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    Sulfonyl-indole derivatives
    6.
    发明授权
    Sulfonyl-indole derivatives 失效
    磺酰基 - 吲哚衍生物

    公开(公告)号：US08138333B2

    公开(公告)日：2012-03-20

    申请号：US12075979

    申请日：2008-03-13

    申请人： Johan Angbrant ,  Peter Brandt ,  Rune Ringom ,  Bengt Lindqvist

    发明人： Johan Angbrant ,  Peter Brandt ,  Rune Ringom ,  Bengt Lindqvist

    IPC分类号： C07D471/06 ,  C07D487/06

    CPC分类号： C07D471/06 ,  C07D487/06

    摘要： The present invention relates to novel compounds of formula (I): wherein R1, R2, R3, R4, and R5 are as described herein, to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds for the preparation of a medicament against 5-HT6 receptor-related disorders.

    摘要翻译： 本发明涉及新的式（I）化合物：其中R 1，R 2，R 3，R 4和R 5如本文所述，包含该化合物的药物组合物，其制备方法以及使用 用于制备抗5-HT 6受体相关病症的药物的化合物。

    New compounds
    7.
    发明申请
    New compounds 审中-公开
    新化合物

    公开(公告)号：US20080255153A1

    公开(公告)日：2008-10-16

    申请号：US12079563

    申请日：2008-03-27

    申请人： Ulf Bremberg ,  Auri Linden ,  Thomas Lundback ,  Jonas Nilsson ,  Marie Wiik ,  Magnus Bergner ,  Peter Brandt ,  Kristin Hammer ,  Rune Ringom

    发明人： Ulf Bremberg ,  Auri Linden ,  Thomas Lundback ,  Jonas Nilsson ,  Marie Wiik ,  Magnus Bergner ,  Peter Brandt ,  Kristin Hammer ,  Rune Ringom

    IPC分类号： A61K31/519 ,  C07D487/04 ,  A61P9/00

    CPC分类号： C07D487/04

    摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, which are useful as inhibitors of human stearoyl-CoA desaturase (SCD). The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment or prevention of medical conditions in which the modulation of SCD activity is beneficial, such as cardiovascular diseases, obesity, non-insulin-dependent diabetes mellitus, hypertension, metabolic syndrome, neurological diseases, immune disorders, cancer and various skin diseases.

    摘要翻译： 本发明涉及可用作人硬脂酰辅酶A去饱和酶（SCD）抑制剂的式（I）化合物及其药学上可接受的盐。 本发明进一步涉及包含这些化合物的药物组合物和这些化合物用于治疗或预防SCD活性调节有益的医学病症的用途，例如心血管疾病，肥胖症，非胰岛素依赖性糖尿病， 高血压，代谢综合征，神经系统疾病，免疫疾病，癌症和各种皮肤疾病。

    Beta-carbolines as growth hormone secretagogue receptor (GHSR) antagonists
    8.
    发明申请
    Beta-carbolines as growth hormone secretagogue receptor (GHSR) antagonists 审中-公开
    β-咔啉作为生长激素促分泌素受体（GHSR）拮抗剂

    公开(公告)号：US20050288316A1

    公开(公告)日：2005-12-29

    申请号：US10995067

    申请日：2004-11-22

    申请人： Roger Crossley ,  Annika Jensen ,  Peter Brandt ,  Ulf Bremberg ,  Malin Nordberg ,  Erik Ringberg ,  Terry Ward

    发明人： Roger Crossley ,  Annika Jensen ,  Peter Brandt ,  Ulf Bremberg ,  Malin Nordberg ,  Erik Ringberg ,  Terry Ward

    IPC分类号： A61K20060101 ,  A61K31/407 ,  A61K31/4747 ,  C07D471/20 ,  C07D491/14 ,  C07D491/20

    CPC分类号： C07D471/20 ,  C07D491/20

    摘要： The present invention relates to compounds of Formula (I): wherein R3-R8, X, and Y are as described herein, processes for preparing the compounds, pharmaceutical compositions comprising the compounds, and use of the compounds and compositions in the prophylaxis or treatment of a GHSR receptor-related disorder. Examples of such disorders are obesity and related disorders such as diabetes type II, dyslipidemia and the metabolic syndrome Prader-Willi syndrome, cardiovascular diseases such as atherosclerotic vascular disease, angina pectoris, myocardial infarction and stroke, acromegaly and cancer, in particular breast, lung, prostate, thyroid and endocrine pituary carcinomas.

    摘要翻译： 本发明涉及式（I）的化合物：其中R 3，R 8，X和Y如本文所述，制备化合物的方法，药物组合物 包括化合物，以及化合物和组合物在预防或治疗GHSR受体相关病症中的用途。 这种障碍的例子是肥胖症和相关疾病，例如II型糖尿病，血脂异常和代谢综合征Prader-Willi综合征，心血管疾病如动脉粥样硬化性血管疾病，心绞痛，心肌梗塞和中风，肢端肥大症和癌症，特别是乳腺，肺 ，前列腺，甲状腺和内分泌胰腺癌。

    Instrument for a motor vehicle
    9.
    发明授权
    Instrument for a motor vehicle 有权
    汽车仪表

    公开(公告)号：US08794776B2

    公开(公告)日：2014-08-05

    申请号：US13439962

    申请日：2012-04-05

    申请人： Peter Brandt ,  Heiko Charle ,  Dino Demma

    发明人： Peter Brandt ,  Heiko Charle ,  Dino Demma

    IPC分类号： G01K1/04

    CPC分类号： B60K37/02 ,  B60K2350/1064 ,  B60K2350/203 ,  B60K2350/2086

    摘要： An instrument is provided for a motor vehicle that includes, but is limited to a display area and a housing, which surrounds the display area. A transparent instrument covering is held spaced from the display area by the housing. The instrument covering is a transparent light conductor panel, in which a symbol display area is arranged. The light conductor panel includes, but is not limited to light-diffusing Nano particles in its volume in the symbol display area.

    摘要翻译： 提供了一种用于机动车辆的仪器，其包括但不限于围绕显示区域的显示区域和外壳。 透明的仪器罩被壳体与显示区域间隔开。 仪器罩是透明导光板，其中布置有符号显示区域。 光导体板包括但不限于其在符号显示区域中的体积中的光散射纳米颗粒。

    COOLING SYSTEM FOR A POWER MODULE
    10.
    发明申请
    COOLING SYSTEM FOR A POWER MODULE 审中-公开
    电源模块冷却系统

    公开(公告)号：US20140076522A1

    公开(公告)日：2014-03-20

    申请号：US14007801

    申请日：2012-04-02

    申请人： Klaus Kristen Olesen ,  Joergen Holst ,  Georg Fosel ,  Peter Brandt ,  Perer Jensen ,  Steen Hornsleth ,  Carsten Rothmann

    发明人： Klaus Kristen Olesen ,  Joergen Holst ,  Georg Fosel ,  Peter Brandt ,  Perer Jensen ,  Steen Hornsleth ,  Carsten Rothmann

    IPC分类号： F25B39/04

    CPC分类号： F25B39/04 ,  H05K7/20309 ,  H05K7/20936

    摘要： A cooling system for a power module (or some other power electronics device) is described, the cooling system having a closed flow path for circulating a cooling fluid, the flow path having a pressure that is reduced to below atmospheric pressure. The cooling fluid is circulated along the flow path to provide cooling of the power module. The flow path is delimited from the exterior environment by a space provided between the flow path and the exterior environment, said space being sealed off from the cooling flow path, and said space being sealed off towards the exterior environment. The flow path has a pressure below atmospheric pressure and the space between the flow path and the exterior environment is evacuated and typically has a pressure lower than the pressure in the flow path.

    摘要翻译： 描述了用于功率模块（或一些其他电力电子设备）的冷却系统，该冷却系统具有用于使冷却流体循环的封闭流动路径，该流动路径具有降低到低于大气压力的压力。 冷却流体沿着流动路径循环以提供功率模块的冷却。 流动路径通过设置在流路和外部环境之间的空间从外部环境界定，所述空间与冷却流路密封，并且所述空间朝向外部环境密封。 流动路径具有低于大气压力的压力，并且流动路径和外部环境之间的空间被抽真空并且通常具有低于流动路径中的压力的​​压力。