公开(公告)号：US06703362B1

公开(公告)日：2004-03-09

申请号：US09079723

申请日：1998-05-15

申请人： Vernon L. Alvarez ,  Daniel J. O'Mahony ,  Imelda J. Lambkin ,  Catherine A. Patterson ,  Judith Singleton ,  Benjamin A. Belinka, Jr. ,  John M. Carter ,  Gerard M. Cagney

发明人： Vernon L. Alvarez ,  Daniel J. O'Mahony ,  Imelda J. Lambkin ,  Catherine A. Patterson ,  Judith Singleton ,  Benjamin A. Belinka, Jr. ,  John M. Carter ,  Gerard M. Cagney

IPC分类号： C12D2106

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K1/047 ,  C07K5/1013 ,  C07K5/1016 ,  C07K14/001

摘要： This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.

摘要翻译： 本发明涉及能够促进活性剂通过人或动物胃肠组织及其衍生物（例如片段）及其类似物以及编码所述蛋白质和衍生物的核苷酸序列的蛋白质（例如肽） 。 本发明的蛋白质用于促进活性剂从GIT的内腔侧输送到全身血液系统中，和/或将活性剂靶向GIT。 因此，例如，通过将本发明的蛋白质（共价或非共价）结合到口服给药的药物，该药物可以靶向已知在人胃肠道中操作的特异性受体位点或转运途径，从而有助于其吸收 进入系统系统。

公开(公告)号：US07053177B1

公开(公告)日：2006-05-30

申请号：US09079678

申请日：1998-05-15

申请人： Vernon L. Alvarez ,  Daniel J. O'Mahony ,  Imelda J. Lambkin ,  Catherine A. Patterson ,  Judith Singleton ,  Benjamin A. Belinka, Jr. ,  John M. Carter ,  Gerard M. Cagney

发明人： Vernon L. Alvarez ,  Daniel J. O'Mahony ,  Imelda J. Lambkin ,  Catherine A. Patterson ,  Judith Singleton ,  Benjamin A. Belinka, Jr. ,  John M. Carter ,  Gerard M. Cagney

IPC分类号： A61K38/00

CPC分类号： A61K38/28 ,  A61K47/58 ,  A61K47/593 ,  A61K47/60 ,  A61K47/62 ,  A61K47/6937

摘要： This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastrointestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.

摘要翻译： 本发明涉及能够促进活性剂通过人或动物胃肠组织及其衍生物（例如片段）及其类似物以及编码所述蛋白质和衍生物的核苷酸序列的蛋白质（例如肽）。 本发明的蛋白质用于促进活性剂从GIT的内腔侧进入全身血液系统，和/或将活性剂靶向GIT。 因此，例如，通过将本发明的蛋白质（共价或非共价）结合到口服给药的药物，该药物可以靶向已知在人胃肠道中操作的特异性受体位点或转运途径，从而有助于其吸收 进入系统系统。

公开(公告)号：US07003285B2

公开(公告)日：2006-02-21

申请号：US10697892

申请日：2003-10-30

申请人： John M. Carter

发明人： John M. Carter

IPC分类号： H04L7/00

CPC分类号： H04L47/10 ,  H04L47/14 ,  H04L47/2433 ,  H04L67/04 ,  H04L67/28 ,  H04L67/2823 ,  H04L67/2842 ,  H04L67/32 ,  H04W4/18

摘要： The present invention provide a method, apparatus and computer program product which enables the mode of use of a multi-sensory device to be used to prioritise the type of data which is sent to the device. The multi-sensory device sends its usage mode, for example, aural or visual, as part of communications to a server. The server then obtains the usage mode and uses this information to prioritise data sent to the device. For example if the device is being used aurally, audio data is prioritised for sending to the device such that data sent to the device is primarily or exclusively audio data.

摘要翻译： 本发明提供一种方法，装置和计算机程序产品，其使得能够使用多感器装置的使用模式来优先发送到设备的数据类型。 多感觉设备将其使用模式（例如，听觉或视觉）作为通信的一部分发送到服务器。 然后，服务器获得使用模式，并使用该信息对发送到设备的数据进行优先级排序。 例如，如果设备被听觉地使用，音频数据被优先发送到设备，使得发送到设备的数据主要或排他地是音频数据。

公开(公告)号：US07135457B1

公开(公告)日：2006-11-14

申请号：US09079819

申请日：1998-05-15

申请人： Vernon L. Alvarez ,  Daniel J. O'Mahony ,  Imelda J. Lambkin ,  Catherine A. Patterson ,  Judith Singleton ,  Benjamin A. Belinka, Jr. ,  John M. Carter ,  Gerard M. Cagney

发明人： Vernon L. Alvarez ,  Daniel J. O'Mahony ,  Imelda J. Lambkin ,  Catherine A. Patterson ,  Judith Singleton ,  Benjamin A. Belinka, Jr. ,  John M. Carter ,  Gerard M. Cagney

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K5/00 ,  C07K7/00

CPC分类号： A61K38/28 ,  A61K9/1635 ,  A61K9/5153 ,  A61K47/593 ,  A61K47/60 ,  A61K47/62 ,  A61K47/6937 ,  B82Y5/00 ,  C07K14/001

摘要： This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.

摘要翻译： 本发明涉及能够促进活性剂通过人或动物胃肠组织及其衍生物（例如片段）及其类似物以及编码所述蛋白质和衍生物的核苷酸序列的蛋白质（例如肽） 。 本发明的蛋白质用于促进活性剂从GIT的内腔侧输送到全身血液系统中，和/或将活性剂靶向GIT。 因此，例如，通过将本发明的蛋白质（共价或非共价）结合到口服给药的药物，该药物可以靶向已知在人胃肠道中操作的特异性受体位点或转运途径，从而有助于其吸收 进入系统系统。

公开(公告)号：US5243540A

公开(公告)日：1993-09-07

申请号：US679990

申请日：1991-04-03

申请人： Stephen A. Van Albert ,  Jaime M. Lee ,  Jeffrey A. Lyon ,  John M. Carter

发明人： Stephen A. Van Albert ,  Jaime M. Lee ,  Jeffrey A. Lyon ,  John M. Carter

IPC分类号： B01J19/00 ,  C07K1/00 ,  C40B40/10 ,  C40B60/14

CPC分类号： C07K1/00 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00725 ,  C40B40/10 ,  C40B60/14

摘要： An automated, computer-driven amino acid indexer for peptide synthesis uses programmed computer, a circuit board controller, and a combination of microtiter sample well trays, light emitting diodes to illuminate each sample well, and circuitry to control the illumination of the diodes. The apparatus simplifies technical difficulties present in large-scale laboratory syntheses of peptides by substantially reducing the time required for dispensing amino acids into sample trays and reducing the occurrence of error in the process to negligible levels in typical syntheses. A programmed, automated technique for synthesizing peptides is also provided.

摘要翻译： 用于肽合成的自动化的计算机驱动的氨基酸分度器使用编程的计算机，电路板控制器以及微量滴定样品阱盘的组合，用于照射每个样品阱的发光二极管以及用于控制二极管照明的电路。 该装置简化了大规模实验室合成肽中存在的技术难题，通过将氨基酸分配到样品盘中所需的时间大大减少，并将该过程中的误差发生减少到典型合成中的可忽略的水平。 还提供了一种用于合成肽的编程自动化技术。