公开(公告)号：US20120108461A1

公开(公告)日：2012-05-03

申请号：US13286078

申请日：2011-10-31

申请人： John E. Bussan ,  Michael R. Nelson ,  Pat N. Morgan ,  Sergey V. Rozhok ,  Jeff Rendlin

发明人： John E. Bussan ,  Michael R. Nelson ,  Pat N. Morgan ,  Sergey V. Rozhok ,  Jeff Rendlin

IPC分类号： C40B30/04 ,  G01N35/00 ,  C40B40/10 ,  G01N33/543

CPC分类号： G01N35/028 ,  G01N35/00029 ,  G01N2035/00138 ,  Y10T436/112499

摘要： An assay device and method of use thereof includes a sample tray comprising a plurality of sample wells having a first volume, and a slide tray comprising a slide, and a liquid dispenser. The slide comprises a plurality of reaction sites on a bottom surface of the slide. The liquid dispenser is configured to dispense a plurality of liquid samples into the sample wells. The sample wells are configured to hold the liquid samples. Each of the liquid samples has a second volume such that the second volume exceeds the first volume and each of the liquid sample sits within and above one of the sample wells. The slide tray and the sample tray are configured such that the slide tray can be placed onto the sample tray, at least one of the reaction sites can be positioned directly above at least one of the sample wells containing a liquid sample, and the liquid sample can be drawn onto the reaction site upon the liquid sample contacting the bottom surface of the slide.

摘要翻译： 测定装置及其使用方法包括包含多个具有第一体积的样品孔的样品盘和包括载玻片的滑动盘和液体分配器。 滑块包括滑块底表面上的多个反应位点。 液体分配器配置成将多个液体样品分配到样品孔中。 样品孔配置成保持液体样品。 每个液体样品具有第二体积，使得第二体积超过第一体积，并且每个液体样品位于一个样品孔内和上面。 滑动托盘和样品托盘被配置为使得滑动托盘可以放置在样品托盘上，至少一个反应位点可以直接位于至少一个含有液体样品的样品孔的上方，液体样品 可以在液体样品接触载玻片的底表面时被吸引到反应部位上。

公开(公告)号：US20100256824A1

公开(公告)日：2010-10-07

申请号：US12718753

申请日：2010-03-05

申请人： Vadim VAL-KHVALABOV ,  Javad M. Vakil ,  John E. Bussan ,  Jeffrey R. Rendlen ,  Michael R. Nelson ,  John Moskal

发明人： Vadim VAL-KHVALABOV ,  Javad M. Vakil ,  John E. Bussan ,  Jeffrey R. Rendlen ,  Michael R. Nelson ,  John Moskal

IPC分类号： G05D23/19 ,  G05D7/06

CPC分类号： F24F3/14 ,  F24F5/0042 ,  F24F11/30 ,  F24F2110/10 ,  F24F2110/20

摘要： Improved environmental control system for improved nanolithography, imaging, detecting, and fabricating. An article comprising: at least one environmental chamber; at least one conditioning chamber adapted to be in gaseous communication with the environmental chamber, wherein the conditioning chamber comprises at least one gas transport device such as a fan, optionally at least one temperature probe, and at least one heating-cooling device such as a thermoelectric device which in operation provides a cold side and a hot side, at least one water vapor source, and at least one temperature sensor, at least one humidity sensor, wherein the fan, the thermoelectric device, the water vapor source, the temperature sensor, and the humidity sensor are adapted for a temperature controlled and humidity controlled gaseous flow. Two fans can be used, wherein the fans can transport air in the same direction or in opposite directions.

摘要翻译： 改进的纳米光刻，成像，检测和制造的改进的环境控制系统。 一种制品，包括：至少一个环境室; 至少一个适于与所述环境室气态连通的调节室，其中所述调节室包括至少一个气体输送装置，例如风扇，可选地至少一个温度探头，以及至少一个加热冷却装置，例如 操作中的热电装置提供冷侧和热侧，至少一个水蒸气源和至少一个温度传感器，至少一个湿度传感器，其中风扇，热电装置，水蒸汽源，温度传感器 ，并且湿度传感器适用于温度控制和湿度控制的气流。 可以使用两个风扇，其中风扇可以沿相同方向或相反方向输送空气。

公开(公告)号：US20100294147A1

公开(公告)日：2010-11-25

申请号：US11305327

申请日：2005-12-19

申请人： Cedric Loiret-Bernal ,  Bjoern Rosner ,  Sylvain Cruchon-Dupeyrat ,  John E. Bussan ,  Michael Nelson

发明人： Cedric Loiret-Bernal ,  Bjoern Rosner ,  Sylvain Cruchon-Dupeyrat ,  John E. Bussan ,  Michael Nelson

IPC分类号： B41F17/36

CPC分类号： B41F19/068 ,  B41F17/36

摘要： Semi-automated or automated manufacturing of micro- or nanostructured identification features on objects and compositions, and especially pharmaceutical compositions. In particular, a motorized stamping apparatus capable of precise hot embossing with or without closed-loop control of the loading; a modular stamp head for a high-throughput parallel stamping apparatus that comprise an array of compact, error-tolerant, individually temperature-controllable stamping elements; inexpensive stamp holders for said elements, as well as associated methods. The inventive features do not reside in the method of making the stamps.

摘要翻译： 在物体和组合物上，特别是药物组合物的半自动或自动化制造微结构或纳米结构的识别特征。 特别是一种电动冲压装置，能够精确地加热或不加负荷闭环控制的热压花; 用于高通量并行冲压装置的模块化压头，其包括紧凑的，容错的，单独的温度可控的冲压元件阵列; 用于所述元件的廉价邮票持有者以及相关方法。 本发明的特征不在于制作邮票的方法。

公开(公告)号：US20100297228A1

公开(公告)日：2010-11-25

申请号：US12260911

申请日：2008-10-29

申请人： Cedric Loiret-Bernal ,  Nabil Amro ,  Sandeep Disawal ,  Bjoern Rosner ,  John E. Bussan ,  Bo He

发明人： Cedric Loiret-Bernal ,  Nabil Amro ,  Sandeep Disawal ,  Bjoern Rosner ,  John E. Bussan ,  Bo He

IPC分类号： A61K9/44 ,  B05D3/12 ,  A61P43/00

CPC分类号： B42D25/425 ,  A61K9/284 ,  B41M3/14 ,  B42D25/29 ,  B42D25/305 ,  B42D2035/16 ,  B44B5/0052 ,  G06K1/12

摘要： To improve anticounterfeiting protection, a method for imprinting pharmaceutical unit compositions comprising: providing a pharmaceutical unit composition, partially coating the exterior of the composition with a coating, stamping the coating with a stamp comprising a plurality of identification features, wherein identification features from the stamp are at least partially transposed in the coating and form a barcode, wherein the plurality of identification features comprise at least one lateral dimension of about 1,000 nm or less. Other objects can be coated and stamped including currency and luxury goods.

摘要翻译： 为了改善防伪保护，一种用于印记药物单位组合物的方法，包括：提供药物单元组合物，用涂层部分地涂覆组合物的外部，用包含多个识别特征的印模冲压涂层，其中印模的识别特征 至少部分地转置在涂层中并形成条形码，其中多个识别特征包括至少一个约1000nm或更小的横向尺寸。 其他物品可以涂上和盖章，包括货币和奢侈品。

公开(公告)号：US20120272845A1

公开(公告)日：2012-11-01

申请号：US13539259

申请日：2012-06-29

申请人： Cedric Loiret-Bernal ,  Bjoern Rosner ,  Sylvain Cruchon-Dupeyrat ,  John E. Bussan ,  Michael Nelson

发明人： Cedric Loiret-Bernal ,  Bjoern Rosner ,  Sylvain Cruchon-Dupeyrat ,  John E. Bussan ,  Michael Nelson

IPC分类号： B44B5/00

CPC分类号： B41F19/068 ,  B41F17/36

摘要： Semi-automated or automated manufacturing of micro- or nanostructured identification features on objects and compositions, and especially pharmaceutical compositions. In particular, a motorized stamping apparatus capable of precise hot embossing with or without closed-loop control of the loading; a modular stamp head for a high-throughput parallel stamping apparatus that comprise an array of compact, error-tolerant, individually temperature-controllable stamping elements; inexpensive stamp holders for said elements, as well as associated methods. The inventive features do not reside in the method of making the stamps.

摘要翻译： 在物体和组合物上，特别是药物组合物的半自动或自动化制造微结构或纳米结构的识别特征。 特别是一种电动冲压装置，能够精确地加热或不加负荷闭环控制的热压花; 用于高通量并行冲压装置的模块化压头，其包括紧凑的，容错的，单独的温度可控的冲压元件阵列; 用于所述元件的廉价邮票持有者以及相关方法。 本发明的特征不在于制作邮票的方法。

公开(公告)号：US4901625A

公开(公告)日：1990-02-20

申请号：US293752

申请日：1989-01-03

申请人： John E. Bussan ,  Christopher F. Bussan ,  Bruce H. Blair

发明人： John E. Bussan ,  Christopher F. Bussan ,  Bruce H. Blair

IPC分类号： G05B19/23

CPC分类号： G05B19/231 ,  G05B2219/31002 ,  G05B2219/34215 ,  G05B2219/41099 ,  G05B2219/42232 ,  G05B2219/43115 ,  Y02P90/285

摘要： A system for positioning equipment quickly and accurately over a plurality of desired positions by employing a "long move" mode of operation and a "short move" mode of operation to adapt the operation of the positioning system to variable and changing conditions. The system generally includes a microprocessor as the controlling means, a controlled valving means, a pressure source coupled to the valving means, an encoder sensing means and a positioning means defined by a pneumatic cylinder.

摘要翻译： 一种用于通过采用“长移动”操作模式和“短移动”操作模式来将设备快速准确地定位在多个期望位置的系统，以使定位系统的操作适应可变和变化的条件。 该系统通常包括作为控制装置的微处理器，受控阀装置，联接到阀装置的压力源，编码器检测装置和由气缸定义的定位装置。