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公开(公告)号：US20110106063A1
公开(公告)日：2011-05-05
申请号：US12995817
申请日：2009-07-03
申请人： Johan F. Dijksman , Anke Pierik , Jeff Shimizu , Hans Zou
发明人： Johan F. Dijksman , Anke Pierik , Jeff Shimizu , Hans Zou
CPC分类号： A61K9/4808 , A61K9/0009 , A61K47/00 , A61K47/38 , A61M31/002
摘要： Electronic pill (1, 11) comprising at least one medicine reservoir (2, 12) with a solid powder or granulate medicine, a discharge opening (3, 13) and an actuator responsive to control circuitry for displacing medicine from the reservoir (2, 12) to the discharge opening (3, 13). The medicine comprises a dispersion of one or more active ingredients—e.g., solids in powder or granulate form—in an inert carrier matrix. Optionally, the active ingredients are dispersed using intestinal moisture absorbed into the pill via a semi-permeable wall section (14).
摘要翻译： 包括具有固体粉末或颗粒药物的至少一个药物储存器（2,12）的电子药丸（1,11），排出口（3,13）和响应于控制电路的致动器，所述控制电路用于将药物从贮存器 12）到排出口（3,13）。 药物包含一种或多种活性成分的分散体，例如粉末或颗粒形式的固体 - 在惰性载体基质中。 任选地，活性成分通过经由半透壁部分（14）吸收到药丸中的肠水分散。
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公开(公告)号：US20110092959A1
公开(公告)日：2011-04-21
申请号：US12992613
申请日：2009-06-18
申请人： Hans Zou , Jeff Shimizu , Lucian R. Albu , Johan F. Dijksman
发明人： Hans Zou , Jeff Shimizu , Lucian R. Albu , Johan F. Dijksman
CPC分类号： A61M31/002
摘要： Electronic pill (1, 11, 21) comprising a plurality of medicine reservoirs (2, 12, 22), each of the reservoirs comprising a discharge opening (3, 13, 23) covered by a removable cover (6, 16, 26). The pill comprises at least one actuator responsive to control circuitry for removing the cover from the discharge opening (3, 13, 23). The actuator can for example be a spring loaded piston (4) breaking a foil cover when dispensing the medicament. 5 Alternatively, the cover can be a rotatable disk (16) or cylinder (26) with an opening (17, 27) which can be brought in line with the discharge opening of a reservoir under the action of the actuator.
摘要翻译： 包括多个药物储存器（2,12,22）的电子药丸（1,11,21），每个储存器包括由可移除的盖（6,16,26）覆盖的排出口（3,13,33） 。 所述药丸包括响应于控制电路的至少一个致动器，用于从所述排放开口（3,13,33）移除所述盖。 致动器可以例如是在分配药物时破坏箔盖的弹簧加载的活塞（4）。 或者，盖可以是具有开口（17,27）的可旋转盘（16）或圆筒（26），该开口可在致动器的作用下与储存器的排出口一致。
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公开(公告)号：US09067011B2
公开(公告)日：2015-06-30
申请号：US12992305
申请日：2009-06-17
申请人： Hans Zou , Jeff Shimizu , Lucian R. Albu , Johan F. Dijksman
发明人： Hans Zou , Jeff Shimizu , Lucian R. Albu , Johan F. Dijksman
CPC分类号： A61M5/14276 , A61M31/002 , A61M2202/064 , A61M2205/3365 , A61M2210/1053 , A61M2210/1064
摘要： A device for placement in an environment, particularly a humid environment, for delivery of medication to said environment. The device comprises a reservoir (103) having an orifice (104), a conveying unit for conveying a reservoir's content (106) through the orifice (104) and an actuator arrangement for driving the conveying unit. In order to provide a reliable delivery of medication in a humid environment, the conveying unit comprises an auger (110) extending in the reservoir (103).
摘要翻译： 一种用于放置在环境中，特别是潮湿环境中用于将药物递送到所述环境的装置。 该装置包括具有孔口（104）的储存器（103），用于通过孔口（104）输送储存器内容物（106）的输送单元和用于驱动输送单元的致动器装置。 为了在潮湿环境中提供药物的可靠递送，输送单元包括在贮存器（103）中延伸的螺旋推运器（110）。
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公开(公告)号：US20110106064A1
公开(公告)日：2011-05-05
申请号：US12992305
申请日：2009-06-17
申请人： Hans Zou , Jeff Shimizu , Lucian R. Albu , Johan F. Dijksman
发明人： Hans Zou , Jeff Shimizu , Lucian R. Albu , Johan F. Dijksman
IPC分类号： A61M37/00
CPC分类号： A61M5/14276 , A61M31/002 , A61M2202/064 , A61M2205/3365 , A61M2210/1053 , A61M2210/1064
摘要： A device for placement in an environment, particularly a humid environment, for delivery of medication to said environment. The device comprises a reservoir (103) having an orifice (104), a conveying unit for conveying a reservoir's content (106) through the orifice (104) and an actuator arrangement for driving the conveying unit. In order to provide a reliable delivery of medication in a humid environment, the conveying unit comprises an auger (110) extending in the reservoir (103).
摘要翻译： 一种用于放置在环境中，特别是潮湿环境中用于将药物递送到所述环境的装置。 该装置包括具有孔口（104）的储存器（103），用于通过孔口（104）输送储存器内容物（106）的输送单元和用于驱动输送单元的致动器装置。 为了在潮湿环境中提供药物的可靠递送，输送单元包括在贮存器（103）中延伸的螺旋推运器（110）。
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公开(公告)号：US08961498B2
公开(公告)日：2015-02-24
申请号：US12992613
申请日：2009-06-18
申请人： Hans Zou , Jeff Shimizu , Lucian R. Albu , Johan F. Dijksman
发明人： Hans Zou , Jeff Shimizu , Lucian R. Albu , Johan F. Dijksman
CPC分类号： A61M31/002
摘要： Electronic pill (1, 11, 21) comprising a plurality of medicine reservoirs (2, 12, 22), each of the reservoirs comprising a discharge opening (3, 13, 23) covered by a removable cover (6, 16, 26). The pill comprises at least one actuator responsive to control circuitry for removing the cover from the discharge opening (3, 13, 23). The actuator can for example be a spring loaded piston (4) breaking a foil cover when dispensing the medicament. 5 Alternatively, the cover can be a rotatable disk (16) or cylinder (26) with an opening (17, 27) which can be brought in line with the discharge opening of a reservoir under the action of the actuator.
摘要翻译： 包括多个药物储存器（2,12,22）的电子药丸（1,11,21），每个储存器包括由可移除的盖（6,16,26）覆盖的排出口（3,13,33） 。 所述药丸包括响应于控制电路的至少一个致动器，用于从所述排放开口（3,13,33）移除所述盖。 致动器可以例如是在分配药物时破坏箔盖的弹簧加载的活塞（4）。 或者，盖可以是具有开口（17,27）的可旋转盘（16）或圆筒（26），该开口可在致动器的作用下与储存器的排出口一致。
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公开(公告)号：US09227011B2
公开(公告)日：2016-01-05
申请号：US12442961
申请日：2007-09-27
CPC分类号： A61M5/14276 , A61B5/073 , A61B2562/0214 , A61M5/1723 , A61M2005/1726 , A61M2210/1053
摘要： A sensor comprising a plurality of electrodes having a miniature size and a lower power consumption and a coating exterior to the electrodes, wherein the coating interacts with a target condition thereby producing a change in an electrical property of the electrodes, wherein the change is transduced into an electrical signal by the electrodes. Further a system for medication delivery comprising such sensor and a pill.
摘要翻译： 一种传感器，包括具有微小尺寸和较低功率消耗的多个电极以及电极外部的涂层，其中所述涂层与目标条件相互作用，从而产生电极的电性能的变化，其中所述变化被转换成 电极的电信号。 另外，用于药物输送的系统包括这种传感器和丸剂。
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公开(公告)号：US09744139B2
公开(公告)日：2017-08-29
申请号：US13262841
申请日：2010-04-02
申请人： Johan Frederik Dijksman , Anke Pierik , Frits Tobi De Jongh , Jeff Shimizu , Hans Zou , Lucian Remus Albu , Olaf Weiner
发明人： Johan Frederik Dijksman , Anke Pierik , Frits Tobi De Jongh , Jeff Shimizu , Hans Zou , Lucian Remus Albu , Olaf Weiner
CPC分类号： A61K9/4808 , A61K9/0009 , A61K9/0097 , A61M31/002
摘要： An ingestible capsule (10) is provided for delivery of a drug, the capsule (10) comprises a first module (11) and a second module (12). The first module (11) has at least one drug compartment (13) for comprising an amount of the drug. The drug compartment (13) is sealed by a foil (14) with an embedded conducting heating wire (15). The second (12) module comprises electronics (18) for providing an electrical pulse to the heating wire (15) in order to open the drug compartment (13) by melting the foil (14). The first module (11) and second module (12) comprise interoperable connection means (19) for securing the first module (11) to the second module (12) such that the heating wire (15) is electronically coupled to the electronics (18).
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8.发明申请MEDICAMENT DELIVERY DEVICE, CAPSULE AND IN VIVO MEDICINE DELIVERY OR DIAGNOSTIC SYSTEM 有权药物输送装置，胶囊和体内药物递送或诊断系统公开(公告)号：US20100056874A1
公开(公告)日：2010-03-04
申请号：US12515383
申请日：2007-11-06
申请人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu , Ventzeslav Iordanov , Hans Marc Bert Boeve
发明人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu , Ventzeslav Iordanov , Hans Marc Bert Boeve
CPC分类号： A61M5/14593 , A61B1/041 , A61B5/01 , A61B5/073 , A61B5/14539 , A61B5/4839 , A61M5/14276 , A61M31/002 , A61M2005/14204 , A61M2205/3561
摘要： A medicament delivery device, which comprises a driving mechanism and a housing (1) having a reservoir (2), which is at least partly filled with a substance and which is sealed at least on one side with a flexible wall (21). The driving mechanism is adapted to press a piston (23) against the flexible wall (21) thereby releasing the substance from the reservoir (2) through an opening (25) in the reservoir (2). This provides for a safe and reliable medicament delivery device.
摘要翻译： 一种药物输送装置，其包括驱动机构和具有储存器（2）的壳体（1），其至少部分地填充有物质，并且至少在一侧上用柔性壁（21）密封。 驱动机构适于将活塞（23）压靠在柔性壁（21）上，从而通过储存器（2）中的开口（25）将物质从储存器（2）释放。 这提供了一种安全可靠的药物输送装置。
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公开(公告)号：US20100063486A1
公开(公告)日：2010-03-11
申请号：US12442408
申请日：2007-09-20
申请人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Michel Pardoel , Frits Tobi De Jongh
发明人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Michel Pardoel , Frits Tobi De Jongh
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61B5/073 , A61B5/4839 , A61M31/00
摘要： An electronic capsule (100) is provided. The capsule (100) has a discrete drive element (300) comprising: a housing (109), electronics for making the electronic capsule (100) operable, a pumping mechanism (115) for dosing and displacing a substance, a power source (105) for powering the electronic capsule (100) and enabling the electronics and the pumping mechanism (115) to operate, and a locking mechanism (130); and a discrete payload element (200) comprising: a housing (109), a reservoir (210) for storing the substance, one or more openings (250) in the housing (109) for releasing the substance from the reservoir (210) and a locking mechanism (230) for engaging the drive element locking mechanism (130). Engagement of the drive element locking mechanism (130) with the payload element locking mechanism (230) secures the drive element (300) to the payload element (200), thereby making the electronic capsule (100) operable and specific.
摘要翻译： 提供电子胶囊（100）。 所述胶囊（100）具有离散驱动元件（300），包括：壳体（109），用于使所述电子胶囊（100）可操作的电子设备，用于计量和移位物质的泵送机构（115），电源（105） ），用于对所述电子胶囊（100）供电并使得所述电子设备和所述泵送机构（115）能够操作;以及锁定机构（130）。 和离散有效载荷元件（200），包括：壳体（109），用于存储物质的储存器（210），用于将物质从储存器（210）释放的壳体（109）中的一个或多个开口（250） 用于接合驱动元件锁定机构（130）的锁定机构（230）。 驱动元件锁定机构（130）与有效载荷元件锁定机构（230）的接合将驱动元件（300）固定到有效载荷元件（200），从而使电子胶囊（100）可操作和特定。
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10.发明申请INGESTIBLE ELECTRONIC CAPSULE AND IN VIVO DRUG DELIVERY OR DIAGNOSTIC SYSTEM 有权不可渗透的电子胶囊和体内药物递送或诊断系统公开(公告)号：US20100049012A1
公开(公告)日：2010-02-25
申请号：US12515424
申请日：2007-11-05
申请人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Claude Jean-Marie Malaurie , Yvan O.J.G. Droinet , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu
发明人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Claude Jean-Marie Malaurie , Yvan O.J.G. Droinet , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu
CPC分类号： A61B5/073 , A61B1/00016 , A61B1/041 , A61B5/4839
摘要： An ingestible electronic capsule (100) for introduction into the bodily lumen comprises a circuit board with at least one electronic component (4,5,7,8,9,11, 12, 13, 14). The circuit board is formed from a flex foil (10), thereby reducing the number of components and improving the robustness and reliability of the ingestible electronic capsule (100).
摘要翻译： 用于引入人体内腔的可摄入电子胶囊（100）包括具有至少一个电子部件（4,5,7,8,9,11,12,13,14）的电路板。 电路板由柔性箔（10）形成，从而减少了组件的数量并提高了可摄取电子胶囊（100）的坚固性和可靠性。
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