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    DNA encoding human .alpha..sub.1 adrenegric receptors and uses thereof
    2.
    发明授权
    DNA encoding human .alpha..sub.1 adrenegric receptors and uses thereof 失效

    公开(公告)号：US5556753A

    公开(公告)日：1996-09-17

    申请号：US334698

    申请日：1994-11-04

    申请人： Jonathan A. Bard ,  Carlos Forray ,  Richard L. Weinshank

    发明人： Jonathan A. Bard ,  Carlos Forray ,  Richard L. Weinshank

    IPC分类号： A01K67/027 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61P3/08 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P27/02 ,  A61P27/16 ,  A61P43/00 ,  C07H21/04 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28 ,  C12N5/06 ,  C12N15/09 ,  C12N15/12 ,  C12N15/85 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/577 ,  G01N33/94 ,  C12Q1/00 ,  C07K1/00 ,  C12P21/06

    CPC分类号： C12Q1/6876 ,  C07K14/70571 ,  C12N15/85 ,  C12N15/8509 ,  C12Q1/6897 ,  G01N33/9433 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/02 ,  A01K2267/03 ,  A01K2267/0393 ,  A61K38/00 ,  C12Q2600/158 ,  G01N2500/10

    摘要： This invention provides an isolated nucleic acid molecule encoding a human .alpha..sub.1a adrenergic receptor, an isolated nucleic acid molecule encoding a human .alpha..sub.1b adrenergic receptor and an isolated nucleic acid molecule encoding a human .alpha..sub.1c adrenergic receptor, an isolated protein which is a human .alpha..sub.1a adrenergic receptor, an isolated protein which is .alpha..sub.1b adrenergic receptor and a isolated protein which is a human .alpha..sub.1c adrenergic receptor, vectors comprising an isolated nucleic acid molecule encoding a human .alpha..sub.1a adrenergic receptor, vectors comprising an isolated nucleic acid molecule encoding a human .alpha..sub.1b adrenergic receptor, and vectors comprising an isolated nucleic acid molecule encoding a human .alpha..sub.1c adrenergic receptor, mammalian cells comprising such vectors, antibodies directed to the human .alpha..sub.1a adrenergic receptor, antibodies directed to the human .alpha..sub.1b adrenergic receptor, and antibodies directed to the human .alpha..sub.1c adrenergic receptor, nucleic acid probes useful for detecting nucleic acid encoding a human .alpha..sub.1a adrenergic receptor, nucleic acid probes useful for detecting nucleic acid encoding a human .alpha..sub.1b adrenergic receptor, and nucleic acid probes useful for detecting nucleic acid encoding a human .alpha..sub.1c adrenergic receptor, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human .alpha..sub.1a adrenergic receptor, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human .alpha..sub.1b adrenergic receptor, and antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human .alpha..sub.1c adrenergic receptor, pharmaceutical compounds related to the human .alpha..sub.1a adrenergic receptor, pharmaceutical compounds related to the human .alpha..sub.1b adrenergic receptors, and pharmaceutical compounds related to the human .alpha..sub.1c adrenergic receptors, and nonhuman transgenic animals which express DNA encoding a normal or a mutant human .alpha..sub.1a adrenergic receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian human .alpha..sub.1b adrenergic receptor, and nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian human .alpha..sub.1c adrenergic receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with human .alpha..sub.1a, .alpha..sub.1b and .alpha..sub.1c adrenergic receptors.

    Method of preparing GALR2 receptors composition
    7.
    发明授权
    Method of preparing GALR2 receptors composition 失效
    制备GALR2受体组成的方法

    公开(公告)号：US07060449B2

    公开(公告)日：2006-06-13

    申请号：US10298992

    申请日：2002-11-18

    申请人： Kelli E. Smith ,  Christophe P. G. Gerald ,  Richard L. Weinshank ,  David Linemeyer ,  Theresa Branchek ,  Carlos Forray

    发明人： Kelli E. Smith ,  Christophe P. G. Gerald ,  Richard L. Weinshank ,  David Linemeyer ,  Theresa Branchek ,  Carlos Forray

    IPC分类号： G01N33/53

    CPC分类号： C12P21/02 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/72

    摘要： This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.

    摘要翻译： 本发明提供了编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含这种载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测编码 哺乳动物甘丙肽受体，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽受体结合的方法。

    DNA encoding galanin GALR2 receptors
    8.
    发明授权
    DNA encoding galanin GALR2 receptors 失效
    编码甘露糖苷GALR2受体的DNA

    公开(公告)号：US06790656B1

    公开(公告)日：2004-09-14

    申请号：US09011553

    申请日：1998-06-04

    申请人： Kelli E. Smith ,  Christophe P. G. Gerald ,  Richard L. Weinshank ,  David Linemeyer ,  Theresa Branchek ,  Carlos Forray

    发明人： Kelli E. Smith ,  Christophe P. G. Gerald ,  Richard L. Weinshank ,  David Linemeyer ,  Theresa Branchek ,  Carlos Forray

    IPC分类号： C12N510

    CPC分类号： C12P21/02 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/72

    摘要： This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.

    摘要翻译： 本发明提供了编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含这种载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测编码 哺乳动物甘丙肽受体，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽受体结合的方法。

    Method of identifying compounds that bind galanin receptor (GALR2)
    9.
    发明授权
    Method of identifying compounds that bind galanin receptor (GALR2) 失效
    识别结合甘丙肽受体（GALR2）的化合物的方法

    公开(公告)号：US06586191B2

    公开(公告)日：2003-07-01

    申请号：US08899112

    申请日：1997-07-23

    申请人： Kelli E. Smith ,  David Linemeyer ,  Christophe P. G. Gerald ,  Theresa Branchek ,  Richard L. Weinshank ,  Carlos Forray

    发明人： Kelli E. Smith ,  David Linemeyer ,  Christophe P. G. Gerald ,  Theresa Branchek ,  Richard L. Weinshank ,  Carlos Forray

    IPC分类号： G01N33566

    CPC分类号： C12P21/02 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/72

    摘要： This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.

    摘要翻译： 本发明提供了编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含这种载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测编码 哺乳动物甘丙肽受体，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽受体结合的方法。

    DNA encoding a human serotonin receptor (5-HT4B) and uses thereof
    10.
    发明授权
    DNA encoding a human serotonin receptor (5-HT4B) and uses thereof 有权
    编码人5-羟色胺受体（5-HT4B）的DNA及其用途

    公开(公告)号：US06300087B1

    公开(公告)日：2001-10-09

    申请号：US09450797

    申请日：1999-11-29

    申请人： Jonathan A. Bard ,  Theresa Branchek ,  Richard L. Weinshank

    发明人： Jonathan A. Bard ,  Theresa Branchek ,  Richard L. Weinshank

    IPC分类号： C12N1518

    CPC分类号： C12N15/8509 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/10 ,  A01K2267/03 ,  A61K38/00 ,  C07K14/70571

    摘要： This invention provides an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor and an isolated nucleic acid molecule encoding a human 5-HT4B receptor, an isolated protein which is mammalian 5-HT4B receptor, vectors comprising an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT4B receptor, mammalian cells comprising such vectors, antibodies directed to the 5-HT4B receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian or human 5-HT4B receptor, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a mammalian or human 5-HT4B receptor, pharmaceutical compounds related to the human 5-HT4B receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with a human 5-HT4B receptor.

    摘要翻译： 本发明提供编码哺乳动物5-HT4B受体的分离的核酸分子和编码人5-HT4B受体的分离的核酸分子，其是哺乳动物5-HT4B受体的分离的蛋白质，载体包含编码哺乳动物的分离的核酸分子 5-HT4B受体的载体，包含编码人5-HT4B受体的分离的核酸分子的载体，包含这种载体的哺乳动物细胞，针对5-HT4B受体的抗体，用于检测编码哺乳动物或人5- HT4B受体，与编码哺乳动物或人类5-HT4B受体的核酸分子的任何序列互补的反义寡核苷酸，与人5-HT4B受体相关的药物化合物。 本发明还提供了用于确定配体结合，检测表达，药物筛选和用于减轻与人5-HT4B受体相关的异常的治疗的方法。