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公开(公告)号:US5688917A
公开(公告)日:1997-11-18
申请号:US724095
申请日:1996-09-30
申请人: Joseph P. Arena , Guoping Feng , Linda M. Hall , Ken Liu , Leonardus H. T. Van Der Ploeg , Peiyi Wang , Jeffrey W. Warmke
发明人: Joseph P. Arena , Guoping Feng , Linda M. Hall , Ken Liu , Leonardus H. T. Van Der Ploeg , Peiyi Wang , Jeffrey W. Warmke
IPC分类号: C12N15/09 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12R1/19 , C12R1/865 , C12R1/91 , C07K1/00 , C07K14/00 , C12P21/06 , C12Q1/00
CPC分类号: C07K14/705 , Y10T428/2984
摘要: DNAs encoding voltage-activated cation channels have been cloned and characterized. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells.
摘要翻译: 编码电压激活阳离子通道的DNA已被克隆和表征。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞纯化。
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公开(公告)号:US5593864A
公开(公告)日:1997-01-14
申请号:US337339
申请日:1994-11-10
申请人: Joseph P. Arena , Guoping Feng , Linda M. Hall , Ken Liu , Leonardus H. T. Van Der Ploeg , Peiyi Wang , Jeffrey W. Warmke
发明人: Joseph P. Arena , Guoping Feng , Linda M. Hall , Ken Liu , Leonardus H. T. Van Der Ploeg , Peiyi Wang , Jeffrey W. Warmke
IPC分类号: C12N15/09 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12R1/19 , C12R1/865 , C12R1/91 , C12P21/06 , C12N5/00
CPC分类号: C07K14/705 , Y10T428/2984
摘要: DNAs encoding voltage-activated cation channels have been cloned and characterized. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells.
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公开(公告)号:US06531314B1
公开(公告)日:2003-03-11
申请号:US09077674
申请日:1998-06-03
申请人: Joseph P. Arena , Doris F. Cully , Scott D. Feighner , Andrew D. Howard , Paul A. Liberator , James M. Schaeffer , Leonardus H. T. Van Der Ploeg
发明人: Joseph P. Arena , Doris F. Cully , Scott D. Feighner , Andrew D. Howard , Paul A. Liberator , James M. Schaeffer , Leonardus H. T. Van Der Ploeg
IPC分类号: C12N1500
CPC分类号: C07B59/002 , A61K38/00 , C07K14/723
摘要: Human, swine and rat growth hormone secretagogue receptors have been isolated, cloned and sequenced. Growth hormone secretagogue receptors are new members of the G-protein family of receptors. The growth hormone secretagogue receptors may be used to screen and identify compounds which bind to the growth hormone secretagogue receptor. Such compounds may be used in the treatment of conditions which occur when there is a shortage of growth hormone, such as observed in growth hormone deficient children, elderly patients with musculoskeletal impairment and recovering from hip fracture and osteoporosis.
摘要翻译: 人,猪和大鼠生长激素促分泌素受体已被分离,克隆和测序。 生长激素促分泌受体是G-蛋白家族受体的新成员。 生长激素促分泌素受体可用于筛选和鉴定结合生长激素促分泌素受体的化合物。 这些化合物可用于治疗当生长激素短缺时发生的病症,例如在生长激素缺乏的儿童,老年骨骼肌损伤患者和从髋部骨折和骨质疏松症中恢复的情况。
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公开(公告)号:US4293021A
公开(公告)日:1981-10-06
申请号:US45938
申请日:1979-06-06
申请人: Joseph P. Arena
发明人: Joseph P. Arena
CPC分类号: E06B9/36 , E06B9/362 , Y10S160/90
摘要: A support member for horizontal members or elements in a traversable opening covering device is disclosed. In the preferred embodiment, the opening covering device is a vertical blind for a window opening. The vertical blind includes a plurality of vanes and carriers supporting the vanes, and a track structure for traversably supporting the carriers. The rod controls movement of the vanes, i.e. traversing or rotating of the vanes. In the preferred embodiment, the carriers are traversed by a cord arrangement and the support member also supports the cord. The support member comprises a body having an opening therein adapted to slidably receive the horizontally extending rod, shoulders or rollers disposed on opposed sides of the body adapted to be traversably received in the track structure, and another opening or a spring arrangement associated with the body adapted to receive a cord therein which is used to traverse the carriers and which is releasably and frictionally engaged with the opening or spring arrangement. Movement of the cord traverses the carriers and also traverses the support member from one end of the track structure to a predetermined supporting location at the central part of track structure. The support member is retained at the predetermined location at the central part of the track structure when the frictional engagement between the cord and support body is overcome so that further movement of the cord traverses the carriers but not the support member.
摘要翻译: 公开了一种用于横向构件的支撑构件或可移动开口覆盖装置中的元件。 在优选实施例中,开口覆盖装置是用于窗口的垂直百叶窗。 垂直百叶窗包括支撑叶片的多个叶片和载体,以及用于可横向地支撑载体的轨道结构。 杆控制叶片的运动,即叶片的横移或旋转。 在优选实施例中,载体由绳索布置穿过,并且支撑构件还支撑绳索。 支撑构件包括其中具有开口的本体,其中适于可滑动地容纳水平延伸的杆,设置在主体的相对侧上的肩部或辊,其适于可横向地容纳在轨道结构中,以及与主体相关联的另一开口或弹簧装置 适于在其中接收用于横越所述载体并且与所述开口或弹簧装置可释放地和摩擦地接合的绳索。 绳索的移动穿过托架并且还将支撑构件从轨道结构的一端穿过轨道结构的中心部分处的预定的支撑位置。 当克服绳索和支撑体之间的摩擦接合时,支撑构件被保持在轨道结构的中心部分的预定位置处,使得绳索的进一步移动穿过托架而不是支撑构件。
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公开(公告)号:US5693492A
公开(公告)日:1997-12-02
申请号:US435933
申请日:1995-05-05
申请人: Doris F. Cully , Joseph P. Arena , Philip S. Paress , Ken K. Liu
发明人: Doris F. Cully , Joseph P. Arena , Philip S. Paress , Ken K. Liu
IPC分类号: G01N33/53 , A61K31/70 , A61K38/00 , A61K45/00 , A61P33/00 , C07K14/435 , C07K14/705 , C07K16/18 , C12N1/21 , C12N15/09 , C12P21/02 , C12R1/19 , G01N33/577 , C12N1/20 , C07H21/04 , C12N15/00
CPC分类号: C07K14/70571 , A61K38/00
摘要: DNA encoding glutamate and avermectin-sensitive chloride channels have been cloned and characterized. The protein is capable of forming channels selectively opened with either avermectin or glutamate. The cDNA has been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified. Receptor modulators active in the method disclosed herein are useful as ectoparasiticides, antiparasitic, anthelmenthic, acaracidal and insecticide agents.
摘要翻译: 已经克隆并表征了编码谷氨酸和除虫菌素敏感性氯通道的DNA。 蛋白质能够形成与阿凡曼菌素或谷氨酸选择性开放的通道。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外,重组宿主细胞用于建立识别受体活性调节剂的方法,并鉴定受体调节剂。 在本文公开的方法中有活性的受体调节剂可用作外寄生虫杀螨剂,抗寄生虫病,止痛药,杀螨剂和杀虫剂。
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公开(公告)号:US5527703A
公开(公告)日:1996-06-18
申请号:US249112
申请日:1994-05-25
IPC分类号: G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/00 , A61P43/00 , C07K14/435 , C07K14/705 , C07K16/18 , C12N5/00 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12R1/91 , G01N33/15 , C12N1/20 , C07H21/04 , C12N15/00
CPC分类号: C07K14/70571 , A61K38/00 , C12N2799/026
摘要: DNAs encoding glutamate and avermectin-sensitive chloride channels have been cloned and characterized. The individual alpha and beta subunits are capable of forming homomeric and heteromeric channels selectively opened with either avermectin or glutamate. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified. Receptor modulators are useful as insecticides and anthelminthic agents.
摘要翻译: 已经克隆并表征了编码谷氨酸和除虫菌素敏感性氯通道的DNA。 单个α和β亚基能够形成与阿维菌素或谷氨酸选择性打开的同源异源通道。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外,重组宿主细胞用于建立识别受体活性调节剂的方法,并鉴定受体调节剂。 受体调节剂可用作杀虫剂和anthelminthic剂。
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公开(公告)号:US4316493A
公开(公告)日:1982-02-23
申请号:US824834
申请日:1977-08-15
申请人: Joseph P. Arena
发明人: Joseph P. Arena
CPC分类号: E06B9/365 , E06B9/362 , Y10S160/90
摘要: Vertical blinds having commonly housed and traversely movable controls for controlling the traverse and rotation of the vanes are disclosed. In a disclosed embodiment, the vanes are supported by carrier members, and a rotation rod extends through the carrier members. The carrier members are slideable along the rotation rod. A control assembly is mounted to slide along and also rotate the rotation rod. Sliding of the control assembly along the rotation rod slides the carrier members to thereby traverse the vanes, and actuation of the control assembly rotates the rotation rod and the vanes. The control assembly includes meshing bevel gears, one of which is coupled to an actuating rod or wand and the other to the rotation rod whereby rotation of the wand causes rotation of the vanes. The control assembly is slid by means of the wand which is universally connected to the control assembly. The wand is thus a unitary control for actuating both traverse and rotation of the vanes.
摘要翻译: 公开了具有用于控制叶片的横移和旋转的通常容纳和横向移动的控制器的垂直百叶窗。 在公开的实施例中,叶片由承载构件支撑,并且旋转杆延伸穿过承载构件。 承载构件可沿着旋转杆滑动。 安装控制组件以沿着旋转杆旋转并旋转。 沿着旋转杆滑动控制组件滑动载体构件从而横过叶片,并且控制组件的致动使旋转杆和叶片旋转。 控制组件包括啮合锥齿轮,其中一个齿轮联接到致动杆或杆,而另一个连接到旋转杆,从而旋转杆引起叶片旋转。 控制组件通过通用连接到控制组件的棒滑动。 因此,魔杖是用于致动叶片的横移和旋转的整体控制。
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公开(公告)号:US4140169A
公开(公告)日:1979-02-20
申请号:US824836
申请日:1977-08-15
申请人: Joseph P. Arena
发明人: Joseph P. Arena
CPC分类号: E06B9/365 , E06B9/362 , E06B9/364 , E06B9/368 , Y10S160/90
摘要: A unitary, one-piece vane carrier for vertical blinds is disclosed. The unitary carrier includes a carrier body and an elongated spacer link extending from one end of the body, the spacer link and body forming a single, unitary piece. In a disclosed embodiment, a tab is disposed at the distal end of the spacer link and a slotted opening is located in the end of the carrier body opposed to the end from which the spacer link extends. In that embodiment, the tab of one carrier cooperates with the slotted opening of an adjacently positioned carrier to limit the maximum spacing between the two carriers. The spacer link extends from the top of one end of the carrier body while the slotted opening is oppositely located at the top of the other end such that the spacer link of one carrier is slidable through the slotted opening of the adjacent carrier. Also in that disclosed embodiment, the spacer link includes a section of reduced width to facilitate insertion and removal of the spacer link into and from the slotted opening of an adjacent carrier and a section of reduced thickness to permit flexing of the spacer link thereat to facilitate stacking of the spacer links when the carriers are bunched.
摘要翻译: 公开了一种用于垂直百叶窗的单件式单片叶片载体。 单一载体包括载体主体和从主体的一端延伸的细长的间隔件连接件,间隔件连接件和主体形成单一的整体件。 在所公开的实施例中,突片设置在间隔连杆的远端处,并且开槽开口位于载体主体的与间隔件连杆从该端延伸的端部相对的端部。 在该实施例中,一个载体的突片与相邻定位的载体的开槽开口配合以限制两个载体之间的最大间距。 间隔连接件从承载体的一端的顶部延伸,而开槽的开口相对地位于另一端的顶部,使得一个载体的间隔连接件能够通过相邻载体的开槽开口滑动。 同样在所公开的实施例中,间隔连接件包括宽度减小的部分,以便于将间隔件连接件插入和移出相邻承载件的开槽开口和从相邻承载件的开槽开口的部分以及减小厚度的部分,以允许间隔件链节在其上弯曲以促进 当载体聚束时,间隔链节的堆叠。
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