。 衍射光学元件可以是透镜。