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公开(公告)号：US07754433B2
公开(公告)日：2010-07-13
申请号：US10309421
申请日：2002-12-02
申请人： John Babcook , Xiao-Chi Jia , Jaspal Singh Kang , Li Zhang
发明人： John Babcook , Xiao-Chi Jia , Jaspal Singh Kang , Li Zhang
IPC分类号： G01N33/53
CPC分类号： G01N33/6854 , G01N33/6857
摘要： Methods are disclosed for determining the relative binding affinities of molecules for their binding partner. One type of molecule is an antibody, which has an antigen binding partner. Antibodies are tested for binding against limited dilutions of antigen. Antibodies that bind to the most dilute antigen concentrations are determined to have a higher relative binding affinity for the antigen than antibodies that only bind to more concentrated antigen preparations.
摘要翻译： 公开了用于确定其结合配偶体的分子的相对结合亲和力的方法。 一种分子是具有抗原结合配偶体的抗体。 测试抗体与抗原的有限稀释度结合。 确定与最稀释的抗原浓度结合的抗体比仅与结合更浓缩的抗原制剂的抗体相比具有比抗原更高的相对结合亲和力。
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公开(公告)号：US08431130B2
公开(公告)日：2013-04-30
申请号：US12843740
申请日：2010-07-26
申请人： Tariq Ghayur , Boris Labkovsky , Jeffrey W. Voss , Larry Green , John Babcook , Xiao-chi Jia , James Wieler , Jaspal Singh Kang , Brad Hedberg
发明人： Tariq Ghayur , Boris Labkovsky , Jeffrey W. Voss , Larry Green , John Babcook , Xiao-chi Jia , James Wieler , Jaspal Singh Kang , Brad Hedberg
IPC分类号： A61K39/395 , C07K16/18 , C07K16/24 , C12P21/08
CPC分类号： C07K16/244 , A61K2039/505 , C07H21/04 , C07K2317/21
摘要： The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
摘要翻译： 本发明包括IL-18结合蛋白，特别是结合人白细胞介素-18（hIL-18）的抗体。 具体地，本发明涉及完全是人抗体的抗体。 优选的抗体对hIL-18具有高亲和力和/或在体外和体内中和hIL-18活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-18和抑制hIL-18活性，例如在患有hIL-18活性有害的病症的人类受试者中。
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公开(公告)号：US20100291088A1
公开(公告)日：2010-11-18
申请号：US12843740
申请日：2010-07-26
申请人： Tariq Ghayur , Boris Labkovsky , Jeffrey W. Voss , Larry Green , John Babcook , Xiao-chi Jia , James Wieler , Jaspal Singh Kang , Brad Hedberg
发明人： Tariq Ghayur , Boris Labkovsky , Jeffrey W. Voss , Larry Green , John Babcook , Xiao-chi Jia , James Wieler , Jaspal Singh Kang , Brad Hedberg
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N1/00 , C12N1/21 , C12N5/10 , C12N1/15 , C12N1/19 , C12P21/02 , A61K38/17 , C07K16/24 , A61P29/00
CPC分类号： C07K16/244 , A61K2039/505 , C07H21/04 , C07K2317/21
摘要： The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
摘要翻译： 本发明包括IL-18结合蛋白，特别是结合人白细胞介素-18（hIL-18）的抗体。 具体地，本发明涉及完全是人抗体的抗体。 优选的抗体对hIL-18具有高亲和力和/或在体外和体内中和hIL-18活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-18和抑制hIL-18活性，例如在患有hIL-18活性有害的病症的人类受试者中。
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公开(公告)号：US07968684B2
公开(公告)日：2011-06-28
申请号：US10988360
申请日：2004-11-12
申请人： Tariq Ghayur , Boris Labkovsky , Jeffrey W. Voss , Larry Green , John Babcook , Xiao-chi Jia , James Wieler , Jaspal Singh Kang , Brad Hedberg
发明人： Tariq Ghayur , Boris Labkovsky , Jeffrey W. Voss , Larry Green , John Babcook , Xiao-chi Jia , James Wieler , Jaspal Singh Kang , Brad Hedberg
IPC分类号： C07K16/00 , A61K39/395 , C12N1/11 , C12N1/15 , C12N1/21 , C12N5/04 , C12N5/07 , C12N15/09 , C12N15/11 , C12N15/13 , C12N15/63
CPC分类号： C07K16/244 , A61K2039/505 , C07H21/04 , C07K2317/21
摘要： The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
摘要翻译： 本发明包括IL-18结合蛋白，特别是结合人白细胞介素-18（hIL-18）的抗体。 具体地，本发明涉及完全是人抗体的抗体。 优选的抗体对hIL-18具有高亲和力和/或在体外和体内中和hIL-18活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-18和抑制hIL-18活性，例如在患有hIL-18活性有害的病症的人类受试者中。
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公开(公告)号：US20130034559A1
公开(公告)日：2013-02-07
申请号：US13511538
申请日：2010-11-24
申请人： Christophe Queva , Michelle Morrow , Scott Hammond , Marat Alimzhanov , John Babcook , Ian Nevin Foltz , Jaspal Singh Kang , Laura Sekirov , Melanie Boyle , Matthieu Chodorge , Ross A. Stewart , Kathleen Ann Mulgrew
发明人： Christophe Queva , Michelle Morrow , Scott Hammond , Marat Alimzhanov , John Babcook , Ian Nevin Foltz , Jaspal Singh Kang , Laura Sekirov , Melanie Boyle , Matthieu Chodorge , Ross A. Stewart , Kathleen Ann Mulgrew
IPC分类号： A61K39/395 , A61P35/00 , C07K16/30 , C12N15/13 , C12N5/10
CPC分类号： C07K16/2827 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/76 , C07K2317/92
摘要： Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity and/or expression of B7-H1 are disclosed. Additionally, hybridomas or other cell lines expressing such antibodies are disclosed
摘要翻译： 公开了针对B7-H1的人单克隆抗体以及这些抗体在诊断中的用途以及用于治疗与B7-H1的活性和/或表达相关的疾病的疾病。 此外，公开了表达这种抗体的杂交瘤或其它细胞系
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公开(公告)号：US08779108B2
公开(公告)日：2014-07-15
申请号：US13511538
申请日：2010-11-24
申请人： Christophe Queva , Michelle Morrow , Scott Hammond , Marat Alimzhanov , John Babcook , Ian Nevin Foltz , Jaspal Singh Kang , Laura Sekirov , Melanie Boyle , Matthieu Chodorge , Ross A. Stewart , Kathleen Ann Mulgrew
发明人： Christophe Queva , Michelle Morrow , Scott Hammond , Marat Alimzhanov , John Babcook , Ian Nevin Foltz , Jaspal Singh Kang , Laura Sekirov , Melanie Boyle , Matthieu Chodorge , Ross A. Stewart , Kathleen Ann Mulgrew
CPC分类号： C07K16/2827 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/76 , C07K2317/92
摘要： Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity and/or expression of B7-H1 are disclosed. Additionally, hybridomas or other cell lines expressing such antibodies are disclosed.
摘要翻译： 公开了针对B7-H1的人单克隆抗体以及这些抗体在诊断中的用途以及用于治疗与B7-H1的活性和/或表达相关的疾病的疾病。 此外，公开了表达这种抗体的杂交瘤或其它细胞系。
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公开(公告)号：US20050100965A1
公开(公告)日：2005-05-12
申请号：US10706689
申请日：2003-11-12
申请人： Tariq Ghayur , Boris Labkovsky , Jeffrey Voss , Larry Green , John Babcook , Xiao-chi Jia , James Wieler , Jaspal Kang , Brad Hedberg
发明人： Tariq Ghayur , Boris Labkovsky , Jeffrey Voss , Larry Green , John Babcook , Xiao-chi Jia , James Wieler , Jaspal Kang , Brad Hedberg
CPC分类号： G01N33/6869 , A61K2039/505 , C07K16/244 , C07K2317/33 , C07K2317/52 , C07K2317/55 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2317/94 , Y02A50/407
摘要： The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
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公开(公告)号：US20050147610A1
公开(公告)日：2005-07-07
申请号：US10988360
申请日：2004-11-12
申请人： Tariq Ghayur , Boris Labkovsky , Jeffrey Voss , Larry Green , John Babcook , Xiao-chi Jia , James Wieler , Jaspal Kang , Brad Hedberg
发明人： Tariq Ghayur , Boris Labkovsky , Jeffrey Voss , Larry Green , John Babcook , Xiao-chi Jia , James Wieler , Jaspal Kang , Brad Hedberg
IPC分类号： A61K39/395 , C07H21/04 , C07K16/24 , C12N5/06 , C12P21/04
CPC分类号： C07K16/244 , A61K2039/505 , C07H21/04 , C07K2317/21
摘要： The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
摘要翻译： 本发明包括IL-18结合蛋白，特别是结合人白细胞介素-18（hIL-18）的抗体。 具体地，本发明涉及完全是人抗体的抗体。 优选的抗体对hIL-18具有高亲和力和/或在体外和体内中和hIL-18活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-18和抑制hIL-18活性，例如在患有hIL-18活性有害的病症的人类受试者中。
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公开(公告)号：US08785600B2
公开(公告)日：2014-07-22
申请号：US12910393
申请日：2010-10-22
IPC分类号： C12P21/08
CPC分类号： C07K16/40 , A61K39/39558 , A61K47/6871 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/573
摘要： Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The antibodies bind an extracellular domain of GCC and can be internalized. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.
摘要翻译： 公开了结合GCC的抗体和抗原结合片段。 抗体结合GCC的细胞外结构域并可以内化。 在一些实施方案中，抗体是人源化的，嵌合的或人的。 还公开了编码抗体或其部分的核酸和载体，含有核酸的重组细胞，以及包含抗体或抗原结合片段的组合物。 本发明还提供了利用本文提供的抗体和抗原结合片段的治疗和诊断方法。
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公开(公告)号：US20110110936A1
公开(公告)日：2011-05-12
申请号：US12910393
申请日：2010-10-22
IPC分类号： A61K39/395 , C07K16/40 , C07H21/00 , C12N5/10 , C12P21/00 , G01N33/573 , A61P35/00
CPC分类号： C07K16/40 , A61K39/39558 , A61K47/6871 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/573
摘要： Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The antibodies bind an extracellular domain of GCC and can be internalized. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.
摘要翻译： 公开了结合GCC的抗体和抗原结合片段。 抗体结合GCC的细胞外结构域并可以内化。 在一些实施方案中，抗体是人源化的，嵌合的或人的。 还公开了编码抗体或其部分的核酸和载体，含有核酸的重组细胞，以及包含抗体或抗原结合片段的组合物。 本发明还提供了利用本文提供的抗体和抗原结合片段的治疗和诊断方法。
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