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1.发明授权公开(公告)号：US08481501B2
公开(公告)日：2013-07-09
申请号：US11628132
申请日：2005-05-31
CPC分类号： C07H17/00 , C07D489/00 , C07D489/02 , C07H7/02
摘要： Disclosed are analgesic-related compositions and methods of using the compositions for modulation of analgesic receptor activity. The compositions and methods are useful for reducing pain, as well as for therapeutic intervention of addictions or other diseases or disorders amenable to treatment or prophylaxis by modulation of analgesic receptor signaling.
摘要翻译： 公开了镇痛相关组合物和使用该组合物调节镇痛受体活性的方法。 组合物和方法可用于减轻疼痛，以及用于通过调节止痛剂受体信号传导治疗或预防的成瘾症或其它疾病或障碍的治疗干预。
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2.发明申请Synthesis Of Metabolically Stable Analgesics, Pain Medications And Other Agents 有权代谢稳定镇痛药，止痛药及其他药物的合成公开(公告)号：US20100190728A1
公开(公告)日：2010-07-29
申请号：US11628132
申请日：2005-05-31
IPC分类号： C07H17/02 , A61K31/7048 , C07H3/02 , A61K31/70 , C07D491/048 , A61K31/4355 , A61P29/00 , A61P25/32 , A61P25/34 , A61P25/36
CPC分类号： C07H17/00 , C07D489/00 , C07D489/02 , C07H7/02
摘要： Disclosed are analgesic-related compositions and methods of using the compositions for modulation of analgesic receptor activity. The compositions and methods are useful for reducing pain, as well as for therapeutic intervention of addictions or other diseases or disorders amenable to treatment or prophylaxis by modulation of analgesic receptor signaling.
摘要翻译： 公开了镇痛相关组合物和使用该组合物调节镇痛受体活性的方法。 组合物和方法可用于减轻疼痛，以及用于通过调节止痛剂受体信号传导治疗或预防的成瘾症或其它疾病或障碍的治疗干预。
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公开(公告)号：US09751831B2
公开(公告)日：2017-09-05
申请号：US13994682
申请日：2011-12-16
申请人： John R. Cashman , Jarosiaw Kalisiak
发明人： John R. Cashman , Jarosiaw Kalisiak
IPC分类号： C07D249/04 , C07D239/06 , C07D233/24 , C07C251/40 , C07C279/12 , C07C257/12 , C07C257/18 , C07C257/14
CPC分类号： C07C251/40 , C07C257/12 , C07C257/14 , C07C257/18 , C07C279/12 , C07D233/24 , C07D239/06 , C07D249/04
摘要： The invention describes pharmaceutical agents capable of crossing the blood brain barrier to protect against organophosphate pesticides and nerve agents or other electrophiles by reactivating inhibited cholinesterase (i.e., acetylcholinesterase and butyrylcholinesterase) and other proteins in the peripheral and central nervous system.
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公开(公告)号：US20140051712A1
公开(公告)日：2014-02-20
申请号：US13994682
申请日：2011-12-16
申请人： John R. Cashman , Jarosiaw Kalisiak
发明人： John R. Cashman , Jarosiaw Kalisiak
IPC分类号： C07C251/40 , C07C279/12 , C07D239/06 , C07D249/04 , C07D233/24
CPC分类号： C07C251/40 , C07C257/12 , C07C257/14 , C07C257/18 , C07C279/12 , C07D233/24 , C07D239/06 , C07D249/04
摘要： The invention describes pharmaceutical agents capable of crossing the blood brain barrier to protect against organophosphate pesticides and nerve agents or other electrophiles by reactivating inhibited cholinesterase (i.e., acetylcholinesterase and butyrylcholinesterase) and other proteins in the peripheral and central nervous system.
摘要翻译： 本发明描述了能够穿过血脑屏障以防止有机磷农药和神经药物或其它亲电试剂通过再激活抑制的胆碱酯酶（即乙酰胆碱酯酶和丁酰胆碱酯酶）以及周围和中枢神经系统中的其它蛋白质的药剂。
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公开(公告)号：US20110263630A1
公开(公告)日：2011-10-27
申请号：US13003564
申请日：2009-07-09
申请人： John R. Cashman
发明人： John R. Cashman
IPC分类号： A61K31/485 , C12N5/00 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , C07D489/00 , C07D489/08
CPC分类号： C07D498/08
摘要： Disclosed herein are compounds of formula (I); as defined herein, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same, and methods of using these compounds for the treatment of substance addiction.
摘要翻译： 本文公开的是式（I）的化合物; 如本文所定义，或其药学上可接受的盐，包含其的药物组合物，以及使用这些化合物治疗物质成瘾的方法。
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6.发明申请SYNTHETIC COMPOUNDS AND DERIVATIVES AS MODULATORS OF SMOKING OR NICOTINE INGESTION AND LUNG CANCER 有权合成化合物和作为吸烟者或非糖尿病患者和肺癌的调节剂的衍生物公开(公告)号：US20100298345A1
公开(公告)日：2010-11-25
申请号：US12848619
申请日：2010-08-02
申请人： John R. Cashman
发明人： John R. Cashman
IPC分类号： A61K31/506 , A61P25/34 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709
CPC分类号： C07D401/04 , C07D405/04 , C07D409/04 , C07D409/14
摘要： Disclosed are nicotine-related compounds that selectively inhibit cytochrome P-450 2A6 (CYP2A6), selectively inhibit cytochrome P-450 2A13 (CYP2A13), and/or selectively modulate a nicotinic acetylcholine receptor (nAChR). Also disclosed are pharmaceutical compositions comprising a compound of the invention, as well as methods of using the pharmaceutical compositions for treating or preventing a disease or disorder associated with nicotine-ingestion, or a disease or disorder amenable to treatment by selective modulation of nAChRs.
摘要翻译： 公开了选择性抑制细胞色素P-450 2A6（CYP2A6），选择性抑制细胞色素P-450 2A13（CYP2A13）和/或选择性调节烟碱乙酰胆碱受体（nAChR）的尼古丁相关化合物。 还公开了包含本发明化合物的药物组合物，以及使用该药物组合物治疗或预防与尼古丁摄入相关的疾病或病症的方法，或适于通过选择性调节nAChR治疗的疾病或病症。
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7.发明授权Synthetic compounds and derivatives as modulators of smoking or nicotine ingestion and lung cancer 有权合成化合物和衍生物作为吸烟或尼古丁摄入和肺癌的调节剂公开(公告)号：US08609708B2
公开(公告)日：2013-12-17
申请号：US12848619
申请日：2010-08-02
申请人： John R. Cashman
发明人： John R. Cashman
IPC分类号： C07D233/02 , A61K31/415
CPC分类号： C07D401/04 , C07D405/04 , C07D409/04 , C07D409/14
摘要： Disclosed are nicotine-related compounds that selectively inhibit cytochrome P-450 2A6 (CYP2A6), selectively inhibit cytochrome P-450 2A13 (CYP2A13), and/or selectively modulate a nicotinic acetylcholine receptor (nAChR). Also disclosed are pharmaceutical compositions comprising a compound of the invention, as well as methods of using the pharmaceutical compositions for treating or preventing a disease or disorder associated with nicotine-ingestion, or a disease or disorder amenable to treatment by selective modulation of nAChRs.
摘要翻译： 公开了选择性抑制细胞色素P-450 2A6（CYP2A6），选择性抑制细胞色素P-450 2A13（CYP2A13）和/或选择性调节烟碱乙酰胆碱受体（nAChR）的尼古丁相关化合物。 还公开了包含本发明化合物的药物组合物，以及使用该药物组合物治疗或预防与尼古丁摄入相关的疾病或病症的方法，或适于通过选择性调节nAChR治疗的疾病或病症。
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公开(公告)号：US20120040976A1
公开(公告)日：2012-02-16
申请号：US13139274
申请日：2009-12-11
申请人： John R. Cashman , Kenneth J. Abel
发明人： John R. Cashman , Kenneth J. Abel
IPC分类号： A61K31/5377 , A61K31/136 , A61K31/122 , A61K31/225 , A61K31/4025 , G01N33/566 , A61K31/4545 , A61P25/28 , A61P25/00 , C12Q1/68 , C12Q1/48 , A61K31/12 , A61K31/4155
CPC分类号： A61K31/24 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5047 , G01N2800/52
摘要： Disclosed are methods for identifying individuals suffering from a CNS disorder (including Alzheimer's Disease, ALS, behavioral disorders, and the like) that could be treated with a CNS drug with greater therapeutic efficacy and lower side effects and the compounds useful for such treatment. Also disclosed are methods for predicting the efficacy of a drug candidate for the treatment of a CNS disorder. The technology is also applicable to drug discovery for evaluation in animal models of neurodegenerative diseases.
摘要翻译： 公开了用于鉴定可以用具有更大治疗功效和较低副作用的CNS药物治疗的CNS病症（包括阿尔茨海默氏病，ALS，行为障碍等）的个体的方法，以及可用于这种治疗的化合物。 还公开了用于预测候选药物治疗CNS病症的功效的方法。 该技术也适用于神经退行性疾病动物模型评估的药物发现。
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公开(公告)号：US20090263492A1
公开(公告)日：2009-10-22
申请号：US12407756
申请日：2009-03-19
申请人： John R. Cashman , Milan Fiala
发明人： John R. Cashman , Milan Fiala
CPC分类号： A61K31/12 , A61K31/136 , A61K31/222 , C07C45/74 , C07C49/248 , C07C49/255 , C07C69/26 , C07C323/22 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5047 , G01N2333/4709 , G01N2333/705 , G01N2333/91102 , G01N2800/2821 , G01N2800/52 , Y10T436/143333
摘要： Disclosed are methods for identifying individuals suffering from a CNS disorder (including Alzheimer's Disease, behavioral disorders, and the like) that could be treated with a CNS drug with greater therapeutic efficacy and lower side effects and the compounds useful for such treatment. Also disclosed are methods for predicting the efficacy of a drug candidate for the treatment of a CNS disorder. The technology is also applicable to drug discovery for use in animal models of neurodegenerative diseases.
摘要翻译： 公开了用于鉴定可以用具有更大治疗功效和较低副作用的CNS药物治疗的CNS病症（包括阿尔茨海默氏病，行为障碍等）的个体的方法，以及可用于这种治疗的化合物。 还公开了用于预测候选药物治疗CNS病症的功效的方法。 该技术也适用于用于神经变性疾病动物模型的药物发现。
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公开(公告)号：US20090247520A1
公开(公告)日：2009-10-01
申请号：US12412091
申请日：2009-03-26
申请人： John C. REED , Ranxin SHI , John R. Cashman , Karl J. OKOLOTOWICZ , Daniel RE
发明人： John C. REED , Ranxin SHI , John R. Cashman , Karl J. OKOLOTOWICZ , Daniel RE
IPC分类号： A61K31/4184 , C07D413/04 , C07D235/04 , A61K31/5377 , A61P43/00
CPC分类号： C07D235/04 , C07D413/04
摘要： A method to identify selective inhibitors of antigen receptor-mediated NF-κB activation is provided, as well as compositions having one or more of those inhibitors and methods of using those inhibitors.
摘要翻译： 提供了鉴定抗原受体介导的NF-κB活化的选择性抑制剂的方法，以及具有一种或多种这些抑制剂的组合物和使用这些抑制剂的方法。
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