公开(公告)号：US5768407A

公开(公告)日：1998-06-16

申请号：US742588

申请日：1996-10-28

申请人： Jian Shen ,  Mykola Yaremko ,  Rosemary Chachowski ,  Josef Atzler ,  Thierry Dupinet ,  Daniel Kittrich ,  Hansjoerg Kunz ,  Karl Puchegger ,  Reiner Rohlfs

发明人： Jian Shen ,  Mykola Yaremko ,  Rosemary Chachowski ,  Josef Atzler ,  Thierry Dupinet ,  Daniel Kittrich ,  Hansjoerg Kunz ,  Karl Puchegger ,  Reiner Rohlfs

IPC分类号： G01N21/82 ,  G06K9/00

CPC分类号： G01N33/4905 ,  G01N21/82

摘要： A method and system for analyzing a solution for an agglutination pattern. The method comprises the steps of producing an illuminated image of the solution on an array of pixels, and assigning to each pixel in the illuminated image, a data value representing the intensity of the illuminated image on the pixel. Those data values are then processed according to a predetermined program to determine if an agglutination pattern is present and, if so, to classify that pattern into one of a plurality of predefined classes. With the preferred processing procedure, the pixel array is separated into a plurality of zones, and the data values for the pixels in each zone are processed according to a respective predetermined procedure to determine values for a predefined set of variables. Then, those determined values are processed to determine whether an agglutination pattern is present in the solution, and if so, to classify that pattern into one of the predefined classes.

摘要翻译： 用于分析凝集图案的方案的方法和系统。 该方法包括以下步骤：在像素阵列上产生解决方案的照明图像，并且向照射图像中的每个像素分配表示像素上的照射图像的强度的数据值。 然后根据预定程序处理那些数据值，以确定是否存在凝集模式，如果是，则将该模式分类为多个预定类别之一。 利用优选的处理过程，将像素阵列分成多个区域，并且根据相应的预定过程处理每个区域中的像素的数据值，以确定预定义变量集合的值。 然后，处理这些确定的值以确定解决方案中是否存在凝集模式，如果是，则将该模式分类为预定义类之一。

公开(公告)号：US5933232A

公开(公告)日：1999-08-03

申请号：US855359

申请日：1997-05-13

申请人： Josef Atzler ,  Karl Puchegger

发明人： Josef Atzler ,  Karl Puchegger

IPC分类号： G01N21/64 ,  G01J3/30

CPC分类号： G01N21/6452

摘要： A fluorimeter has a flash lamp, a measurement station with a receiver for microtitration plates, at least one measurement head disposed at the receiver and an evaluation station having a detector. Emission signals given off by a sample are evaluated by the detector. Light guides extend from the flash lamp to the measurement head from the measurement head to the detector. At the measurement station one measurement head is arranged above a sample and one measurement head beneath the sample. A change-over switch is formed by a pivotal bar which connects the light guides selectively to the upper or the lower measurement heads. On the pivotal bar are connections for the light guides which lead to the upper and the lower measurement heads. Connection of a respective measurement head can be brought selectively into correlation with the light source and the detector.

摘要翻译： 荧光计具有闪光灯，具有用于微量滴定板的接收器的测量站，设置在接收器处的至少一个测量头和具有检测器的评估站。 由样品发出的发射信号由检测器评估。 光导从闪光灯延伸到测量头从测量头到检测器。 在测量站，一个测量头设置在样品上方，样品下方有一个测量头。 转换开关通过将光导选择性地连接到上测量头或下测量头的枢转棒形成。 在枢轴上是导向上下测量头的导光板的连接。 可以使各测量头的连接选择性地与光源和检测器相关。

公开(公告)号：US5733775A

公开(公告)日：1998-03-31

申请号：US606944

申请日：1996-02-26

申请人： Karl Puchegger ,  Andreas Erlbacher ,  Josef Atzler

发明人： Karl Puchegger ,  Andreas Erlbacher ,  Josef Atzler

IPC分类号： B01L3/00 ,  B01L7/00 ,  C12M3/00

CPC分类号： B01L3/50851 ,  B01L7/52

摘要： A temperature control device controls the temperature of the contents of a pan-shaped specimen container, in particular for the temperature control of specimen strips by hybridization assays. The specimen container can be set sealingly into a movably supported housing for a water bath.

摘要翻译： 温度控制装置控制盘形样品容器的内容物的温度，特别是通过杂交测定法对样品条的温度控制。 样品容器可以密封地设置在可移动的支撑的水浴的壳体中。

公开(公告)号：US5594808A

公开(公告)日：1997-01-14

申请号：US163996

申请日：1993-12-08

申请人： Jian Shen ,  Mykola Yaremko ,  Rosemary Chachowski ,  Josef Atzler ,  Thierry Dupinet ,  Daniel Kittrich ,  Hansjoerg Kunz ,  Karl Puchegger ,  Reiner Rohlfs

发明人： Jian Shen ,  Mykola Yaremko ,  Rosemary Chachowski ,  Josef Atzler ,  Thierry Dupinet ,  Daniel Kittrich ,  Hansjoerg Kunz ,  Karl Puchegger ,  Reiner Rohlfs

IPC分类号： G01N21/82 ,  G06K9/00

CPC分类号： G01N33/4905 ,  G01N21/82

摘要： A method and system for analyzing a solution for an agglutination pattern. The method comprises the steps of producing an illustrated image of the solution on an array of pixels, and assigning to each pixel in the illuminated image, a data value representing the intensity of the illuminated image on the pixel. Those data values are then processed according to a predetermined program to determine if an agglutination pattern is present and, if so, to classify that pattern into one of a plurality of predefined classes. With the preferred processing procedure, the pixel array is separated into a plurality of zones, and the data values for the pixels in each zone are processed according to a respective predetermined procedure to determine values for a predefined set of variables. Then, those determined values are processed to determine whether an agglutination pattern is present in the solution, and if so, to classify that pattern into one of the predefined classes.

摘要翻译： 用于分析凝集图案的方案的方法和系统。 该方法包括以下步骤：在像素阵列上产生解决方案的所示图像，并且向照射图像中的每个像素分配表示像素上的照射图像的强度的数据值。 然后根据预定程序处理那些数据值，以确定是否存在凝集模式，如果是，则将该模式分类为多个预定类别之一。 利用优选的处理过程，将像素阵列分成多个区域，并且根据相应的预定过程处理每个区域中的像素的数据值，以确定预定义变量集合的值。 然后，处理这些确定的值以确定解决方案中是否存在凝集模式，如果是，则将该模式分类为预定义类之一。

公开(公告)号：US20070183931A1

公开(公告)日：2007-08-09

申请号：US11351181

申请日：2006-02-08

申请人： Daniel Stock ,  Josef Atzler

发明人： Daniel Stock ,  Josef Atzler

IPC分类号： G01N21/00

CPC分类号： G01N21/645 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/427 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/763 ,  G01N2021/1738 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/024 ,  G01N2201/0618 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0692 ,  G01N2201/0696

摘要： A cartridge and cartridge system for use in an apparatus for analyzing a sample is provided. The cartridge has one or more light sources and/or optical systems and other components that are specific for a certain type of application such as fluorescence, absorbance, or luminescence. The light source, optical systems, and other components for a specific application are housed in a single cartridge. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with the apparatus in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed.

摘要翻译： 提供了一种用于分析样品的装置中的盒和盒系统。 盒具有一个或多个光源和/或光学系统以及其它特定于某种类型的应用，如荧光，吸光度或发光的组件。 用于特定应用的光源，光学系统和其他部件容纳在单个盒中。 该系统具有用于多模仪器的不同应用的多个盒。 盒可以以“插入”格式可移除地与设备接合，使得一个盒可以从设备移除，并且另一个盒可以容易地安装。

公开(公告)号：US07355710B2

公开(公告)日：2008-04-08

申请号：US11559483

申请日：2006-11-14

申请人： Andreas Gfrörer ,  Josef Atzler

发明人： Andreas Gfrörer ,  Josef Atzler

IPC分类号： G01N21/25

CPC分类号： B01L3/50855 ,  B01L9/06 ,  G01N21/64 ,  G02B21/16

摘要： An optical system for exciting and measuring fluorescence of samples has a first laser; a deflection element; a mirror; and an optic fixed in relation to one another. A unit is linearly movable back and forth along the optical axis and is mechanically connected to an oscillating linear drive. The optic acts as a collimator and the mirror acts to deflect the collimated light diametrically opposite to the bundled light of the laser. A table for receiving sample holders for samples; an optical arrangement for imaging a second focal point; an aperture plate in the second focal point; a first spectral filter; and a first detector are parts of the optical system and a focusing beam of the light emitted by the laser and is deflected by the deflection element toward the mirror.

摘要翻译： 用于激发和测量样品荧光的光学系统具有第一激光器; 偏转元件; 一面镜子; 和相对于彼此固定的光学元件。 一个单元可以沿光轴前后移动并机械地连接到振荡线性驱动器上。 光学器件用作准直器，并且反射镜用于使与激光束的光束径向相反的准直光偏转。 用于接收样品的样品架的表格; 用于对第二焦点进行成像的光学装置; 第二焦点中的孔板; 第一光谱滤波器; 并且第一检测器是光学系统的一部分和由激光器发射的光的聚焦光束，并且被偏转元件偏转到反射镜。

公开(公告)号：US20070086005A1

公开(公告)日：2007-04-19

申请号：US11559483

申请日：2006-11-14

申请人： Andreas Gfrorer ,  Josef Atzler

发明人： Andreas Gfrorer ,  Josef Atzler

IPC分类号： G01N21/64

CPC分类号： B01L3/50855 ,  B01L9/06 ,  G01N21/64 ,  G02B21/16

摘要： An optical system and a method of exciting and measuring fluorescence on or in samples treated using fluorescent pigments using such an optical system are disclosed. The optical system comprises at least one first laser (1); a deflection element (7); a mirror (4); an optic (8); and a unit (10), which includes mirror (4) and optic (8) mounted fixed in relation to one another. The unit (10) is positioned so it is linearly movable back and forth along the optical axis (5) and is mechanically connected to an oscillating linear drive (11). The optic (8) additionally acts as a collimator and the mirror (4) additionally acts to deflect the collimated light (12) diametrically opposite to the direction of incidence of the bundled light of the laser (1). The optical system additionally includes a table (13) for receiving sample holders (14) for samples (6); an optical arrangement (16) for imaging a second focal point (17); an aperture plate (18) positioned in the second focal point (17); a first spectral filter (19); and a first detector (20). The optical system is distinguished in that a focusing beam (25) of the light (2), which is emitted by the laser (1) and is deflected by the deflection element (7) into the direction of the mirror (4), is arranged to extend off-center and in a distance (A) to an optical axis (5) of this optical system. A preferred embodiment of the optical system is distinguished in that the oscillating linear drive (11) comprises a connecting rod for linearly moving back and forth the unit (10).

摘要翻译： 公开了使用这种光学系统激光和测量使用荧光颜料处理的样品中的荧光的方法和光学系统。 光学系统包括至少一个第一激光器（1）; 偏转元件（7）; 镜子（4）; 光学（8）; 以及包括相对于彼此固定的镜子（4）和光学装置（8）的单元（10）。 单元（10）被定位成使其能够沿光轴（5）前后移动并机械连接到振荡线性驱动器（11）。 光学元件（8）还用作准直器，并且反射镜（4）还用于使与激光器（1）的束缚光的入射方向直径相反的准直光（12）偏转。 光学系统还包括用于接收样品（6）的样品架（14）的台（13）。 用于对第二焦点（17）成像的光学装置（16）; 位于所述第二焦点（17）中的孔板（18）; 第一光谱滤光器（19）; 和第一检测器（20）。 光学系统的特征在于，由激光器（1）发射并被偏转元件（7）偏转到反射镜（4）的方向的光（2）的聚焦光束（25）是 布置成偏离中心并且在该光学系统的光轴（5）的距离（A）处延伸。 光学系统的优选实施例的特征在于，振荡线性驱动器（11）包括用于线性地来回移动单元（10）的连杆。

公开(公告)号：US20110278472A1

公开(公告)日：2011-11-17

申请号：US13166595

申请日：2011-06-22

申请人： Josef Atzler

发明人： Josef Atzler

IPC分类号： G01N21/64

CPC分类号： G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/427 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/645 ,  G01N21/763 ,  G01N2021/1738 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/024 ,  G01N2201/0618 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0692 ,  G01N2201/0696

摘要： A cartridge and cartridge system for use in an apparatus for analyzing a sample are provided. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with a cartridge support in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed. The cartridge support includes a plurality of cartridge positions that receive cartridges concurrently. One of the cartridges is a wavelength-tunable cartridge in which different light sources, excitation filters, and/or emission filters may be selected. Tuning is further accomplished by tilting the excitation or emission filters at desired angles relative to a beam of exciting light or emitted light.

摘要翻译： 提供了用于分析样品的装置中的盒和盒系统。 该系统具有用于多模仪器的不同应用的多个盒。 盒以“插入”格式可拆卸地与盒支撑接合，使得一个盒可以从装置移除，另一个盒可以容易地安装。 盒支架包括同时接收盒的多个盒位置。 其中一个墨盒是波长可调的墨盒，其中可以选择不同的光源，激发滤光片和/或发射滤光片。 通过将激发或发射滤光片相对于激发光束或发射光以期望的角度倾斜来进一步完成调谐。

公开(公告)号：US07158226B2

公开(公告)日：2007-01-02

申请号：US10470154

申请日：2002-01-10

申请人： Andreas Gfrörer ,  Josef Atzler

发明人： Andreas Gfrörer ,  Josef Atzler

IPC分类号： G01J3/30

CPC分类号： B01L3/50855 ,  B01L9/06 ,  G01N21/64 ,  G02B21/16

摘要： An optical system and method of exciting and measuring fluorescence on or in samples treated using fluorescent pigments using such an optical system having at least one first laser (1); a mirror (4); a deflection element (7); an optic (8); and a unit (10), which includes mirror (4) and optic (8) mounted fixed in relation to one another. The unit (10) is positioned so it is linearly movable back and forth along the optical axis (5) and is mechanically connected to an oscillating linear drive (11). The optic (8) additionally acts as a collimator and the mirror (4) additionally acts to deflect the collimated light (12) parallel to the optical axis (5).

摘要翻译： 使用具有至少一个第一激光器（1）的光学系统激发和测量使用荧光颜料处理的样品中的荧光的光学系统和方法; 镜子（4）; 偏转元件（7）; 光学（8）; 以及包括相对于彼此固定的镜子（4）和光学装置（8）的单元（10）。 单元（10）被定位成使其能够沿光轴（5）前后移动并机械连接到振荡线性驱动器（11）。 光学元件（8）另外用作准直器，反射镜（4）还用于使准直光（12）平行于光轴（5）偏转。