公开(公告)号：US5652221A

公开(公告)日：1997-07-29

申请号：US335015

申请日：1994-11-07

申请人： Joseph Larner ,  John Price ,  Thomas Picariello ,  Laura Huang

发明人： Joseph Larner ,  John Price ,  Thomas Picariello ,  Laura Huang

IPC分类号： C07H15/04 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61P3/08 ,  C07H15/207 ,  C07H17/04

CPC分类号： C07H17/04 ,  C07H15/207 ,  Y10S514/866

摘要： A synthetic insulin mimetic compound is disclosed. Small synthetic amines of disaccharides, such as 2-deoxy-2-amino-galactopyranosyl pinitol are shown to mimic the action of insulin and to modulate its action.

摘要翻译： 公开了合成的胰岛素模拟化合物。 二恶烷的小合成胺，例如2-脱氧-2-氨基 - 吡喃半乳糖基肉豆蔻糖显示模拟胰岛素的作用并调节其作用。

公开(公告)号：US6093697A

公开(公告)日：2000-07-25

申请号：US902338

申请日：1997-07-29

申请人： Joseph Larner ,  John Price ,  Thomas Piccariello ,  Laura Huang

发明人： Joseph Larner ,  John Price ,  Thomas Piccariello ,  Laura Huang

IPC分类号： C07H15/04 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61P3/08 ,  A61P3/10 ,  C07H15/207 ,  C07H17/04 ,  C07H15/00

CPC分类号： C07H17/04 ,  C07H15/207 ,  Y10S514/866

摘要： Compounds are disclosed which have the formula (I) ##STR1## wherein R.sub.1 -R.sub.2 are each independently selected from the group consisting of: (a) a hydrogen atom; and (b) a lower alkyl group, straight or branched chain, having 1 to 8 carbon atoms; or R.sub.1 -R.sub.2 and the nitrogen atom to which they are bonded may together form a heterocyclic group; R.sub.3 -R.sub.10 are each independently selected from the group consisting of: (a) a hydrogen atom; (b) an alkyl group, straight or branched chain, having 1 to 24 carbon atoms; (c) a cycloalkyl group having 3 to 10 carbon atoms; (d) an alkenyl group, straight or branched chain, having 2 to 24 carbon atoms; (e) a cycloalkenyl group having 4 to 10 carbon atoms and one or more non-adjacent double bonds; (f) an aryl group having 6 to 10 carbon atoms; (g) an aralkyl group having 7 to 34 carbons atoms; (h) a heteroaryl group having 4 to 9 carbon atoms and at least one heteroatom selected from the group consisting of oxygen, nitrogen and sulfur; (i) a carboxyalkyl group, straight or branched chain, having 2 to 24 carbon atoms; (j) a carboxyaryl group having 7 to 34 carbon atoms; and (k) a heterocyclic group having 2 to 9 carbon atoms and at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen; or any adjacent two of R.sub.3 -R.sub.10 may together form a cycloalkyl group or heterocyclic group; and X.sub.1 and X.sub.2 are each independently selected from the group consisting of an oxygen atom, a sulfur atom and a nitrogen atom. Pharmaceutical compositions containing these compounds and the use thereof for the treatment of disorders of glucose metabolism are also disclosed.

摘要翻译： 公开了具有式（I）的化合物，其中R 1 -R 2各自独立地选自：（a）氢原子; 和（b）具有1至8个碳原子的直链或支链的低级烷基; 或R 1 -R 2和它们所键合的氮原子可以一起形成杂环基; R3-R10各自独立地选自：（a）氢原子; （b）具有1至24个碳原子的直链或支链烷基; （c）碳原子数3〜10的环烷基; （d）具有2至24个碳原子的直链或支链烯基; （e）具有4-10个碳原子和一个或多个不相邻双键的环烯基; （f）具有6〜10个碳原子的芳基; （g）碳原子数为7〜34的芳烷基; （h）具有4至9个碳原子的杂芳基和至少一个选自氧，氮和硫的杂原子; （i）具有2至24个碳原子的直链或支链的羧基烷基; （j）具有7至34个碳原子的羧基芳基; 和（k）具有2至9个碳原子的杂环基和至少一个选自氧，硫和氮的杂原子; 或R 3 -R 10任意相邻的两个可以一起形成环烷基或杂环基; X 1和X 2各自独立地选自氧原子，硫原子和氮原子。 还公开了含有这些化合物的药物组合物及其用于治疗葡萄糖代谢紊乱的用途。

公开(公告)号：US5122603A

公开(公告)日：1992-06-16

申请号：US320484

申请日：1989-03-08

申请人： Joseph Larner ,  Alison Kennington ,  Laura Huang ,  Tsung Y. Shen

发明人： Joseph Larner ,  Alison Kennington ,  Laura Huang ,  Tsung Y. Shen

IPC分类号： G01N33/50 ,  A61K31/70 ,  A61K35/407 ,  A61K49/00 ,  A61P3/08 ,  A61P43/00 ,  C07K1/14 ,  C07K1/16 ,  C07K1/18 ,  C07K1/22 ,  C07K14/00 ,  C07K14/47 ,  G01N30/88 ,  C07K15/00 ,  A01N57/00 ,  C12N9/88

CPC分类号： C07K14/47 ,  Y10S514/866

摘要： A method for purifying two distinct insulin mediators to substantial homogeneity, and relative purity values above 80%, comprises adsorption on first anion exchange resin and subsequently on a chelex cation exchange resin column. The chelex resin ion exchange column substantially increases the activity of the recovered mediator. Following purification, the already treated fraction is subjected to three successive thin layer chromatography purification steps, the last giving, in the presence of ninhydrin stain, a characteristic salmon-color spot, which is indicative of the presence of the mediator. This process can also be used as a screening process, the absence of the salmon-colored spot being indicative of the diabetic state. Structure information on the insulin mediators obtained is given.

摘要翻译： 一种用于纯化两种不同胰岛素介质以达到基本均匀的方法，并且相对纯度值高于80％的方法包括在第一阴离子交换树脂上吸附，随后在Chelex阳离子交换树脂柱上进行吸附。 衣壳树脂离子交换柱显着增加了回收的介体的活性。 纯化后，已经处理的级分经过三次连续的薄层色谱纯化步骤，最后在茚三酮染色剂存在下给出特征性鲑鱼色斑，这表明存在介体。 该过程也可用作筛选过程，没有鲑鱼色斑点指示糖尿病状态。 给出了获得的胰岛素介质的结构信息。

公开(公告)号：US06836478B1

公开(公告)日：2004-12-28

申请号：US09475673

申请日：1999-12-30

申请人： Laura Huang ,  Fen-Chung Kung ,  Jesse Eugene Russell ,  Hopeton Walker ,  Spencer Wang

发明人： Laura Huang ,  Fen-Chung Kung ,  Jesse Eugene Russell ,  Hopeton Walker ,  Spencer Wang

IPC分类号： H04L1266

CPC分类号： H04L12/66

摘要： A broadband communication system including an Internet Protocol Telephony Network and public switched telephone network, including apparatus and methods for placing a call on hold in a way that significantly reduces the amount of network bandwidth utilized by the call while the call is on hold. When a call is placed on hold, embodiments of the architecture of the telephony network of the present invention allows the network to essentially “forget” about the call placed on hold. In other words, a call that is on hold may require very little, or even zero, bandwidth within the telephony network. Accordingly, the total necessary bandwidth capacity of the telephony network may be smaller than it would be if calls on hold were to consume precious network bandwidth as is found in existing telephony systems.

摘要翻译： 一种包括因特网协议电话网络和公共交换电话网络的宽带通信系统，包括用于在呼叫保持时显着减少呼叫所使用的网络带宽量的方式来将呼叫置于保持状态的装置和方法。 当呼叫被置于保持状态时，本发明的电话网络的体系结构的实施例允许网络基本上“忘记”关于搁置的呼叫。 换句话说，处于保持状态的呼叫可能在电话网络内可能需要很少或甚至零的带宽。 因此，电话网络的总需要的带宽容量可能小于如果呼叫保持消耗如现有电话系统中发现的宝贵的网络带宽的话。

公开(公告)号：US07558251B1

公开(公告)日：2009-07-07

申请号：US10940444

申请日：2004-09-14

申请人： Laura Huang ,  Fen-Chung Kung ,  Jesse Eugene Russell ,  Hopeton Walker ,  Spencer Wang

发明人： Laura Huang ,  Fen-Chung Kung ,  Jesse Eugene Russell ,  Hopeton Walker ,  Spencer Wang

IPC分类号： H04L12/66

CPC分类号： H04L12/66

摘要： A broadband communication system including an Internet Protocol Telephony Network and public switched telephone network, including apparatus and methods for placing a call on hold in a way that significantly reduces the amount of network bandwidth utilized by the call while the call is on hold. When a call is placed on hold, embodiments of the architecture of the telephony network of the present invention allows the network to essentially “forget” about the call placed on hold. In other words, a call that is on hold may require very little, or even zero, bandwidth within the telephony network. Accordingly, the total necessary bandwidth capacity of the telephony network may be smaller than it would be if calls on hold were to consume precious network bandwidth as is found in existing telephony systems.

摘要翻译： 一种包括因特网协议电话网络和公共交换电话网络的宽带通信系统，包括用于在呼叫保持时显着减少呼叫所使用的网络带宽量的方式来将呼叫置于保持状态的装置和方法。 当呼叫被置于保持状态时，本发明的电话网络的体系结构的实施例允许网络基本上“忘记”关于搁置的呼叫。 换句话说，处于保持状态的呼叫可能在电话网络内可能需要很少或甚至零的带宽。 因此，电话网络的总需要的带宽容量可能小于如果呼叫保持消耗如现有电话系统中发现的宝贵的网络带宽的话。