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公开(公告)号:US07134639B2
公开(公告)日:2006-11-14
申请号:US11099014
申请日:2005-04-04
IPC分类号: F16K31/02
CPC分类号: F16K99/0001 , F15C5/00 , F16K99/0005 , F16K99/0007 , F16K99/0009 , F16K99/0015 , F16K99/0046 , F16K99/0048 , F16K2099/0069 , F16K2099/0071 , F16K2099/0074 , F16K2099/0076 , F16K2099/008 , F16K2099/0084 , G05D7/0694 , Y10T29/49412 , Y10T137/87314
摘要: A latching microregulator for regulating liquid flow on micro-scale levels comprises a substrate having an inlet port and an outlet port, a valve element defining a valve chamber for opening and closing the inlet port, and an actuator assembly for actuating the valve element. The valve chamber is configured to contain a volume of fluid, and the inlet port and the outlet port are in fluid communication with the valve chamber to provide a liquid flow path through the chamber. The actuator assembly comprises a cantilever beam for moving the valve element between an open position and a closed position, an actuator, such as a piezoelectric element, for moving the cantilever beam, and a latch, such as a permanent magnet, for securing the cantilever beam in the closed position. A flow regulation system comprises a plurality of fluid channels of varied flow conductance and a plurality of latching microregulators for selectively blocking or allowing flow through each of the fluid channels.
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公开(公告)号:US20120009025A1
公开(公告)日:2012-01-12
申请号:US13179084
申请日:2011-07-08
IPC分类号: B65G53/16
CPC分类号: B65G51/08 , B01F13/0062 , B01F13/0064 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N15/1404 , G01N15/1484 , G01N2015/1409
摘要: A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.
摘要翻译: 用于产生鞘流的微细鞘层流动结构包括用于输送护套流体的初级鞘流动通道,用于将样品注入主鞘流道中的鞘液中的样品入口,用于将样品聚焦在 护套流体和辅助聚焦区域,用于提供样品在护套液体内的附加聚焦。 次要聚焦区域可以由与主鞘流道相交的流动通道形成,以从选定的方向将另外的鞘流体注入主鞘流动通道。 护套流动系统可以包括在微流体芯片上并行操作的多个护套流动结构。
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公开(公告)号:US20100111616A1
公开(公告)日:2010-05-06
申请号:US12610753
申请日:2009-11-02
CPC分类号: B65G51/08 , B01F13/0062 , B01F13/0064 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N15/1404 , G01N15/1484 , G01N2015/1409
摘要: A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.
摘要翻译: 用于产生鞘流的微细鞘层流动结构包括用于输送护套流体的初级鞘流动通道,用于将样品注入主鞘流道中的鞘液中的样品入口,用于将样品聚焦在 护套流体和辅助聚焦区域,用于提供样品在护套液体内的附加聚焦。 次要聚焦区域可以由与主鞘流道相交的流动通道形成,以从选定的方向将另外的鞘流体注入主鞘流动通道。 护套流动系统可以包括在微流体芯片上并行操作的多个护套流动结构。
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公开(公告)号:US20080166188A1
公开(公告)日:2008-07-10
申请号:US11998557
申请日:2007-11-30
IPC分类号: B65G51/00
CPC分类号: B65G51/08 , B01F13/0062 , B01F13/0064 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N15/1404 , G01N15/1484 , G01N2015/1409
摘要: A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.
摘要翻译: 用于产生鞘流的微细鞘层流动结构包括用于输送护套流体的初级鞘流动通道,用于将样品注入主鞘流道中的鞘液中的样品入口,用于将样品聚焦在 护套流体和辅助聚焦区域,用于提供样品在护套液体内的附加聚焦。 次要聚焦区域可以由与主鞘流道相交的流动通道形成,以从选定的方向将另外的鞘流体注入主鞘流动通道。 护套流动系统可以包括在微流体芯片上并行操作的多个护套流动结构。
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公开(公告)号:US08529161B2
公开(公告)日:2013-09-10
申请号:US13179084
申请日:2011-07-08
IPC分类号: B65G51/00
CPC分类号: B65G51/08 , B01F13/0062 , B01F13/0064 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N15/1404 , G01N15/1484 , G01N2015/1409
摘要: A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.
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公开(公告)号:US08123044B2
公开(公告)日:2012-02-28
申请号:US11800469
申请日:2007-05-04
IPC分类号: B07C5/00
CPC分类号: B07C5/34 , B01L3/502761 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2400/0439 , B01L2400/0487 , C12M47/04
摘要: An improved actuator for use in a microfluidic particle sorting system utilizes a staggered packing scheme for a plurality of actuators used to selectively deflect a particle in an associated sorting channel from a stream of channels. An actuator block may be provided for housing a two-dimensional array of actuators, each configured to align with an actuation port in an associated sorting chip containing a plurality of sorting channels. The actuator block may include a built-in stressing means to pre-stress each actuator housed by the block. An actuator comprising a piezo-electric stack may employ contact-based electrical connection rather than soldered wires to improve packing density. The actuator may be an external actuator. That is, the external actuator is external to the substrate in which the sorting channels are formed.
摘要翻译: 用于微流体粒子分选系统的改进的致动器利用交错填充方案用于多个致动器,用于选择性地偏转相关分拣通道中的粒子与通道流。 可以提供致动器块,用于容纳致动器的二维阵列,每个致动器阵列被配置为与包含多个分选通道的相关分选芯片中的致动端口对齐。 致动器块可以包括内置的应力装置,用于预加载由该块所容纳的每个致动器。 包括压电叠层的致动器可以使用基于接触的电连接而不是焊接线来改善堆积密度。 致动器可以是外部致动器。 也就是说,外部致动器在其中形成分拣通道的基板的外部。
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公开(公告)号:US08863962B2
公开(公告)日:2014-10-21
申请号:US13371277
申请日:2012-02-10
CPC分类号: B07C5/34 , B01L3/502761 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2400/0439 , B01L2400/0487 , C12M47/04
摘要: An improved actuator for use in a microfluidic particle sorting system utilizes a staggered packing scheme for a plurality of actuators used to selectively deflect a particle in an associated sorting channel from a stream of channels. An actuator block may be provided for housing a two-dimensional array of actuators, each configured to align with an actuation port in an associated sorting chip containing a plurality of sorting channels. The actuator block may include a built-in stressing means to pre-stress each actuator housed by the block. An actuator comprising a piezo-electric stack may employ contact-based electrical connection rather than soldered wires to improve packing density. The actuator may be an external actuator. That is, the external actuator is external to the substrate in which the sorting channels are formed.
摘要翻译: 用于微流体粒子分选系统的改进的致动器利用交错填充方案用于多个致动器,用于选择性地偏转相关分拣通道中的粒子与通道流。 可以提供致动器块,用于容纳致动器的二维阵列,每个致动器阵列被配置为与包含多个分选通道的相关分选芯片中的致动端口对齐。 致动器块可以包括内置的应力装置,用于预加载由该块所容纳的每个致动器。 包括压电叠层的致动器可以使用基于接触的电连接而不是焊接线来改善堆积密度。 致动器可以是外部致动器。 也就是说,外部致动器在其中形成分拣通道的基板的外部。
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公开(公告)号:US20120138513A1
公开(公告)日:2012-06-07
申请号:US13371277
申请日:2012-02-10
IPC分类号: B07C5/00 , H01L41/053
CPC分类号: B07C5/34 , B01L3/502761 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2400/0439 , B01L2400/0487 , C12M47/04
摘要: An improved actuator for use in a microfluidic particle sorting system utilizes a staggered packing scheme for a plurality of actuators used to selectively deflect a particle in an associated sorting channel from a stream of channels. An actuator block may be provided for housing a two-dimensional array of actuators, each configured to align with an actuation port in an associated sorting chip containing a plurality of sorting channels. The actuator block may include a built-in stressing means to pre-stress each actuator housed by the block. An actuator comprising a piezo-electric stack may employ contact-based electrical connection rather than soldered wires to improve packing density. The actuator may be an external actuator. That is, the external actuator is external to the substrate in which the sorting channels are formed.
摘要翻译: 用于微流体粒子分选系统的改进的致动器利用交错的填充方案用于多个致动器,用于选择性地偏转相关分拣通道中的粒子与通道流。 可以提供致动器块,用于容纳致动器的二维阵列,每个致动器阵列被配置为与包含多个分选通道的相关分选芯片中的致动端口对齐。 致动器块可以包括内置的应力装置,用于预加载由该块所容纳的每个致动器。 包括压电叠层的致动器可以使用基于接触的电连接而不是焊接线来改善堆积密度。 致动器可以是外部致动器。 也就是说,外部致动器在其中形成分拣通道的基板的外部。
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公开(公告)号:US07997831B2
公开(公告)日:2011-08-16
申请号:US12610753
申请日:2009-11-02
IPC分类号: B65G51/00
CPC分类号: B65G51/08 , B01F13/0062 , B01F13/0064 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N15/1404 , G01N15/1484 , G01N2015/1409
摘要: A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.
摘要翻译: 用于产生鞘流的微细鞘层流动结构包括用于输送护套流体的初级鞘流动通道,用于将样品注入主鞘流道中的鞘液中的样品入口,用于将样品聚焦在 护套流体和辅助聚焦区域,用于提供样品在护套液体内的附加聚焦。 次要聚焦区域可以由与主鞘流道相交的流动通道形成,以从选定的方向将另外的鞘流体注入主鞘流动通道。 护套流动系统可以包括在微流体芯片上并行操作的多个护套流动结构。
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公开(公告)号:US07611309B2
公开(公告)日:2009-11-03
申请号:US11998557
申请日:2007-11-30
IPC分类号: B65G51/00
CPC分类号: B65G51/08 , B01F13/0062 , B01F13/0064 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N15/1404 , G01N15/1484 , G01N2015/1409
摘要: A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.
摘要翻译: 用于产生鞘流的微细鞘层流动结构包括用于输送护套流体的初级鞘流动通道,用于将样品注入主鞘流道中的鞘液中的样品入口,用于将样品聚焦在 护套流体和辅助聚焦区域,用于提供样品在护套液体内的附加聚焦。 次要聚焦区域可以由与主鞘流道相交的流动通道形成,以从选定的方向将另外的鞘流体注入主鞘流动通道。 护套流动系统可以包括在微流体芯片上并行操作的多个护套流动结构。
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