Sulfonyl-indole derivatives
    6.
    发明授权
    Sulfonyl-indole derivatives 失效
    磺酰基 - 吲哚衍生物

    公开(公告)号:US08138333B2

    公开(公告)日:2012-03-20

    申请号:US12075979

    申请日:2008-03-13

    IPC分类号: C07D471/06 C07D487/06

    CPC分类号: C07D471/06 C07D487/06

    摘要: The present invention relates to novel compounds of formula (I): wherein R1, R2, R3, R4, and R5 are as described herein, to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds for the preparation of a medicament against 5-HT6 receptor-related disorders.

    摘要翻译: 本发明涉及新的式(I)化合物:其中R 1,R 2,R 3,R 4和R 5如本文所述,包含该化合物的药物组合物,其制备方法以及使用 用于制备抗5-HT 6受体相关病症的药物的化合物。

    New compounds
    7.
    发明申请
    New compounds 审中-公开
    新化合物

    公开(公告)号:US20080255153A1

    公开(公告)日:2008-10-16

    申请号:US12079563

    申请日:2008-03-27

    CPC分类号: C07D487/04

    摘要: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, which are useful as inhibitors of human stearoyl-CoA desaturase (SCD). The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment or prevention of medical conditions in which the modulation of SCD activity is beneficial, such as cardiovascular diseases, obesity, non-insulin-dependent diabetes mellitus, hypertension, metabolic syndrome, neurological diseases, immune disorders, cancer and various skin diseases.

    摘要翻译: 本发明涉及可用作人硬脂酰辅酶A去饱和酶(SCD)抑制剂的式(I)化合物及其药学上可接受的盐。 本发明进一步涉及包含这些化合物的药物组合物和这些化合物用于治疗或预防SCD活性调节有益的医学病症的用途,例如心血管疾病,肥胖症,非胰岛素依赖性糖尿病, 高血压,代谢综合征,神经系统疾病,免疫疾病,癌症和各种皮肤疾病。