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17 条记录 (耗时 0.044 秒)

    Antibodies to Alpha Synuclein
    8.
    发明申请
    Antibodies to Alpha Synuclein 有权
    Alpha突触核蛋白抗体

    公开(公告)号：US20130072663A1

    公开(公告)日：2013-03-21

    申请号：US13604441

    申请日：2012-09-05

    申请人： Tamie J. Chilcote ,  Jason Goldstein ,  John P. Anderson ,  Donald Walker

    发明人： Tamie J. Chilcote ,  Jason Goldstein ,  John P. Anderson ,  Donald Walker

    IPC分类号： C07K16/18

    CPC分类号： C07K16/18 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2227/706 ,  A01K2267/0356 ,  A61K38/00 ,  C07K2317/33 ,  C07K2317/34 ,  C12N15/8509 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/2835

    摘要： The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.

    摘要翻译： 该应用鉴定了路易体病（LBD）患者和其转基因动物模型中的α-突触核蛋白的新片段。 这些疾病的特征在于α-突触核蛋白的聚集。 片段相对于全长α-突触核蛋白具有截短的C-末端。 一些片段的特征在于分子量约12kDa，通过SDS胶体电泳在三氯缓冲液中测定，并从天然α-突触核蛋白的C末端截断至少十个相邻的氨基酸。 切割位点优选在残基117之后和天然α-突触核蛋白的残基126之前发生。 这些新型α-突触核蛋白片段的鉴定在药物发现，诊断，治疗和转基因动物中有许多应用。

    Truncated fragments of alpha-synuclein in Lewy body disease
    10.
    发明授权
    Truncated fragments of alpha-synuclein in Lewy body disease 有权
    路易体疾病中α-突触核蛋白的截断片段

    公开(公告)号：US07306945B2

    公开(公告)日：2007-12-11

    申请号：US10969335

    申请日：2004-10-19

    申请人： Tamie J Chilcote ,  Jason Goldstein ,  John P Anderson ,  Wei Ping Gai

    发明人： Tamie J Chilcote ,  Jason Goldstein ,  John P Anderson ,  Wei Ping Gai

    IPC分类号： C12N15/00 ,  C12P21/06 ,  C12Q1/00 ,  C07K14/00

    CPC分类号： A01K67/027 ,  C07K14/47 ,  C12N15/10 ,  C12N15/1096 ,  C12Q1/68

    摘要： The application identifies fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.

    摘要翻译： 该应用程序识别路易体病（LBD）患者和其转基因动物模型中α-突触核蛋白的片段。 这些疾病的特征在于α-突触核蛋白的聚集。 片段相对于全长α-突触核蛋白具有截短的C-末端。 一些片段的特征在于分子量约12kDa，通过SDS胶体电泳在三氯缓冲液中测定，并从天然α-突触核蛋白的C末端截断至少十个相邻的氨基酸。 切割位点优选在残基117之后和天然α-突触核蛋白的残基126之前发生。 这些新型α-突触核蛋白片段的鉴定在药物发现，诊断，治疗和转基因动物中有许多应用。