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17 条记录 (耗时 0.026 秒)

    Chemical and biochemical adducts as biomarkers for organophosphate exposure
    1.
    发明授权
    Chemical and biochemical adducts as biomarkers for organophosphate exposure 有权
    化学和生化加合物作为有机磷酸盐暴露的生物标志物

    公开(公告)号：US09549991B2

    公开(公告)日：2017-01-24

    申请号：US12937957

    申请日：2009-04-14

    申请人： John R. Cashman ,  Mary T. MacDonald

    发明人： John R. Cashman ,  Mary T. MacDonald

    IPC分类号： C07K16/44 ,  C07K7/06 ,  G01N33/68 ,  A61K47/48

    CPC分类号： C07K7/06 ,  A61K47/643 ,  A61K47/646 ,  C07K16/18 ,  C07K16/44 ,  C12P21/005 ,  G01N33/6842 ,  G01N33/6893 ,  G01N2333/76 ,  G01N2410/00 ,  G01N2430/00 ,  G01N2430/10 ,  G01N2800/42

    摘要： The present disclosure provides organophosphorous (OP) compounds of Formula (I), Formula (II) and Formula (III): OP-Peptide-Linker-CP  (I), OP-Peptide-Linker  (II); and wherein OP is including that structure corresponding to a reactive organophosphorous reagent, nerve agent or pesticide, or a pesticide P═S to P═O metabolite; P is the Sp or Rp stereoisomer; X is oxygen, sulfur, selenium or imino; R and R′ are as described; Peptide is a sequence of amino acids containing a serine, threonine or tyrosine to which the OP is attached, wherein the total number of amino acids is between 7 and 41; Linker is an amino acid or is derived from another bifunctional reagent capable of covalently attaching an OP-peptide to a CP; and CP is a carrier protein used to display haptens for antibody generation. The disclosure also provides methods for generating monoclonal or polyclonal antibodies specific for an OP-Peptide of a compound of Formula (I) or Formula (II) that can be used to diagnose the presence, identity, and quantity of OP adducts.

    摘要翻译： 提供了一种鉴定OP曝光的OP-加合的生物标志物的方法以及含有可以提供OP加合物的OP的化合物。

    Synthesis of metabolically stable analgesics, pain medications and other agents
    4.
    发明授权
    Synthesis of metabolically stable analgesics, pain medications and other agents 有权
    合成代谢稳定止痛药，止痛药等

    公开(公告)号：US08481501B2

    公开(公告)日：2013-07-09

    申请号：US11628132

    申请日：2005-05-31

    申请人： John R. Cashman ,  James M. Macdougall

    发明人： John R. Cashman ,  James M. Macdougall

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： C07H17/00 ,  C07D489/00 ,  C07D489/02 ,  C07H7/02

    摘要： Disclosed are analgesic-related compositions and methods of using the compositions for modulation of analgesic receptor activity. The compositions and methods are useful for reducing pain, as well as for therapeutic intervention of addictions or other diseases or disorders amenable to treatment or prophylaxis by modulation of analgesic receptor signaling.

    摘要翻译： 公开了镇痛相关组合物和使用该组合物调节镇痛受体活性的方法。 组合物和方法可用于减轻疼痛，以及用于通过调节止痛剂受体信号传导治疗或预防的成瘾症或其它疾病或障碍的治疗干预。

    SYNTHETIC COMPOUNDS AND DERIVATIVES AS MODULATORS OF SMOKING OR NICOTINE INGESTION AND LUNG CANCER
    7.
    发明申请
    SYNTHETIC COMPOUNDS AND DERIVATIVES AS MODULATORS OF SMOKING OR NICOTINE INGESTION AND LUNG CANCER 有权
    合成化合物和作为吸烟者或非糖尿病患者和肺癌的调节剂的衍生物

    公开(公告)号：US20100298345A1

    公开(公告)日：2010-11-25

    申请号：US12848619

    申请日：2010-08-02

    申请人： John R. Cashman

    发明人： John R. Cashman

    IPC分类号： A61K31/506 ,  A61P25/34 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709

    CPC分类号： C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14

    摘要： Disclosed are nicotine-related compounds that selectively inhibit cytochrome P-450 2A6 (CYP2A6), selectively inhibit cytochrome P-450 2A13 (CYP2A13), and/or selectively modulate a nicotinic acetylcholine receptor (nAChR). Also disclosed are pharmaceutical compositions comprising a compound of the invention, as well as methods of using the pharmaceutical compositions for treating or preventing a disease or disorder associated with nicotine-ingestion, or a disease or disorder amenable to treatment by selective modulation of nAChRs.

    摘要翻译： 公开了选择性抑制细胞色素P-450 2A6（CYP2A6），选择性抑制细胞色素P-450 2A13（CYP2A13）和/或选择性调节烟碱乙酰胆碱受体（nAChR）的尼古丁相关化合物。 还公开了包含本发明化合物的药物组合物，以及使用该药物组合物治疗或预防与尼古丁摄入相关的疾病或病症的方法，或适于通过选择性调节nAChR治疗的疾病或病症。

    Synthetic compounds and derivatives as modulators of smoking or nicotine ingestion and lung cancer
    8.
    发明授权
    Synthetic compounds and derivatives as modulators of smoking or nicotine ingestion and lung cancer 有权
    合成化合物和衍生物作为吸烟或尼古丁摄入和肺癌的调节剂

    公开(公告)号：US08609708B2

    公开(公告)日：2013-12-17

    申请号：US12848619

    申请日：2010-08-02

    申请人： John R. Cashman

    发明人： John R. Cashman

    IPC分类号： C07D233/02 ,  A61K31/415

    CPC分类号： C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14

    摘要： Disclosed are nicotine-related compounds that selectively inhibit cytochrome P-450 2A6 (CYP2A6), selectively inhibit cytochrome P-450 2A13 (CYP2A13), and/or selectively modulate a nicotinic acetylcholine receptor (nAChR). Also disclosed are pharmaceutical compositions comprising a compound of the invention, as well as methods of using the pharmaceutical compositions for treating or preventing a disease or disorder associated with nicotine-ingestion, or a disease or disorder amenable to treatment by selective modulation of nAChRs.

    摘要翻译： 公开了选择性抑制细胞色素P-450 2A6（CYP2A6），选择性抑制细胞色素P-450 2A13（CYP2A13）和/或选择性调节烟碱乙酰胆碱受体（nAChR）的尼古丁相关化合物。 还公开了包含本发明化合物的药物组合物，以及使用该药物组合物治疗或预防与尼古丁摄入相关的疾病或病症的方法，或适于通过选择性调节nAChR治疗的疾病或病症。