公开(公告)号：US08784655B2

公开(公告)日：2014-07-22

申请号：US13240610

申请日：2011-09-22

申请人： Yan Liu ,  Christopher A. Pohl ,  Nebojsa Avdalovic ,  John M. Riviello ,  Archava Siriraks

发明人： Yan Liu ,  Christopher A. Pohl ,  Nebojsa Avdalovic ,  John M. Riviello ,  Archava Siriraks

IPC分类号： G01N30/96 ,  G01N30/62

CPC分类号： G01N30/96 ,  G01N30/62 ,  G01N2030/965

摘要： A liquid chromatographic system is provided including catalytically combining hydrogen and oxygen gases in the chromatography eluent stream in a catalytic gas elimination chamber, to form water and thereby reduce the gas content in the eluent stream. Also, a liquid ion chromatographic system in which the effluent from the detector is recycled to a membrane suppressor and then is mixed with a source of eluent for recycle to the chromatographic column.

摘要翻译： 提供液相色谱系统，其包括在催化气体消除室中的色谱洗脱液流中催化结合氢气和氧气，形成水，从而降低洗脱液流中的气体含量。 此外，液体离子色谱系统将来自检测器的流出物再循环至膜抑制剂，然后与洗脱液混合以再循环至色谱柱。

公开(公告)号：US08404094B2

公开(公告)日：2013-03-26

申请号：US12450783

申请日：2008-04-17

申请人： John M. Riviello

发明人： John M. Riviello

IPC分类号： B01D61/48

CPC分类号： B01D61/485 ,  B01D61/44 ,  B01D61/48 ,  B01D2313/28 ,  B01D2313/30 ,  C02F1/4695

摘要： The present invention relates generally to the deionization of liquids through the use of electrodeionization methods and apparatuses. The apparatuses may be configured to produce purified liquids for use in analytical techniques such as ion chromatography, inductively coupled plasma mass spectrometry and atomic absorption spectroscopy, among others, and to provide continuous regeneration of the ion exchange materials. The apparatuses may be configured according to the desired levels of deionization for anions, cations, or both. Finally, methods are presented for various uses of the apparatus specifically claimed.

摘要翻译： 本发明一般涉及通过使用电去离子法和设备去除液体。 这些装置可以被配置为产生用于诸如离子色谱法，电感耦合等离子体质谱法和原子吸收光谱学等分析技术的纯化液体，并提供离子交换材料的连续再生。 可以根据阴离子，阳离子或两者的去离子的期望水平来配置装置。 最后，给出了具体要求保护的装置的各种用途的方法。

公开(公告)号：US20120255910A1

公开(公告)日：2012-10-11

申请号：US13481488

申请日：2012-05-25

申请人： Yan Liu ,  Christopher A. Pohl ,  Nebojsa Avdalovic ,  John M. Riviello ,  Archava Siriraks

发明人： Yan Liu ,  Christopher A. Pohl ,  Nebojsa Avdalovic ,  John M. Riviello ,  Archava Siriraks

IPC分类号： B01D15/08

CPC分类号： G01N30/96 ,  G01N30/62 ,  G01N2030/965

摘要： A liquid chromatographic system is provided including catalytically combining hydrogen and oxygen gases in the chromatography eluent stream in a catalytic gas elimination chamber, to form water and thereby reduce the gas content in the eluent stream. Also, a liquid ion chromatographic system in which the effluent from the detector is recycled to a membrane suppressor and then is mixed with a source of eluent for recycle to the chromatographic column.

公开(公告)号：US08021555B2

公开(公告)日：2011-09-20

申请号：US12337435

申请日：2008-12-17

申请人： Yan Liu ,  Victor Manuel Berber Barreto ,  Christopher A. Pohl ,  John M. Riviello

发明人： Yan Liu ,  Victor Manuel Berber Barreto ,  Christopher A. Pohl ,  John M. Riviello

IPC分类号： B01D15/08

CPC分类号： G01N30/96 ,  G01N2030/965

摘要： A suppressed ion chromatographic apparatus using a regenerant recycle loop, comprising (a) an ion separation device, (b) a membrane suppressor, (c) a detector, (d) a container for regenerant solution, (e) a first conduit between the ion separation device and the suppressor, (f) a second conduit between the regenerant solution container and the suppressor, (g) a third conduit between the suppressor and the regenerant solution container, and (h) a regenerant solution recycle loop out of fluid communication with the detector outlet.

摘要翻译： 一种使用再生剂循环回路的抑制离子色谱装置，包括（a）离子分离装置，（b）膜抑制剂，（c）检测器，（d）用于再生剂溶液的容器，（e） 离子分离装置和抑制器，（f）再生剂溶液容器和抑制剂之间的第二导管，（g）抑制剂和再生剂溶液容器之间的第三导管，和（h）流体连通的再生剂溶液循环回路 与检测器出口。

公开(公告)号：US06610546B1

公开(公告)日：2003-08-26

申请号：US09648377

申请日：2000-08-25

申请人： Yan Liu ,  Kannan Srinivasan ,  Nebojsa Avdalovic ,  Hamish Small ,  John M. Riviello

发明人： Yan Liu ,  Kannan Srinivasan ,  Nebojsa Avdalovic ,  Hamish Small ,  John M. Riviello

IPC分类号： G01N3002

CPC分类号： G01N30/96 ,  G01N2030/965 ,  G01N30/6069

摘要： An electrolytic suppressor including (a) packing (a suppressor bed of ion exchange resin or a flow-through monolith), (b) an electrode chamber adjacent the suppressor, (c) a first electrode in the electrode chamber, (d) a barrier separating the packing from the first electrode chamber preventing significant liquid flow but permitting transport of ions only of the same charge as the packing, (e) a second electrode in electrical communication with the resin bed, and (f) a recycle conduit between the suppressor outlet port and said electrode chamber. Charged transverse partitions with openings may be included to create a serpentine liquid path. For anion analysis, the method of using the apparatus includes: (a) flowing an aqueous liquid sample stream containing anions to be detected and cation hydroxide through the separator bed, (b) flowing the aqueous effluent from the separator bed through the flow-through packing, (c) flowing the effluent liquid from the suppressor past a detector, (d) recycling said liquid effluent from the detector through a cathode chamber proximate to the packing and separated by the first barrier, and (e) applying an electrical potential between the cathode and the anode. Water is electrolyzed at the anode to cause cations on the cation exchange packing to electromigrate toward the barrier and to be transported across the barrier toward the cathode while water in the cathode chamber is electrolyzed to generate hydroxide ions which combine with the transported cations to form cation hydroxide in the cathode chamber.

摘要翻译： 一种电解抑制器，其包括（a）填充（离子交换树脂或流通式整料的抑制床），（b）与抑制器相邻的电极室，（c）电极室中的第一电极，（d） 将填料从第一电极室分离以防止显着的液体流动，但允许仅与填料相同的电荷输送离子，（e）与树脂床电连通的第二电极，和（f）抑制器之间的再循环导管 出口和所述电极室。 可以包括具有开口的带电的横向隔板以产生蛇形液体路径。 对于阴离子分析，使用该装置的方法包括：（a）使含有待检测的阴离子和阳离子氢氧化物的含水液体样品流通过分离床，（b）使来自分离器床的水性流出物流过流过 包装，（c）使来自抑制器的流出液体流过检测器，（d）将来自检测器的所述液体流出物循环通过邻近填料的阴极室并由第一屏障分离，以及（e） 阴极和阳极。 在阳极处电解阳极以使阳离子交换填料上的阳离子电迁移到屏障上，并将阴极室内的水转移到阴极，同时电解阴极室中的水以产生氢氧化物离子，这些氢离子与运送的阳离子结合形成阳离子 氢氧化物在阴极室中。

公开(公告)号：US5633171A

公开(公告)日：1997-05-27

申请号：US397998

申请日：1995-03-03

申请人： Hamish Small ,  John M. Riviello ,  Steven B. Rabin

发明人： Hamish Small ,  John M. Riviello ,  Steven B. Rabin

IPC分类号： G01N30/02 ,  G01N30/60 ,  G01N30/96

CPC分类号： G01N30/96 ,  G01N2030/965 ,  Y10T436/25125

摘要： A method and apparatus for ion analysis by ion chromatography uses periodic electrolytic regeneration of a packed bed suppressor. First and second sets of columns, suppressors and detectors connected in series are linked by appropriate valving so that the effluent from the second suppressor can be passed to the first suppressor to be used in the electrolytic regeneration of the first suppressor after detection of analyte in the second detector.

摘要翻译： 通过离子色谱法进行离子分析的方法和装置使用填充床抑制剂的周期性电解再生。 串联连接的第一和第二组柱，抑制器和检测器通过适当的阀门连接，使得来自第二抑制器的流出物可以被传递到第一抑制器以用于在检测到第一抑制器的分析物的电解再生中 第二检测器。

公开(公告)号：US5403451A

公开(公告)日：1995-04-04

申请号：US206136

申请日：1994-03-04

申请人： John M. Riviello ,  Gordon Wallace ,  Omowunmi A. Sadik

发明人： John M. Riviello ,  Gordon Wallace ,  Omowunmi A. Sadik

IPC分类号： G01N27/447 ,  G01N27/327 ,  G01N27/38 ,  G01N27/416 ,  G01N27/42 ,  G01N27/48 ,  G01N30/64 ,  G01N30/78 ,  G01N27/26

CPC分类号： G01N27/3277

摘要： In a first embodiment, a target analyte in solution is detected by exposing the solution to an electrode that includes a conducting electroactive polymer to which a periodic alternating voltage is coupled. Upon exposure to the analyte, an electrode characteristic is varied, which variation is detected by measuring electrode current as a function of time and as a function of the periodic alternating voltage. The alternating voltage waveform has an oxidizing time period and a reduction time period, which periods and waveform duty cycle may be controlled to enhance electrode sensitivity, selectivity, and to substantially eliminate electrode fouling and data hysteresis. In a second embodiment, a receptor is bound to the electrode, to which is coupled an alternating voltage waveform that permits a mating target substance to reversibly bind to the receptor such that measurement of electrode current provides a measure of such reversible binding. The second embodiment is especially useful for detecting antibodies, antigens, haptens, DNA, RNA, and enzymes. Either embodiment may be used for detection in flow-through electrochemical cells, flow injection analysis, liquid, and ion chromatography, as well as in capillary electrophoresis.

摘要翻译： 在第一实施方案中，溶液中的目标分析物通过将溶液暴露于包括连接有周期性交流电压的导电电活性聚合物的电极来检测。 在暴露于分析物时，改变电极特性，通过测量电极电流作为时间的函数并且作为周期性交变电压的函数来检测该变化。 交流电压波形具有氧化时间段和减少时间周期，可以控制这些周期和波形占空比以增强电极灵敏度，选择性，并且基本上消除电极结垢和数据滞后。 在第二实施方案中，受体结合到电极，其耦合交流电压波形，其允许配对目标物质可逆地结合受体，使得电极电流的测量提供了这种可逆结合的量度。 第二个实施方案对于检测抗体，抗原，半抗原，DNA，RNA和酶特别有用。 两种实施方案可用于流通电化学电池中的检测，流动注射分析，液体和离子色谱法以及毛细管电泳。

公开(公告)号：US20170212087A1

公开(公告)日：2017-07-27

申请号：US15530578

申请日：2015-08-18

申请人： John M RIVIELLO

发明人： John M. Riviello

IPC分类号： G01N30/96 ,  B01D15/16 ,  B01D15/36

CPC分类号： G01N30/96 ,  B01D15/166 ,  B01D15/22 ,  B01D15/36 ,  B01D15/361

摘要： A chambered ion reflux device for ion chromatography which electrolytically produces an eluent from a water pumped phase, suppresses the eluent and recovers (refluxes) the eluent ions for reuse. In the chambered ion reflux device, the eluent never passes through the electrode chambers. Since the eluent ions are refluxed and the eluent is produced electrolytically, the chambered ion reflux device can be used for isocratic or gradient ion chromatography. A chambered ion reflux device which integrates an electrolytic ion removal chamber is also disclosed.

公开(公告)号：US08709225B2

公开(公告)日：2014-04-29

申请号：US13694111

申请日：2012-10-26

申请人： John M. Riviello

发明人： John M. Riviello

IPC分类号： B01D61/48

CPC分类号： B01D61/485 ,  B01D61/44 ,  B01D61/48 ,  B01D2313/28 ,  B01D2313/30 ,  C02F1/4695

摘要： The present invention relates generally to the deionization of liquids through the use of electrodeionization methods and apparatuses. The apparatuses may be configured to minimize the fouling of the electrode chambers and to provide continuous regeneration of the ion exchange materials. The apparatuses may be configured according to the desired levels of deionization for anions, cations, or both. Finally, methods are presented for various uses of the apparatuses.

摘要翻译： 本发明一般涉及通过使用电去离子法和设备去除液体。 这些装置可以被配置为使电极室的结垢最小化并提供离子交换材料的连续再生。 可以根据阴离子，阳离子或两者的去离子的期望水平来配置装置。 最后，提出了用于装置的各种用途的方法。

公开(公告)号：US20130312500A1

公开(公告)日：2013-11-28

申请号：US13956491

申请日：2013-08-01

申请人： John M. Riviello

发明人： John M. Riviello

IPC分类号： C25B15/08 ,  G01N30/00

CPC分类号： C25B15/08 ,  G01N30/00 ,  G01N30/96 ,  G01N2030/965

摘要： An electrolytic CO2-removal device for anion analysis of a liquid sample. The device includes a basic chamber and CO2-permeable tubing in the basic chamber. Anion exchange membranes are disposed on opposite sides of the basic chamber, and electrodes are disposed outside the membranes. The device can be integral with a suppressor in an ion chromatography system and/or an aqueous stream purifier. Also, methods performed by the device.

摘要翻译： 用于液体样品阴离子分析的电解CO2去除装置。 该装置包括在基本室中的基本室和二氧化碳可渗透管。 阴离子交换膜设置在基本室的相对侧上，电极设置在膜外。 该装置可以与离子色谱系统和/或含水流净化器中的抑制器成一体。 另外，由该装置执行的方法。