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    Compound
    3.
    发明申请
    Compound 审中-公开
    复合

    公开(公告)号：US20100056524A1

    公开(公告)日：2010-03-04

    申请号：US12384477

    申请日：2009-04-02

    申请人： Edward Giles Mciver ,  Justin Stephen Bryans ,  Ela Smiljanic ,  Stephen John Lewis ,  Joanne Hough ,  Thomas Drake

    发明人： Edward Giles Mciver ,  Justin Stephen Bryans ,  Ela Smiljanic ,  Stephen John Lewis ,  Joanne Hough ,  Thomas Drake

    IPC分类号： A61K31/5377 ,  C07D239/02 ,  C07D403/12 ,  C07D413/12 ,  A61K31/505 ,  A61K31/506

    CPC分类号： C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D407/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D471/04

    摘要： A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein: R1 is C3-8-cycloalkyl; X is O, NR7 or C3-6-heterocycloalkyl; R2 is aryl, heteroaryl, fused or unfused aryl-C3-6-heterocycloalkyl or fused or unfused heteroaryl-C3-6-heterocycloalkyl, each of which is optionally substituted by one or more substitutents selected from aryl, heteroaryl, C1-6-alkyl, C3-7-cycloalkyl and a group A, wherein said C1-6-alkyl group is optionally substituted by one or more substituents selected from aryl, heteroaryl, R10 and a group A, said heteroaryl group is optionally substituted by one or more R10 groups; and wherein said C3-6-heterocycloalkyl group optionally contains one or more groups selected from oxygen, sulfur, nitrogen and CO; R3 is C1-6-alkyl optionally substituted by one or more substituents selected from aryl, heteroaryl, —NR4R5, —OR6, —NR7(CO)R6, —NR7(CO)NR4R5, —NR7SO2R6, —NR7COOR7, —CONR4R5, C3-6-heterocycloalkyl and wherein R4-7 and A are as defined in the claims.Further aspects relate to the use of said compounds in the treatment of various therapeutic disorders, and more particularly as inhibitors of one or more kinases.

    摘要翻译： 本发明的第一方面涉及式（I）化合物或其药学上可接受的盐或酯，其中：R 1为C 3-8 - 环烷基; X是O，NR 7或C 3-6 - 杂环烷基; R 2是芳基，杂芳基，稠合或未稠合的芳基-C 3-6 - 杂环烷基或稠合或未稠合的杂芳基-C 3-6 - 杂环烷基，其各自任选被一个或多个选自芳基，杂芳基，C 1-6 - 烷基 C 3-7 - 环烷基和基团A，其中所述C 1-6 - 烷基任选被一个或多个选自芳基，杂芳基，R 10和A基团的取代基取代，所述杂芳基任选地被一个或多个R 10 团体 并且其中所述C 3-6杂环烷基任选地含有一个或多个选自氧，硫，氮和CO的基团; R 3是任选被一个或多个选自芳基，杂芳基，-NR 4 R 5，-OR 6，-NR 7（CO）R 6，-NR 7（CO）NR 4 R 5，-NR 7 SO 2 R 6，-NR 7 COOR 7，-CONR 4 R 5，C 3 -6-杂环烷基，其中R 4-7和A如权利要求中所定义。 其它方面涉及所述化合物在治疗各种治疗性疾病中的用途，更具体地涉及一种或多种激酶的抑制剂。

    Method and apparatus for inserting empty memory cells into a data flow of network connections of a computer network
    4.
    发明授权
    Method and apparatus for inserting empty memory cells into a data flow of network connections of a computer network 有权
    将空的存储器单元插入到计算机网络的网络连接的数据流中的方法和装置

    公开(公告)号：US07359325B1

    公开(公告)日：2008-04-15

    申请号：US10045290

    申请日：2001-10-18

    申请人： Stephen John Lewis ,  Nils Ramon Marchant ,  Mike Reynolds

    发明人： Stephen John Lewis ,  Nils Ramon Marchant ,  Mike Reynolds

    IPC分类号： H04L12/26

    CPC分类号： H04L41/0896

    摘要： A method and an apparatus are provided for inserting empty memory cells into a data flow of network connections of a computer network. In one example, the method includes receiving an insertion request for an empty memory cell to be inserted into the data flow. A base connection identification (CID) associated with the insertion request is also received. An appropriate insertion scheme for carrying out the insertion request is determined. Based on the appropriate insertion scheme, the insertion request is sent to an insertion device that is configured to insert the empty memory cell into the data flow. The memory cell is inserted prior to traffic shaping of the data flow.

    摘要翻译： 提供了一种用于将空的存储器单元插入到计算机网络的网络连接的数据流中的方法和装置。 在一个示例中，该方法包括接收对要插入到数据流中的空的存储器单元的插入请求。 还接收与插入请求相关联的基本连接标识（CID）。 确定用于执行插入请求的适当插入方案。 基于适当的插入方案，插入请求被发送到被配置为将空的存储器单元插入到数据流中的插入装置。 在数据流的流量整形之前插入存储单元。