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公开(公告)号：US08552060B2
公开(公告)日：2013-10-08
申请号：US11922128
申请日：2006-06-13
申请人： Joseph Palumbo , Jonathan Sporn , Thomas Steckler , Yong Choi , James S. Lee
发明人： Joseph Palumbo , Jonathan Sporn , Thomas Steckler , Yong Choi , James S. Lee
IPC分类号： A61K31/24
CPC分类号： A61K31/165
摘要： This invention is directed to a method of treating sexual dysfunction in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, CI, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and O to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.
摘要翻译： 本发明涉及治疗受试者的性功能障碍的方法，其包括施用治疗有效量的式（I）化合物或其药学上可接受的盐或酯的步骤，其中Rx是选自下组的成员 由氢，1至8个碳原子的低级烷基，选自F，Cl，Br和I的卤素，含有1至3个碳原子的烷氧基，硝基，羟基，三氟甲基和含有1至3个碳原子的硫代烷氧基组成; x为1〜3的整数，条件是当x为2或3时R可以相同或不同; R 1和R 2可以相同或不同，并且独立地选自氢，1至8个碳原子的低级烷基，芳基，芳基烷基，3至7个碳原子的环烷基; R1和R2可以连接形成被选自氢，烷基和芳基的成员所取代的5至7元杂环，其中环状化合物可包含1至2个氮原子和0至1个氧原子 其中氮原子彼此不直接连接或与氧原子直接连接。
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公开(公告)号：US20090221553A1
公开(公告)日：2009-09-03
申请号：US11922128
申请日：2006-06-13
IPC分类号： A61K31/553 , A61K31/27 , A61K31/55 , A61P15/00
CPC分类号： A61K31/165
摘要： This invention is directed to a method of treating sexual dysfunction in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, CI, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and O to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.
摘要翻译： 本发明涉及治疗受试者的性功能障碍的方法，其包括施用治疗有效量的式（I）化合物或其药学上可接受的盐或酯的步骤，其中Rx是选自下组的成员 由氢，1至8个碳原子的低级烷基，选自F，Cl，Br和I的卤素，含有1至3个碳原子的烷氧基，硝基，羟基，三氟甲基和含有1至3个碳原子的硫代烷氧基组成; x为1〜3的整数，条件是当x为2或3时R可以相同或不同; R 1和R 2可以相同或不同，并且独立地选自氢，1至8个碳原子的低级烷基，芳基，芳基烷基，3至7个碳原子的环烷基; R1和R2可以连接形成被选自氢，烷基和芳基的成员所取代的5至7元杂环，其中环状化合物可包含1至2个氮原子和0至1个氧原子 其中氮原子彼此不直接连接或与氧原子直接连接。
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公开(公告)号：US20090312416A1
公开(公告)日：2009-12-17
申请号：US11921995
申请日：2006-06-07
CPC分类号： C07C271/12 , A61K9/0053 , A61K31/165 , A61K31/27
摘要： This invention is directed to a method of treating Excessive daytime Sleepiness (EDS) in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): Formula (I) or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the ox en atom.
摘要翻译： 本发明涉及一种治疗受试者过度白昼睡眠（EDS）的方法，包括施用治疗有效量的式（I）化合物：式（I）或其药学上可接受的盐或酯的步骤，其中 Rx是选自氢，1至8个碳原子的低级烷基，选自F，Cl，Br和I的卤素，含有1至3个碳原子的烷氧基，硝基，羟基，三氟甲基和含有1个 至3个碳原子; x为1〜3的整数，条件是当x为2或3时R可以相同或不同; R 1和R 2可以相同或不同，并且独立地选自氢，1至8个碳原子的低级烷基，芳基，芳基烷基，3至7个碳原子的环烷基; R1和R2可以连接形成被选自氢，烷基和芳基的成员取代的5至7元杂环，其中环状化合物可包含1至2个氮原子和0至1个氧原子 ，其中氮原子彼此不直接连接或与氧原子直接连接。
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公开(公告)号：US08440715B2
公开(公告)日：2013-05-14
申请号：US11921995
申请日：2006-06-07
CPC分类号： C07C271/12 , A61K9/0053 , A61K31/165 , A61K31/27
摘要： This invention is directed to a method of treating Excessive daytime Sleepiness (EDS) in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): Formula (I) or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the ox en atom.
摘要翻译： 本发明涉及一种治疗受试者过度白昼睡眠（EDS）的方法，包括施用治疗有效量的式（I）化合物：式（I）或其药学上可接受的盐或酯的步骤，其中 Rx是选自氢，1至8个碳原子的低级烷基，选自F，Cl，Br和I的卤素，含有1至3个碳原子的烷氧基，硝基，羟基，三氟甲基和含有1个 至3个碳原子; x为1〜3的整数，条件是当x为2或3时R可以相同或不同; R 1和R 2可以相同或不同，并且独立地选自氢，1至8个碳原子的低级烷基，芳基，芳基烷基，3至7个碳原子的环烷基; R1和R2可以连接形成被选自氢，烷基和芳基的成员取代的5至7元杂环，其中环状化合物可包含1至2个氮原子和0至1个氧原子 ，其中氮原子彼此不直接连接或与氧原子直接连接。
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公开(公告)号：US20170340951A1
公开(公告)日：2017-11-30
申请号：US15163168
申请日：2016-05-24
申请人： Joseph Palumbo
发明人： Joseph Palumbo
IPC分类号： A63B71/14 , A41D19/015
CPC分类号： A63B71/141 , A41D19/01523 , A63B71/143 , A63B2102/24
摘要： Here is disclosed a sports glove having a glove housing with four finger portions, a thumb portion, and a palm portion. The finger portions, thumb portion and palm portions of the glove housing each have an anterior surface with a series of flexible shock absorbing blocks formed thereon. The shock absorbing blocks are separated by gaps of less than 5 mm in width. The flexible shock absorbing blocks on the finger portions are divided by parallel upper and lower grooves formed along the anterior surface of the finger portions, the upper and lower grooves having a width of greater than 5 mm, the upper and lower grooves extending across each of the finger portions. An elongated palm groove is provided which extends across the anterior surface of the palm portion roughly parallel to the upper and lower grooves, the palm groove having a width of greater than 5 mm.
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公开(公告)号：US20050034408A1
公开(公告)日：2005-02-17
申请号：US10630389
申请日：2003-07-30
申请人： Joseph Palumbo , Frank DeFranscesco
发明人： Joseph Palumbo , Frank DeFranscesco
CPC分类号： E04B2/7457 , B65D2571/00111 , B65D2571/00925 , E04B2002/7488
摘要： A stud wall framing system having a number of studs, and a floor and a ceiling track that are marked at spaced intervals to indicate the location of the studs when erected.
摘要翻译： 具有多个螺柱的螺柱壁框架系统，以及以间隔的间隔标记的地板和天花板轨道，以指示竖立时螺柱的位置。
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