摘要:
The present invention is directed to compounds of formula (I), which antagonize of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.
摘要:
The present invention is directed to compounds of formula (I), which antagonize of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.
摘要:
The present invention relates to compounds of formula (I): wherein R1, R3, X, Q, Z, A, 9, m, and n are defined herein Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.
摘要:
The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要:
A method, system, and computer-readable media are provided for adjusting one or more video parameters of a video communication session based on a type of use for the video communication session. At least one method includes detecting a use for a certain video communication session and applying a profile of video parameters to the session based on the use. The method further includes detecting a network constraint and adjusting one or more of the video parameters based on the network constraint.
摘要:
Acoustic weight or mass sensing technology (referred to here as Acoustic Weigh In Motion (AWIN)) provides accurate weighing of any type of moving load moving over a load bearing medium. Acoustic transducers are affixed to or embedded in the load bearing medium. One or more source acoustic transducers propagate an acoustic wave over an acoustic path through the medium between the source and receiver transducers when the medium is in an unloaded state. The wave is detected at one or more receiving acoustic transducers. A propagation time delay is determined for the unloaded state. When a moving load travels over the acoustic path in the medium, the acoustic propagation time delay for that loaded state is determined. The difference between the acoustic propagation time delays for the unloaded and loaded states is determined. That acoustic propagation time delay difference is used to determine the weight or mass of the moving load.
摘要:
A method of measuring bone strength under dynamic loading is provided using an ultrasonic probe wave sensor to sense a low-frequency pump wave and an ultrasonic probe wave implemented to the bone. The bone is cyclically loaded with compressional and rarefactional pump waves, and probed with the probe wave that is timed according to the pump wave to determine the wave velocity of the probe wave. Bone strength is interpreted by measuring wave velocity changes during the pump wave cycles. Ultrasonic velocity derivatives are used to determine bone third-order (nonlinear) elastic constants that are linked to bone strength. High-resolution second-order (linear) elastic constants are provided through measurement of absolute phase velocity. A pulsed phase lock loop is locked at intervals as the probe wave phase is modulated over 360 degrees providing probe wave harmonic numbers that are correlated with the pump wave frequency to determine the probe wave velocity.
摘要:
Catalyst systems of the Ziegler-Natta type comprise as active constituents a) a solid component comprising a compound of titanium or vanadium, a compound of magnesium, a particulate inorganic oxide as support and an internal electron donor compound, and as cocatalyst b) an aluminum compound and c) if desired, a further, external electron donor compound, wherein the particulate, inorganic oxide used has a specific surface area of from 350 to 1000 m2/g and a mean particle diameter {overscore (D)} in the range from 5 to 60 &mgr;m and comprises particles which are composed of primary particles having a mean particle diameter {overscore (d)} in the range from 1 to 10 &mgr;m and contain voids or channels between the primary particles, where the macroscopic proportion of voids or channels having a diameter of greater than 1 &mgr;m in the particles of the inorganic oxides is in the range from 5 to 30% by volume and the molar ratio of the compound of magnesium to the particulate, inorganic oxide is from 0.5:1 to 2.0:1.
摘要:
Vinyl monomers are polymerized in the aqueous phase in the presence of at least one N-oxyl compound of a secondary amine, having no hydrogen atoms bonded to the &agr; carbon atoms. This process substantially eliminates deposits on reactor surfaces.
摘要:
A method for evaluating changes in the intensity of polychromatic radiation that is transmitted by a source having a known frequency spectrum (e.g. an X-band spectrum), and received by a sensor after having passed through a certain thickness of a body or sample consisting of one or more phases having a known composition, whereby artifact-related reconstruction errors may be corrected. The method is characterized in that the changes in intensity are evaluated by modeling the influences of a number of predetermined parameters related to the nature of each phase on the absorption coefficient of the body in one or more spectral bands of the polychromatic radiation. The method is useful for the tomographic analysis of geological samples or the human body.