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    New compounds
    5.
    发明申请
    New compounds 审中-公开
    新化合物

    公开(公告)号：US20080255153A1

    公开(公告)日：2008-10-16

    申请号：US12079563

    申请日：2008-03-27

    申请人： Ulf Bremberg ,  Auri Linden ,  Thomas Lundback ,  Jonas Nilsson ,  Marie Wiik ,  Magnus Bergner ,  Peter Brandt ,  Kristin Hammer ,  Rune Ringom

    发明人： Ulf Bremberg ,  Auri Linden ,  Thomas Lundback ,  Jonas Nilsson ,  Marie Wiik ,  Magnus Bergner ,  Peter Brandt ,  Kristin Hammer ,  Rune Ringom

    IPC分类号： A61K31/519 ,  C07D487/04 ,  A61P9/00

    CPC分类号： C07D487/04

    摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, which are useful as inhibitors of human stearoyl-CoA desaturase (SCD). The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment or prevention of medical conditions in which the modulation of SCD activity is beneficial, such as cardiovascular diseases, obesity, non-insulin-dependent diabetes mellitus, hypertension, metabolic syndrome, neurological diseases, immune disorders, cancer and various skin diseases.

    摘要翻译： 本发明涉及可用作人硬脂酰辅酶A去饱和酶（SCD）抑制剂的式（I）化合物及其药学上可接受的盐。 本发明进一步涉及包含这些化合物的药物组合物和这些化合物用于治疗或预防SCD活性调节有益的医学病症的用途，例如心血管疾病，肥胖症，非胰岛素依赖性糖尿病， 高血压，代谢综合征，神经系统疾病，免疫疾病，癌症和各种皮肤疾病。

    NOVEL COMPOUNDS AND THEIR USE IN THERAPY
    6.
    发明申请
    NOVEL COMPOUNDS AND THEIR USE IN THERAPY 有权
    新化合物及其在治疗中的应用

    公开(公告)号：US20140135322A1

    公开(公告)日：2014-05-15

    申请号：US14232442

    申请日：2012-07-13

    申请人： Peter Asberg ,  Kristin Hammer ,  Johan Olsson ,  Martin Henriksson

    发明人： Peter Asberg ,  Kristin Hammer ,  Johan Olsson ,  Martin Henriksson

    IPC分类号： C07D333/24 ,  C07D261/20 ,  C07D235/20 ,  C07D409/14 ,  C07D417/14

    CPC分类号： C07D261/20 ,  C07D235/20 ,  C07D333/18 ,  C07D333/24 ,  C07D333/60 ,  C07D403/10 ,  C07D409/04 ,  C07D409/10 ,  C07D409/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14

    摘要： The present invention relates to novel chemical compounds formula (I) (C)n—B-(A)m-B—(C)n (I) wherein m is 0 or 1, and n is independently 0, 1, 2 or 3, A, each B and each C are independently selected from phenylene and five- and six-membered heteroaromatic rings, and for a terminal ring B or C also from bicyclic heteroaromatic fused rings having seven to ten ring members, wherein the bond between at least two of the rings A to C may be replaced by a carbonyl group (—CO—), wherein at least two of the rings A to C are substituted with one or two groups R, and wherein each ring A to C further optionally is substituted with one or two groups R1. The compounds are useful in therapy, especially therapy of a mammal suffering from a disease involving misfolded or aggregated forms of proteins.

    摘要翻译： 本发明涉及式（I）（C）n-B-（A）mB-（C）n（I）的新化合物，其中m为0或1，n独立地为0,1,2或3， A，每个B和每个C独立地选自亚苯基和五元和六元杂芳环，对于末端环B或C也可以具有七至十个环成员的双环杂芳族稠环，其中至少两个 环A至C可以被羰基（-CO-）代替，其中至少两个环A至C被一个或两个基团R取代，并且其中每个环A至C进一步任选被 一组或两组R1。 该化合物可用于治疗，特别是治疗患有涉及错误折叠或聚集形式的蛋白质的疾病的哺乳动物。