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    Actuation of parallel microfluidic arrays
    1.
    发明授权
    Actuation of parallel microfluidic arrays 有权
    平行微流体阵列的启动

    公开(公告)号：US08123044B2

    公开(公告)日：2012-02-28

    申请号：US11800469

    申请日：2007-05-04

    申请人： Andrew Johnson ,  John R. Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    发明人： Andrew Johnson ,  John R. Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    IPC分类号： B07C5/00

    CPC分类号： B07C5/34 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0439 ,  B01L2400/0487 ,  C12M47/04

    摘要： An improved actuator for use in a microfluidic particle sorting system utilizes a staggered packing scheme for a plurality of actuators used to selectively deflect a particle in an associated sorting channel from a stream of channels. An actuator block may be provided for housing a two-dimensional array of actuators, each configured to align with an actuation port in an associated sorting chip containing a plurality of sorting channels. The actuator block may include a built-in stressing means to pre-stress each actuator housed by the block. An actuator comprising a piezo-electric stack may employ contact-based electrical connection rather than soldered wires to improve packing density. The actuator may be an external actuator. That is, the external actuator is external to the substrate in which the sorting channels are formed.

    摘要翻译： 用于微流体粒子分选系统的改进的致动器利用交错填充方案用于多个致动器，用于选择性地偏转相关分拣通道中的粒子与通道流。 可以提供致动器块，用于容纳致动器的二维阵列，每个致动器阵列被配置为与包含多个分选通道的相关分选芯片中的致动端口对齐。 致动器块可以包括内置的应力装置，用于预加载由该块所容纳的每个致动器。 包括压电叠层的致动器可以使用基于接触的电连接而不是焊接线来改善堆积密度。 致动器可以是外部致动器。 也就是说，外部致动器在其中形成分拣通道的基板的外部。

    Actuation of parallel microfluidic arrays
    2.
    发明授权
    Actuation of parallel microfluidic arrays 有权
    平行微流体阵列的启动

    公开(公告)号：US08863962B2

    公开(公告)日：2014-10-21

    申请号：US13371277

    申请日：2012-02-10

    申请人： Andrew Johnson ,  John R. Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    发明人： Andrew Johnson ,  John R. Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    IPC分类号： B07C5/00 ,  B07C5/34 ,  B01L3/00

    CPC分类号： B07C5/34 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0439 ,  B01L2400/0487 ,  C12M47/04

    摘要： An improved actuator for use in a microfluidic particle sorting system utilizes a staggered packing scheme for a plurality of actuators used to selectively deflect a particle in an associated sorting channel from a stream of channels. An actuator block may be provided for housing a two-dimensional array of actuators, each configured to align with an actuation port in an associated sorting chip containing a plurality of sorting channels. The actuator block may include a built-in stressing means to pre-stress each actuator housed by the block. An actuator comprising a piezo-electric stack may employ contact-based electrical connection rather than soldered wires to improve packing density. The actuator may be an external actuator. That is, the external actuator is external to the substrate in which the sorting channels are formed.

    摘要翻译： 用于微流体粒子分选系统的改进的致动器利用交错填充方案用于多个致动器，用于选择性地偏转相关分拣通道中的粒子与通道流。 可以提供致动器块，用于容纳致动器的二维阵列，每个致动器阵列被配置为与包含多个分选通道的相关分选芯片中的致动端口对齐。 致动器块可以包括内置的应力装置，用于预加载由该块所容纳的每个致动器。 包括压电叠层的致动器可以使用基于接触的电连接而不是焊接线来改善堆积密度。 致动器可以是外部致动器。 也就是说，外部致动器在其中形成分拣通道的基板的外部。

    Actuation of Parallel Microfluidic Arrays
    3.
    发明申请
    Actuation of Parallel Microfluidic Arrays 有权
    平行微流体阵列的驱动

    公开(公告)号：US20120138513A1

    公开(公告)日：2012-06-07

    申请号：US13371277

    申请日：2012-02-10

    申请人： Andrew Johnson ,  John R. Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    发明人： Andrew Johnson ,  John R. Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    IPC分类号： B07C5/00 ,  H01L41/053

    CPC分类号： B07C5/34 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0439 ,  B01L2400/0487 ,  C12M47/04

    摘要： An improved actuator for use in a microfluidic particle sorting system utilizes a staggered packing scheme for a plurality of actuators used to selectively deflect a particle in an associated sorting channel from a stream of channels. An actuator block may be provided for housing a two-dimensional array of actuators, each configured to align with an actuation port in an associated sorting chip containing a plurality of sorting channels. The actuator block may include a built-in stressing means to pre-stress each actuator housed by the block. An actuator comprising a piezo-electric stack may employ contact-based electrical connection rather than soldered wires to improve packing density. The actuator may be an external actuator. That is, the external actuator is external to the substrate in which the sorting channels are formed.

    摘要翻译： 用于微流体粒子分选系统的改进的致动器利用交错的填充方案用于多个致动器，用于选择性地偏转相关分拣通道中的粒子与通道流。 可以提供致动器块，用于容纳致动器的二维阵列，每个致动器阵列被配置为与包含多个分选通道的相关分选芯片中的致动端口对齐。 致动器块可以包括内置的应力装置，用于预加载由该块所容纳的每个致动器。 包括压电叠层的致动器可以使用基于接触的电连接而不是焊接线来改善堆积密度。 致动器可以是外部致动器。 也就是说，外部致动器在其中形成分拣通道的基板的外部。

    Actuation of parallel microfluidic arrays
    4.
    发明申请
    Actuation of parallel microfluidic arrays 有权
    平行微流体阵列的启动

    公开(公告)号：US20080087584A1

    公开(公告)日：2008-04-17

    申请号：US11800469

    申请日：2007-05-04

    申请人： Andrew Johnson ,  John Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    发明人： Andrew Johnson ,  John Gilbert ,  Manish Deshpande ,  Hugh Lewis ,  Bernard Bunner

    IPC分类号： B07C5/36

    CPC分类号： B07C5/34 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0439 ,  B01L2400/0487 ,  C12M47/04

    摘要： An improved actuator for use in a microfluidic particle sorting system utilizes a staggered packing scheme for a plurality of actuators used to selectively deflect a particle in an associated sorting channel from a stream of channels. An actuator block may be provided for housing a two-dimensional array of actuators, each configured to align with an actuation port in an associated sorting chip containing a plurality of sorting channels. The actuator block may include a built-in stressing means to pre-stress each actuator housed by the block. An actuator comprising a piezo-electric stack may employ contact-based electrical connection rather than soldered wires to improve packing density. The actuator may be an external actuator. That is, the external actuator is external to the substrate in which the sorting channels are formed.

    摘要翻译： 用于微流体粒子分选系统的改进的致动器利用交错填充方案用于多个致动器，用于选择性地偏转相关分拣通道中的粒子与通道流。 可以提供致动器块，用于容纳致动器的二维阵列，每个致动器阵列被配置为与包含多个分选通道的相关分选芯片中的致动端口对齐。 致动器块可以包括内置的应力装置，用于预加载由该块所容纳的每个致动器。 包括压电叠层的致动器可以使用基于接触的电连接而不是焊接线来改善堆积密度。 致动器可以是外部致动器。 也就是说，外部致动器在其中形成分拣通道的基板的外部。

    Apparatus for ultrasonic tissue investigation
    9.
    发明授权
    Apparatus for ultrasonic tissue investigation 失效
    超声波组织调查装置

    公开(公告)号：US6073045A

    公开(公告)日：2000-06-06

    申请号：US894791

    申请日：1998-02-09

    申请人： Mary Dyson ,  Hugh Lewis ,  Stephen Robert Young ,  John Andrew Lynch ,  Walter Raymond Dyson deceased, late of

    发明人： Mary Dyson ,  Hugh Lewis ,  Stephen Robert Young ,  John Andrew Lynch ,  Walter Raymond Dyson deceased, late of

    IPC分类号： A61B8/00 ,  A61B8/08 ,  G01S15/89 ,  G06T1/00

    CPC分类号： G01S15/8938 ,  A61B8/0858

    摘要： The apparatus for ultrasonic tissue investigation comprises an ultrasonic transducer (1) adapted to emit pulsed emissions into tissue and means (2) to move the transducer to scan an area of tissue to be investigated. Signals reflected from interfaces between acoustically different tissue components are received and converted into a representation of the tissue, which may be visually displayed. The emissions of ultrasonic radiation are so pulsed that each pulse has a very rapid fall back period, enabling better discrimination. Interpretation of the images may be facilitated by use of such techniques as fractal analysis.

    摘要翻译： PCT No.PCT / GB96 / 00566 Sec。 371日期：1998年2月9日 102（e）1998年2月9日PCT 1996年3月11日PCT公布。 公开号WO96 / 28096 日期1996年9月19日超声波组织研究装置包括适于向组织中发射脉冲发射的超声波换能器（1）和用于移动换能器以扫描待研究的组织区域的装置（2）。 从声学上不同的组织组分之间的界面反射的信号被接收并转换成可以可视地显示的组织的表示。 超声辐射的发射是如此的脉冲，使得每个脉冲具有非常快的回退周期，使得能够更好地辨别。 可以通过使用诸如分形分析的技术来促进图像的解释。

    Sterile flow cytometer and sorter with mechanical isolation between flow chamber and sterile enclosure and methods for using same
    10.
    发明授权
    Sterile flow cytometer and sorter with mechanical isolation between flow chamber and sterile enclosure and methods for using same 失效
    无菌流式细胞仪和分选机，在流动室和无菌外壳之间进行机械隔离，并使用相同的方法

    公开(公告)号：US5776781A

    公开(公告)日：1998-07-07

    申请号：US803439

    申请日：1997-02-20

    申请人： Michael H. Vardanega ,  Raymond Swan ,  John Joubran ,  David J. Medeiros ,  Edie Tichenor ,  Hugh Lewis

    发明人： Michael H. Vardanega ,  Raymond Swan ,  John Joubran ,  David J. Medeiros ,  Edie Tichenor ,  Hugh Lewis

    IPC分类号： B01L1/04 ,  G01N15/14 ,  G01N35/00 ,  G01N29/00

    CPC分类号： G01N15/1404 ,  B01L1/04 ,  G01N2015/149 ,  G01N2035/00277

    摘要： An apparatus and process for measuring particles that prevents the particles from being contaminated during the measuring and optional sorting process wherein a flow chamber or region is mechanically isolated from a sterile enclosure which surrounds the flow chamber. The present invention in one embodiment provides an apparatus comprising of a droplet generator, a charging system, a deflecting system, a sterilization system, a light source, a detector, a cooling system and a vacuum system. The droplet generator and the charging system and the flow chamber associated with the droplet generator operate within an illumination frame where the particles (e.g. biological cells) are actually measured. In order to prevent the biological cells from being contaminated, the illumination frame is located within an isolation chamber which provides an environment that can be sterilized before and after the actual measuring and sorting of the cells, but the illumination frame is mechanically isolated from the isolation chamber. The sterilization system, located outside the isolation chamber sterilizes the isolation chamber before cells are measured and sorted within the isolation chamber, and furthermore, ensures that the isolation chamber is maintained at a pressure above (or alternatively, below) atmospheric pressure during the measuring and sorting of the biological cells. The illumination frame, the light source and the detector are supported by a table to enable the light beam(s) from the light source to intersect the biological cells flowing through the illumination frame, thereby emitting flashes of light (or otherwise effecting the light beam) which are detected by the detector.

    摘要翻译： 用于测量在测量和任选的分选过程中防止颗粒被污染的颗粒的装置和方法，其中流动室或区域与围绕流动室的无菌外壳机械隔离。 本发明在一个实施例中提供了一种包括液滴发生器，充电系统，偏转系统，灭菌系统，光源，检测器，冷却系统和真空系统的装置。 液滴发生器和与液滴发生器相关联的充气系统和流动室在其中实际测量颗粒（例如生物细胞）的照明框架内操作。 为了防止生物细胞被污染，照明框架位于隔离室内，该隔离室提供在实际测量和分选细胞之前和之后可以消毒的环境，但是照明框架与隔离件机械隔离 房间。 位于隔离室外部的灭菌系统在隔离室内测量和分选细胞之前对隔离室进行消毒，此外，确保隔离室在测量过程中保持在大气压（或者低于）大气压力以下， 生物细胞的分选。 照明框架，光源和检测器由桌子支撑，以使得来自光源的光束能够与流过照明框架的生物细胞相交，从而发​​出闪光（或以其他方式影响光束 ），由检测器检测。