公开(公告)号：US20100068249A1

公开(公告)日：2010-03-18

申请号：US12621595

申请日：2009-11-19

申请人： John R. Hart ,  Steven C. Anderson ,  Melissa A. Vanblaricom ,  Ellen R. Bosl

发明人： John R. Hart ,  Steven C. Anderson ,  Melissa A. Vanblaricom ,  Ellen R. Bosl

IPC分类号： A61K31/445 ,  A61K9/70 ,  A61P25/00

CPC分类号： A61K9/7061 ,  A61K9/7092 ,  A61K31/4468 ,  A61K31/485

摘要： The present invention comprises a transdermal dosage form comprising an active agent component having a skin contacting surface, an adverse agent component, and a barrier. The dosage form comprises at least one channel passing between proximal and distal surfaces of the active agent component. The barrier is interposed between the active agent component and the adverse agent component. In one aspect, the barrier is permeable to selected solvents and impermeable to diffusion of active and adverse agents in the absence of said solvent. In another aspect, the barrier is discontinuous, impermeable to diffusion of active and adverse agents, and the dosage form comprises at least one channel passing between the skin-contacting surface and the adverse agent component.

摘要翻译： 本发明包括透皮剂型，其包含具有皮肤接触表面的活性剂组分，不利剂组分和屏障。 所述剂型包含至少一个在活性剂组分的近端和远端表面之间通过的通道。 阻挡层介于活性剂组分和不利剂组分之间。 在一个方面，所述屏障对于所选择的溶剂是可渗透的，并且在不存在所述溶剂的情况下不可渗透活性和不利剂。 在另一方面，屏障是不连续的，不渗透活性剂和不利剂的扩散，并且剂型包含通过皮肤接触表面和不利剂组分之间的至少一个通道。

公开(公告)号：US20130071890A1

公开(公告)日：2013-03-21

申请号：US13421771

申请日：2012-03-15

申请人： Craig S. Criddle ,  John R. Hart ,  Wei-Min Wu ,  Eric R. Sundstrom ,  Margaret C. Morse ,  Sarah L. Billington ,  Katherine H. Rostkowski ,  Curtis W. Frank

发明人： Craig S. Criddle ,  John R. Hart ,  Wei-Min Wu ,  Eric R. Sundstrom ,  Margaret C. Morse ,  Sarah L. Billington ,  Katherine H. Rostkowski ,  Curtis W. Frank

IPC分类号： C12P7/62

CPC分类号： C12P7/625 ,  C07D319/12 ,  C08J11/12 ,  C08J2367/04 ,  Y02E50/343 ,  Y02W30/703

摘要： Methods for producing bioplastics from biogas include techniques for the production of PHB using a dirty biogas (e.g., methane from landfill, digester) as both a power source for the process and as feedstock. Biogas is split into two streams, one for energy to drive the process, another as feedstock. Advantageously, the techniques may be implemented off the power grid with no dependence upon agricultural products for feedstock.

摘要翻译： 用于从沼气生产生物塑料的方法包括使用脏生物气体（例如来自垃圾填埋场，蒸煮器的甲烷）作为工艺的动力源和作为原料生产PHB的技术。 生物气分为两股，一种是用于驱动该过程的能量，另一种是原料。 有利地，这些技术可以从电力网上实施，而不依赖于农产品用于原料。

公开(公告)号：US5103368A

公开(公告)日：1992-04-07

申请号：US519731

申请日：1990-05-07

申请人： John R. Hart

发明人： John R. Hart

IPC分类号： G01F23/26

CPC分类号： G01F23/268 ,  G01F23/266

摘要： A device that determines liquid level or volume by means of charging a plurality of capacitors in sequence. Each capacitor is charged for a fixed time interval. The voltage level obtained is a function of the liquid level and is compared with a known voltage to obtain an output signal that can be used to represent liquid depth. The capacitors are formed by two concentric tubes, one inside the other in a spaced relationship. The tubes reduce the effect of sloshing in the tank, resulting in a more stable reading. To measure volume or level in an irregular shaped tank, the capacitors can be arranged in a non-linear manner. The device has no moving parts to wear out and thus results in higher reliability and longer life.

摘要翻译： 一种通过依次对多个电容器进行充电来确定液位或体积的装置。 每个电容器以固定的时间间隔充电。 获得的电压水平是液位的函数，并与已知电压进行比较，以获得可用于表示液体深度的输出信号。 电容器由两个同心的管形成，一个以间隔的关系形成。 管子减少了罐内晃动的影响，导致读数更稳定。 为了测量不规则形状的容器中的体积或电平，可以非线性地布置电容器。 该装置没有移动部件磨损，从而导致更高的可靠性和更长的使用寿命。

公开(公告)号：US4473228A

公开(公告)日：1984-09-25

申请号：US278689

申请日：1981-06-29

申请人： John R. Hart

发明人： John R. Hart

IPC分类号： A63F9/08

CPC分类号： A63F9/0838 ,  A63F2009/0853

摘要： A three-dimensional interchange linkage which permits any of a number of devices abounding a core to be laterally interchanged. A preferred form of the linkage is found in an icosahedral puzzle in which groups of five separate pieces can be rotated to re-order and re-arrange the pieces in the manner of a puzzle. The linkage which retains the pieces of the puzzle to the core while allowing lateral interchanges is essential to the operation of the puzzle.

摘要翻译： 一种三维交换连接，其允许多个设置在芯上的多个设备中的任一个被横向互换。 联系的优选形式存在于二十面体拼图中，其中可以旋转五组单独的组，以按拼图的方式重新排列和重新排列。 将拼图的块保留到核心同时允许横向互换的连接对于拼图的操作是至关重要的。

公开(公告)号：US20080108958A1

公开(公告)日：2008-05-08

申请号：US11720464

申请日：2005-12-05

申请人： Chad J. Carter ,  Franklyn L. Frederickson ,  Richard G. Hansen ,  John R. Hart ,  Donald T. Landin ,  Jeffrey H. Tokie ,  David J. Wirtanen

发明人： Chad J. Carter ,  Franklyn L. Frederickson ,  Richard G. Hansen ,  John R. Hart ,  Donald T. Landin ,  Jeffrey H. Tokie ,  David J. Wirtanen

IPC分类号： A61M5/34

CPC分类号： A61M37/0015 ,  A61M2037/0023

摘要： A medical device (20) is provided that is suitable for use in the delivery of active component into or through the skin. The medical device comprises: an extension member (22) having a first major surface (24) and a second major surface (26), the first major surface comprising a first portion and a second portion; an array retaining member (28) extending from the first portion of the first major surface of the extension member, the array retaining member comprising an array surface (30) having at least one microneedle (32) extending from the array surface; and pressure sensitive adhesive (34) disposed on the second portion of the first major surface of the extension member to facilitate the adhesive attachment of the device to mammalian skin when the at least one microneedle is inserted through the stratum corneum.

摘要翻译： 提供了适用于将活性成分输送入皮肤或通过皮肤的医疗装置（20）。 医疗装置包括：具有第一主表面（24）和第二主表面（26）的延伸构件（22），所述第一主表面包括第一部分和第二部分; 阵列保持构件（28），其从所述延伸构件的所述第一主表面的第一部分延伸，所述阵列保持构件包括具有从所述阵列表面延伸的至少一个微针（32）的阵列表面（30） 以及设置在延伸构件的第一主表面的第二部分上的压敏粘合剂（34），以便当至少一个微针穿过角质层时，便于将装置粘附到哺乳动物皮肤上。

公开(公告)号：US5302934A

公开(公告)日：1994-04-12

申请号：US41856

申请日：1993-04-02

申请人： John R. Hart ,  Lowell F. Kline

发明人： John R. Hart ,  Lowell F. Kline

IPC分类号： G01K7/16 ,  G01K7/22 ,  H01C7/10 ,  H01C3/04

CPC分类号： G01K7/22 ,  G01K7/16

摘要： A thermistor positioned within a tubular probe adjacent its closed distal end has lead wires connected with terminals by both crimp and weld connections that are independent of one another. A non-rigid heat transfer medium fills the distal end portion of the probe in surrounding relationship to the thermistor. An opening in the sensor housing leads to the interior of the probe and receives a dielectric sleeve in which tail end portions of the terminals are positioned.

摘要翻译： 位于管状探针内的热敏电阻位于其封闭的远端附近，具有通过彼此独立的压接和焊接连接与端子连接的引线。 非刚性传热介质以与热敏电阻相关的关系填充探针的远端部分。 传感器外壳中的一个开口通向探头的内部，并接收一个电介质套管，端子的末端部分位于该介质套筒中。

公开(公告)号：US5385736A

公开(公告)日：1995-01-31

申请号：US90330

申请日：1993-07-12

申请人： Joan K. Kappes ,  John R. Hart

发明人： Joan K. Kappes ,  John R. Hart

IPC分类号： A61K9/70 ,  A61K31/40 ,  A61K47/10 ,  A61K47/18 ,  A61F13/02

CPC分类号： A61K9/7053 ,  A61K9/7061

摘要： A pressure sensitive adhesive coated sheet material for delivering melatonin through the skin. The sheet material has a flexible backing bearing a pressure sensitive adhesive coating involving an acrylic copolymer, melatonin, 2-(2-ethoxyethoxy)ethanol, and optionally N,N-dimethyldodecylamine-N-oxide.

摘要翻译： 用于通过皮肤递送褪黑激素的压敏粘合剂涂层片材。 片材具有柔性背衬，其承载包含丙烯酸共聚物，褪黑素，2-（2-乙氧基乙氧基）乙醇和任选的N，N-二甲基十二烷基胺-N-氧化物的压敏粘合剂涂层。

公开(公告)号：US4340442A

公开(公告)日：1982-07-20

申请号：US161664

申请日：1980-06-23

申请人： John R. Hart ,  Stanley G. Juergens ,  William E. McCormack

发明人： John R. Hart ,  Stanley G. Juergens ,  William E. McCormack

IPC分类号： D01D5/00 ,  D01F9/00 ,  D21H5/12

CPC分类号： D21H13/30 ,  D01D5/00 ,  D01F9/00 ,  D21H5/1227

摘要： Starch fibrids useful in enhancing the physical properties of non-woven webs, e.g., paper, are produced by a process which comprises providing an aqueous, alkaline solution of a water-insoluble starch in a finely divided form, e.g., in the form of an aerosol, and introducing the finely divided starch solution into an agitated, aqueous precipitating medium comprising a precipitating salt to thereby produce starch fibrids characterized by having both film and fiber morphology. The starch fibrids are recovered from the salt-containing liquid and may be incorporated into paper to improve the physical properties thereof.

摘要翻译： 用于增强非织造纤维网（例如纸）的物理性能的淀粉纤维是通过一种方法生产的，该方法包括以细碎形式提供水不溶性淀粉的水溶液，例如以 气溶胶，并将细碎淀粉溶液引入包含沉淀盐的搅拌的含水沉淀介质中，从而产生特征在于具有膜和纤维形态的淀粉纤维。 淀粉纤维素从含盐液体中回收，并且可以加入到纸中以改善其物理性能。

公开(公告)号：US4205025A

公开(公告)日：1980-05-27

申请号：US643501

申请日：1975-12-22

申请人： John R. Hart ,  Donald W. Lare ,  James J. Nault

发明人： John R. Hart ,  Donald W. Lare ,  James J. Nault

IPC分类号： D01D5/40 ,  B29C23/00

CPC分类号： D01D5/40 ,  D21H11/00 ,  D21H5/12

摘要： Polymeric fibrids and paper-like structures produced therefrom are disclosed. These fibrids are produced by preparing an aqueous solution of a film forming polymer, injecting the solution into a liquid precipitating medium miscible with water but in which the polymer is insoluble, and providing sufficient shear to directly and rapidly precipitate the polymer to fibrid morphology. The fibrids, which are desirably first treated to render them more hydrophobic, may be formed into a web and dried utilizing conventional paper-making techniques to obtain the paper-like structures of the invention.

摘要翻译： 公开了由其制备的聚合物纤维素和纸状结构。 这些纤条体是通过制备成膜聚合物的水溶液制备的，将该溶液注入与水混合的液体沉淀介质中，但聚合物不溶于其中，并且提供足够的剪切以直接且快速地将聚合物沉淀至纤条体形态。 理想地首先处理以使其更具疏水性的纤条体可以形成为网状物并且使用常规造纸技术干燥以获得本发明的纸状结构。

公开(公告)号：US07182955B2

公开(公告)日：2007-02-27

申请号：US10744996

申请日：2003-12-23

申请人： John R. Hart ,  Deanna L. Stebbings

发明人： John R. Hart ,  Deanna L. Stebbings

IPC分类号： A61K9/70

CPC分类号： B09B3/0075 ,  A61K9/7061 ,  A61K9/7092 ,  A61K31/4468 ,  A61K31/485 ,  B09B2220/14

摘要： The invention comprises a transdermal dosage form comprising a active agent component comprising a polymeric matrix and an abusable drug substance, an overlay backing, a porous material, and an antagonist reservoir comprising an antagonist to the abusable drug substance. The porous material adjoins the antagonist reservoir and is in fluid communication with the skin-contacting surface defined by the active agent component. In one embodiment, the device comprises a barrier layer interposed between the active agent component and the antagonist reservoir.

摘要翻译： 本发明包括透皮剂型，其包含包含聚合物基质和可滥用药物的活性剂组分，覆盖背衬，多孔材料和包含对可滥用药物物质的拮抗剂的拮抗剂储库。 多孔材料邻接拮抗剂储存器并且与由活性剂组分限定的皮肤接触表面流体连通。 在一个实施方案中，该装置包括置于活性剂组分和拮抗剂储库之间的阻隔层。