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1.发明授权Method of screening inhibitors of mevalonate-independent isoprenoid biosynthetic pathway 有权筛选甲羟戊酸依赖型异戊二烯生物合成途径抑制剂的方法公开(公告)号：US07286973B1
公开(公告)日：2007-10-23
申请号：US10240636
申请日：2001-05-03
CPC分类号： C12N9/1205 , C40B30/02 , G06F19/16 , G06F19/706 , Y02A90/26
摘要： The present invention provides the structure of the enzyme 4-diphosphocytidyl-2-C-methylerythritol (CDP-ME) synthase, a member of the cytidyltransferase family of enzymes from Escherichia coli. CDP-ME is a critical intermediate in the mevalonate-independent pathway for isoprenoid biosynthesis in a number of prokaryotic organisms, in algae, in the plastids of plants, and in the malaria parasite. Since vertebrates synthesize isoprenoid precursors using a mevalonate pathway, CDP-ME synthase and other enzymes of the mevalonate-independent pathway for isoprenoid production represent attractive targets for the structure-based design of selective antibacterial, herbicidal, and antimalarial drugs. Accordingly, the present invention provides methods for screening for compounds that inhibit enzymes of the mevalonate-independent pathway and pharmaceutical compositions and antibacterial formulations thereof. Further provided are methods of inhibiting the enzymes of the pathway and bacterial terpenoid synthesis and methods for treating a subject suffering from a bacterial infection.
摘要翻译： 本发明提供了来自大肠杆菌的酶的β-二磷酸胞苷基-2-C-甲基赤藓糖醇（CDP-ME）合酶的细胞质转移酶家族的成员的结构。 CDP-ME是许多原核生物，藻类，植物质体和疟疾寄生虫中异戊二烯生物合成中甲羟甲酸非依赖途径的关键中间体。 由于脊椎动物使用甲羟戊酸途径合成类异戊二烯前体，所以CDP-ME合酶和甲醛酸非依赖性途径用于类异戊二烯生产的其它酶代表了选择性抗菌，除草和抗疟药物基于结构的设计的有吸引力的目标。 因此，本发明提供了筛选抑制甲羟戊酸依赖性途径的酶的化合物的方法及其药物组合物及其抗菌制剂。 还提供了抑制途径的酶和细菌萜类化合物合成的方法以及治疗患有细菌感染的受试者的方法。
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2.发明授权Metabolic engineering of lipid metabolism by improving fatty acid binding and transport 有权通过改善脂肪酸结合和转运来代谢脂质代谢工程公开(公告)号：US08252973B2
公开(公告)日：2012-08-28
申请号：US13107558
申请日：2011-05-13
IPC分类号： C12N15/82
CPC分类号： C12N9/90 , C12N15/8247
摘要： CHI like fatty acid binding proteins and genes, recombinant cells and organisms, methods of metabolic pathway engineering to improve lipid production in cells, Crystal structures of CHI like fatty acid binding proteins, methods of engineering CHI like fatty acid binding proteins and systems thereof are provided.
摘要翻译： CHI如脂肪酸结合蛋白和基因，重组细胞和生物体，代谢途径工程方法，以改善细胞中的脂质生成，提供CHI类脂肪酸结合蛋白的晶体结构，工程化CHI如脂肪酸结合蛋白的方法及其系统 。
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3.发明申请METABOLIC ENGINEERING OF LIPID METABOLISM BY IMPROVING FATTY ACID BINDING AND TRANSPORT 有权通过改善脂肪酸结合和运输来代谢脂肪代谢的代谢工程公开(公告)号：US20110223667A1
公开(公告)日：2011-09-15
申请号：US13107558
申请日：2011-05-13
IPC分类号： C12N5/10
CPC分类号： C12N9/90 , C12N15/8247
摘要： CHI like fatty acid binding proteins and genes, recombinant cells and organisms, methods of metabolic pathway engineering to improve lipid production in cells, Crystal structures of CHI like fatty acid binding proteins, methods of engineering CHI like fatty acid binding proteins and systems thereof are provided.
摘要翻译： CHI如脂肪酸结合蛋白和基因，重组细胞和生物体，代谢途径工程方法，以改善细胞中的脂质生成，提供CHI类脂肪酸结合蛋白的晶体结构，工程化CHI如脂肪酸结合蛋白的方法及其系统 。
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4.发明申请Metabolic engineering of lipid metabolism by improving fatty acid binding and transport 审中-公开通过改善脂肪酸结合和转运来代谢脂质代谢工程公开(公告)号：US20090158468A1
公开(公告)日：2009-06-18
申请号：US11879026
申请日：2007-07-13
CPC分类号： C12N9/90 , C12N15/8247
摘要： CHI like fatty acid binding proteins and genes, recombinant cells and organisms, methods of metabolic pathway engineering to improve lipid production in cells, Crystal structures of CHI like fatty acid binding proteins, methods of engineering CHI like fatty acid binding proteins and systems thereof are provided.
摘要翻译： CHI如脂肪酸结合蛋白和基因，重组细胞和生物体，代谢途径工程方法，以改善细胞中的脂质生成，提供CHI类脂肪酸结合蛋白的晶体结构，工程化CHI如脂肪酸结合蛋白的方法及其系统 。
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5.发明授权Lighting and/or indicating device equipped with a device for regulating the luminous flux for a halogen bulb 失效配备有用于调节卤素灯泡的光通量的装置的照明和/或指示装置公开(公告)号：US08760070B2
公开(公告)日：2014-06-24
申请号：US11048537
申请日：2005-02-01
申请人： Loic Flandre , Stephane Richard
发明人： Loic Flandre , Stephane Richard
IPC分类号： H05B41/16
CPC分类号： H05B39/047 , B60Q1/0094 , B60Q1/143 , F21S41/17 , Y02B20/144
摘要： The present invention relates to a lighting and/or indicating device, such as a vehicle headlamp, equipped with at least one halogen bulb, wherein it comprises a switch-mode power supply device for supplying power to the halogen bulb, said switch-mode power supply device comprising means for regulating the luminous flux provided by the halogen bulb and being installed close to the halogen bulb so as to minimize electromagnetic interference and dispersion of the supply voltage at the terminals of the halogen bulb.
摘要翻译： 本发明涉及一种配备有至少一个卤素灯泡的照明和/或指示装置，例如车辆前照灯，其中包括用于向卤素灯泡供电的开关模式电源装置，所述开关模式电源 供给装置包括用于调节由卤素灯泡提供的光通量并且安装在卤素灯泡附近的装置，以便使卤素灯泡的端子处的电磁干扰和电源电压的分散最小化。
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6.发明申请Lighting and/or indicating device equipped with a device for regulating the luminous flux for a halogen bulb 失效配备有用于调节卤素灯泡的光通量的装置的照明和/或指示装置公开(公告)号：US20050169005A1
公开(公告)日：2005-08-04
申请号：US11048537
申请日：2005-02-01
申请人： Loic Flandre , Stephane Richard
发明人： Loic Flandre , Stephane Richard
CPC分类号： H05B39/047 , B60Q1/0094 , B60Q1/143 , F21S41/17 , Y02B20/144
摘要： The present invention relates to a lighting and/or indicating device, such as a vehicle headlamp, equipped with at least one halogen bulb, wherein it comprises a switch-mode power supply device for supplying power to the halogen bulb, said switch-mode power supply device comprising means for regulating the luminous flux provided by the halogen bulb and being installed close to the halogen bulb so as to minimize electromagnetic interference and dispersion of the supply voltage at the terminals of the halogen bulb.
摘要翻译： 本发明涉及一种配备有至少一个卤素灯泡的照明和/或指示装置，例如车辆前照灯，其中包括用于向卤素灯泡供电的开关模式电源装置，所述开关模式电源 供给装置包括用于调节由卤素灯泡提供的光通量并且安装在卤素灯泡附近的装置，以便使卤素灯泡的端子处的电磁干扰和电源电压的分散最小化。
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公开(公告)号：US08419243B2
公开(公告)日：2013-04-16
申请号：US13007427
申请日：2011-01-14
申请人： Loic Flandre , Stephane Richard , Benjamin Touzet
发明人： Loic Flandre , Stephane Richard , Benjamin Touzet
IPC分类号： B60Q1/00
CPC分类号： H05B33/0848
摘要： The invention relates to a device for controlling diode lamps comprising a lighting module having at least one diode lamp, the diode lamp pertaining to a predefined range, at least one device for transmitting a unique signature representing the range, and an associated control module comprising reception means (for receiving a unique signature transmitted by the lighting module, and current adjustment means for adjusting and supplying, as a function of the transmitted signature, a current to said lighting module to cause the diode lamp to operate.
摘要翻译： 本发明涉及一种用于控制二极管灯的装置，其包括具有至少一个二极管灯的照明模块，属于预定范围的二极管灯，用于发送表示该范围的唯一签名的至少一个装置，以及包括接收的相关控制模块 用于接收由照明模块发送的唯一签名的装置，以及用于根据发送的签名调整和供应到所述照明模块以使二极管灯工作的电流的电流调节装置。
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公开(公告)号：US20070258256A1
公开(公告)日：2007-11-08
申请号：US11353333
申请日：2006-02-14
申请人： Stephane Richard , Vincent Bernard
发明人： Stephane Richard , Vincent Bernard
IPC分类号： B60Q1/00
CPC分类号： B60J3/0282
摘要： The present invention relates to an illumination device for vanity mirrors of motor vehicle sun visors. The illumination device does not use cables as conducting elements nor external mechanical elements such as switches, simplifying the assembly operations. A conducting laminar element performs all of these functions: in addition to being the conducting means it acts as a switch for the device. This device is actuated by a cover that covers the mirror and is operated at the user's will. The device is characterised in that it is only illuminated in one position, in which the cover is not covering the mirror and the visor is in a shading position.
摘要翻译： 本发明涉及一种汽车遮阳板的梳妆镜的照明装置。 照明装置不使用电缆作为导电元件，也不使用诸如开关的外部机械元件，从而简化组装操作。 导电层状元件执行所有这些功能：除了作为导电装置之外，它还用作器件的开关。 该装置由覆盖镜子的盖子驱动，并以用户的意愿操作。 该装置的特征在于它仅在一个位置被照亮，其中盖不覆盖反射镜并且遮阳板处于遮蔽位置。
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9.发明申请公开(公告)号：US20060148116A1
公开(公告)日：2006-07-06
申请号：US11286161
申请日：2005-11-22
IPC分类号： H01L21/00
CPC分类号： H05K1/148 , H05K1/0278 , H05K1/0366 , H05K1/056 , H05K1/181 , H05K2201/09036 , H05K2201/09745 , H05K2201/10106 , H05K2203/302
摘要： The present invention relates to a method of making supports for light emitting diodes, wherein rigid substrates are used as supports for light emitting diodes, it being proposed, in particular, to render the substrates more fragile in order to make certain zones of a lower layer of the said substrate more flexible so that the substrate is able to deform in the region of the zones thus made flexible, the deformation then taking place without causing the electrical conduction of a top layer, on which the diodes are disposed, to be broken. In one particular embodiment of the invention it is proposed to provide as many rigid substrate plates as there are support planes in the three-dimensional environment, and to connect these various substrate plates together by means of deformable conductive components disposed in accordance with surface mounted component technology
摘要翻译： 本发明涉及制造用于发光二极管的支撑体的方法，其中使用刚性基板作为发光二极管的支撑体，特别是提出了使基板更脆弱以便使下层的某些区域 所述基板更柔性，使得基板能够在由此制成的区域的区域中变形，从而发生变形，而不会导致其上设置二极管的顶层的导电被破坏。 在本发明的一个具体实施方案中，提出提供与三维环境中的支撑平面一样多的刚性基板，并且通过根据表面安装部件设置的可变形导电部件将这些各种基板连接在一起 技术
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公开(公告)号：US20120094386A1
公开(公告)日：2012-04-19
申请号：US13255878
申请日：2010-03-11
申请人： Michael Mendez , Su-Chiung Fang , Stephane Richard
发明人： Michael Mendez , Su-Chiung Fang , Stephane Richard
CPC分类号： C12N15/8273 , C12N1/36 , C12N9/0065 , C12N9/14 , C12N9/88 , C12N15/74 , C12Y306/01003 , C12Y402/03016 , C12Y402/0302
摘要： Provided herein are compositions and methods for engineering salt tolerance and producing products by photosynthetic organisms. The photosynthetic organisms can be genetically modified to be salt tolerant as compared to an unmodified organism and to produce useful products. The methods and compositions of the disclosure are useful in many therapeutic and industrial applications.
摘要翻译： 本文提供了通过光合生物工程耐盐性和产生产物的组合物和方法。 与未修饰的生物体相比，光合生物体可以进行遗传修饰以耐盐性，并产生有用的产物。 本公开的方法和组合物在许多治疗和工业应用中是有用的。
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