公开(公告)号：US6093697A

公开(公告)日：2000-07-25

申请号：US902338

申请日：1997-07-29

申请人： Joseph Larner ,  John Price ,  Thomas Piccariello ,  Laura Huang

发明人： Joseph Larner ,  John Price ,  Thomas Piccariello ,  Laura Huang

IPC分类号： C07H15/04 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61P3/08 ,  A61P3/10 ,  C07H15/207 ,  C07H17/04 ,  C07H15/00

CPC分类号： C07H17/04 ,  C07H15/207 ,  Y10S514/866

摘要： Compounds are disclosed which have the formula (I) ##STR1## wherein R.sub.1 -R.sub.2 are each independently selected from the group consisting of: (a) a hydrogen atom; and (b) a lower alkyl group, straight or branched chain, having 1 to 8 carbon atoms; or R.sub.1 -R.sub.2 and the nitrogen atom to which they are bonded may together form a heterocyclic group; R.sub.3 -R.sub.10 are each independently selected from the group consisting of: (a) a hydrogen atom; (b) an alkyl group, straight or branched chain, having 1 to 24 carbon atoms; (c) a cycloalkyl group having 3 to 10 carbon atoms; (d) an alkenyl group, straight or branched chain, having 2 to 24 carbon atoms; (e) a cycloalkenyl group having 4 to 10 carbon atoms and one or more non-adjacent double bonds; (f) an aryl group having 6 to 10 carbon atoms; (g) an aralkyl group having 7 to 34 carbons atoms; (h) a heteroaryl group having 4 to 9 carbon atoms and at least one heteroatom selected from the group consisting of oxygen, nitrogen and sulfur; (i) a carboxyalkyl group, straight or branched chain, having 2 to 24 carbon atoms; (j) a carboxyaryl group having 7 to 34 carbon atoms; and (k) a heterocyclic group having 2 to 9 carbon atoms and at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen; or any adjacent two of R.sub.3 -R.sub.10 may together form a cycloalkyl group or heterocyclic group; and X.sub.1 and X.sub.2 are each independently selected from the group consisting of an oxygen atom, a sulfur atom and a nitrogen atom. Pharmaceutical compositions containing these compounds and the use thereof for the treatment of disorders of glucose metabolism are also disclosed.

摘要翻译： 公开了具有式（I）的化合物，其中R 1 -R 2各自独立地选自：（a）氢原子; 和（b）具有1至8个碳原子的直链或支链的低级烷基; 或R 1 -R 2和它们所键合的氮原子可以一起形成杂环基; R3-R10各自独立地选自：（a）氢原子; （b）具有1至24个碳原子的直链或支链烷基; （c）碳原子数3〜10的环烷基; （d）具有2至24个碳原子的直链或支链烯基; （e）具有4-10个碳原子和一个或多个不相邻双键的环烯基; （f）具有6〜10个碳原子的芳基; （g）碳原子数为7〜34的芳烷基; （h）具有4至9个碳原子的杂芳基和至少一个选自氧，氮和硫的杂原子; （i）具有2至24个碳原子的直链或支链的羧基烷基; （j）具有7至34个碳原子的羧基芳基; 和（k）具有2至9个碳原子的杂环基和至少一个选自氧，硫和氮的杂原子; 或R 3 -R 10任意相邻的两个可以一起形成环烷基或杂环基; X 1和X 2各自独立地选自氧原子，硫原子和氮原子。 还公开了含有这些化合物的药物组合物及其用于治疗葡萄糖代谢紊乱的用途。

公开(公告)号：US5652221A

公开(公告)日：1997-07-29

申请号：US335015

申请日：1994-11-07

申请人： Joseph Larner ,  John Price ,  Thomas Picariello ,  Laura Huang

发明人： Joseph Larner ,  John Price ,  Thomas Picariello ,  Laura Huang

IPC分类号： C07H15/04 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61P3/08 ,  C07H15/207 ,  C07H17/04

CPC分类号： C07H17/04 ,  C07H15/207 ,  Y10S514/866

摘要： A synthetic insulin mimetic compound is disclosed. Small synthetic amines of disaccharides, such as 2-deoxy-2-amino-galactopyranosyl pinitol are shown to mimic the action of insulin and to modulate its action.

摘要翻译： 公开了合成的胰岛素模拟化合物。 二恶烷的小合成胺，例如2-脱氧-2-氨基 - 吡喃半乳糖基肉豆蔻糖显示模拟胰岛素的作用并调节其作用。

公开(公告)号：US20060258754A1

公开(公告)日：2006-11-16

申请号：US11386150

申请日：2006-03-22

申请人： Joseph Larner ,  John Price ,  Michael Brownlee ,  Manasses Fonteles

发明人： Joseph Larner ,  John Price ,  Michael Brownlee ,  Manasses Fonteles

IPC分类号： A61K31/075

CPC分类号： A61K31/05 ,  A61K31/085 ,  A61K31/09

摘要： A composition, either as a nutritional supplement or pharmaceutical, for the treatment of oxidative stress, endothelial dysfunction and related disease states which comprises administration of D-chiroinositol (DCI) congeners, acting as an antioxidant or glucose uptake promoter and metabolic normalizer, is disclosed. A composition of treating oxidative stress comprising administration of DCI is also disclosed. The administration of DCI derivatives comprises administering to the whole animal a dose in an amount sufficient to normalize blood glucose and triglycerides and to ameliorate endothelial dysfunction. The administration can be an oral, injectable, intranasal, or patch dosage forms. DCI is found in the food chain and has been shown to be very safe in large doses and, therefore, the amounts sufficient to achieve the desired therapeutic antioxidant effect will be low relative to the amounts reaching toxic levels. Therefore, DCI can be administered orally as a prophylactic nutritional supplement.

摘要翻译： 公开了作为营养补充剂或药物用于治疗氧化应激，内皮功能障碍和相关疾病状态的组合物，其包括施用作为抗氧化剂或葡萄糖摄取促进剂和代谢规范化酶的D-二羟基肌醇（DCI）同系物， 。 还公开了包含施用DCI的治疗氧化应激的组合物。 DCI衍生物的施用包括向整个动物施用足以使血糖和甘油三酯正常化并改善内皮功能障碍的剂量。 给药可以是口服，可注射，鼻内或贴剂剂型。 DCI在食物链中发现，并且已被证明在大剂量下非常安全，因此，足以达到所需治疗性抗氧化作用的量相对于达到毒性水平的量将低。 因此，DCI可以口服给药作为预防性营养补充剂。

公开(公告)号：US20130018346A1

公开(公告)日：2013-01-17

申请号：US13495691

申请日：2012-06-13

申请人： Roger Huckfeldt ,  Cindy Lowe ,  Keela Davis ,  Martin Reuter ,  John Price ,  Debbie Sue Mikkelson

发明人： Roger Huckfeldt ,  Cindy Lowe ,  Keela Davis ,  Martin Reuter ,  John Price ,  Debbie Sue Mikkelson

IPC分类号： A61F13/45 ,  A61F13/53 ,  A61F13/531

CPC分类号： A61G9/006 ,  A61B10/007 ,  A61F5/4556 ,  A61G2200/12

摘要： A sanitary disposable urine device is provided that includes an inner ring and outer ring each having a top surface and opposing bottom surface. The outer ring is substantially concentric with the inner ring and may be offset. At least one of the top surfaces of the inner and outer rings conforms to a body contour of a user's perineum. The device includes a hand holder coupled to the bottom surface of the inner ring, the hand holder having an opening configured to match to the inner ring. The device includes a fluid containing bag having an open end attached to the hand holder such that fluid flows through the inner ring and the opening of the hand holder into the fluid containing bag during usage. The device includes an inner bag inside the fluid containing bag having an absorbent material and an outer sealable bag to secure the device after use.

摘要翻译： 提供了一种卫生一次性尿液装置，其包括内环和外环，每个内环和外环具有顶表面和相对的底表面。 外环与内圈基本上同心并且可以偏移。 内环和外环的至少一个顶表面符合使用者会阴的身体轮廓。 该装置包括联接到内环的底表面的手持架，手持架具有被配置为与内圈相匹配的开口。 该装置包括具有附接到手持架的开口端的流体容纳袋，使得流体在使用期间流过内圈和手持架的开口进入流体容纳袋。 该装置包括在具有吸收材料的流体容纳袋内的内袋和用于在使用后固定装置的外部可密封袋。

公开(公告)号：US08214996B2

公开(公告)日：2012-07-10

申请号：US12330702

申请日：2008-12-09

申请人： Jerry Stametz ,  John Price ,  Eugene Reynolds ,  Kenneth Barsch

发明人： Jerry Stametz ,  John Price ,  Eugene Reynolds ,  Kenneth Barsch

IPC分类号： B21D39/00 ,  B21G1/12

CPC分类号： A61B17/06004 ,  A61B2017/00526 ,  A61B2017/06028 ,  Y10T29/49925

摘要： In a method of attaching a suture to a needle barrel, a first compression stroke compresses the radially-defined top of the barrel against a suture in the bore of the barrel while restraining the bottom and sides of the barrel against deformation. A second compression stroke compresses the bottom of the barrel against the suture while restraining the sides against deformation. In another method, the top and bottom are compressed concurrently while the sides are restrained against deformation. An apparatus for attaching a suture to a needle barrel includes two die sets, each including a die with a groove therein. In one die set, the groove protects the bottom and sides of the barrel from deformation while the top is compressed. In the other die set, the groove protects the sides of the barrel from deformation while the bottom is compressed.

摘要翻译： 在将缝合线附接到针筒的方法中，第一压缩冲程将筒的径向限定的顶部压靠在筒的孔中的缝合线上，同时限制筒的底部和侧面的变形。 第二压缩冲程在限制侧面不变形的同时使针筒的底部相对于缝线压缩。 在另一种方法中，顶部和底部同时被压缩，同时这些侧面被约束不变形。 用于将缝合线附接到针筒的装置包括两个模具组，每个模具包括其中具有凹槽的模具。 在一个模具组中，当顶部被压缩时，槽保护筒的底部和侧面不变形。 在另一个模具组中，当底部被压缩时，槽保护筒的侧面不会变形。

公开(公告)号：US20100166166A1

公开(公告)日：2010-07-01

申请号：US11919802

申请日：2006-05-04

申请人： Steven Smith ,  John Price

发明人： Steven Smith ,  John Price

IPC分类号： H04W4/00

CPC分类号： H04M3/4228 ,  H04M3/2218 ,  H04M3/38 ,  H04M3/42059 ,  H04M3/42153 ,  H04M3/42178 ,  H04M3/42221 ,  H04M3/42289 ,  H04M3/428 ,  H04M3/436 ,  H04M3/527 ,  H04M3/53 ,  H04M3/53308 ,  H04M2201/38 ,  H04M2201/40 ,  H04M2201/52 ,  H04M2203/052 ,  H04M2203/2072 ,  H04M2203/551

摘要： The present invention relates to an apparatus (10) for handling telephone calls which comprises: means for configuring the operation of the apparatus based on user preferences relating to the handling of calls from particular callers, means for storing the user preferences, means for processing incoming calls based on the user preferences, and means for receiving updates to the user preferences in dependence on changes to a preference database for storing the preferences of at least one user. The invention also relates to a telecommunications system, and to an associated server.

摘要翻译： 本发明涉及一种用于处理电话呼叫的装置（10），其包括：用于根据与来自特定呼叫者的呼叫的处理有关的用户偏好来配置装置的操作的装置，用于存储用户偏好的装置，用于处理进入 基于用户偏好的呼叫以及用于根据对用于存储至少一个用户的偏好的偏好数据库的改变来接收对用户偏好的更新的装置。 本发明还涉及电信系统和相关联的服务器。

公开(公告)号：US20070192315A1

公开(公告)日：2007-08-16

申请号：US11706046

申请日：2007-02-12

申请人： Paul S. Drzaic ,  Curtis L. Carrender ,  Raj Bridgelall ,  John Price

发明人： Paul S. Drzaic ,  Curtis L. Carrender ,  Raj Bridgelall ,  John Price

IPC分类号： G06F17/30

CPC分类号： G06F16/242 ,  G06F16/24575

摘要： Methods and apparatuses for extracting information from a database based on tag data are provided. One method includes interrogating a plurality of RFID tags coupled with objects within in an area to obtain tag data. The contextual environment of the area is determined based on the tag data. A search of a database relating to an item in the area is conducted. Relevance rankings of search results are adjusted based upon the determined contextual environment. Search results can be displayed in order of relevance rankings.

摘要翻译： 提供了基于标签数据从数据库提取信息的方法和装置。 一种方法包括询问与区域内的对象耦合的多个RFID标签以获得标签数据。 该区域的上下文环境基于标签数据确定。 进行与该区域中的项目有关的数据库的搜索。 搜索结果的相关性排名根据确定的情境环境进行调整。 搜索结果可以按照相关性排名的顺序显示。

公开(公告)号：US20060098780A1

公开(公告)日：2006-05-11

申请号：US10904286

申请日：2004-11-02

申请人： Bruce Dunham ,  John Price ,  Colin Wilson

发明人： Bruce Dunham ,  John Price ,  Colin Wilson

IPC分类号： H05G2/00 ,  G21G4/00 ,  H01J35/00

CPC分类号： H01J35/065 ,  A61B6/032 ,  A61B6/4028

摘要： An electron emitter assembly and a method for adjusting a size of electron beams are provided. The electron emitter assembly includes a laser configured to emit a first light beam. The electron emitter assembly further includes a lens assembly configured to receive the first light beam. The lens assembly is configured to adjust a size of the first light beam between a first predetermined size and a second predetermined size larger than the first predetermined size. The lens assembly emits the first light beam toward a photo-cathode. The photo-cathode is configured to emit a first electron beam having a third predetermined size when the first light beam having the first predetermined size contacts the photo-cathode. The photo-cathode is further configured to emit a second electron beam having a fourth predetermined size when the first light beam having the second predetermined size contacts the photo-cathode. The electron emitter assembly further includes an anode configured to receive the first and second electrons beams from the photo-cathode.

公开(公告)号：US20060002515A1

公开(公告)日：2006-01-05

申请号：US11048159

申请日：2005-02-01

申请人： William Huber ,  Colin Wilson ,  John Price ,  Peter Edic ,  Mark Vermilyea ,  Forrest Hopkins

发明人： William Huber ,  Colin Wilson ,  John Price ,  Peter Edic ,  Mark Vermilyea ,  Forrest Hopkins

IPC分类号： G21G4/00 ,  H01J35/30 ,  H01J35/00 ,  H05G2/00

CPC分类号： H01J35/06 ,  H01J35/14 ,  H01J35/16 ,  H01J35/30 ,  H01J2235/068

摘要： A system and method for forming x-rays. One exemplary system includes a target and electron emission subsystem with a plurality of electron sources. Each of the plurality of electron sources is configured to generate a plurality of discrete spots on the target from which x-rays are emitted. Another exemplary system includes a target, an electron emission subsystem with a plurality of electron sources, each of which generates at least one of the plurality of spots on the target, and a transient beam protection subsystem for protecting the electron emission subsystem from transient beam currents and material emissions from the target.

摘要翻译： 一种用于形成x射线的系统和方法。 一个示例性系统包括具有多个电子源的靶和电子发射子系统。 多个电子源中的每一个被配置为在从其发射X射线的目标上产生多个离散点。 另一个示例性系统包括目标，具有多个电子源的电子发射子系统，每个电子源产生目标上的多个点中的至少一个，以及用于保护电子发射子系统免受瞬态束电流的瞬态波束保护子系统 和目标物质排放。

公开(公告)号：US20050175151A1

公开(公告)日：2005-08-11

申请号：US10708048

申请日：2004-02-05

申请人： Bruce Dunham ,  Colin Wilson ,  John Price

发明人： Bruce Dunham ,  Colin Wilson ,  John Price

IPC分类号： G21K5/02 ,  A61B6/03 ,  G21K5/04 ,  H01J35/00 ,  H01J35/06 ,  H01J35/14 ,  H01J35/22 ,  H01J35/32 ,  H05G1/60

CPC分类号： A61B6/032 ,  A61B6/4028 ,  A61B6/4488 ,  H01J35/065 ,  H01J35/14 ,  H01J2235/02 ,  H01J2235/06

摘要： An field emitter array system (10) includes a housing (50). An emitter array (80) generates an electron beam and has multiple emitter elements (81) that are disposed within the housing (50). Each of the emitter elements has multiple activation connections (92).

摘要翻译： 场发射器阵列系统（10）包括壳体（50）。 发射极阵列（80）产生电子束并具有设置在壳体（50）内的多个发射极元件（81）。 每个发射器元件具有多个激活连接（92）。