-
1.发明申请N-(1-(2,3-Dihydro-1H-Inden-5Yl)-2-Oxo-3-Pyrrolidinyl)-Sulfonamide Derivatives for Use as Factor Xa Inhibitors 审中-公开用作因子Xa抑制剂的N-（1-（2,3-二氢-1H-茚-5-基）-2-氧代-3-吡咯烷基） - 磺酰胺衍生物公开(公告)号：US20070249705A1
公开(公告)日：2007-10-25
申请号：US11574694
申请日：2005-09-02
申请人： John Harling , Savvas Kleanthous , Nigel Watson , Robert West , Robert Young
发明人： John Harling , Savvas Kleanthous , Nigel Watson , Robert West , Robert Young
IPC分类号： A61K31/402 , A61K31/4025 , A61K31/404 , A61P7/02 , C07D207/273 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12
CPC分类号： C07D207/273 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The invention relates to at least one chemical entity chosen from compounds of formula (I): and pharmaceutically acceptable derivative(s) thereof. The invention also relates to processes for the preparation of compound(s) of formula (I), pharmaceutical compositions containing compound(s) of formula (I) and to the use of compound(s) of formula (I) in medicine, particularly in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译： 本发明涉及至少一种选自式（I）化合物的化学实体：及其药学上可接受的衍生物。 本发明还涉及制备式（I）化合物的方法，含有式（I）化合物的药物组合物和式（I）化合物在医药中的用途，特别是 在改善指定因子Xa抑制剂的临床病症中。
-
2.发明申请3-Sulfonylamino-pyrrolindine -2- one derivatives as inhibitors of factor xa 失效3-磺酰基氨基 - 吡咯啉-2-酮衍生物作为因子xa的抑制剂公开(公告)号：US20060178419A1
公开(公告)日：2006-08-10
申请号：US10561328
申请日：2004-06-17
申请人： Alan Borthwick , John Harling , Wendy Irving , Savvas Kleanthous , Nigel Watson , Robert Young
发明人： Alan Borthwick , John Harling , Wendy Irving , Savvas Kleanthous , Nigel Watson , Robert Young
IPC分类号： A61K31/404 , A61K31/4025 , A61K31/4015 , C07D409/14 , C07D409/02 , C07D403/02
CPC分类号： C07D207/273 , C07D401/10 , C07D403/10 , C07D409/12
摘要： The invention relates to compounds of formula (I): wherein substituents are as defined.
摘要翻译： 本发明涉及式（I）的化合物：其中取代基如所定义。
-
3.发明申请2-(3-Sulfonylamino-2-oxopyrrolidin-1-yl)propanamides as factor xa inhibitors 失效2-（3-磺酰基氨基-2-氧代吡咯烷-1-基）丙酰胺作为因子xa抑制剂公开(公告)号：US20050004119A1
公开(公告)日：2005-01-06
申请号：US10495586
申请日：2002-11-13
申请人： Alan Borthwick , Matthew Campbell , Chuen Chan , Henry Kelly , Nigel King , Savvas Kleanthous , Andrew Mason , Stefan Senger , Paul Smith , Nigel Watson , Robert Young
发明人： Alan Borthwick , Matthew Campbell , Chuen Chan , Henry Kelly , Nigel King , Savvas Kleanthous , Andrew Mason , Stefan Senger , Paul Smith , Nigel Watson , Robert Young
IPC分类号： A61K31/4015 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/501 , A61K31/5377 , A61K31/55 , A61K38/00 , A61K38/55 , A61P3/00 , A61P7/00 , A61P7/02 , A61P9/10 , A61P9/14 , A61P11/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/04 , A61P41/00 , A61P43/00 , C07D207/26 , C07D207/273 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07K1/02 , C07K5/06 , A61K31/535
CPC分类号： C07D207/273 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The invention relates to compounds of formula (I) pharmaceutical compositions containing the same as well as methods of treating patients suffering from a condition susceptible to amelioration by a Factor Xa inhibitor using the same.
摘要翻译： 本发明涉及式（I）化合物，其含有相同的药物组合物，以及治疗患有易因因子Xa抑制剂改善的病症的患者的方法。
-
公开(公告)号：US20050059726A1
公开(公告)日：2005-03-17
申请号：US10499529
申请日：2002-12-20
申请人： Alan Borthwick , Chuen Chan , Henry Kelly , Nigel King , Savvas Kleanthous , Andrew Mason , Ivan Pinto , Derek Pollard , Stefan Senger , Gita Shah , Nigel Watson , Robert Young
发明人： Alan Borthwick , Chuen Chan , Henry Kelly , Nigel King , Savvas Kleanthous , Andrew Mason , Ivan Pinto , Derek Pollard , Stefan Senger , Gita Shah , Nigel Watson , Robert Young
IPC分类号： A61K31/402 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4365 , A61K31/4439 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/546 , A61P3/00 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P11/08 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P41/00 , A61P43/00 , C07D207/26 , C07D207/273 , C07D401/12 , C07D403/10 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/10 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/404 , C07D43/02 , C07D45/02 , C07D49/02
CPC分类号： C07D207/273 , C07D401/12 , C07D403/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D417/04
摘要： The present invention relates to novel compounds and pharmaceutically acceptable derivatives thereof. The invention also relates to processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and to the use of compounds in medicine, particularly in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译： 本发明涉及新化合物及其药学上可接受的衍生物。 本发明还涉及制备化合物的方法，含有该化合物的药物组合物，以及化合物在医药中的用途，特别是在改善指定因子Xa抑制剂的临床病症中。
-
5.发明申请1-Phenyl-2-oxo-3-sulfonylamino-pyrrolidine derivatives and related compounds as factor xa inhibitors for the treatment of acute vascular diseases 失效1-苯基-2-氧-3-磺酰氨基 - 吡咯烷衍生物和相关化合物作为治疗急性血管疾病的因子xa抑制剂公开(公告)号：US20060148879A1
公开(公告)日：2006-07-06
申请号：US10561545
申请日：2004-06-17
申请人： Alan Borthwick , Chuen Chan , Henry Kelly , Savvas Kleanthous , Andrew Mason , Nigel Watson
发明人： Alan Borthwick , Chuen Chan , Henry Kelly , Savvas Kleanthous , Andrew Mason , Nigel Watson
IPC分类号： A61K31/405 , A61K31/4025 , A61K31/4015 , C07D409/02
CPC分类号： C07D413/14 , C07D409/12 , C07D409/14
摘要： The invention relates to compounds of formula (I): wherein substituents are as defined.
摘要翻译： 本发明涉及式（I）的化合物：其中取代基如所定义。
-
6.发明申请公开(公告)号：US20060166985A1
公开(公告)日：2006-07-27
申请号：US10537646
申请日：2003-12-04
申请人： Alan Borthwick , Chuen Chan , Henry Kelly , Simon Peace , Stefan Senger , Gita Shah , Stefan Smith , Steven Smith , Nigel Watson , Robert West , Robert Young
发明人： Alan Borthwick , Chuen Chan , Henry Kelly , Simon Peace , Stefan Senger , Gita Shah , Stefan Smith , Steven Smith , Nigel Watson , Robert West , Robert Young
IPC分类号： A61K31/5377 , A61K31/4015 , C07D413/02 , C07D207/273
CPC分类号： C07D207/273 , C07D401/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The invention relates to novel chemical compounds, pharmaceutically acceptable derivatives thereof, processes for their preparation, pharmaceutical compositions containing them, and to their use in medicine, particularly use in the amelioration of a clinical condition for which a thrombin inhibitor is indicated.
摘要翻译： 本发明涉及新型化合物，其药学上可接受的衍生物，其制备方法，含有它们的药物组合物及其在医药中的用途，特别是用于改善指示凝血酶抑制剂的临床病症。
-
公开(公告)号：US20060167079A1
公开(公告)日：2006-07-27
申请号：US10561414
申请日：2004-07-17
申请人： Alan Borthwick , Henry Kelly , Nigel Watson , Robert Young
发明人： Alan Borthwick , Henry Kelly , Nigel Watson , Robert Young
IPC分类号： A61K31/405 , A61K31/4025 , A61K31/4015 , C07D409/02 , C07D403/02
CPC分类号： C07D409/14
摘要： The invention relates to compounds of formula (I): wherein substituents are as defined.
摘要翻译： 本发明涉及式（I）的化合物：其中取代基如所定义。
-
公开(公告)号：US20070155745A1
公开(公告)日：2007-07-05
申请号：US11548395
申请日：2006-10-11
申请人： Chuen Chan , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Caroline Whitworth , Robert Young
发明人： Chuen Chan , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Caroline Whitworth , Robert Young
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D413/14 , A61K31/5377 , C07D207/12 , C07D413/06 , C07D417/14 , C07D495/04
摘要： The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
-
公开(公告)号：US20070142375A1
公开(公告)日：2007-06-21
申请号：US11548404
申请日：2006-10-11
申请人： Chuen CHAN , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Caroline Whitworth , Robert Young
发明人： Chuen CHAN , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Caroline Whitworth , Robert Young
IPC分类号： A61K31/5377 , C07D413/02
CPC分类号： C07D413/14 , A61K31/5377 , C07D207/12 , C07D413/06 , C07D417/14 , C07D495/04
摘要： The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
-
公开(公告)号：US20070142374A1
公开(公告)日：2007-06-21
申请号：US11548402
申请日：2006-10-11
申请人： Chuen CHAN , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Carolin Whitworth , Robert Young
发明人： Chuen CHAN , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Carolin Whitworth , Robert Young
IPC分类号： A61K31/5377
CPC分类号： C07D413/14 , A61K31/5377 , C07D207/12 , C07D413/06 , C07D417/14 , C07D495/04
摘要： The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译： 本发明涉及式（I）化合物的制备方法，含有它们的药物组合物及其在医药中的用途，特别是用于改善指定因子Xa抑制剂的临床病症。
-
-
-
-
-
-
-
-
-
搜索结果
18 条记录 (耗时 0.032 秒)
