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公开(公告)号：US20090123984A1
公开(公告)日：2009-05-14
申请号：US11911660
申请日：2006-04-18
申请人： Joe Chappell , Shuiqin Wu , Michel Schalk , Athony Clark
发明人： Joe Chappell , Shuiqin Wu , Michel Schalk , Athony Clark
CPC分类号： C12N9/1085 , C12N9/88 , C12N15/8243
摘要： The present invention relates to transformed plants with an altered terpene content, preferably over-accumulating a mono- or sesqui-terpene. By transformation of plants with genes encoding terpene synthases (TS), and prenyl transferases (PRT), plants accumulating at least 1000 ng/per g of fresh leaf of a specific terpene were obtained. The present invention provides an advantageous system for production of terpenes in that any desired mono- or sesqui-terpene at the choice of the skilled person can be produced in plants. Preferably, the transformed plants contain at least one recombinant plastid targeted TS and PRT.
摘要翻译： 本发明涉及具有改变的萜烯含量的转化植物，优选地过度积聚单或三萜烯。 通过用编码萜烯合成酶（TS）和异戊烯基转移酶（PRT）的基因转化植物，获得了累积至少1000ng / g特定萜烯新鲜叶的植物。 本发明提供了一种用于生产萜烯的有利系统，因为可以在植物中生产本领域技术人员可选择的任何所需的单或三萜烯。 优选地，转化的植物含有至少一种靶向TS和PRT的重组质体。
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公开(公告)号：US20080201796A1
公开(公告)日：2008-08-21
申请号：US11916272
申请日：2006-06-26
申请人： Joe Chappell , Shuiqin Wu , Michel Schalk , Athony Clark
发明人： Joe Chappell , Shuiqin Wu , Michel Schalk , Athony Clark
CPC分类号： C12N15/8243 , C12N9/0006 , C12N9/1085
摘要： The present invention relates to plant expressing transgenes and to plants transformed to comprise additional copies of genes, said genes encoding at least a HMGR-CoA reductase and a terpene synthase. The invention further claims methods for preparing the plants, and a method for producing terpenes. The present thus provides a reliable and cost effective platform for generating any terpene, in particular any mono- and/or sesquiterpene of interest. For example, the skilled person may use any gene encoding a sesquiterpene synthase for accumulating the respective sesquiterpene in the plant of the present invention.
摘要翻译： 本发明涉及表达转基因的植物和转化成包含编码另外的基因拷贝的植物，所述基因编码至少HMGR-CoA还原酶和萜烯合酶。 本发明进一步要求制备植物的方法以及萜烯的制备方法。 因此，本发明提供了用于产生任何萜烯，特别是感兴趣的任何单 - 和/或倍半萜的可靠和具有成本效益的平台。 例如，技术人员可以使用编码倍半萜合酶的任何基因来在本发明的植物中积累相应的倍半萜烯。
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公开(公告)号：US08017835B2
公开(公告)日：2011-09-13
申请号：US11911660
申请日：2006-04-18
申请人： Joe Chappell , Shuiqin Wu , Michel Schalk , Athony Clark
发明人： Joe Chappell , Shuiqin Wu , Michel Schalk , Athony Clark
CPC分类号： C12N9/1085 , C12N9/88 , C12N15/8243
摘要： The present invention relates to transformed plants with an altered terpene content, preferably over-accumulating a mono- or sesqui-terpene. By transformation of plants with genes encoding terpene synthases (TS), and prenyl transferases (PRT), plants accumulating at least 1000 ng/per g of fresh leaf of a specific terpene were obtained. The present invention provides an advantageous system for production of terpenes in that any desired mono- or sesqui-terpene at the choice of the skilled person can be produced in plants. Preferably, the transformed plants contain at least one recombinant plastid targeted TS and PRT.
摘要翻译： 本发明涉及具有改变的萜烯含量的转化植物，优选地过度积聚单或三萜烯。 通过用编码萜烯合成酶（TS）和异戊烯基转移酶（PRT）的基因转化植物，获得了累积至少1000ng / g特定萜烯新鲜叶的植物。 本发明提供了一种用于生产萜烯的有利系统，因为可以在植物中生产本领域技术人员可选择的任何所需的单或三萜烯。 优选地，转化的植物含有至少一种靶向TS和PRT的重组质体。
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公开(公告)号：US07442785B2
公开(公告)日：2008-10-28
申请号：US10899356
申请日：2004-07-26
申请人： Joe Chappell , Brian Greenhagen
发明人： Joe Chappell , Brian Greenhagen
CPC分类号： C12P5/007 , C12N9/88 , C12Y402/03047 , C12Y402/03073
摘要： The invention relates to sesquiterpene synthases and methods for their production and use. Particularly, the invention provides nucleic acids comprising the nucleotide sequence of citrus valencene synthase (CVS) which codes for at least one CVS. The invention further provides nucleic acids comprising the nucleotide sequence coding for amino acid residues forming the tier 1 and tier 2 domains of CVS. The invention also provides for methods of making and using the nucleic acids and amino acids of the current invention.
摘要翻译： 本发明涉及倍半萜合酶及其生产和使用的方法。 特别地，本发明提供了包含编码至少一个CVS的柑橘类戊烯合酶（CVS）的核苷酸序列的核酸。 本发明还提供了包含编码形成CVS的1级和2级结构域的氨基酸残基的核苷酸序列的核酸。 本发明还提供制备和使用本发明的核酸和氨基酸的方法。
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5.发明授权Botryoccocus braunii triterpene synthase proteins and nucleic acid molecules, and methods for their use 有权Botryoccocus braunii三萜合酶蛋白和核酸分子及其使用方法公开(公告)号：US07985568B2
公开(公告)日：2011-07-26
申请号：US12539442
申请日：2009-08-11
申请人： Joe Chappell , Shigeru Okada , Tom Niehaus , Tim Devarenne
发明人： Joe Chappell , Shigeru Okada , Tom Niehaus , Tim Devarenne
IPC分类号： C12P5/00
CPC分类号： C12P5/007 , C12N9/1085
摘要： This application relates to the functional identification and characterization of a nucleic acid molecule encoding a triterpene synthase, in particular botryococcene synthase. Also described are host cells comprising the nucleic acid molecules of this invention, proteins encoded by the nucleic acid molecules and methods for using the nucleic acid molecules, transformed hosts and encoded proteins to produce high levels of triterpene hydrocarbons.
摘要翻译： 本申请涉及编码三萜合酶，特别是山梨酸合成酶的核酸分子的功能鉴定和表征。 还描述了包含本发明的核酸分子，由核酸分子编码的蛋白质和使用核酸分子，转化宿主和编码蛋白质以产生高水平三萜烷烃的方法的宿主细胞。
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公开(公告)号：US20060218661A1
公开(公告)日：2006-09-28
申请号：US10899356
申请日：2004-07-26
申请人： Joe Chappell , Bryan Greenhagen
发明人： Joe Chappell , Bryan Greenhagen
CPC分类号： C12P5/007 , C12N9/88 , C12Y402/03047 , C12Y402/03073
摘要： The invention relates to sesquiterpene synthases and methods for their production and use. Particularly, the invention provides nucleic acids comprising the nucleotide sequence of citrus valencene synthase (CVS) which codes for at least one CVS. The invention further provides nucleic acids comprising the nucleotide sequence coding for amino acid residues forming the tier 1 and tier 2 domains of CVS. The invention also provides for methods of making and using the nucleic acids and amino acids of the current invention.
摘要翻译： 本发明涉及倍半萜合酶及其生产和使用的方法。 特别地，本发明提供了包含编码至少一个CVS的柑橘类戊烯合酶（CVS）的核苷酸序列的核酸。 本发明还提供了包含编码形成CVS的1级和2级结构域的氨基酸残基的核苷酸序列的核酸。 本发明还提供制备和使用本发明的核酸和氨基酸的方法。
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7.发明授权公开(公告)号：US08822187B1
公开(公告)日：2014-09-02
申请号：US13458668
申请日：2012-04-27
CPC分类号： C12N9/90 , C12P5/026 , C12P7/00 , C12Y504/99
摘要： This application relates to the polypeptides, nucleic acid molecules, vectors, transfected cells, and methods for synthesis of triterpenes, including botryococcene.
摘要翻译： 本申请涉及多肽，核酸分子，载体，转染细胞和用于合成三萜烯（包括肉豆蔻烯）的方法。
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8.发明授权Botryoccocus braunii triterpene synthase proteins and nucleic acid molecules, and methods for their use 有权Botryoccocus braunii三萜合酶蛋白和核酸分子及其使用方法公开(公告)号：US08592180B2
公开(公告)日：2013-11-26
申请号：US13186185
申请日：2011-07-19
申请人： Joe Chappell , Shigeru Okada , Tom Niehaus , Tim Devarenne
发明人： Joe Chappell , Shigeru Okada , Tom Niehaus , Tim Devarenne
IPC分类号： C12P21/06
CPC分类号： C12P5/007 , C12N9/1085
摘要： This application relates to the functional identification and characterization of a nucleic acid molecule encoding a triterpene synthase, in particular botryococcene synthase. Also described are host cells comprising the nucleic acid molecules of this invention, proteins encoded by the nucleic acid molecules and methods for using the nucleic acid molecules, transformed hosts and encoded proteins to produce high levels of triterpene hydrocarbons.
摘要翻译： 本申请涉及编码三萜合酶，特别是山梨酸合成酶的核酸分子的功能鉴定和表征。 还描述了包含本发明的核酸分子，由核酸分子编码的蛋白质和使用核酸分子，转化宿主和编码蛋白质以产生高水平三萜烷烃的方法的宿主细胞。
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9.发明申请Botryoccocus braunii Triterpene Synthase Proteins and Nucleic Acid Molecules, and Methods for Their Use 有权Botryoccocus braunii三萜合酶蛋白和核酸分子及其使用方法公开(公告)号：US20110294182A1
公开(公告)日：2011-12-01
申请号：US13186185
申请日：2011-07-19
申请人： Joe Chappell , Shigeru Okada , Tom Niehaus , Tim Devarenne
发明人： Joe Chappell , Shigeru Okada , Tom Niehaus , Tim Devarenne
IPC分类号： C12P5/02 , C12N15/63 , C12N1/21 , C07H21/00 , C12N1/13 , C12N1/19 , C12N5/10 , C12P5/00 , C12N9/10 , C12N1/15
CPC分类号： C12P5/007 , C12N9/1085
摘要： This application relates to the functional identification and characterization of a nucleic acid molecule encoding a triterpene synthase, in particular botryococcene synthase. Also described are host cells comprising the nucleic acid molecules of this invention, proteins encoded by the nucleic acid molecules and methods for using the nucleic acid molecules, transformed hosts and encoded proteins to produce high levels of triterpene hydrocarbons.
摘要翻译： 本申请涉及编码三萜合酶，特别是山梨酸合成酶的核酸分子的功能鉴定和表征。 还描述了包含本发明的核酸分子，由核酸分子编码的蛋白质和使用核酸分子，转化宿主和编码蛋白质以产生高水平三萜烷烃的方法的宿主细胞。
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