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    Silylamine modified nanoparticulate carriers
    3.
    发明申请
    Silylamine modified nanoparticulate carriers 审中-公开
    硅烷改性纳米颗粒载体

    公开(公告)号：US20070292688A1

    公开(公告)日：2007-12-20

    申请号：US11206362

    申请日：2005-08-18

    申请人： Joseph Bringley ,  Tiecheng Qiao

    发明人： Joseph Bringley ,  Tiecheng Qiao

    IPC分类号： B32B5/16 ,  B32B15/02

    CPC分类号： C03C17/30 ,  A61K9/1676 ,  A61K9/5115 ,  A61K9/5146 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0093 ,  C03C4/0007 ,  C03C11/002 ,  Y10T428/2991 ,  Y10T428/2995

    摘要： A composition comprising a colloid that is stable under physiological pH and ionic strength is disclosed. The colloid comprises particles having a core and a shell: a) wherein said shell comprises a silylamine coupling agent; b) wherein the particles have a volume-weighted mean particle size diameter of less than 200 nm, and c) wherein greater than 35% of said silylamine coupling agent present in the colloid is bound to the core surfaces. These core-shell nanoparticulate materials are capable of carrying biological, pharmaceutical or diagnostic components. The components, which might include drugs, therapeutics, diagnostics, and targeting moieties can then be delivered directly to diseased tissue or bones and be released in close proximity to the disease and reduce the risk of side effects to the patient.

    摘要翻译： 公开了包含在生理pH和离子强度下稳定的胶体的组合物。 胶体包括具有核和壳的颗粒：a）其中所述壳包含甲硅烷基偶联剂; b）其中所述颗粒具有小于200nm的体积加权平均粒度直径，以及c）其中存在于胶体中的大于35％的所述甲硅烷基偶联剂与芯表面结合。 这些核 - 壳纳米颗粒材料能够携带生物，药物或诊断成分。 可能包括药物，治疗，诊断和靶向部分的组分可以直接递送到患病组织或骨骼，并且在疾病附近释放并降低对患者的副作用的风险。

    Composition comprising layered host material with intercalated functional-active organic compound
    9.
    发明申请
    Composition comprising layered host material with intercalated functional-active organic compound 审中-公开
    组合物，其包含具有插层的官能活性有机化合物的层状主体材料

    公开(公告)号：US20050260271A1

    公开(公告)日：2005-11-24

    申请号：US10850492

    申请日：2004-05-20

    申请人： Joseph Bringley

    发明人： Joseph Bringley

    IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K33/24 ,  A61K38/17 ,  A61K47/02 ,  A61K47/48 ,  A61K48/00

    CPC分类号： B82Y5/00 ,  A61K47/02 ,  A61K47/6905 ,  A61K47/6923 ,  A61K48/0008

    摘要： An aqueous dispersion comprising particles of a layered host material and functional-active organic compound dispersed in an aqueous medium, wherein the weight ratio of layered host material to functional-active compound is less than 20 and at least 50% of the functional-active organic compound in the dispersion is intercalated between layers of the layered host material particles, and further wherein the aqueous medium comprises additional soluble salts or ionized molecules or polymers distinct from the functional-active compound and has an ionic strength of greater than 5 mS/cm. A method of delivering a desired functional-active organic compound to a target system, comprising delivering such an aqueous dispersion to the target system, wherein the aqueous dispersion comprises the desired functional-active organic compound intercalated in a layered host material, and additional soluble salts or ionized molecules or polymers which are distinct from the functional-active compound and which are also present in the target system to which the functional-active compound is delivered.

    摘要翻译： 一种水分散体，其包含分散在水性介质中的层状主体材料和功能活性有机化合物的颗粒，其中层状主体材料与官能化合物的重量比小于20且至少50％的官能活性有机化合物 分散体中的化合物插入层状主体材料颗粒的层之间，并且其中水性介质包含与功能活性化合物不同的额外的可溶性盐或离子化分子或聚合物，并具有大于5mS / cm的离子强度。 将期望的官能活性有机化合物递送到靶系统的方法，包括将这种水性分散体输送到靶系统，其中所述水分散体包含插入层状主体材料中的所需功能活性有机化合物，以及另外的可溶性盐 或与功能活性化合物不同的电离分子或聚合物，并且也存在于递送功能活性化合物的靶系统中。