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公开(公告)号：US07781160B2
公开(公告)日：2010-08-24
申请号：US11871752
申请日：2007-10-12
申请人： John Ryals , Mike Milburn , Matthew W. Mitchell , Kay A. Lawton
发明人： John Ryals , Mike Milburn , Matthew W. Mitchell , Kay A. Lawton
IPC分类号： C12Q1/00
CPC分类号： G01N33/5091 , C12Q1/6876 , C12Q1/6883 , G01N30/7233 , G01N33/5023 , G01N2800/7042
摘要： Biomarkers relating to metabolic age are provided, as well as methods for using such biomarkers as biomarkers for determining metabolic age. In addition, methods for modulating the metabolic age of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for metabolic age.
摘要翻译： 提供与代谢年龄相关的生物标志物，以及使用这些生物标志物作为生物标志物来确定代谢年龄的方法。 此外，还提供了调节受试者的代谢年龄的方法。 还提供了小分子实体的套件作为代谢年龄的生物标志物。
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公开(公告)号：US20100279337A1
公开(公告)日：2010-11-04
申请号：US12835307
申请日：2010-07-13
申请人： John Ryals , Mike Milburn , Matthew W. Mitchell , Kay A. Lawton
发明人： John Ryals , Mike Milburn , Matthew W. Mitchell , Kay A. Lawton
CPC分类号： G01N33/5091 , C12Q1/6876 , C12Q1/6883 , G01N30/7233 , G01N33/5023 , G01N2800/7042
摘要： Biomarkers relating to metabolic age are provided, as well as methods for using such biomarkers as biomarkers for determining metabolic age. In addition, methods for modulating the metabolic age of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for metabolic age.
摘要翻译： 提供与代谢年龄相关的生物标志物，以及使用这些生物标志物作为生物标志物来确定代谢年龄的方法。 此外，还提供了调节受试者的代谢年龄的方法。 还提供了小分子实体的套件作为代谢年龄的生物标志物。
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公开(公告)号：US20080124752A1
公开(公告)日：2008-05-29
申请号：US11871752
申请日：2007-10-12
申请人： John RYALS , Mike Milburn , Matthew W. Mitchell , Kay A. Lawton
发明人： John RYALS , Mike Milburn , Matthew W. Mitchell , Kay A. Lawton
CPC分类号： G01N33/5091 , C12Q1/6876 , C12Q1/6883 , G01N30/7233 , G01N33/5023 , G01N2800/7042
摘要： Biomarkers relating to metabolic age are provided, as well as methods for using such biomarkers as biomarkers for determining metabolic age. In addition, methods for modulating the metabolic age of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for metabolic age.
摘要翻译： 提供与代谢年龄相关的生物标志物，以及使用这些生物标志物作为生物标志物来确定代谢年龄的方法。 此外，还提供了调节受试者的代谢年龄的方法。 还提供了小分子实体的套件作为代谢年龄的生物标志物。
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4.发明申请Biomarkers for pre-diabetes, cardiovascular diseases, and other metabolic-syndrome related disorders and methods using the same 有权用于糖尿病前期，心血管疾病和其他代谢综合征相关疾病的生物标志物及其使用方法公开(公告)号：US20090155826A1
公开(公告)日：2009-06-18
申请号：US12218980
申请日：2008-07-17
申请人： Yun Fu Hu , Costel Chirila , Danny Alexander , Michael Milburn , Matthew W. Mitchell , Walter Gall , Kay A. Lawton
发明人： Yun Fu Hu , Costel Chirila , Danny Alexander , Michael Milburn , Matthew W. Mitchell , Walter Gall , Kay A. Lawton
CPC分类号： G01N33/5308 , G01N33/483 , G01N33/487 , G01N33/5091 , G01N33/6893 , G01N2800/04 , G01N2800/042 , G01N2800/044 , G01N2800/32 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy.
摘要翻译： 提供了与胰岛素抵抗，前期糖尿病，2型糖尿病，代谢综合征，动脉粥样硬化和心肌病有关的生物标志物，以及使用这样的生物标志物作为胰岛素抵抗，前期糖尿病，2型糖尿病，代谢综合征的生物标志物的方法 ，动脉粥样硬化和心肌病。 此外，还提供了用于调节受试者的各种病症或病症的方法。 还提供了小分子实体作为胰岛素抵抗，糖尿病前期，2型糖尿病，代谢综合征，动脉粥样硬化和心肌病的生物标志物的套件。
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5.发明授权公开(公告)号：US08809008B2
公开(公告)日：2014-08-19
申请号：US13966475
申请日：2013-08-14
申请人： Yun Fu Hu , Costel Chirila , Danny Alexander , Michael Milburn , Matthew W. Mitchell , Walter Gall , Kay A. Lawton
发明人： Yun Fu Hu , Costel Chirila , Danny Alexander , Michael Milburn , Matthew W. Mitchell , Walter Gall , Kay A. Lawton
IPC分类号： C12Q1/54
CPC分类号： G01N33/5308 , G01N33/483 , G01N33/487 , G01N33/5091 , G01N33/6893 , G01N2800/04 , G01N2800/042 , G01N2800/044 , G01N2800/32 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy.
摘要翻译： 提供了与胰岛素抵抗，前期糖尿病，2型糖尿病，代谢综合征，动脉粥样硬化和心肌病有关的生物标志物，以及使用这样的生物标志物作为胰岛素抵抗，前期糖尿病，2型糖尿病，代谢综合征的生物标志物的方法 ，动脉粥样硬化和心肌病。 此外，还提供了用于调节受试者的各种病症或病症的方法。 还提供了小分子实体作为胰岛素抵抗，糖尿病前期，2型糖尿病，代谢综合征，动脉粥样硬化和心肌病的生物标志物的套件。
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公开(公告)号：US20140051601A1
公开(公告)日：2014-02-20
申请号：US13958158
申请日：2013-08-02
申请人： Arul M. Chinnaiyan , Arun Sreekumar , Matthew W. Mitchell , Kay A. Lawton , Alvin Berger , Christopher Beecher
发明人： Arul M. Chinnaiyan , Arun Sreekumar , Matthew W. Mitchell , Kay A. Lawton , Alvin Berger , Christopher Beecher
IPC分类号： G01N33/483 , G01N33/493
CPC分类号： G01N33/4833 , G01N33/493 , G01N33/57434 , G01N33/6806 , Y02A90/22 , Y02A90/26
摘要： The present invention relates to cancer markers. In particular, the present invention provides metabolites that are differentially present in prostate cancer.
摘要翻译： 本发明涉及癌症标志物。 特别地，本发明提供在前列腺癌中差异存在的代谢物。
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公开(公告)号：US08187830B2
公开(公告)日：2012-05-29
申请号：US12218980
申请日：2008-07-17
申请人： Yun Fu Hu , Costel Chirila , Danny Alexander , Michael Milburn , Matthew W. Mitchell , Walter Gall , Kay A. Lawton
发明人： Yun Fu Hu , Costel Chirila , Danny Alexander , Michael Milburn , Matthew W. Mitchell , Walter Gall , Kay A. Lawton
IPC分类号： C12Q1/54
CPC分类号： G01N33/5308 , G01N33/483 , G01N33/487 , G01N33/5091 , G01N33/6893 , G01N2800/04 , G01N2800/042 , G01N2800/044 , G01N2800/32 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy.
摘要翻译： 提供了与胰岛素抵抗，前期糖尿病，2型糖尿病，代谢综合征，动脉粥样硬化和心肌病有关的生物标志物，以及使用这样的生物标志物作为胰岛素抵抗，前期糖尿病，2型糖尿病，代谢综合征的生物标志物的方法 ，动脉粥样硬化和心肌病。 此外，还提供了用于调节受试者的各种病症或病症的方法。 还提供了小分子实体作为胰岛素抵抗，糖尿病前期，2型糖尿病，代谢综合征，动脉粥样硬化和心肌病的生物标志物的套件。
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公开(公告)号：US20130309697A1
公开(公告)日：2013-11-21
申请号：US13950581
申请日：2013-07-25
IPC分类号： G01N33/68
CPC分类号： G01N33/68 , G01N33/57434 , G01N33/6812 , Y10T436/173845 , Y10T436/201666
摘要： Methods for identifying and evaluating suites of biochemical and/or gene entities useful as biomarkers for early prediction of prostate cancer, disease grading, target identification/validation, and monitoring of drug efficacy are provided. Also provided are suites of small molecule entities as biomarkers for prostate cancer.
摘要翻译： 提供了用于鉴定和评估用作用于早期预测前列腺癌，疾病分级，靶标鉴定/验证和药物功效监测的生物标志物的生物化学和/或基因实体的套件的方法。 还提供了小分子实体的套件作为前列腺癌的生物标志物。
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9.发明申请公开(公告)号：US20120122981A1
公开(公告)日：2012-05-17
申请号：US13258780
申请日：2010-03-31
申请人： Yun Fu Hu , Costel Chirila , Danny Alexander , Michael Milburn , Matthew W. Mitchell , Walter Gall , Kay A. Lawton
发明人： Yun Fu Hu , Costel Chirila , Danny Alexander , Michael Milburn , Matthew W. Mitchell , Walter Gall , Kay A. Lawton
IPC分类号： A61K31/201 , C12Q1/25 , C12Q1/02 , H01J49/26 , A61P3/10 , G01N30/00 , G01R33/46 , G01N21/35 , G01N33/53 , C07C57/03
CPC分类号： G01N33/5038 , G01N2800/042 , G01N2800/50 , G01N2800/56
摘要： Biomarkers relating to glucose disposal rate, insulin resistance, and/or insulin resistance-related disorders are provided. Methods based on the same biomarkers are also provided.
摘要翻译： 提供了与葡萄糖处理率，胰岛素抵抗和/或胰岛素抵抗相关疾病有关的生物标志物。 还提供了基于相同生物标志物的方法。
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10.发明申请Biomarkers for Pre-Diabetes, Cardiovascular Diseases, and Other Metabolic-Syndrome Related Disorders and Methods Using the Same 有权糖尿病，心血管疾病和其他代谢综合征相关疾病的生物标志物及其使用方法公开(公告)号：US20150005195A1
公开(公告)日：2015-01-01
申请号：US14324689
申请日：2014-07-07
申请人： Yun Fu HU , Costel Chirila , Danny Alexander , Michael Milburn , Matthew W. Mitchell , Walter Gall , Kay A. Lawton
发明人： Yun Fu HU , Costel Chirila , Danny Alexander , Michael Milburn , Matthew W. Mitchell , Walter Gall , Kay A. Lawton
IPC分类号： G01N33/487
CPC分类号： G01N33/5308 , G01N33/483 , G01N33/487 , G01N33/5091 , G01N33/6893 , G01N2800/04 , G01N2800/042 , G01N2800/044 , G01N2800/32 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy.
摘要翻译： 提供了与胰岛素抵抗，前期糖尿病，2型糖尿病，代谢综合征，动脉粥样硬化和心肌病有关的生物标志物，以及使用这样的生物标志物作为胰岛素抵抗，前期糖尿病，2型糖尿病，代谢综合征的生物标志物的方法 ，动脉粥样硬化和心肌病。 此外，还提供了用于调节受试者的各种病症或病症的方法。 还提供了小分子实体作为胰岛素抵抗，糖尿病前期，2型糖尿病，代谢综合征，动脉粥样硬化和心肌病的生物标志物的套件。
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