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1.发明授权Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity 失效具有抗焦虑和抗惊厥活性的苯并吡喃衍生物
公开(公告)号：US5624954A
公开(公告)日：1997-04-29
申请号：US425329
申请日：1995-04-17
申请人： John M. Evans , Mervyn Thompson , Neil Upton
发明人： John M. Evans , Mervyn Thompson , Neil Upton
IPC分类号： C07D215/48 , C07D311/68 , C07D311/70 , C07D311/72 , C07D491/04 , A61K31/35
CPC分类号： C07D491/04 , C07D215/48 , C07D311/68 , C07D311/70 , C07D311/72
摘要： 4-(Fluorobenzoylamino)-3,4-dihydro-benzopyran derivatives are disclosed to possess anxiolytic and anti-convulsant activities.
摘要翻译： 公开了4-（氟苯甲酰氨基）-3,4-二氢 - 苯并吡喃衍生物具有抗焦虑作用和抗惊厥活性。
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2.发明授权Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity 失效具有抗焦虑和抗惊厥活性的苯并吡喃衍生物
公开(公告)号：US5889044A
公开(公告)日：1999-03-30
申请号：US454890
申请日：1995-05-31
申请人： John Morris Evans , Mervyn Thompson , Neil Upton
发明人： John Morris Evans , Mervyn Thompson , Neil Upton
IPC分类号： C07D215/48 , C07D311/68 , C07D311/70 , C07D311/72 , C07D491/04 , A61K31/35 , C07D311/04
CPC分类号： C07D491/04 , C07D215/48 , C07D311/68 , C07D311/70 , C07D311/72
摘要： Benzopyran-3-ols having anxiolytic and anticonvulsant activity are claimed.
摘要翻译： 要求具有抗焦虑和抗惊厥活性的苯并吡喃-3-醇。
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公开(公告)号：US5908860A
公开(公告)日：1999-06-01
申请号：US448518
申请日：1995-07-06
申请人： Mervyn Thompson , John Morris Evans , Neil Upton , Wai Ngor Chan , Kuok Keong Vong , Robert Nicholas Willette
发明人： Mervyn Thompson , John Morris Evans , Neil Upton , Wai Ngor Chan , Kuok Keong Vong , Robert Nicholas Willette
IPC分类号： C07D215/42 , A61K31/35 , A61K31/352 , A61K31/353 , A61K31/381 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/497 , A61P9/10 , A61P25/00 , A61P25/06 , C07D311/68 , C07D311/70 , C07D405/12 , C07D407/12 , C07D409/12 , C07D491/052 , C07D311/06 , C07D315/00
CPC分类号： C07D405/12 , C07D311/68 , C07D407/12 , C07D409/12
摘要： This invention relates to the method of treatment and/or prophylaxis of anxiety and/or disorders treatable and/or preventable with anti-convulsive agents, such as epilepsy, using compounds of the formula (Ia): ##STR1##
摘要翻译： PCT No.PCT / GB93 / 02512 Sec。 371日期：1995年7月6日 102（e）日期1995年7月6日PCT提交1993年12月8日PCT公布。 公开号WO94 / 13656 日期1994年6月23日本发明涉及使用式（Ia）的化合物治疗和/或预防用抗惊厥药如癫痫治疗和/或预防的焦虑和/或障碍的方法：
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公开(公告)号：US06492415B2
公开(公告)日：2002-12-10
申请号：US09909215
申请日：2001-07-19
申请人： Andrew Parsons , Mervyn Thompson , Neil Upton , John Morris Evans
发明人： Andrew Parsons , Mervyn Thompson , Neil Upton , John Morris Evans
IPC分类号： A61K31353
CPC分类号： A61K31/353
摘要： Benzopyran derivatives and analogs are disclosed as useful for the treatment and/or prophylaxis of neuralgia, trigeminal neuralgia, neuropathic pain, dental pain and cancer pain.
摘要翻译： 公开了苯并吡喃衍生物和类似物用于治疗和/或预防神经痛，三叉神经痛，神经性疼痛，牙痛和癌症疼痛。
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公开(公告)号：US07977337B2
公开(公告)日：2011-07-12
申请号：US12847039
申请日：2010-07-30
申请人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
发明人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
IPC分类号： A61K31/47 , A61K31/496
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
摘要翻译： 公开了对5-HT 6受体具有亲和性并具有下式的喹啉化合物：其中R1，R2，R3，R4，R5，n，m，p和A如本文所定义，及其盐，含有这些化合物和盐的组合物 制作和使用相同的过程。
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6.发明申请PIPERAZINYL-SULFONAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF GPR38 RECEPTOR MEDIATED DISEASES 失效用于治疗GPR38受体介导的疾病的哌嗪 - 磺酰胺衍生物公开(公告)号：US20100256364A1
公开(公告)日：2010-10-07
申请号：US12744367
申请日：2008-11-26
申请人： Darren Jason Mitchell , Jonathan Thomas Seal , Geoffrey Stemp , Mervyn Thompson , Susan Marie Westaway
发明人： Darren Jason Mitchell , Jonathan Thomas Seal , Geoffrey Stemp , Mervyn Thompson , Susan Marie Westaway
IPC分类号： C07D413/14 , C07D401/12 , C07D401/14
CPC分类号： C07D401/12 , C07D241/02
摘要： Disclosed are motilin agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译： 公开了胃动素激动剂，其制备方法，含有它们的药物组合物及其在治疗各种疾病中的用途。
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公开(公告)号：US07538121B2
公开(公告)日：2009-05-26
申请号：US10503648
申请日：2003-02-13
申请人： Gregor James MacDonald , Darren Jason Mitchell , Harshad Kantilal Rami , Mervyn Thompson , Susan Marie Westaway
发明人： Gregor James MacDonald , Darren Jason Mitchell , Harshad Kantilal Rami , Mervyn Thompson , Susan Marie Westaway
IPC分类号： C07D403/02 , A61K31/47
CPC分类号： C07D401/12 , C07D215/38 , C07D409/12 , C07D409/14
摘要： Certain compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, P, X, Y, q, r ans s are as defined in the specification, a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds in medicine.
摘要翻译： 某些式（I）化合物或其药学上可接受的盐或溶剂合物，其中R 1，R 2，R 3，P，X，Y，q，r s s如本说明书中所定义，制备此类化合物的方法， 包含这些化合物的药物组合物和这些化合物在医药中的用途。
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公开(公告)号：US20080306083A1
公开(公告)日：2008-12-11
申请号：US12096104
申请日：2006-12-01
IPC分类号： A61K31/496 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to novel biaryl derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.
摘要翻译： 本发明涉及新型联芳基衍生物，例如具有作为GPR38受体激动剂的活性的式（I）化合物以及这些化合物或其药物组合物在治疗胃肠道疾病中的用途。
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公开(公告)号：US07452888B2
公开(公告)日：2008-11-18
申请号：US10509078
申请日：2003-03-25
申请人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James Macdonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
发明人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James Macdonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
IPC分类号： A61K31/496 , C07D215/40
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are novel quinoline compounds of formula (I), processes for their preparation, compositions containing them and their use in the treatment of CNS disorders.
摘要翻译： 公开了式（I）的新型喹啉化合物，其制备方法，含有它们的组合物及其在治疗CNS障碍中的用途。
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公开(公告)号：US07109201B2
公开(公告)日：2006-09-19
申请号：US10471433
申请日：2002-03-11
申请人： Mervyn Thompson , Paul Adrian Wyman
发明人： Mervyn Thompson , Paul Adrian Wyman
IPC分类号： A61K31/496 , C07D403/04 , C07D401/14
CPC分类号： C07D401/10 , C07D209/08
摘要： Compounds of formula (I) or a pharmaceutically acceptable salt thereof are disclosed: in which Ra is a group of formula (i) wherein P2 is phenyl, naphthyl, heteroaryl or a 5 to 7 membered heterocyclic ring; P3 is phenyl, naphthyl or heteroaryl; R1 is NR4COR5, NR4SO2R5, CH2NR4SO2R5, CH2NR4COR5 or CH2NR4CO2R5 where R4 and R5 are independently hydrogen or C1-6alkyl; R2 and R3 are independently halogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkoxy, COC1-6alkyl, haloC1-6alkyl, cyano or NR6R7 where R6 and R7 are independently hydrogen or C1-6alkyl; b and c are independently 0, 1, 2 or 3; Y is a single bond, CH2 or NH; W is —(CR9R10)t—where t is 2, 3 or 4 and R9 and R10 are independently hydrogen or C1-6alkyl or W is a group CH═CH; Rb is hydrogen, halogen, C1-6alkyl, haloC1-6alkyl, COC1-6alkyl, cyano or C1-6alkoxy; and Rc is hydrogen or C1-6alkyl. Processes for preparation of the compounds and their uses in therapy, particularly depression, are also disclosed.
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