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公开(公告)号：US08545864B2
公开(公告)日：2013-10-01
申请号：US11773775
申请日：2007-07-05
申请人： John W. Morris , David A. Knaack , Lawrence A. Shimp , Keyvan Behnam , Robert P. Skinner , Randal R. Betz
发明人： John W. Morris , David A. Knaack , Lawrence A. Shimp , Keyvan Behnam , Robert P. Skinner , Randal R. Betz
CPC分类号： A61L27/3608 , A61L24/0005 , A61L24/046 , A61L27/18 , A61L27/3683 , A61L27/54 , A61L2300/418 , A61L2400/04 , C08L71/02
摘要： The present invention provides a hemostatic bone graft product and method. Hemostatic bone grafts may include demineralized bone matrix in combination with additives. In one embodiment, the graft comprises demineralized bone and polyethylene glycol. Methods for producing the hemostatic bone graft may include mixing demineralized bone with additives to facilitate protein precipitation, surface tension reduction in blood, and/or a cytolytic effect on cells at a bleeding site.
摘要翻译： 本发明提供止血性骨移植物产品及方法。 止血骨移植物可以包括与添加剂组合的脱矿质骨基质。 在一个实施方案中，移植物包含软化骨和聚乙二醇。 用于制备止血骨移植物的方法可以包括将脱矿质骨与添加剂混合以促进蛋白沉淀，血液中的表面张力降低和/或在出血部位的细胞的溶细胞效应。
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公开(公告)号：US20110054408A1
公开(公告)日：2011-03-03
申请号：US12705330
申请日：2010-02-12
申请人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp , Sigurd Berven , Randal R. Betz , Michael F. O'Brien , Alexis Shelokov , Robert Cohen , Alexander Vaccaro , Scott Boden , Harvinder Sandhu , Daryl R. Sybert , Munish Chandra Gupta , Georgiana Shelokov
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp , Sigurd Berven , Randal R. Betz , Michael F. O'Brien , Alexis Shelokov , Robert Cohen , Alexander Vaccaro , Scott Boden , Harvinder Sandhu , Daryl R. Sybert , Munish Chandra Gupta , Georgiana Shelokov
CPC分类号： A61F2/28 , A61B17/68 , A61B17/7022 , A61B17/7059 , A61B17/7097 , A61B17/8085 , A61F2/0095 , A61F2/2846 , A61F2/3099 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2878 , A61F2002/30576 , A61F2002/30581 , A61F2002/30622 , A61F2002/3068 , A61F2002/30971 , A61F2250/0068
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering is suitable for a variety of procedure specific uses. Implantation tools may be provided for placing the covering at a surgical site. Kits may be provided including variously sized or shaped coverings and one or more tools for use in placing the covering.
摘要翻译： 提供了将物质或材料输送到手术部位的覆盖物。 其中提供的物质的覆盖物可以被称为递送系统。 通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多隔室结构，直到将覆盖物放置在手术部位。 放置时，覆盖物可以促进物质或周围材料的转移。 例如，物质可以被主动地或被动地释放到手术部位。 覆盖物可以参与，控制或以其他方式调节物质的释放。 在各种实施例中，覆盖物适用于各种程序特定用途。 可以提供植入工具用于将覆盖物放置在手术部位。 可以提供包括各种尺寸或形状的覆盖物和用于放置覆盖物的一个或多个工具的套件。
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公开(公告)号：US20090234277A1
公开(公告)日：2009-09-17
申请号：US12171168
申请日：2008-07-10
申请人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Sigurd H. Berven , Randal R. Betz , Michael F. O'Brien , Alexis P. Shelokov
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Sigurd H. Berven , Randal R. Betz , Michael F. O'Brien , Alexis P. Shelokov
IPC分类号： A61B17/70
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
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公开(公告)号：US09220598B2
公开(公告)日：2015-12-29
申请号：US12705253
申请日：2010-02-12
申请人： Randal R. Betz , Scott Boden , Munish Chandra Gupta , Michael F. O'Brien , Harvinder Sandhu , Alexis Shelokov , Georgiana Shelokov , Daryl R. Sybert , Alexander Vaccaro , Guobao Wei , Todd M. Boyce , Robert Cohen , Cristy Richards , Lawrence A. Shimp
发明人： Randal R. Betz , Scott Boden , Munish Chandra Gupta , Michael F. O'Brien , Harvinder Sandhu , Alexis Shelokov , Daryl R. Sybert , Alexander Vaccaro , Guobao Wei , Todd M. Boyce , Robert Cohen , Cristy Richards , Lawrence A. Shimp
CPC分类号： A61B17/8819 , A61B17/823 , A61B17/8825 , A61B2017/8813 , A61F2/30 , A61F2/4603 , A61F2002/0086 , A61F2002/2825 , A61F2002/2835 , A61F2002/30059 , A61F2002/30064 , A61F2002/3007 , A61F2002/30072 , A61F2002/30588 , A61F2002/30677 , A61F2002/3068 , A61F2002/3093 , A61F2002/30971 , A61F2002/4623 , A61F2002/4627 , A61F2250/0068 , A61F2310/00592 , A61F2310/00958 , A61F2310/0097
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering is suitable for a variety of procedure specific uses. Implantation tools may be provided for placing the covering at a surgical site. Kits may be provided including variously sized or shaped coverings and one or more tools for use in placing the covering.
摘要翻译： 提供了将物质或材料输送到手术部位的覆盖物。 其中提供的物质的覆盖物可以被称为递送系统。 通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多室结构，直到覆盖物被放置在手术部位。 放置时，覆盖物可以促进物质或周围材料的转移。 例如，物质可以被主动地或被动地释放到手术部位。 覆盖物可以参与，控制或以其他方式调节物质的释放。 在各种实施例中，覆盖物适用于各种程序特定用途。 可以提供植入工具用于将覆盖物放置在手术部位。 可以提供包括各种尺寸或形状的覆盖物和用于放置覆盖物的一个或多个工具的套件。
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公开(公告)号：US20100268232A1
公开(公告)日：2010-10-21
申请号：US12705253
申请日：2010-02-12
申请人： Randal R. Betz , Scott Boden , Munish Chandra Gupta , Michael F. O'Brien , Harvinder Sandhu , Alexis Shelokov , Georgiana Shelokov , Daryl R. Sybert , Alexander Vaccaro , Guobao Wei , Todd M. Boyce , Robert Cohen , Cristy Richards , Lawrence A. Shimp
发明人： Randal R. Betz , Scott Boden , Munish Chandra Gupta , Michael F. O'Brien , Harvinder Sandhu , Alexis Shelokov , Georgiana Shelokov , Daryl R. Sybert , Alexander Vaccaro , Guobao Wei , Todd M. Boyce , Robert Cohen , Cristy Richards , Lawrence A. Shimp
CPC分类号： A61B17/8819 , A61B17/823 , A61B17/8825 , A61B2017/8813 , A61F2/30 , A61F2/4603 , A61F2002/0086 , A61F2002/2825 , A61F2002/2835 , A61F2002/30059 , A61F2002/30064 , A61F2002/3007 , A61F2002/30072 , A61F2002/30588 , A61F2002/30677 , A61F2002/3068 , A61F2002/3093 , A61F2002/30971 , A61F2002/4623 , A61F2002/4627 , A61F2250/0068 , A61F2310/00592 , A61F2310/00958 , A61F2310/0097
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering is suitable for a variety of procedure specific uses. Implantation tools may be provided for placing the covering at a surgical site. Kits may be provided including variously sized or shaped coverings and one or more tools for use in placing the covering.
摘要翻译： 提供了将物质或材料输送到手术部位的覆盖物。 其中提供的物质的覆盖物可以被称为递送系统。 通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多隔室结构，直到将覆盖物放置在手术部位。 放置时，覆盖物可以促进物质或周围材料的转移。 例如，物质可以被主动地或被动地释放到手术部位。 覆盖物可以参与，控制或以其他方式调节物质的释放。 在各种实施例中，覆盖物适用于各种程序特定用途。 可以提供植入工具用于将覆盖物放置在手术部位。 可以提供包括各种尺寸或形状的覆盖物和用于放置覆盖物的一个或多个工具的套件。
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公开(公告)号：US08268008B2
公开(公告)日：2012-09-18
申请号：US11489262
申请日：2006-07-19
申请人： Randal R. Betz , Scott D. Boden , Christine Clark , Nanette Forsyth , John W. Morris , Kathy Traianedes
发明人： Randal R. Betz , Scott D. Boden , Christine Clark , Nanette Forsyth , John W. Morris , Kathy Traianedes
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/4455 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/30059 , A61F2002/30075 , A61F2002/30153 , A61F2002/30329 , A61F2002/30593 , A61F2002/30677 , A61F2002/30805 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0061 , A61F2220/0025 , A61F2230/0019 , A61F2310/00293 , A61F2310/00329 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3658 , A61L27/38 , A61L31/005 , A61L2430/02
摘要： An osteoimplant is made up of a coherent aggregate of elongate bone particles.
摘要翻译： 骨植入物由细长骨颗粒的相干骨料组成。
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公开(公告)号：US09393116B2
公开(公告)日：2016-07-19
申请号：US13618599
申请日：2012-09-14
申请人： Randal R. Betz , Scott D. Boden , Christine Clark , Nanette Forsyth , John W. Morris , Kathy Traianedes
发明人： Randal R. Betz , Scott D. Boden , Christine Clark , Nanette Forsyth , John W. Morris , Kathy Traianedes
CPC分类号： A61F2/28 , A61F2/4455 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/30059 , A61F2002/30075 , A61F2002/30153 , A61F2002/30329 , A61F2002/30593 , A61F2002/30677 , A61F2002/30805 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0061 , A61F2220/0025 , A61F2230/0019 , A61F2310/00293 , A61F2310/00329 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3658 , A61L27/38 , A61L31/005 , A61L2430/02
摘要： A method of repairing and/or treating bone is provided. The method includes implanting at a repair site an osteoimplant having a coherent aggregate of entangled elongate bone particles mixed with a biocompatible fluid carrier, the osteoimplant being flexible and further being formed as a strip at least one end of which possesses a tab for facilitating combination with another implant.
摘要翻译： 提供了修复和/或治疗骨的方法。 该方法包括在修复部位植入具有与生物相容性流体载体混合的缠结细长骨颗粒的相干聚集体的骨植入体，所述骨植入物是柔性的并且进一步形成为条带，其至少一端具有用于促进与 另一种种植体。
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公开(公告)号：US20130013071A1
公开(公告)日：2013-01-10
申请号：US13618599
申请日：2012-09-14
申请人： Randal R. Betz , Scott D. Boden , Christine Clark , Nanette Forsyth , John W. Morris , Kathy Traianedes
发明人： Randal R. Betz , Scott D. Boden , Christine Clark , Nanette Forsyth , John W. Morris , Kathy Traianedes
CPC分类号： A61F2/28 , A61F2/4455 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/30059 , A61F2002/30075 , A61F2002/30153 , A61F2002/30329 , A61F2002/30593 , A61F2002/30677 , A61F2002/30805 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0061 , A61F2220/0025 , A61F2230/0019 , A61F2310/00293 , A61F2310/00329 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3658 , A61L27/38 , A61L31/005 , A61L2430/02
摘要： An osteoimplant is made up of a coherent aggregate of elongate bone particles.
摘要翻译： 骨植入物由细长骨颗粒的相干骨料组成。
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公开(公告)号：US20100082072A1
公开(公告)日：2010-04-01
申请号：US12413013
申请日：2009-03-27
申请人： Daryl R. Sybert , Sigurd Berven , Randal R. Betz , Oheneba Boachie-Adjei , Scott Boden , Michael F. O'Brien , Alexis P. Shelokov , John M. Winterbottom
发明人： Daryl R. Sybert , Sigurd Berven , Randal R. Betz , Oheneba Boachie-Adjei , Scott Boden , Michael F. O'Brien , Alexis P. Shelokov , John M. Winterbottom
CPC分类号： A61B17/68 , A61B17/686 , A61B2017/00004 , A61B2017/00946 , A61C8/0012
摘要： Bone anchors and related methods for their use are described. The inventive anchor is suitable for placement in bone and for use in orthopedic surgery and dentistry. The bone anchor can be made from a bone/polymer or bone substitute/polymer composite, and can provide a firm and secure base for attaching a fastening device. The bone anchor can be used in various orthopedic and dental procedures including spinal surgery, where normal, cancellous, cortical, diseased or osteoporotic bone is present. The bone anchor can be resorbed and/or replaced with native bone tissue over a period of time. In certain embodiments, the bone anchor is made malleable or flowable and formed in situ or in vivo.
摘要翻译： 描述骨锚及其使用的相关方法。 本发明的锚适用于放置在骨骼中并用于整形外科和牙科。 骨锚可以由骨/聚合物或骨替代物/聚合物复合物制成，并且可以提供用于附接紧固装置的牢固且牢固的基部。 骨锚可用于各种矫形和牙科手术，包括脊柱手术，其中存在正常的松质骨，皮层，患病或骨质疏松的骨。 骨锚可在一段时间内被天然骨组织吸收和/或替代。 在某些实施方案中，骨锚被制造为可延展的或可流动的并且在原位或体内形成。
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10.发明授权Portable functional electrical stimulation (FES) system for upper or lower extremity applications 有权便携式功能电刺激（FES）系统用于上肢或下肢应用公开(公告)号：US06424868B1
公开(公告)日：2002-07-23
申请号：US09436013
申请日：1999-11-09
申请人： Brian T. Smith , Brian McGee , John Douglas , Randal R. Betz , Michael Ignatoski
发明人： Brian T. Smith , Brian McGee , John Douglas , Randal R. Betz , Michael Ignatoski
IPC分类号： A61N108
CPC分类号： A61N1/36003
摘要： A functional electrical stimulation system for generating a data file storing stimulation patterns that can be provided to a stimulator is described. The system includes a host computer system for producing a data structure or data file that describes the patterns and a portable stimulator that using the data structure or data file applies electrical pulses to electrodes carried by a patient. The host computer system and the stimulator system each have a memory storing a table having control and pattern generation information with indexes into a table that separately stores electrode characterization data for each electrode used by the portable stimulator.
摘要翻译： 描述用于产生存储可以提供给刺激器的刺激模式的数据文件的功能电刺激系统。 该系统包括用于产生描述模式的数据结构或数据文件的主计算机系统，以及使用数据结构或数据文件将电脉冲施加到由患者携带的电极的便携式刺激器。 主计算机系统和刺激器系统各自具有存储具有控制的表和具有索引的图形生成信息的表的存储器，该表具有单独存储由便携式刺激器使用的每个电极的电极表征数据的表格。
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